iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000037020.16	ENSMUST00000134570.7	ENSMUSP00000116139.1
ENSMUSG00000037020.16	ENSMUST00000145027.7	ENSMUSP00000116772.1
ENSMUSG00000037020.16	ENSMUST00000108190.7	ENSMUSP00000103825.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.60e-28	96.9	154	191
UBD/Beta-Prp	5.50e-53	181.2	492	745

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGs..dDgtikvWDlrtgv 34
           gH+ +v c+af ++ +++vs +  +D ++ vWD++++ 
   Q: 154  GHKYGVACVAFsPNmKHIVSMGyqHDMVLNVWDWKKDI 191
           89**********888*****9989*********98765 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk...ilvtgseDrtikvwdls.tgkcvhtlkgh 93
           +k+ ++++++spd+++la+g r+g +++++++ ++ l +++ h+aev ++++s+ +    +l+++s+Dr+i+v +++ ++   +tl  h
   Q: 492  MKAGVRVMQVSPDGQHLASGDRSGNLRIHELHFMDELIKVEAHDAEVLCLEYSKPETgvtLLASASRDRLIHVLNVEkNYNLEQTLDDH 580
           566788999******************************************9988878999************9999778888999*** PP
   S: 94   edsvlslsfspsg.dklvsGshdrtirvwdletgqclee.......tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl...ktgkl 171
           ++s+++++f  ++   ++s ++d+ i     ++ q  ++           ++ +   + ++ ++++++ ++ Dr vr+++    k++k+
   Q: 581  SSSITAIKFAGTRdVQMISCGADKSIYF---RSAQQASDglhfvrtHHVAEKTTLYDMDIDITQKYVAVACQDRNVRVYNTvsgKQKKC 666
           ***********7757899******9976...333333333444332112222233446777778***************9977788888 PP
   S: 172  lrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl 251
            +  +g +++s  ++ +d++g++l++   d+++ l d+ +gecv ++ gh++ v+ ++f+ +  +l+++s D  ++iW l
   Q: 667  YKGSQG-DEGSLLKVHVDPSGTFLATSCSDKSISLIDFYSGECVAKMFGHSEIVTGMKFTYDCRHLITVSGDSCVFIWHL 745
           888888.999999999**************************************************************43 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MMAALAAGGY TRSDTIEKLS SVMAGVPARR NQSSPPPAPP LCLRRRTRLA AAPEDTVQNR 60
VTLEKVLGIT AQNSSGLTCD PGTGHVAYLA GCVVVVLNPK ENKQQHIFNT TRKSLSALAF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTCCCGCG GCCATTCGCT ATTCGAGTGG GTGCTGGCTA CAGGCGGCTG TTAAGAAGCG 60
TAACGGACAC TGGTCTCCGA CAGCATGATG GCTGCCTTAG CGGCCGGAGG TTATACGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
IPR030545--WDR62

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005634--C:nucleus
GO:0000922--C:spindle pole
GO:0007099--P:centriole replication
GO:0021987--P:cerebral cortex development
GO:0007052--P:mitotic spindle organization
GO:0022008--P:neurogenesis

KEGG

mmu:233064

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001371	Ailuropoda melanoleuca	74.62	0.00e+00	2172.00
IUUC-Aca-004935	Anolis carolinensis	71.19	0.00e+00	1004.00
IUUC-Afl-008426	Aspergillus flavus	23.18	1.00e-28	122.00
IUUC-Afu-008757	Aspergillus fumigatus	21.90	4.00e-28	120.00
IUUC-Aor-009966	Aspergillus oryzae	23.18	1.00e-28	122.00
IUUC-Bta-013336	Bos taurus	73.22	0.00e+00	2064.00
IUUC-Cja-019094	Callithrix jacchus	73.99	0.00e+00	2113.00
IUUC-Cfa-020529	Canis familiaris	75.08	0.00e+00	2185.00
IUUC-Cpo-021970	Cavia porcellus	83.50	0.00e+00	1613.00
IUUC-Csa-024161	Chlorocebus sabaeus	74.49	0.00e+00	2104.00
IUUC-Cho-024310	Choloepus hoffmanni	79.32	0.00e+00	1101.00
IUUC-Cgl-026454	Colletotrichum gloeosporioides	23.80	2.00e-24	108.00
IUUC-Dno-029933	Dasypus novemcinctus	71.81	0.00e+00	2006.00
IUUC-Dor-031147	Dipodomys ordii	73.10	0.00e+00	2005.00
IUUC-Dse-031501	Dothistroma septosporum	23.82	3.00e-35	144.00
IUUC-Eca-033675	Equus caballus	75.03	0.00e+00	2124.00
IUUC-Fca-035826	Felis catus	74.74	0.00e+00	2231.00
IUUC-Fso-038440	Fusarium solani	23.91	4.00e-35	144.00
IUUC-Gma-043644	Glycine max	31.20	2.00e-101	364.00
IUUC-Ggo-045152	Gorilla gorilla	75.45	0.00e+00	2093.00
IUUC-Hsa-045891	Homo sapiens	75.26	0.00e+00	2111.00
IUUC-Itr-048019	Ictidomys tridecemlineatus	90.27	0.00e+00	1521.00
IUUC-Lch-049669	Latimeria chalumnae	56.92	0.00e+00	1006.00
IUUC-Loc-052488	Lepisosteus oculatus	60.26	0.00e+00	1023.00
IUUC-Laf-053992	Loxodonta africana	76.22	0.00e+00	2171.00
IUUC-Mcc-054994	Macaca mulatta	75.70	0.00e+00	2090.00
IUUC-Meu-056815	Macropus eugenii	79.37	0.00e+00	1386.00
IUUC-Mmr-060693	Microcebus murinus	73.93	0.00e+00	2032.00
IUUC-Mdo-063007	Monodelphis domestica	73.19	0.00e+00	1588.00
IUUC-Mpu-066532	Mustela putorius furo	75.02	0.00e+00	2224.00
IUUC-Mlu-066982	Myotis lucifugus	73.17	0.00e+00	2008.00
IUUC-Nle-070042	Nomascus leucogenys	81.09	0.00e+00	1859.00
IUUC-Opr-070397	Ochotona princeps	73.51	0.00e+00	2145.00
IUUC-Ocu-074274	Oryctolagus cuniculus	73.89	0.00e+00	2056.00
IUUC-Oga-088577	Otolemur garnettii	74.68	0.00e+00	2149.00
IUUC-Oar-090117	Ovis aries	72.60	0.00e+00	2016.00
IUUC-Ptr-090553	Pan troglodytes	75.51	0.00e+00	2138.00
IUUC-Pan-092559	Papio anubis	64.49	0.00e+00	944.00
IUUC-Psi-093710	Pelodiscus sinensis	64.35	0.00e+00	1388.00
IUUC-Pab-098510	Pongo abelii	74.82	0.00e+00	2034.00
IUUC-Pop-099155	Populus trichocarpa	32.42	2.00e-99	357.00
IUUC-Pca-100323	Procavia capensis	67.46	0.00e+00	1272.00
IUUC-Pva-102895	Pteropus vampyrus	75.03	0.00e+00	2158.00
IUUC-Rno-105598	Rattus norvegicus	90.86	0.00e+00	2644.00
IUUC-Sha-107013	Sarcophilus harrisii	63.77	0.00e+00	1717.00
IUUC-Smo-109134	Selaginella moellendorffii	37.34	3.00e-136	480.00
IUUC-Sar-113261	Sorex araneus	70.14	0.00e+00	1961.00
IUUC-Ssc-115317	Sus scrofa	74.70	0.00e+00	2088.00
IUUC-Tsy-118799	Tarsius syrichta	88.18	0.00e+00	837.00
IUUC-Tni-120316	Tetraodon nigroviridis	56.64	0.00e+00	789.00
IUUC-Tca-121475	Theobroma cacao	30.30	6.00e-96	346.00
IUUC-Tre-122008	Trichoderma reesei	23.86	2.00e-32	135.00
IUUC-Tvi-122281	Trichoderma virens	23.96	2.00e-31	131.00
IUUC-Tbe-127555	Tupaia belangeri	89.40	0.00e+00	979.00
IUUC-Ttr-128722	Tursiops truncatus	72.04	0.00e+00	2061.00
IUUC-Vda-129957	Verticillium dahliae	24.02	2.00e-31	131.00
IUUC-Vpa-130392	Vicugna pacos	62.83	1.00e-97	350.00
IUUC-Vvi-131035	Vitis vinifera	33.56	2.00e-106	380.00
IUUC-Xtr-131789	Xenopus tropicalis	59.41	0.00e+00	976.00
IUUC-Yli-134437	Yarrowia lipolytica	26.42	4.00e-17	84.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence