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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045894
UUCD1 version UUC-HoS-01249
Ensembl Protein ID ENSP00000264515.6
UniProt Accession Q15291; A8K272; Q7Z6D8; Q8NDZ7; RBBP5_HUMAN
Genbank Protein ID CAA59446.1; BAF82826.1; CAI15286.1; CAI15286.1; CAI15287.1; CAI15287.1; EAW91537.1; EAW91538.1; AAH37284.1; AAH53856.1; AAH75059.1; AAH75060.1
Protein Name Retinoblastoma-binding protein 5; Retinoblastoma-binding protein RBQ-3
Genbank Nucleotide ID X85134; AK290137; AL583832; AC093422; AL583832; AC093422; CH471067; CH471067; BC037284; BC053856; BC075059; BC075060
Gene Name RBBP5; RBQ3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000117222.13 ENST00000264515.10 ENSP00000264515.6
ENSG00000117222.13 ENST00000367164.1 ENSP00000356132.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD WD_repeat 17588513
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.20e-11 44.7 65 102
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H  +v++l++  d + lvs+s D+ +  WD+ +g++ +
   Q: 65   HIHPVCSLCWsRDgHKLVSASTDNIVSQWDVLSGDCDQ 102
           889********88799*******************976 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
 In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.
Protein Sequence
(Fasta)
MNLELLESFG QNYPEEADGT LDCISMALTC TFNRWGTLLA VGCNDGRIVI WDFLTRGIAK 60
IISAHIHPVC SLCWSRDGHK LVSASTDNIV SQWDVLSGDC DQRFRFPSPI LKVQYHPRDQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045894|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGGGCCTT CTAAGGCCGA AAGTCTTCGG AGCTTGCGCC AGTCTCTTCG CGGCGTCCAC 60
CACTTAGACG CAAGTTGCTG AAGCCGGCCG GGGAGAAGGT GTTGTTGCCG GAGCTGAGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045894|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0071339--C:MLL1 complex
GO:0044666--C:MLL3/4 complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048188--C:Set1C/COMPASS complex
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0035064--F:methylated histone binding
GO:0044212--F:transcription regulatory region DNA binding
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0006974--P:cellular response to DNA damage stimulus
GO:0051568--P:histone H3-K4 methylation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0043627--P:response to estrogen
GO:0006351--P:transcription, DNA-templated
KEGG hsa:5929
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000616 Aegilops tauschii 35.67 7.00e-64 238.00
IUUC-Aml-002118 Ailuropoda melanoleuca 98.32 0.00e+00 1017.00
IUUC-Atr-002777 Amborella trichopoda 36.19 2.00e-61 229.00
IUUC-Apl-004056 Anas platyrhynchos 97.20 0.00e+00 1009.00
IUUC-Aca-004999 Anolis carolinensis 96.44 0.00e+00 978.00
IUUC-Aly-006092 Arabidopsis lyrata 35.22 2.00e-56 213.00
IUUC-Ath-006947 Arabidopsis thaliana 33.09 2.00e-58 220.00
IUUC-Ago-007753 Ashbya gossypii 31.47 9.00e-39 154.00
IUUC-Acl-008105 Aspergillus clavatus 32.89 2.00e-47 183.00
IUUC-Afl-008633 Aspergillus flavus 32.72 1.00e-46 180.00
IUUC-Afu-009075 Aspergillus fumigatus 35.98 1.00e-30 127.00
IUUC-Ani-009233 Aspergillus nidulans 33.78 8.00e-57 214.00
IUUC-Ang-009695 Aspergillus niger 33.49 1.00e-46 181.00
IUUC-Aor-009988 Aspergillus oryzae 32.72 1.00e-46 180.00
IUUC-Ate-010313 Aspergillus terreus 31.99 4.00e-46 179.00
IUUC-Ame-011134 Astyanax mexicanus 80.04 0.00e+00 796.00
IUUC-Bgr-012302 Blumeria graminis 32.48 4.00e-47 182.00
IUUC-Bta-012946 Bos taurus 100.00 0.00e+00 1046.00
IUUC-Bci-013968 Botrytis cinerea 35.21 1.00e-54 207.00
IUUC-Bdi-014387 Brachypodium distachyon 36.78 4.00e-71 262.00
IUUC-Bra-017414 Brassica rapa 36.75 1.00e-58 221.00
IUUC-Cel-018610 Caenorhabditis elegans 42.13 5.00e-83 301.00
IUUC-Cja-019938 Callithrix jacchus 100.00 0.00e+00 1032.00
IUUC-Cfa-020726 Canis familiaris 97.78 0.00e+00 1026.00
IUUC-Cpo-021560 Cavia porcellus 100.00 0.00e+00 646.00
IUUC-Cre-022588 Chlamydomonas reinhardtii 50.43 3.00e-29 122.00
IUUC-Csa-024192 Chlorocebus sabaeus 100.00 0.00e+00 1046.00
IUUC-Cho-024355 Choloepus hoffmanni 100.00 0.00e+00 902.00
IUUC-Cin-025285 Ciona intestinalis 67.28 0.00e+00 632.00
IUUC-Csv-026366 Ciona savignyi 66.32 3.00e-173 601.00
IUUC-Cgl-026450 Colletotrichum gloeosporioides 30.95 9.00e-43 167.00
IUUC-Cne-027092 Cryptococcus neoformans 31.27 2.00e-47 183.00
IUUC-Cme-027137 Cyanidioschyzon merolae 32.54 6.00e-26 112.00
IUUC-Dre-027374 Danio rerio 90.41 0.00e+00 862.00
IUUC-Dno-030003 Dasypus novemcinctus 93.87 0.00e+00 945.00
IUUC-Dor-030355 Dipodomys ordii 98.70 0.00e+00 1033.00
IUUC-Dse-031442 Dothistroma septosporum 33.07 6.00e-50 191.00
IUUC-Dme-031932 Drosophila melanogaster 67.14 0.00e+00 682.00
IUUC-Ete-032858 Echinops telfairi 92.79 0.00e+00 784.00
IUUC-Eca-034217 Equus caballus 99.44 0.00e+00 1043.00
IUUC-Eeu-035024 Erinaceus europaeus 96.84 0.00e+00 1006.00
IUUC-Fca-035370 Felis catus 98.69 0.00e+00 1019.00
IUUC-Fal-036628 Ficedula albicollis 91.81 0.00e+00 813.00
IUUC-Fox-037739 Fusarium oxysporum 31.47 5.00e-46 178.00
IUUC-Fso-038094 Fusarium solani 31.65 3.00e-44 172.00
IUUC-Gmo-039088 Gadus morhua 89.13 0.00e+00 861.00
IUUC-Ggr-040063 Gaeumannomyces graminis 33.16 4.00e-54 205.00
IUUC-Gga-041160 Gallus gallus 97.40 0.00e+00 999.00
IUUC-Gac-041333 Gasterosteus aculeatus 90.55 0.00e+00 879.00
IUUC-Gma-043909 Glycine max 36.62 6.00e-65 241.00
IUUC-Ggo-044657 Gorilla gorilla 100.00 0.00e+00 1046.00
IUUC-Hvu-047662 Hordeum vulgare 34.71 2.00e-64 240.00
IUUC-Itr-048125 Ictidomys tridecemlineatus 99.42 0.00e+00 988.00
IUUC-Kpa-049095 Komagataella pastoris 29.58 3.00e-37 149.00
IUUC-Lch-049495 Latimeria chalumnae 69.33 0.00e+00 632.00
IUUC-Lpe-051038 Leersia perrieri 34.21 2.00e-60 226.00
IUUC-Loc-052680 Lepisosteus oculatus 91.60 0.00e+00 949.00
IUUC-Laf-053717 Loxodonta africana 99.43 0.00e+00 1017.00
IUUC-Mcc-055007 Macaca mulatta 96.95 0.00e+00 979.00
IUUC-Meu-056494 Macropus eugenii 96.76 2.00e-132 466.00
IUUC-Mor-057173 Magnaporthe oryzae 33.43 3.00e-54 206.00
IUUC-Mpo-057622 Magnaporthe poae 32.01 5.00e-54 205.00
IUUC-Mtr-057672 Medicago truncatula 37.82 1.00e-70 260.00
IUUC-Mla-059057 Melampsora laricipopulina 34.45 1.00e-47 184.00
IUUC-Mga-060037 Meleagris gallopavo 96.84 0.00e+00 1006.00
IUUC-Mvi-060321 Microbotryum violaceum 33.50 3.00e-51 196.00
IUUC-Mmr-060755 Microcebus murinus 98.67 0.00e+00 1004.00
IUUC-Mdo-061859 Monodelphis domestica 98.51 0.00e+00 1017.00
IUUC-Mmu-063755 Mus musculus 99.07 0.00e+00 1036.00
IUUC-Mac-065292 Musa acuminata 35.19 1.00e-72 268.00
IUUC-Mpu-065896 Mustela putorius furo 99.80 0.00e+00 953.00
IUUC-Mlu-067927 Myotis lucifugus 99.44 0.00e+00 1032.00
IUUC-Nfi-068429 Neosartorya fischeri 32.66 3.00e-48 186.00
IUUC-Ncr-068738 Neurospora crassa 32.06 5.00e-48 185.00
IUUC-Nle-069608 Nomascus leucogenys 100.00 0.00e+00 1046.00
IUUC-Opr-070319 Ochotona princeps 99.06 0.00e+00 1023.00
IUUC-Ont-071451 Oreochromis niloticus 91.39 0.00e+00 902.00
IUUC-Oan-073445 Ornithorhynchus anatinus 97.83 0.00e+00 852.00
IUUC-Ocu-074341 Oryctolagus cuniculus 99.81 0.00e+00 1043.00
IUUC-Oba-075664 Oryza barthii 34.80 4.00e-65 242.00
IUUC-Obr-076630 Oryza brachyantha 34.15 3.00e-61 229.00
IUUC-Ogl-077847 Oryza glaberrima 34.68 8.00e-65 241.00
IUUC-Ogu-077970 Oryza glumaepatula 36.02 4.00e-63 235.00
IUUC-Oin-079374 Oryza indica 34.62 5.00e-65 242.00
IUUC-Olo-080992 Oryza longistaminata 34.62 9.00e-65 241.00
IUUC-Ome-081683 Oryza meridionalis 36.30 4.00e-62 232.00
IUUC-Oni-082594 Oryza nivara 34.62 5.00e-65 242.00
IUUC-Opu-083907 Oryza punctata 35.20 5.00e-66 245.00
IUUC-Oru-084400 Oryza rufipogon 34.62 6.00e-65 241.00
IUUC-Osa-085442 Oryza sativa 34.62 6.00e-65 241.00
IUUC-Ola-086569 Oryzias latipes 90.91 0.00e+00 826.00
IUUC-Oga-088947 Otolemur garnettii 92.12 0.00e+00 937.00
IUUC-Oar-090358 Ovis aries 98.32 0.00e+00 1017.00
IUUC-Ptr-091601 Pan troglodytes 100.00 0.00e+00 1030.00
IUUC-Pan-092466 Papio anubis 100.00 0.00e+00 1046.00
IUUC-Psi-093614 Pelodiscus sinensis 97.57 0.00e+00 1012.00
IUUC-Pma-094450 Petromyzon marinus 88.64 0.00e+00 763.00
IUUC-Pno-094819 Phaeosphaeria nodorum 33.41 2.00e-48 187.00
IUUC-Ppa-095157 Physcomitrella patens 34.74 4.00e-27 115.00
IUUC-Pfo-096312 Poecilia formosa 90.08 0.00e+00 872.00
IUUC-Pab-098058 Pongo abelii 100.00 0.00e+00 1046.00
IUUC-Pop-099039 Populus trichocarpa 37.34 4.00e-63 235.00
IUUC-Pca-100623 Procavia capensis 95.17 0.00e+00 987.00
IUUC-Ppe-102053 Prunus persica 37.82 4.00e-71 262.00
IUUC-Pva-102779 Pteropus vampyrus 96.47 0.00e+00 984.00
IUUC-Pgr-103398 Puccinia graminis 35.14 1.00e-51 197.00
IUUC-Ptt-103912 Puccinia triticina 35.31 4.00e-51 196.00
IUUC-Pte-104246 Pyrenophora teres 33.26 2.00e-49 189.00
IUUC-Pyt-104582 Pyrenophora triticirepentis 33.56 2.00e-49 190.00
IUUC-Rno-104838 Rattus norvegicus 99.26 0.00e+00 1037.00
IUUC-Sce-106229 Saccharomyces cerevisiae 30.97 3.00e-34 139.00
IUUC-Sha-106527 Sarcophilus harrisii 98.33 0.00e+00 1015.00
IUUC-Sja-107862 Schizosaccharomyces japonicus 34.47 3.00e-58 219.00
IUUC-Spo-108025 Schizosaccharomyces pombe 37.08 1.00e-55 210.00
IUUC-Ssl-108544 Sclerotinia sclerotiorum 34.72 2.00e-53 202.00
IUUC-Smo-109474 Selaginella moellendorffii 34.62 3.00e-52 199.00
IUUC-Sit-110687 Setaria italica 35.79 5.00e-57 215.00
IUUC-Sly-111597 Solanum lycopersicum 37.16 1.00e-62 234.00
IUUC-Stu-112389 Solanum tuberosum 36.49 4.00e-62 232.00
IUUC-Sar-113284 Sorex araneus 86.06 0.00e+00 861.00
IUUC-Sbi-114362 Sorghum bicolor 32.11 6.00e-57 215.00
IUUC-Sre-115146 Sporisorium reilianum 29.02 5.00e-36 145.00
IUUC-Ssc-115604 Sus scrofa 98.69 0.00e+00 1019.00
IUUC-Tgu-117010 Taeniopygia guttata 83.59 2.00e-77 281.00
IUUC-Tru-118258 Takifugu rubripes 89.80 0.00e+00 890.00
IUUC-Tsy-119169 Tarsius syrichta 87.37 0.00e+00 640.00
IUUC-Tni-119668 Tetraodon nigroviridis 89.22 0.00e+00 870.00
IUUC-Tca-121010 Theobroma cacao 37.77 2.00e-70 260.00
IUUC-Tre-121944 Trichoderma reesei 31.99 2.00e-45 176.00
IUUC-Tvi-122283 Trichoderma virens 32.32 7.00e-44 171.00
IUUC-Tur-126395 Triticum urartu 36.20 2.00e-65 243.00
IUUC-Tme-127150 Tuber melanosporum 36.69 2.00e-64 239.00
IUUC-Tbe-127745 Tupaia belangeri 81.29 2.00e-141 495.00
IUUC-Ttr-129187 Tursiops truncatus 94.24 0.00e+00 942.00
IUUC-Uma-129654 Ustilago maydis 28.26 9.00e-33 135.00
IUUC-Vda-129788 Verticillium dahliae 28.93 1.00e-46 180.00
IUUC-Vpa-130182 Vicugna pacos 99.50 0.00e+00 757.00
IUUC-Vvi-131557 Vitis vinifera 37.34 1.00e-70 260.00
IUUC-Xtr-132007 Xenopus tropicalis 92.39 0.00e+00 924.00
IUUC-Xma-133909 Xiphophorus maculatus 90.04 0.00e+00 888.00
IUUC-Yli-134524 Yarrowia lipolytica 36.65 9.00e-58 217.00
IUUC-Zma-134821 Zea mays 32.70 5.00e-59 222.00
Created Date 25-Jun-2017

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