iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020653

Ensembl Protein ID

ENSCAFP00000031812.2

UniProt Accession

E2QUA4; E2QUA4_CANLF

Genbank Protein ID

ENSCAFP00000031812

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AAEX03006856

Gene Name

URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000023618.2	ENSCAFT00000036436.2	ENSCAFP00000031812.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	42.42	6.00e-17	80.10	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Canis familiaris

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPLSVEVE FGGGAELLFD GVKKHQVTLP GQEEPWDIRS LLVWIKKNLL KERPELFIQG 60
DSVRPGILVL VNDADWELLG ELDYQLQDQD SILFISTLHG G 101

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Nucleotide Sequence
(Fasta)

ATGGCGGCGC CCTTGTCAGT GGAGGTGGAG TTCGGGTGAG TCACAGAGCT GGGGCGCCGT 60
GGGGATGGAT TGAAGTCGTC GGGCCCGGAG CTCCCCTCCC TCTGCTCTAG GCCCTGTCAC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016783--F:sulfurtransferase activity
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	97.03	3.00e-53	199.00
IUUC-Atr-003089	Amborella trichopoda	57.58	2.00e-30	122.00
IUUC-Apl-003382	Anas platyrhynchos	85.71	9.00e-43	164.00
IUUC-Aca-004981	Anolis carolinensis	81.19	1.00e-47	180.00
IUUC-Aly-005517	Arabidopsis lyrata	56.52	9.00e-28	114.00
IUUC-Ath-006718	Arabidopsis thaliana	57.14	2.00e-24	103.00
IUUC-Ago-007917	Ashbya gossypii	41.41	1.00e-19	87.40
IUUC-Acl-008054	Aspergillus clavatus	66.00	3.00e-15	72.40
IUUC-Afl-008704	Aspergillus flavus	55.06	9.00e-21	90.90
IUUC-Aor-009890	Aspergillus oryzae	57.43	3.00e-25	107.00
IUUC-Bta-012448	Bos taurus	99.01	7.00e-54	201.00
IUUC-Bci-013865	Botrytis cinerea	46.53	1.00e-21	94.40
IUUC-Bdi-014980	Brachypodium distachyon	61.04	5.00e-24	102.00
IUUC-Bol-016055	Brassica oleracea	56.25	6.00e-24	101.00
IUUC-Bra-016845	Brassica rapa	56.25	6.00e-24	101.00
IUUC-Cel-018485	Caenorhabditis elegans	33.98	1.00e-11	60.80
IUUC-Cja-019587	Callithrix jacchus	97.03	3.00e-53	199.00
IUUC-Cpo-021622	Cavia porcellus	97.03	3.00e-53	199.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	51.02	4.00e-25	105.00
IUUC-Csa-023756	Chlorocebus sabaeus	96.20	3.00e-40	156.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	45.54	5.00e-21	92.40
IUUC-Cne-026953	Cryptococcus neoformans	56.31	7.00e-28	115.00
IUUC-Cme-027314	Cyanidioschyzon merolae	43.75	5.00e-18	82.00
IUUC-Dre-027884	Danio rerio	76.24	2.00e-44	169.00
IUUC-Dno-029262	Dasypus novemcinctus	91.36	6.00e-39	152.00
IUUC-Dor-030601	Dipodomys ordii	64.36	2.00e-27	113.00
IUUC-Dme-031893	Drosophila melanogaster	60.78	6.00e-32	128.00
IUUC-Ete-032773	Echinops telfairi	91.09	1.00e-48	183.00
IUUC-Eca-034187	Equus caballus	98.02	2.00e-53	199.00
IUUC-Eeu-034808	Erinaceus europaeus	95.05	4.00e-52	195.00
IUUC-Fca-036107	Felis catus	97.03	4.00e-53	198.00
IUUC-Fal-036607	Ficedula albicollis	84.62	3.00e-42	162.00
IUUC-Fox-037698	Fusarium oxysporum	47.12	3.00e-23	99.80
IUUC-Gmo-039492	Gadus morhua	74.26	1.00e-43	167.00
IUUC-Ggr-039965	Gaeumannomyces graminis	48.08	1.00e-20	92.40
IUUC-Gga-041268	Gallus gallus	85.15	3.00e-48	182.00
IUUC-Gac-042111	Gasterosteus aculeatus	78.22	3.00e-46	176.00
IUUC-Gma-043240	Glycine max	53.57	7.00e-23	98.20
IUUC-Ggo-045176	Gorilla gorilla	93.67	4.00e-32	129.00
IUUC-Hsa-046077	Homo sapiens	94.06	6.00e-45	171.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	94.38	3.00e-38	149.00
IUUC-Kpa-049157	Komagataella pastoris	48.48	4.00e-20	89.00
IUUC-Lch-049889	Latimeria chalumnae	79.21	9.00e-46	174.00
IUUC-Lpe-050783	Leersia perrieri	55.42	1.00e-22	97.40
IUUC-Loc-052400	Lepisosteus oculatus	77.23	5.00e-45	171.00
IUUC-Lma-053259	Leptosphaeria maculans	45.54	5.00e-21	92.40
IUUC-Laf-053596	Loxodonta africana	94.17	2.00e-51	193.00
IUUC-Mcc-054845	Macaca mulatta	89.80	6.00e-47	177.00
IUUC-Meu-055968	Macropus eugenii	91.09	7.00e-51	191.00
IUUC-Mor-057126	Magnaporthe oryzae	44.23	2.00e-19	87.80
IUUC-Mpo-057311	Magnaporthe poae	49.50	8.00e-22	95.90
IUUC-Mtr-058266	Medicago truncatula	51.16	1.00e-22	97.80
IUUC-Mla-058847	Melampsora laricipopulina	40.78	3.00e-12	63.50
IUUC-Mga-059468	Meleagris gallopavo	85.71	7.00e-43	164.00
IUUC-Mvi-060235	Microbotryum violaceum	35.76	3.00e-19	87.40
IUUC-Mdo-061948	Monodelphis domestica	90.10	1.00e-50	190.00
IUUC-Mmu-063946	Mus musculus	95.05	4.00e-52	195.00
IUUC-Mac-064812	Musa acuminata	57.14	2.00e-24	103.00
IUUC-Mpu-066763	Mustela putorius furo	97.03	3.00e-52	196.00
IUUC-Mlu-066970	Myotis lucifugus	97.47	2.00e-40	156.00
IUUC-Ncr-068824	Neurospora crassa	44.55	8.00e-20	88.60
IUUC-Nle-069849	Nomascus leucogenys	94.94	9.00e-40	155.00
IUUC-Opr-070227	Ochotona princeps	97.03	3.00e-53	199.00
IUUC-Ont-072530	Oreochromis niloticus	79.21	4.00e-46	175.00
IUUC-Oan-073191	Ornithorhynchus anatinus	81.44	5.00e-42	161.00
IUUC-Ocu-074460	Oryctolagus cuniculus	97.96	3.00e-51	192.00
IUUC-Oba-075499	Oryza barthii	64.06	2.00e-22	97.80
IUUC-Obr-076896	Oryza brachyantha	55.00	1.00e-21	96.30
IUUC-Ogl-077834	Oryza glaberrima	64.06	6.00e-23	98.20
IUUC-Ogu-078622	Oryza glumaepatula	64.06	6.00e-23	98.20
IUUC-Oin-079358	Oryza indica	64.06	2.00e-22	98.60
IUUC-Olo-081035	Oryza longistaminata	49.51	2.00e-23	101.00
IUUC-Oni-082425	Oryza nivara	64.06	6.00e-23	98.20
IUUC-Opu-083461	Oryza punctata	63.49	4.00e-22	97.10
IUUC-Oru-084875	Oryza rufipogon	57.75	8.00e-21	91.30
IUUC-Oga-089128	Otolemur garnettii	97.03	3.00e-53	199.00
IUUC-Oar-089896	Ovis aries	99.01	7.00e-54	201.00
IUUC-Ptr-091618	Pan troglodytes	93.67	4.00e-32	130.00
IUUC-Pan-092238	Papio anubis	96.20	4.00e-40	156.00
IUUC-Psi-093879	Pelodiscus sinensis	83.17	2.00e-47	179.00
IUUC-Pma-094484	Petromyzon marinus	79.21	1.00e-35	140.00
IUUC-Ppa-095801	Physcomitrella patens	56.79	1.00e-22	97.40
IUUC-Pfo-097192	Poecilia formosa	80.20	4.00e-46	175.00
IUUC-Pab-098203	Pongo abelii	93.07	1.00e-44	170.00
IUUC-Pop-099614	Populus trichocarpa	57.14	7.00e-24	101.00
IUUC-Pca-100507	Procavia capensis	98.73	1.00e-40	157.00
IUUC-Ppe-101174	Prunus persica	55.56	1.00e-28	117.00
IUUC-Pva-102735	Pteropus vampyrus	95.05	2.00e-49	186.00
IUUC-Pgr-103510	Puccinia graminis	39.81	6.00e-12	62.80
IUUC-Ptt-103918	Puccinia triticina	35.92	4.00e-10	56.60
IUUC-Pte-104173	Pyrenophora teres	47.57	4.00e-23	99.40
IUUC-Pyt-104806	Pyrenophora triticirepentis	47.57	4.00e-23	99.40
IUUC-Rno-105820	Rattus norvegicus	96.04	2.00e-52	196.00
IUUC-Sce-106366	Saccharomyces cerevisiae	42.42	2.00e-17	80.10
IUUC-Sja-107727	Schizosaccharomyces japonicus	41.67	2.00e-16	77.00
IUUC-Spo-108074	Schizosaccharomyces pombe	40.82	4.00e-10	55.50
IUUC-Smo-108944	Selaginella moellendorffii	59.55	3.00e-26	109.00
IUUC-Sit-110277	Setaria italica	54.76	1.00e-23	100.00
IUUC-Sly-111505	Solanum lycopersicum	53.57	6.00e-24	101.00
IUUC-Stu-112076	Solanum tuberosum	54.76	2.00e-24	103.00
IUUC-Sbi-114274	Sorghum bicolor	59.74	3.00e-24	103.00
IUUC-Sre-114953	Sporisorium reilianum	57.84	1.00e-27	114.00
IUUC-Ssc-115418	Sus scrofa	96.04	8.00e-53	197.00
IUUC-Tgu-117311	Taeniopygia guttata	84.62	3.00e-42	162.00
IUUC-Tru-118598	Takifugu rubripes	80.90	2.00e-40	156.00
IUUC-Tni-120109	Tetraodon nigroviridis	76.47	5.00e-43	165.00
IUUC-Tca-120942	Theobroma cacao	55.42	2.00e-23	99.80
IUUC-Tre-122099	Trichoderma reesei	48.39	6.00e-16	75.10
IUUC-Tvi-122285	Trichoderma virens	51.92	7.00e-21	92.00
IUUC-Tae-125193	Triticum aestivum	55.42	5.00e-23	98.60
IUUC-Tur-126677	Triticum urartu	48.42	2.00e-20	90.50
IUUC-Tme-127120	Tuber melanosporum	48.08	3.00e-24	103.00
IUUC-Tbe-128050	Tupaia belangeri	70.30	1.00e-33	134.00
IUUC-Ttr-129019	Tursiops truncatus	94.06	7.00e-50	187.00
IUUC-Uma-129483	Ustilago maydis	54.90	4.00e-25	105.00
IUUC-Vda-129690	Verticillium dahliae	41.07	2.00e-16	77.40
IUUC-Vvi-131174	Vitis vinifera	59.04	2.00e-24	103.00
IUUC-Xma-133862	Xiphophorus maculatus	80.20	4.00e-46	175.00
IUUC-Yli-134398	Yarrowia lipolytica	46.46	4.00e-19	85.90
IUUC-Zma-134964	Zea mays	57.32	2.00e-22	97.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence