iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/ULP	1.70e-70	237.0	748	990

Active Site

Position(s)	Description	Evidence
847	N/A	{ECO:0000250}
979		{ECO:0000250}

Domain Profile

DUB/ULP

   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerr................rvktwtrkvdlfekd 74
            vtnedl+cLeegeflnDviidfylkyl+lek+++e ver hifssffyk+l++ke++                rv+twtr++++f+kd
   Q: 748  GVTNEDLECLEEGEFLNDVIIDFYLKYLLLEKASDELVERSHIFSSFFYKCLTRKENNltednpdlsvaqrrhrRVRTWTRHINIFNKD 836
           69******************************************************99******************************* PP
   S: 75   lifvpineaaHWslavvcf..............................................................kkksilll 101
           +ifvp+ne++HW+lav+cf                                                              k+++il+l
   Q: 837  YIFVPVNESSHWYLAVICFpwleeavyedfpqtvsqefqdqqsqhdnktidndphttstvftsaeesqstetsmsvpkkmcKRPCILIL 925
           ***************************************************************************************** PP
   S: 102  DSlrgasksnvvkklreylev..evkkkskrefskeklkgsnpkvpqQkNssDCGvyvlqyvesl 164
           DSl++as +n+v++lreylev  evk+k++refsk+++ + +pkvp+Q+NssDCGvy+lqyves+
   Q: 926  DSLKAASIQNTVQNLREYLEVewEVKRKTHREFSKTNMVDLCPKVPKQDNSSDCGVYLLQYVESF 990
           *********************999***************************************97 PP

Organism

Rattus norvegicus

Functional Description
(View)

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity).

Protein Sequence
(Fasta)

MDRARPGRRR ASSEIVTEGK RKKSSPADLQ KITKLLTVKS EDVLAQSPLP KLRGSECWWT 60
RSLRNKVICL DHKTTKAAHG CPPKALPKRH LKVMLTNVLW TDLGREFRKT LPRNDAKLCD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGCGACTA CTAGTGCGCA AGCGCGAATC CCACTTCTGG CTTTCTCTCT TCCCCTCCCC 60
CTCCCTTCCC CAGCCCGAGG GGTCCTGAGG TGACAGCGCC TGGAAGTGGG ACTGGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0008234--F:cysteine-type peptidase activity
GO:0004930--F:G-protein coupled receptor activity
GO:0007188--P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway

KEGG

rno:288167

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001517	Ailuropoda melanoleuca	73.10	0.00e+00	1456.00
IUUC-Atr-002817	Amborella trichopoda	31.73	2.00e-24	108.00
IUUC-Apl-003302	Anas platyrhynchos	43.03	0.00e+00	736.00
IUUC-Aca-005089	Anolis carolinensis	40.75	0.00e+00	679.00
IUUC-Aly-005759	Arabidopsis lyrata	27.48	2.00e-26	114.00
IUUC-Ath-006613	Arabidopsis thaliana	27.81	4.00e-28	119.00
IUUC-Ago-007729	Ashbya gossypii	26.67	4.00e-20	94.00
IUUC-Acl-008018	Aspergillus clavatus	40.52	1.00e-20	95.90
IUUC-Afl-008482	Aspergillus flavus	36.11	3.00e-20	94.70
IUUC-Afu-008974	Aspergillus fumigatus	32.00	1.00e-21	98.20
IUUC-Ani-009366	Aspergillus nidulans	38.98	6.00e-21	96.70
IUUC-Ate-010553	Aspergillus terreus	29.75	4.00e-21	97.40
IUUC-Ame-011446	Astyanax mexicanus	51.14	5.00e-102	364.00
IUUC-Bgr-012266	Blumeria graminis	29.58	3.00e-27	117.00
IUUC-Bta-012652	Bos taurus	70.38	0.00e+00	1365.00
IUUC-Bci-013906	Botrytis cinerea	39.01	2.00e-19	92.40
IUUC-Bdi-014139	Brachypodium distachyon	32.69	7.00e-26	112.00
IUUC-Bol-016126	Brassica oleracea	30.52	1.00e-25	112.00
IUUC-Bra-017420	Brassica rapa	29.47	3.00e-28	120.00
IUUC-Cja-018890	Callithrix jacchus	71.94	0.00e+00	1290.00
IUUC-Cfa-020923	Canis familiaris	72.24	0.00e+00	1419.00
IUUC-Cpo-022468	Cavia porcellus	68.06	0.00e+00	1182.00
IUUC-Csa-024235	Chlorocebus sabaeus	73.49	0.00e+00	1328.00
IUUC-Cho-024942	Choloepus hoffmanni	71.51	0.00e+00	769.00
IUUC-Cin-025522	Ciona intestinalis	41.38	4.00e-68	251.00
IUUC-Cgl-026623	Colletotrichum gloeosporioides	29.83	2.00e-26	114.00
IUUC-Dre-027818	Danio rerio	38.42	2.00e-106	380.00
IUUC-Dno-029935	Dasypus novemcinctus	55.58	7.00e-146	510.00
IUUC-Dor-030139	Dipodomys ordii	46.84	5.00e-96	345.00
IUUC-Dme-031729	Drosophila melanogaster	40.94	4.00e-56	212.00
IUUC-Ete-032892	Echinops telfairi	66.58	0.00e+00	921.00
IUUC-Eca-033398	Equus caballus	73.12	0.00e+00	1323.00
IUUC-Eeu-034595	Erinaceus europaeus	66.77	0.00e+00	1188.00
IUUC-Fca-036245	Felis catus	71.61	0.00e+00	1405.00
IUUC-Fal-036736	Ficedula albicollis	42.17	0.00e+00	665.00
IUUC-Fox-038045	Fusarium oxysporum	31.31	3.00e-28	120.00
IUUC-Fso-038416	Fusarium solani	32.76	5.00e-29	123.00
IUUC-Gmo-039168	Gadus morhua	52.38	6.00e-32	130.00
IUUC-Gga-040895	Gallus gallus	42.71	0.00e+00	690.00
IUUC-Gac-041712	Gasterosteus aculeatus	47.83	3.00e-79	287.00
IUUC-Gma-043078	Glycine max	32.23	1.00e-29	125.00
IUUC-Ggo-044423	Gorilla gorilla	72.27	0.00e+00	1419.00
IUUC-Hsa-046011	Homo sapiens	71.70	0.00e+00	1406.00
IUUC-Hvu-047202	Hordeum vulgare	30.14	8.00e-17	80.50
IUUC-Itr-048853	Ictidomys tridecemlineatus	71.77	0.00e+00	1439.00
IUUC-Lch-050229	Latimeria chalumnae	44.44	5.00e-116	411.00
IUUC-Loc-052810	Lepisosteus oculatus	41.32	2.00e-113	403.00
IUUC-Laf-053556	Loxodonta africana	72.98	0.00e+00	1316.00
IUUC-Mcc-055633	Macaca mulatta	71.77	0.00e+00	1424.00
IUUC-Mtr-058081	Medicago truncatula	29.64	2.00e-26	114.00
IUUC-Mga-059926	Meleagris gallopavo	42.41	0.00e+00	655.00
IUUC-Mmr-061064	Microcebus murinus	72.59	0.00e+00	1426.00
IUUC-Mdo-061950	Monodelphis domestica	55.76	0.00e+00	1073.00
IUUC-Mmu-063995	Mus musculus	88.82	0.00e+00	1718.00
IUUC-Mac-065083	Musa acuminata	30.19	6.00e-28	119.00
IUUC-Mpu-066660	Mustela putorius furo	72.48	0.00e+00	1454.00
IUUC-Mlu-067173	Myotis lucifugus	71.06	0.00e+00	1252.00
IUUC-Nfi-068345	Neosartorya fischeri	34.05	5.00e-22	100.00
IUUC-Nle-070111	Nomascus leucogenys	71.51	0.00e+00	1400.00
IUUC-Opr-070785	Ochotona princeps	53.65	0.00e+00	821.00
IUUC-Ont-072672	Oreochromis niloticus	47.92	2.00e-97	349.00
IUUC-Oan-073520	Ornithorhynchus anatinus	47.22	0.00e+00	801.00
IUUC-Ocu-074146	Oryctolagus cuniculus	68.38	0.00e+00	1182.00
IUUC-Obr-076515	Oryza brachyantha	32.04	8.00e-30	126.00
IUUC-Ogl-077267	Oryza glaberrima	32.04	5.00e-30	126.00
IUUC-Oin-080091	Oryza indica	31.39	3.00e-30	127.00
IUUC-Osa-086169	Oryza sativa	31.39	3.00e-30	127.00
IUUC-Olu-087762	Ostreococcus lucimarinus	29.01	6.00e-31	129.00
IUUC-Oga-088400	Otolemur garnettii	70.92	0.00e+00	1372.00
IUUC-Oar-090273	Ovis aries	70.28	0.00e+00	1387.00
IUUC-Ptr-090796	Pan troglodytes	71.96	0.00e+00	1413.00
IUUC-Pan-091782	Papio anubis	70.64	0.00e+00	1229.00
IUUC-Psi-093935	Pelodiscus sinensis	44.88	0.00e+00	673.00
IUUC-Pno-094801	Phaeosphaeria nodorum	36.76	8.00e-20	92.80
IUUC-Ppa-095571	Physcomitrella patens	29.52	3.00e-22	100.00
IUUC-Pfo-096792	Poecilia formosa	45.38	1.00e-87	318.00
IUUC-Pab-098505	Pongo abelii	70.16	0.00e+00	1386.00
IUUC-Pop-099422	Populus trichocarpa	32.13	2.00e-27	118.00
IUUC-Pca-100196	Procavia capensis	89.39	1.00e-137	484.00
IUUC-Ppe-101347	Prunus persica	28.90	1.00e-20	95.10
IUUC-Pva-102390	Pteropus vampyrus	68.35	0.00e+00	1260.00
IUUC-Pgr-103328	Puccinia graminis	24.68	1.00e-19	93.20
IUUC-Pte-104039	Pyrenophora teres	30.39	5.00e-17	84.00
IUUC-Sce-106359	Saccharomyces cerevisiae	25.34	2.00e-16	81.60
IUUC-Sha-107054	Sarcophilus harrisii	55.89	0.00e+00	979.00
IUUC-Sja-107700	Schizosaccharomyces japonicus	33.12	6.00e-35	142.00
IUUC-Spo-108052	Schizosaccharomyces pombe	34.41	4.00e-38	152.00
IUUC-Ssl-108654	Sclerotinia sclerotiorum	37.65	1.00e-12	68.60
IUUC-Smo-109565	Selaginella moellendorffii	29.51	3.00e-23	102.00
IUUC-Sit-110025	Setaria italica	31.91	1.00e-30	129.00
IUUC-Sly-111049	Solanum lycopersicum	30.03	5.00e-27	116.00
IUUC-Stu-111985	Solanum tuberosum	23.30	9.00e-11	62.00
IUUC-Sar-113324	Sorex araneus	87.90	0.00e+00	632.00
IUUC-Sre-115211	Sporisorium reilianum	36.59	3.00e-17	84.70
IUUC-Ssc-116333	Sus scrofa	70.77	0.00e+00	1410.00
IUUC-Tgu-116626	Taeniopygia guttata	56.22	1.00e-150	526.00
IUUC-Tsy-119022	Tarsius syrichta	69.21	0.00e+00	1285.00
IUUC-Tni-120181	Tetraodon nigroviridis	52.02	2.00e-52	198.00
IUUC-Tca-121862	Theobroma cacao	31.17	9.00e-22	99.40
IUUC-Tre-121879	Trichoderma reesei	30.23	7.00e-30	126.00
IUUC-Tvi-122488	Trichoderma virens	32.52	1.00e-30	129.00
IUUC-Tae-125285	Triticum aestivum	32.26	5.00e-31	130.00
IUUC-Tbe-127624	Tupaia belangeri	74.00	2.00e-144	506.00
IUUC-Ttr-129225	Tursiops truncatus	68.19	0.00e+00	1336.00
IUUC-Vda-129950	Verticillium dahliae	27.98	3.00e-23	104.00
IUUC-Vpa-130805	Vicugna pacos	72.57	0.00e+00	1369.00
IUUC-Xtr-132908	Xenopus tropicalis	57.78	4.00e-117	414.00
IUUC-Xma-133567	Xiphophorus maculatus	48.48	2.00e-95	342.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence