iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040635

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AADN04000390

Gene Name

USP5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000014525.5	ENSGALT00000023441.5	ENSGALP00000023395.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.40e-62	210.6	325	852
UBD/Alpha-Helix/UBA	1.10e-22	79.8	721	759

Active Site

Position(s)	Description	Evidence
334	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
815	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel..................wkskkkavspr 71
           tG++NlgN+CY+NSv+Q+L++ip++++ + + k ek+ +++p++p+++++++++kl + l                  +k+ ++ ++pr
   Q: 325  TGIRNLGNSCYLNSVMQVLFSIPDFQRKYVD-KLEKIFQSAPSDPTQDFSTQVAKLGHGLlsgeyskpasaegeqqpdQKGVQNGIAPR 412
           7******************************.99999999********************666666666555554333355566***** PP
   S: 72   ellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecd 160
           ++++ ++k ++efs+++qqDaqEf+ ++++ +e+++                             ++++  +++F++ +++++kcl+ +
   Q: 413  MFKALIGKGHPEFSTNRQQDAQEFFLHFINMVERNC-----------------------------RSSENPNEVFRFLVEEKLKCLATE 472
           ************************************.............................6788899***************** PP
   S: 161  nvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeaekklk 222
           +v+ ++   + ++lpvp++   +k                             +++cLe++ ++e++++   ++++  ++k+ a k+++
   Q: 473  KVKYTQRVDYIMQLPVPMDAALNKDelleyeekkrqaeeekqplpelvrakvPFSSCLEAYGAPEQVDD---FWSTALQAKSVALKTTR 558
           ******************998877799****************************************97...***************** PP
   S: 223  lkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............................................ 267
           + ++P++L++++k+f+f  + ++++k++ ++e+p+eLd+s    +                                            
   Q: 559  FASFPDYLVIQIKKFTFGLD-WVPKKLDVSIEMPEELDISALQGTglqdgeeempdiapplvtpdepkgslgfygnedddsfcsphfss 646
           *****************997.*******************8776677777777777777777777777777777777777777777777 PP
   S: 268  .............................................................................peekqke..... 274
                                                                                        +     +     
   Q: 647  ptspmldesviiqlvemgfpmdacrkavyytgnsgveaamnwvmshmddpdfanplvlpgssgpgstiacpdppsedS-----Vativs 730
           777666666666666666666666666666666666666666666666666666666666666666666655555550.....055555 PP
   S: 275  ................................................................kkkYeLiavvvHsG.slssGHYvay 298
                                                                           + kY+L+a ++H+G s+ +GHYv++
   Q: 731  mgfsrdqamkalratnnsleravdwifshiddldaeaamdisegrsaaesisesvpvgpkvrngPGKYQLFAFISHMGtSTMCGHYVCH 819
           5555555556666666666667777777777777777777777777777888888888888888************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 820  IKK-DGRWVIYNDQKVCAS--EKPPK---DLGYIYFYQR 852
           ***.9***********999..78888...89******98 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +ed ++ +v+MGF+r++a +aLra+nn+le+Av++++++
   Q: 721  SEDSVATIVSMGFSRDQAMKALRATNNSLERAVDWIFSH 759
           699**********************************97 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAELSEALLS VLPSIRVPKA GDRVHKDECA FSFDTPESDG GLYICMNTFL GFGKQYVEKH 60
YQKTGQRVYL HLKRTRKPKE EDANSSAGDP PRKKPTRLAI GVEGGFDITE EKFEYDEDVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGAGC TGAGCGAAGC GCTGCTCTCG GTGTTGCCGT CCATCCGGGT GCCTAAGGCC 60
GGCGACCGGG TCCATAAGGA CGAGTGCGCC TTCTCCTTCG ACACGCCGGT AAGCTCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

gga:418290

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	44.30	0.00e+00	660.00
IUUC-Aml-002104	Ailuropoda melanoleuca	91.05	0.00e+00	1547.00
IUUC-Atr-002580	Amborella trichopoda	46.15	0.00e+00	744.00
IUUC-Apl-003774	Anas platyrhynchos	98.90	0.00e+00	1658.00
IUUC-Aca-005368	Anolis carolinensis	91.81	0.00e+00	1609.00
IUUC-Aly-005727	Arabidopsis lyrata	47.26	0.00e+00	753.00
IUUC-Ath-006974	Arabidopsis thaliana	47.49	0.00e+00	754.00
IUUC-Ago-007890	Ashbya gossypii	28.64	8.00e-81	294.00
IUUC-Acl-008057	Aspergillus clavatus	34.11	5.00e-125	441.00
IUUC-Afl-008547	Aspergillus flavus	35.88	1.00e-116	413.00
IUUC-Afu-008805	Aspergillus fumigatus	34.65	2.00e-118	419.00
IUUC-Ani-009441	Aspergillus nidulans	33.16	3.00e-100	358.00
IUUC-Ang-009720	Aspergillus niger	33.91	7.00e-119	421.00
IUUC-Aor-010111	Aspergillus oryzae	33.88	4.00e-127	448.00
IUUC-Ate-010531	Aspergillus terreus	31.57	6.00e-105	375.00
IUUC-Ame-011893	Astyanax mexicanus	64.68	0.00e+00	1003.00
IUUC-Bgr-012183	Blumeria graminis	33.95	1.00e-123	437.00
IUUC-Bta-013179	Bos taurus	91.26	0.00e+00	1552.00
IUUC-Bci-013858	Botrytis cinerea	33.80	1.00e-129	457.00
IUUC-Bdi-014904	Brachypodium distachyon	47.31	0.00e+00	728.00
IUUC-Bol-015296	Brassica oleracea	47.66	0.00e+00	760.00
IUUC-Bra-017939	Brassica rapa	47.55	0.00e+00	763.00
IUUC-Cel-018625	Caenorhabditis elegans	35.17	4.00e-134	471.00
IUUC-Cja-019063	Callithrix jacchus	89.53	0.00e+00	1520.00
IUUC-Cfa-020976	Canis familiaris	88.67	0.00e+00	1497.00
IUUC-Cpo-022265	Cavia porcellus	88.33	0.00e+00	1487.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	38.95	1.00e-115	410.00
IUUC-Csa-024177	Chlorocebus sabaeus	87.69	0.00e+00	1360.00
IUUC-Cho-024702	Choloepus hoffmanni	85.44	0.00e+00	948.00
IUUC-Cin-025411	Ciona intestinalis	50.59	0.00e+00	840.00
IUUC-Csv-026347	Ciona savignyi	45.65	0.00e+00	795.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	34.53	3.00e-114	405.00
IUUC-Cne-026831	Cryptococcus neoformans	35.42	3.00e-130	458.00
IUUC-Dre-027982	Danio rerio	67.05	0.00e+00	1116.00
IUUC-Dno-029034	Dasypus novemcinctus	91.26	0.00e+00	1564.00
IUUC-Dor-030479	Dipodomys ordii	88.83	0.00e+00	679.00
IUUC-Dse-031467	Dothistroma septosporum	35.16	5.00e-132	465.00
IUUC-Dme-032075	Drosophila melanogaster	49.89	0.00e+00	816.00
IUUC-Ete-032865	Echinops telfairi	81.59	0.00e+00	1379.00
IUUC-Eca-034059	Equus caballus	91.43	0.00e+00	1561.00
IUUC-Eeu-035304	Erinaceus europaeus	86.19	0.00e+00	1419.00
IUUC-Fca-035515	Felis catus	91.15	0.00e+00	1553.00
IUUC-Fal-037271	Ficedula albicollis	95.56	0.00e+00	1554.00
IUUC-Fox-037745	Fusarium oxysporum	35.24	4.00e-128	452.00
IUUC-Fso-038158	Fusarium solani	35.01	4.00e-126	445.00
IUUC-Gmo-039071	Gadus morhua	64.76	0.00e+00	1087.00
IUUC-Ggr-040098	Gaeumannomyces graminis	32.83	4.00e-119	422.00
IUUC-Gac-042528	Gasterosteus aculeatus	64.07	0.00e+00	1093.00
IUUC-Gma-043614	Glycine max	46.74	0.00e+00	723.00
IUUC-Ggo-044602	Gorilla gorilla	91.03	0.00e+00	1548.00
IUUC-Hsa-045959	Homo sapiens	91.03	0.00e+00	1548.00
IUUC-Hvu-047563	Hordeum vulgare	47.80	6.00e-172	597.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	90.21	0.00e+00	1550.00
IUUC-Kpa-049156	Komagataella pastoris	33.60	2.00e-116	413.00
IUUC-Lch-049648	Latimeria chalumnae	81.66	0.00e+00	1395.00
IUUC-Lpe-051523	Leersia perrieri	46.88	0.00e+00	731.00
IUUC-Loc-052520	Lepisosteus oculatus	62.30	0.00e+00	1027.00
IUUC-Lma-053216	Leptosphaeria maculans	34.32	5.00e-116	413.00
IUUC-Laf-054327	Loxodonta africana	90.67	0.00e+00	1546.00
IUUC-Mcc-055443	Macaca mulatta	90.91	0.00e+00	1545.00
IUUC-Meu-056298	Macropus eugenii	90.80	0.00e+00	1036.00
IUUC-Mor-057106	Magnaporthe oryzae	35.95	4.00e-131	462.00
IUUC-Mpo-057589	Magnaporthe poae	33.84	5.00e-123	435.00
IUUC-Mtr-058680	Medicago truncatula	47.68	0.00e+00	736.00
IUUC-Mla-058903	Melampsora laricipopulina	32.20	1.00e-122	433.00
IUUC-Mga-059669	Meleagris gallopavo	98.78	0.00e+00	1658.00
IUUC-Mvi-060476	Microbotryum violaceum	34.96	3.00e-124	439.00
IUUC-Mmr-060575	Microcebus murinus	91.26	0.00e+00	1556.00
IUUC-Mdo-062183	Monodelphis domestica	89.37	0.00e+00	1493.00
IUUC-Mmu-063592	Mus musculus	91.38	0.00e+00	1556.00
IUUC-Mac-065634	Musa acuminata	43.33	0.00e+00	704.00
IUUC-Mpu-066082	Mustela putorius furo	88.19	0.00e+00	1486.00
IUUC-Mlu-067345	Myotis lucifugus	88.59	0.00e+00	1521.00
IUUC-Nfi-068558	Neosartorya fischeri	35.31	5.00e-127	448.00
IUUC-Ncr-068960	Neurospora crassa	34.76	9.00e-115	407.00
IUUC-Nle-070173	Nomascus leucogenys	88.31	0.00e+00	1488.00
IUUC-Opr-070556	Ochotona princeps	90.67	0.00e+00	1558.00
IUUC-Ont-071502	Oreochromis niloticus	64.42	0.00e+00	1094.00
IUUC-Ocu-074861	Oryctolagus cuniculus	88.19	0.00e+00	1504.00
IUUC-Oba-075109	Oryza barthii	47.07	0.00e+00	739.00
IUUC-Obr-076292	Oryza brachyantha	48.24	0.00e+00	737.00
IUUC-Ogl-077065	Oryza glaberrima	48.48	0.00e+00	770.00
IUUC-Ogu-078776	Oryza glumaepatula	47.30	0.00e+00	750.00
IUUC-Oin-080048	Oryza indica	48.24	0.00e+00	763.00
IUUC-Olo-080711	Oryza longistaminata	45.61	0.00e+00	681.00
IUUC-Ome-081506	Oryza meridionalis	46.68	0.00e+00	694.00
IUUC-Oni-082320	Oryza nivara	46.61	0.00e+00	736.00
IUUC-Opu-083801	Oryza punctata	47.18	0.00e+00	728.00
IUUC-Oru-085139	Oryza rufipogon	46.50	0.00e+00	741.00
IUUC-Osa-085713	Oryza sativa	48.59	0.00e+00	773.00
IUUC-Ola-086951	Oryzias latipes	64.88	0.00e+00	1085.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.11	2.00e-180	625.00
IUUC-Oga-088625	Otolemur garnettii	90.09	0.00e+00	1532.00
IUUC-Oar-089995	Ovis aries	88.71	0.00e+00	1526.00
IUUC-Ptr-090640	Pan troglodytes	88.78	0.00e+00	1544.00
IUUC-Pan-091974	Papio anubis	90.00	0.00e+00	1528.00
IUUC-Psi-093957	Pelodiscus sinensis	95.45	0.00e+00	1714.00
IUUC-Pma-094242	Petromyzon marinus	71.77	3.00e-170	590.00
IUUC-Pno-094835	Phaeosphaeria nodorum	34.36	8.00e-109	387.00
IUUC-Ppa-095901	Physcomitrella patens	48.79	0.00e+00	794.00
IUUC-Pfo-097148	Poecilia formosa	65.66	0.00e+00	1099.00
IUUC-Pab-098068	Pongo abelii	84.32	0.00e+00	1383.00
IUUC-Pop-098943	Populus trichocarpa	46.96	0.00e+00	731.00
IUUC-Pca-100738	Procavia capensis	83.83	0.00e+00	1397.00
IUUC-Pva-102154	Pteropus vampyrus	90.06	0.00e+00	1526.00
IUUC-Pgr-103343	Puccinia graminis	33.47	9.00e-108	384.00
IUUC-Ptt-103928	Puccinia triticina	30.14	4.00e-106	379.00
IUUC-Pte-104306	Pyrenophora teres	31.65	3.00e-104	372.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.37	4.00e-108	385.00
IUUC-Rno-105801	Rattus norvegicus	91.15	0.00e+00	1555.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.43	4.00e-74	272.00
IUUC-Sha-107635	Sarcophilus harrisii	88.90	0.00e+00	1494.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	30.96	1.00e-104	374.00
IUUC-Spo-108144	Schizosaccharomyces pombe	32.44	1.00e-114	406.00
IUUC-Smo-108848	Selaginella moellendorffii	47.23	0.00e+00	753.00
IUUC-Sit-110728	Setaria italica	47.78	0.00e+00	780.00
IUUC-Sly-111523	Solanum lycopersicum	47.63	0.00e+00	783.00
IUUC-Stu-112122	Solanum tuberosum	37.10	2.00e-09	56.20
IUUC-Sbi-114419	Sorghum bicolor	47.42	0.00e+00	766.00
IUUC-Sre-115225	Sporisorium reilianum	34.29	1.00e-123	437.00
IUUC-Ssc-115686	Sus scrofa	89.15	0.00e+00	1539.00
IUUC-Tgu-117346	Taeniopygia guttata	98.36	0.00e+00	1701.00
IUUC-Tru-118350	Takifugu rubripes	64.90	0.00e+00	1118.00
IUUC-Tni-120658	Tetraodon nigroviridis	66.20	0.00e+00	1105.00
IUUC-Tca-121585	Theobroma cacao	47.80	0.00e+00	743.00
IUUC-Tre-122043	Trichoderma reesei	34.19	6.00e-119	421.00
IUUC-Tvi-122303	Trichoderma virens	34.19	3.00e-122	432.00
IUUC-Tae-123798	Triticum aestivum	47.32	0.00e+00	748.00
IUUC-Tur-126732	Triticum urartu	44.71	0.00e+00	698.00
IUUC-Tme-126909	Tuber melanosporum	34.72	1.00e-118	420.00
IUUC-Tbe-127261	Tupaia belangeri	86.02	0.00e+00	988.00
IUUC-Uma-129599	Ustilago maydis	33.48	2.00e-131	463.00
IUUC-Vda-129688	Verticillium dahliae	33.53	4.00e-119	422.00
IUUC-Vvi-131116	Vitis vinifera	47.29	0.00e+00	719.00
IUUC-Xtr-131953	Xenopus tropicalis	79.70	0.00e+00	1387.00
IUUC-Xma-133837	Xiphophorus maculatus	65.77	0.00e+00	1101.00
IUUC-Yli-134510	Yarrowia lipolytica	35.53	5.00e-130	458.00
IUUC-Zma-135786	Zea mays	47.31	0.00e+00	734.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence