iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108144

UUCD1 version

UUC-ScP-00300

Ensembl Protein ID

SPBC6B1.06c.1:pep

UniProt Accession

Q11119; UBP14_SCHPO

Genbank Protein ID

CAA17049.1; BAA12032.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 14; Deubiquitinating enzyme 14; UBA domain-containing protein 2; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14

Genbank Nucleotide ID

CU329671; D83659

Gene Name

ubp14; ucp2; SPBC6B1.06c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC6B1.06c	SPBC6B1.06c.1	SPBC6B1.06c.1:pep

Annotation

mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	12672455

Classification

Family	E-value	Score	Start	End
DUB/USP	6.00e-52	174.9	300	773
UBD/Alpha-Helix/UBA	2.30e-19	67.0	578	617
UBD/ZnF/ZnF_UBP	2.30e-27	93.1	173	242

Active Site

Position(s)	Description	Evidence
309	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
730	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkk....................avspre 72
           tGlkNlgN+CY+ S++Q+L++i+e++   l+ ++ + n    ++p+++l ++l kl   l+++k +                       p +
   Q: 300  TGLKNLGNSCYLASTMQSLFSIKEFAIHELNLFN-TYNSV-CQTPTTDLQCQLGKLADGLVSGKFSkpskigllnnpsssilpyqdGLRPFM 389
           7*************************99999333.33333.36899**************74443334556677777777777777999999 PP
   S: 73   llkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvss 164
           +++++++ ++ef +++qqDa Efl +ll +++++                                k+ i+++F++++++++ cl+c++v  
   Q: 390  FKDVVGQGHSEFGTSQQQDAYEFLLYLLGKIRKSS-----------------------------IAKTDITKIFDFETEQKLSCLSCKRVRY 452
           *******************************9988.............................67889**********************9 PP
   S: 165  reepfldlslpvpgkeetkke........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrek 248
           +  + + l+l vp+ +  + e        s+++cL++  +++++e    y ce ck+k  a+ ++ +k++P+vLil+ +Rf  + ++++ +k
   Q: 453  SSFSSQGLTLTVPRVKIGEIEgeqiyeevSIDQCLDATIQPDQME----YTCEACKSKLGATTTTAMKSFPKVLILQANRF--DLQGYQVKK 538
           99999********7777766677777788***************9....********************************..777788889 PP
   S: 249  inkkvefple..Ldlspfcts....................................................................... 267
           ++  + +++    + ++ +++                                                                       
   Q: 539  LSIPIIVNEDgiYNFDRLMAKdhpndedylpektetiewnqsaieqlqamgfplvrcqrallatgnsdtetamnwlfehmedpeidkpievs 630
           99999888777578888888866666666666666666666666666666666666666666666665555555555555555555555555 PP
   S: 268  ........peekqke.....................................................................kkkYeLia 282
                   +     +                                                                     +++Y+L a
   Q: 631  ellpkadsS-----VseenvqslcefgftvaqarkgllesnnnieravdwilnhpdesfeepplegsdssiknenmgswestnvPVNYNLKA 717
           555555550.....0555555566666666666666666666666666666666666666677777777777777777777777******** PP
   S: 283  vvvHsG.slssGHYvayvkn...ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++H+G s++ GHYva++++    k++W+lf+D+kV +v   e  +   +t+Yv++++r
   Q: 718  IISHKGsSAHAGHYVAFIRKeidGKQQWVLFNDEKVLQVASLEEAK---TTGYVYLFER 773
           ********************6555777************6655555...8*****9987 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           +++++eql++MGF+  ++++aL+a+ n + e A+++L+++
   Q: 578  NQSAIEQLQAMGFPLVRCQRALLATgNSDTETAMNWLFEH 617
           799***********************************97 PP

UBD/ZnF/ZnF_UBP

   S: 2    kcsvcdktenlWlcLtcgsvgCGRyveg......HalkHyeetqhpl.....vlsls.tlsvycYacddy 59
           +cs+cd  enlW+cLtcg   CGR + g      Hal+Hy +t hpl     ++s + ++++ycY cd++
   Q: 173  TCSKCDLAENLWMCLTCGALSCGRKQYGggggngHALSHYDDTGHPLavklkSISPDgQADIYCYSCDEE 242
           6***********************8877789999*************99999888873579*******85 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MSCPHLTETN VVIPDNSQVI YREECVRCFN SQDEEGGIDL CLTCFQSGCG ETGLKHSLVH 60
FEQTLHPIVV TIARQPKQKI NDEPPQKITK LEIREDSDED LYDYFYVPKC LVCNIILDIQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTAATCAAC AAGATGCACG TATATTATTA ACTAATGTTA ATATTCTGCC TACCTCATGT 60
CCATCCATCC ATAAACACCT ATAGCAACCC ATGTCGTGTC CGCACCTCAC AGAGACAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0071108--P:protein K48-linked deubiquitination

KEGG

spo:SPBC6B1.06c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	31.35	1.00e-94	338.00
IUUC-Aml-002104	Ailuropoda melanoleuca	32.29	7.00e-114	402.00
IUUC-Atr-002580	Amborella trichopoda	33.03	2.00e-111	395.00
IUUC-Apl-003774	Anas platyrhynchos	33.21	8.00e-111	392.00
IUUC-Aca-005368	Anolis carolinensis	33.17	6.00e-118	416.00
IUUC-Aly-005727	Arabidopsis lyrata	34.68	2.00e-110	391.00
IUUC-Ath-006974	Arabidopsis thaliana	34.60	7.00e-111	392.00
IUUC-Ago-007890	Ashbya gossypii	31.20	2.00e-97	348.00
IUUC-Acl-008057	Aspergillus clavatus	39.84	3.00e-163	566.00
IUUC-Afl-008547	Aspergillus flavus	41.08	2.00e-147	513.00
IUUC-Afu-008805	Aspergillus fumigatus	38.13	1.00e-143	501.00
IUUC-Ani-009441	Aspergillus nidulans	38.71	2.00e-133	468.00
IUUC-Ang-009720	Aspergillus niger	42.42	5.00e-174	602.00
IUUC-Aor-010111	Aspergillus oryzae	40.48	2.00e-174	603.00
IUUC-Ate-010531	Aspergillus terreus	37.06	2.00e-145	507.00
IUUC-Ame-011470	Astyanax mexicanus	30.72	2.00e-104	371.00
IUUC-Bgr-012183	Blumeria graminis	40.22	3.00e-170	590.00
IUUC-Bta-013179	Bos taurus	32.29	4.00e-113	400.00
IUUC-Bci-013858	Botrytis cinerea	42.62	3.00e-180	623.00
IUUC-Bdi-014904	Brachypodium distachyon	33.09	1.00e-99	355.00
IUUC-Bol-015536	Brassica oleracea	35.09	1.00e-111	395.00
IUUC-Bra-017619	Brassica rapa	33.49	3.00e-109	387.00
IUUC-Cel-018625	Caenorhabditis elegans	30.01	4.00e-79	287.00
IUUC-Cja-019063	Callithrix jacchus	31.87	2.00e-111	394.00
IUUC-Cfa-020976	Canis familiaris	32.90	3.00e-117	414.00
IUUC-Cpo-022265	Cavia porcellus	32.47	4.00e-116	410.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	30.23	5.00e-59	220.00
IUUC-Csa-024078	Chlorocebus sabaeus	30.31	2.00e-101	361.00
IUUC-Cho-024702	Choloepus hoffmanni	30.84	9.00e-67	246.00
IUUC-Cin-025411	Ciona intestinalis	31.17	7.00e-88	316.00
IUUC-Csv-026347	Ciona savignyi	31.35	6.00e-89	320.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	42.26	1.00e-167	581.00
IUUC-Cne-026831	Cryptococcus neoformans	40.53	6.00e-161	559.00
IUUC-Cme-027335	Cyanidioschyzon merolae	26.65	8.00e-63	233.00
IUUC-Dre-027651	Danio rerio	31.09	6.00e-107	379.00
IUUC-Dno-029034	Dasypus novemcinctus	32.45	1.00e-113	402.00
IUUC-Dor-030130	Dipodomys ordii	33.04	6.00e-47	180.00
IUUC-Dse-031467	Dothistroma septosporum	40.89	2.00e-166	577.00
IUUC-Dme-032075	Drosophila melanogaster	30.95	7.00e-89	320.00
IUUC-Ete-032865	Echinops telfairi	29.49	3.00e-92	330.00
IUUC-Eca-034059	Equus caballus	32.18	3.00e-112	397.00
IUUC-Eeu-035304	Erinaceus europaeus	34.03	1.00e-103	369.00
IUUC-Fca-035515	Felis catus	32.33	7.00e-114	402.00
IUUC-Fal-037271	Ficedula albicollis	33.50	4.00e-112	397.00
IUUC-Fox-037745	Fusarium oxysporum	42.37	3.00e-178	616.00
IUUC-Fso-038158	Fusarium solani	42.60	5.00e-177	612.00
IUUC-Gmo-038906	Gadus morhua	31.73	4.00e-107	380.00
IUUC-Ggr-040098	Gaeumannomyces graminis	42.20	2.00e-171	594.00
IUUC-Gga-040635	Gallus gallus	32.44	1.00e-115	408.00
IUUC-Gac-042528	Gasterosteus aculeatus	31.12	9.00e-99	352.00
IUUC-Gma-042656	Glycine max	35.22	9.00e-108	382.00
IUUC-Ggo-044602	Gorilla gorilla	32.18	8.00e-113	399.00
IUUC-Hsa-045959	Homo sapiens	32.18	8.00e-113	399.00
IUUC-Hvu-047563	Hordeum vulgare	36.78	2.00e-96	344.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	32.11	8.00e-114	402.00
IUUC-Kpa-049156	Komagataella pastoris	37.42	4.00e-141	493.00
IUUC-Lch-049648	Latimeria chalumnae	32.21	1.00e-106	379.00
IUUC-Lpe-051523	Leersia perrieri	32.48	3.00e-102	364.00
IUUC-Loc-052072	Lepisosteus oculatus	30.73	2.00e-101	362.00
IUUC-Lma-053216	Leptosphaeria maculans	43.26	2.00e-168	585.00
IUUC-Laf-054327	Loxodonta africana	32.18	3.00e-113	400.00
IUUC-Mcc-055443	Macaca mulatta	32.06	2.00e-112	398.00
IUUC-Meu-056298	Macropus eugenii	31.75	3.00e-75	275.00
IUUC-Mor-057106	Magnaporthe oryzae	43.00	2.00e-180	624.00
IUUC-Mpo-057589	Magnaporthe poae	42.64	2.00e-174	603.00
IUUC-Mtr-058680	Medicago truncatula	34.22	5.00e-112	396.00
IUUC-Mla-058903	Melampsora laricipopulina	38.40	7.00e-154	535.00
IUUC-Mga-059669	Meleagris gallopavo	32.74	1.00e-110	392.00
IUUC-Mvi-060476	Microbotryum violaceum	41.76	3.00e-161	560.00
IUUC-Mmr-060575	Microcebus murinus	32.56	2.00e-113	401.00
IUUC-Mdo-062183	Monodelphis domestica	32.46	4.00e-113	400.00
IUUC-Mmu-063592	Mus musculus	32.57	2.00e-114	404.00
IUUC-Mac-065634	Musa acuminata	36.23	3.00e-59	221.00
IUUC-Mpu-066082	Mustela putorius furo	33.18	2.00e-116	411.00
IUUC-Mlu-067345	Myotis lucifugus	32.13	6.00e-112	396.00
IUUC-Nfi-068558	Neosartorya fischeri	39.41	1.00e-158	551.00
IUUC-Ncr-068960	Neurospora crassa	42.71	3.00e-166	577.00
IUUC-Nle-070173	Nomascus leucogenys	32.54	2.00e-115	408.00
IUUC-Opr-070556	Ochotona princeps	32.72	2.00e-114	404.00
IUUC-Ont-071502	Oreochromis niloticus	31.52	9.00e-102	362.00
IUUC-Oan-072959	Ornithorhynchus anatinus	41.52	3.00e-43	166.00
IUUC-Ocu-074861	Oryctolagus cuniculus	32.78	3.00e-116	410.00
IUUC-Oba-075109	Oryza barthii	32.47	2.00e-106	378.00
IUUC-Obr-076292	Oryza brachyantha	32.41	1.00e-101	362.00
IUUC-Ogl-077065	Oryza glaberrima	33.33	2.00e-111	394.00
IUUC-Ogu-078776	Oryza glumaepatula	32.48	3.00e-106	377.00
IUUC-Oin-080048	Oryza indica	32.81	5.00e-107	380.00
IUUC-Olo-080711	Oryza longistaminata	31.99	1.00e-95	342.00
IUUC-Ome-081506	Oryza meridionalis	33.16	1.00e-98	352.00
IUUC-Oni-082320	Oryza nivara	32.10	5.00e-107	380.00
IUUC-Opu-083801	Oryza punctata	31.99	3.00e-99	354.00
IUUC-Oru-085139	Oryza rufipogon	32.10	2.00e-107	381.00
IUUC-Osa-085713	Oryza sativa	33.33	3.00e-112	397.00
IUUC-Ola-086951	Oryzias latipes	30.94	2.00e-94	338.00
IUUC-Olu-087822	Ostreococcus lucimarinus	31.96	5.00e-76	277.00
IUUC-Oga-088625	Otolemur garnettii	31.99	1.00e-112	398.00
IUUC-Oar-089995	Ovis aries	32.28	6.00e-112	396.00
IUUC-Ptr-090640	Pan troglodytes	32.94	2.00e-115	407.00
IUUC-Pan-091974	Papio anubis	31.87	3.00e-112	397.00
IUUC-Psi-093957	Pelodiscus sinensis	32.02	1.00e-113	402.00
IUUC-Pma-094242	Petromyzon marinus	33.06	2.00e-52	197.00
IUUC-Pno-094835	Phaeosphaeria nodorum	43.27	1.00e-151	528.00
IUUC-Ppa-095901	Physcomitrella patens	34.31	9.00e-122	429.00
IUUC-Pfo-097148	Poecilia formosa	31.62	5.00e-104	370.00
IUUC-Pab-098068	Pongo abelii	29.88	3.00e-93	334.00
IUUC-Pop-098943	Populus trichocarpa	34.36	4.00e-106	377.00
IUUC-Pca-100738	Procavia capensis	32.41	6.00e-81	293.00
IUUC-Ppe-101315	Prunus persica	33.37	5.00e-105	373.00
IUUC-Pva-102154	Pteropus vampyrus	32.10	1.00e-111	395.00
IUUC-Pgr-103343	Puccinia graminis	38.13	4.00e-120	423.00
IUUC-Ptt-103928	Puccinia triticina	33.17	6.00e-117	412.00
IUUC-Pte-104306	Pyrenophora teres	43.34	6.00e-160	555.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	42.27	2.00e-161	560.00
IUUC-Rno-105801	Rattus norvegicus	32.11	4.00e-114	403.00
IUUC-Sce-106304	Saccharomyces cerevisiae	32.40	5.00e-97	346.00
IUUC-Sha-107635	Sarcophilus harrisii	32.54	6.00e-114	402.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	51.16	0.00e+00	808.00
IUUC-Smo-108703	Selaginella moellendorffii	33.09	4.00e-102	363.00
IUUC-Sit-110728	Setaria italica	33.41	8.00e-109	385.00
IUUC-Sly-111523	Solanum lycopersicum	34.91	6.00e-114	402.00
IUUC-Sar-113733	Sorex araneus	34.54	2.00e-56	211.00
IUUC-Sbi-114419	Sorghum bicolor	33.21	1.00e-108	385.00
IUUC-Sre-115225	Sporisorium reilianum	38.81	2.00e-156	544.00
IUUC-Ssc-115686	Sus scrofa	32.30	4.00e-113	400.00
IUUC-Tgu-117346	Taeniopygia guttata	31.99	4.00e-113	400.00
IUUC-Tru-118627	Takifugu rubripes	30.01	5.00e-104	370.00
IUUC-Tsy-119278	Tarsius syrichta	29.82	2.00e-83	301.00
IUUC-Tni-120658	Tetraodon nigroviridis	30.91	1.00e-93	335.00
IUUC-Tca-121585	Theobroma cacao	33.62	5.00e-104	370.00
IUUC-Tre-122043	Trichoderma reesei	42.42	7.00e-169	585.00
IUUC-Tvi-122303	Trichoderma virens	42.48	3.00e-173	600.00
IUUC-Tae-123798	Triticum aestivum	33.58	9.00e-107	379.00
IUUC-Tur-126732	Triticum urartu	31.14	1.00e-98	352.00
IUUC-Tme-126909	Tuber melanosporum	39.95	6.00e-157	545.00
IUUC-Tbe-127261	Tupaia belangeri	29.48	2.00e-38	152.00
IUUC-Ttr-129119	Tursiops truncatus	34.22	2.00e-52	199.00
IUUC-Uma-129599	Ustilago maydis	38.43	2.00e-159	554.00
IUUC-Vda-129688	Verticillium dahliae	41.88	1.00e-168	584.00
IUUC-Vpa-130170	Vicugna pacos	34.26	4.00e-47	181.00
IUUC-Vvi-131116	Vitis vinifera	33.94	1.00e-104	372.00
IUUC-Xtr-131953	Xenopus tropicalis	31.46	8.00e-102	362.00
IUUC-Xma-133837	Xiphophorus maculatus	31.62	3.00e-104	370.00
IUUC-Yli-134510	Yarrowia lipolytica	38.07	2.00e-153	533.00
IUUC-Zma-135786	Zea mays	33.09	7.00e-103	366.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence