iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067852

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02048977

Gene Name

TBL1Y

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000027637.1	ENSMLUT00000028453.1	ENSMLUP00000017848.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-54	179.8	399	437
UBD/Beta-Prp	5.30e-73	245.8	223	471

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           H+++v+++af +d ++l+sGs D+ +++W++ +g l++s
   Q: 399  HQEPVYSVAFsPDgKYLASGSFDKCVHIWNTQSGSLVHS 437
           9**********999******************9999875 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           hk++i ++k+ ++++++++++ d+t+++wd++tg + +++  h+a+  +v++++++ +++++s+D+ i+v  ls   +v t++gh+++v
   Q: 223  HKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNT-TFASCSTDMCIHVCRLSCDRPVKTFQGHTNEV 310
           8999999************************************************8.9******************************* PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee.......tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgg 178
            +++++psg  l+s s+d t+++w +++++c+++       + +++ + +  ++++p++  +l+s+s D+tvrlWd+++g +++tlt+ 
   Q: 311  NAIKWDPSGMLLASCSDDMTLKIWSMKQDTCVHDlqahskeIYTIKWSPTGPATSNPNAnIMLASASFDSTVRLWDVERGVCIHTLTK- 398
           *********************************7555555555555555555666777766899***********************9. PP
   S: 179  htdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlr 252
           h+++vys++f+++gk+l+sgs d+ v +w+ q+g+ v++++g    + +    + d+  +s+s Dgs+ + dlr
   Q: 399  HQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARGDKVGASAS-DGSVCVLDLR 471
           ******************************************999888777777888888876.9999888887 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

QDGTVFDGRP IESLSLIDAV MPDVVQTRQQ AFREKLAQQQ ASAAAAAAAA AAASAAAAAA 60
ATVATAATTA TVTPAAVSQP NAPKNGEATV NGEENGAHAI NNHSKPMEID GDVEIPPSKA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGATGGCA CGGTATTCGA TGGCCGCCCC ATAGAGTCCC TGTCCCTGAT CGACGCCGTG 60
ATGCCTGACG TGGTGCAGAC GAGGCAGCAG GCCTTCCGGG AGAAGCTGGC GCAGCAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005667--C:transcription factor complex
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0045444--P:fat cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043627--P:response to estrogen
GO:0048545--P:response to steroid hormone

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cpo-021682	Cavia porcellus	91.74	0.00e+00	859.00
IUUC-Cre-022979	Chlamydomonas reinhardtii	62.09	4.00e-131	461.00
IUUC-Cne-026946	Cryptococcus neoformans	38.01	1.00e-30	128.00
IUUC-Dme-031939	Drosophila melanogaster	81.74	5.00e-175	607.00
IUUC-Itr-048236	Ictidomys tridecemlineatus	98.39	0.00e+00	773.00
IUUC-Kpa-049338	Komagataella pastoris	28.33	4.00e-32	132.00
IUUC-Mvi-060557	Microbotryum violaceum	37.30	2.00e-70	261.00
IUUC-Sly-111336	Solanum lycopersicum	58.00	2.00e-129	456.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence