iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004370

UUCD1 version

UUC-AnC-00253

Ensembl Protein ID

ENSACAP00000004723.2

UniProt Accession

H9G9J7; H9G9J7_ANOCA

Protein Name

Ribosome biogenesis protein WDR12; WD repeat-containing protein 12

Gene Name

WDR12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000004774.3	ENSACAT00000004830.3	ENSACAP00000004723.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.00e-46	152.6	343	378
UBD/Beta-Prp	7.30e-48	163.2	248	414

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sd.tllvsGsdDgtikvWDlrtgv 34
           Ht++vtc+++  +    l+sGs D+++k+WD+r+++
   Q: 343  HTGWVTCVKWspTHeQQLISGSLDNVVKLWDTRSCK 378
           **********9533678**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkl 171
           t++++ tl+gh++sv s+ +s  +d + s+s+d ti++wd+etg   + tl+g++ v n+++++p ++ l+sGs+Dr +rlWd +t++ 
   Q: 248  TRTPITTLSGHTESVSSVLWSD-TDEICSASWDHTIKIWDVETGGLKS-TLTGNK-VFNSISYSPLCQRLASGSTDRHIRLWDPRTKDG 333
           678899***************9.9***********************9.***987.99**************************88764 PP
   S: 172  lrtl...tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
              l   t+ ht+ v++++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v++++ + +  +l+sg++D+ ++ +
   Q: 334  SLVLlslTS-HTGWVTCVKWSPTHeQQLISGSLDNVVKLWDTRsCKAPLYDLAAHEDKVLCIEWT-EAGLLLSGGADNKLYSY 414
           444444387.************9889*****************54566****************9.999********998876 PP

Organism

Anolis carolinensis

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQARFFT DDPKYIVDDV PFSVPASSEV ADLSNVINKL LEAKNEGHKY VEFDFLVKGQ 60
FLRMPLVKHM EVENISTEDV VEIEYVEKYT APQPEECMLH DDWISSIEAT EEWILSGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAAGCATT ATCAACCGGC TGCTGAGCTA TCCATCGGTT CTTTGAGCCA CGTGGGGCGA 60
GAGCGGGGCT TACGGCTGAG CTCCATTGGC TGGAAGCATG GCGCAGCTTC AGGCTCGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0043021--F:ribonucleoprotein complex binding
GO:0008283--P:cell proliferation
GO:0000460--P:maturation of 5.8S rRNA
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470--P:maturation of LSU-rRNA
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway

KEGG

acs:100567600

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	32.38	6.00e-62	231.00
IUUC-Aml-001997	Ailuropoda melanoleuca	84.22	0.00e+00	647.00
IUUC-Atr-002544	Amborella trichopoda	33.81	5.00e-59	221.00
IUUC-Apl-003981	Anas platyrhynchos	86.51	0.00e+00	630.00
IUUC-Aly-006455	Arabidopsis lyrata	34.96	2.00e-61	229.00
IUUC-Ath-006669	Arabidopsis thaliana	34.88	3.00e-57	215.00
IUUC-Ago-007864	Ashbya gossypii	30.39	6.00e-41	161.00
IUUC-Acl-008177	Aspergillus clavatus	29.67	4.00e-39	155.00
IUUC-Afl-008617	Aspergillus flavus	29.49	2.00e-37	150.00
IUUC-Afu-008752	Aspergillus fumigatus	29.49	3.00e-36	145.00
IUUC-Ani-009136	Aspergillus nidulans	30.00	5.00e-38	152.00
IUUC-Ang-009701	Aspergillus niger	28.97	3.00e-36	145.00
IUUC-Aor-009884	Aspergillus oryzae	29.49	4.00e-37	149.00
IUUC-Ame-011432	Astyanax mexicanus	75.06	0.00e+00	669.00
IUUC-Bgr-012218	Blumeria graminis	28.37	2.00e-38	153.00
IUUC-Bta-012829	Bos taurus	85.18	0.00e+00	676.00
IUUC-Bci-013953	Botrytis cinerea	28.11	7.00e-39	154.00
IUUC-Bdi-014351	Brachypodium distachyon	33.97	6.00e-58	218.00
IUUC-Bol-016190	Brassica oleracea	34.54	5.00e-57	214.00
IUUC-Bra-017876	Brassica rapa	33.99	2.00e-59	223.00
IUUC-Cel-018569	Caenorhabditis elegans	33.09	2.00e-50	193.00
IUUC-Cja-019468	Callithrix jacchus	84.71	0.00e+00	656.00
IUUC-Cfa-020471	Canis familiaris	82.35	0.00e+00	667.00
IUUC-Cpo-022260	Cavia porcellus	84.94	0.00e+00	662.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	30.63	9.00e-42	164.00
IUUC-Csa-023989	Chlorocebus sabaeus	84.47	0.00e+00	657.00
IUUC-Cho-024426	Choloepus hoffmanni	82.02	1.00e-136	479.00
IUUC-Cin-025789	Ciona intestinalis	43.68	6.00e-98	350.00
IUUC-Cne-027063	Cryptococcus neoformans	23.52	1.00e-20	94.00
IUUC-Dre-027907	Danio rerio	77.88	0.00e+00	697.00
IUUC-Dno-029225	Dasypus novemcinctus	84.00	0.00e+00	672.00
IUUC-Dor-031082	Dipodomys ordii	72.24	2.00e-148	518.00
IUUC-Dse-031308	Dothistroma septosporum	29.87	3.00e-41	162.00
IUUC-Dme-032189	Drosophila melanogaster	41.09	7.00e-96	343.00
IUUC-Ete-032247	Echinops telfairi	80.00	4.00e-180	624.00
IUUC-Eca-034285	Equus caballus	84.24	0.00e+00	669.00
IUUC-Eeu-035322	Erinaceus europaeus	75.50	2.00e-163	568.00
IUUC-Fca-036114	Felis catus	83.76	0.00e+00	670.00
IUUC-Fal-036891	Ficedula albicollis	87.64	7.00e-171	592.00
IUUC-Fox-037965	Fusarium oxysporum	25.37	7.00e-35	141.00
IUUC-Fso-038244	Fusarium solani	25.17	1.00e-32	134.00
IUUC-Gmo-039040	Gadus morhua	75.53	0.00e+00	669.00
IUUC-Ggr-040093	Gaeumannomyces graminis	25.35	6.00e-20	92.00
IUUC-Gga-040610	Gallus gallus	84.00	0.00e+00	704.00
IUUC-Gac-042117	Gasterosteus aculeatus	75.29	0.00e+00	652.00
IUUC-Gma-043146	Glycine max	35.41	8.00e-65	240.00
IUUC-Ggo-045179	Gorilla gorilla	84.24	0.00e+00	649.00
IUUC-Hsa-046114	Homo sapiens	84.94	0.00e+00	654.00
IUUC-Hvu-047331	Hordeum vulgare	32.65	2.00e-56	213.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	85.41	0.00e+00	679.00
IUUC-Kpa-049304	Komagataella pastoris	30.60	1.00e-45	177.00
IUUC-Lch-050655	Latimeria chalumnae	76.11	6.00e-143	499.00
IUUC-Lpe-051675	Leersia perrieri	34.45	8.00e-64	237.00
IUUC-Loc-052868	Lepisosteus oculatus	80.47	0.00e+00	696.00
IUUC-Lma-053258	Leptosphaeria maculans	27.59	6.00e-37	150.00
IUUC-Laf-053993	Loxodonta africana	83.53	0.00e+00	669.00
IUUC-Mcc-055128	Macaca mulatta	68.71	3.00e-145	507.00
IUUC-Meu-056501	Macropus eugenii	74.13	1.00e-147	515.00
IUUC-Mor-057114	Magnaporthe oryzae	26.52	2.00e-31	129.00
IUUC-Mtr-058367	Medicago truncatula	36.24	3.00e-62	232.00
IUUC-Mla-059107	Melampsora laricipopulina	26.03	7.00e-32	131.00
IUUC-Mga-059745	Meleagris gallopavo	82.35	0.00e+00	683.00
IUUC-Mvi-060362	Microbotryum violaceum	27.81	5.00e-33	135.00
IUUC-Mdo-062257	Monodelphis domestica	81.32	0.00e+00	683.00
IUUC-Mmu-063546	Mus musculus	84.00	0.00e+00	670.00
IUUC-Mac-065540	Musa acuminata	32.30	1.00e-58	219.00
IUUC-Mpu-066284	Mustela putorius furo	84.24	0.00e+00	672.00
IUUC-Mlu-067241	Myotis lucifugus	84.24	0.00e+00	673.00
IUUC-Nfi-068260	Neosartorya fischeri	30.00	6.00e-37	148.00
IUUC-Ncr-068719	Neurospora crassa	26.11	7.00e-29	121.00
IUUC-Nle-068981	Nomascus leucogenys	84.47	0.00e+00	655.00
IUUC-Opr-071218	Ochotona princeps	76.75	3.00e-174	604.00
IUUC-Ont-071646	Oreochromis niloticus	77.03	0.00e+00	653.00
IUUC-Oan-073453	Ornithorhynchus anatinus	84.94	0.00e+00	730.00
IUUC-Ocu-074008	Oryctolagus cuniculus	84.24	0.00e+00	672.00
IUUC-Oba-075712	Oryza barthii	30.84	6.00e-48	184.00
IUUC-Obr-076721	Oryza brachyantha	34.13	3.00e-64	238.00
IUUC-Ogl-077229	Oryza glaberrima	34.45	2.00e-62	233.00
IUUC-Ogu-078977	Oryza glumaepatula	30.84	3.00e-48	186.00
IUUC-Oin-079683	Oryza indica	34.45	6.00e-63	234.00
IUUC-Olo-080291	Oryza longistaminata	29.25	1.00e-31	129.00
IUUC-Ome-081834	Oryza meridionalis	34.69	9.00e-64	237.00
IUUC-Oni-082507	Oryza nivara	33.57	2.00e-59	222.00
IUUC-Opu-083396	Oryza punctata	34.69	3.00e-64	239.00
IUUC-Oru-085220	Oryza rufipogon	33.81	3.00e-59	222.00
IUUC-Osa-085767	Oryza sativa	34.45	6.00e-63	234.00
IUUC-Ola-087420	Oryzias latipes	75.06	0.00e+00	669.00
IUUC-Olu-087740	Ostreococcus lucimarinus	29.27	5.00e-40	158.00
IUUC-Oga-088264	Otolemur garnettii	83.06	0.00e+00	667.00
IUUC-Oar-089335	Ovis aries	84.47	0.00e+00	671.00
IUUC-Ptr-091320	Pan troglodytes	84.94	0.00e+00	654.00
IUUC-Pan-092833	Papio anubis	84.94	0.00e+00	658.00
IUUC-Psi-093504	Pelodiscus sinensis	88.94	0.00e+00	727.00
IUUC-Pma-094189	Petromyzon marinus	69.88	2.00e-168	584.00
IUUC-Pno-094929	Phaeosphaeria nodorum	27.65	5.00e-38	151.00
IUUC-Ppa-095429	Physcomitrella patens	34.82	2.00e-63	236.00
IUUC-Pfo-096337	Poecilia formosa	74.59	0.00e+00	667.00
IUUC-Pab-097571	Pongo abelii	84.47	0.00e+00	653.00
IUUC-Pop-099977	Populus trichocarpa	35.08	2.00e-65	243.00
IUUC-Pca-100394	Procavia capensis	79.81	8.00e-175	605.00
IUUC-Ppe-101848	Prunus persica	36.92	7.00e-63	234.00
IUUC-Pva-102921	Pteropus vampyrus	82.73	2.00e-100	359.00
IUUC-Pgr-103637	Puccinia graminis	29.40	7.00e-39	154.00
IUUC-Ptt-103781	Puccinia triticina	29.06	6.00e-39	155.00
IUUC-Pte-104135	Pyrenophora teres	27.19	2.00e-36	148.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.99	4.00e-35	142.00
IUUC-Rno-105114	Rattus norvegicus	83.53	0.00e+00	671.00
IUUC-Sce-106401	Saccharomyces cerevisiae	30.85	1.00e-43	170.00
IUUC-Sha-107122	Sarcophilus harrisii	82.08	0.00e+00	652.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	31.42	7.00e-51	194.00
IUUC-Spo-108134	Schizosaccharomyces pombe	30.28	2.00e-42	166.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	29.06	4.00e-40	158.00
IUUC-Smo-108720	Selaginella moellendorffii	33.81	1.00e-55	210.00
IUUC-Sit-110311	Setaria italica	34.10	9.00e-60	223.00
IUUC-Sly-111178	Solanum lycopersicum	32.76	6.00e-59	221.00
IUUC-Stu-112778	Solanum tuberosum	34.36	2.00e-62	232.00
IUUC-Sar-113596	Sorex araneus	69.88	1.00e-150	526.00
IUUC-Sbi-114193	Sorghum bicolor	35.64	1.00e-60	226.00
IUUC-Sre-115002	Sporisorium reilianum	24.45	2.00e-13	70.50
IUUC-Ssc-116066	Sus scrofa	84.47	0.00e+00	671.00
IUUC-Tgu-117048	Taeniopygia guttata	86.51	0.00e+00	631.00
IUUC-Tsy-119573	Tarsius syrichta	53.57	5.00e-112	397.00
IUUC-Tni-119820	Tetraodon nigroviridis	75.84	0.00e+00	643.00
IUUC-Tca-121605	Theobroma cacao	35.32	3.00e-62	232.00
IUUC-Tre-121947	Trichoderma reesei	25.95	5.00e-37	148.00
IUUC-Tvi-122481	Trichoderma virens	26.50	3.00e-37	149.00
IUUC-Tae-125861	Triticum aestivum	32.62	2.00e-62	232.00
IUUC-Tur-126586	Triticum urartu	32.65	1.00e-58	220.00
IUUC-Tme-126900	Tuber melanosporum	31.29	9.00e-52	197.00
IUUC-Tbe-127736	Tupaia belangeri	63.75	2.00e-128	452.00
IUUC-Ttr-129041	Tursiops truncatus	73.65	8.00e-169	586.00
IUUC-Vpa-130260	Vicugna pacos	84.71	0.00e+00	675.00
IUUC-Vvi-131009	Vitis vinifera	34.52	3.00e-61	229.00
IUUC-Xtr-132083	Xenopus tropicalis	80.71	0.00e+00	669.00
IUUC-Xma-133094	Xiphophorus maculatus	74.59	0.00e+00	665.00
IUUC-Yli-134531	Yarrowia lipolytica	25.00	1.00e-21	97.80
IUUC-Zma-135509	Zea mays	34.20	3.00e-61	229.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence