iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-036344

Ensembl Protein ID

ENSFCAP00000023652.1

UniProt Accession

M3XAJ8; M3XAJ8_FELCA

Genbank Protein ID

ENSFCAP00000023652

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02115731

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000027111.1	ENSFCAT00000028121.1	ENSFCAP00000023652.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.80e-108	361.9	550	876

Active Site

Position(s)	Description	Evidence
845	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 550  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 633
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 634  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGNVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 720
           *************************************.7799986.99***9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt+ds  i+ Fwe++++f++e+++ fLq
   Q: 721  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRDSVLIREFWEIVHSFTDEQKRLFLQ 809
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 810  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 876
           *****************...8888866666**************************************97 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MATACKRSPG EPQSDNIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFLR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG APNNSCSDIK MNKKEGQGAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGACCGGGC GGAGCGCGCT GCCTGCTGGG ATACTCGGCC CGCCCAGCCA GTCCTCCCGG 60
CTTGCGCTGC GGCGGCGAGA TCCGCGTTTT TCCCAAGATG GTGGCGCTGG GTTCGGGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

fca:101089941

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	99.18	0.00e+00	1623.00
IUUC-Atr-003144	Amborella trichopoda	45.80	5.00e-96	344.00
IUUC-Apl-003742	Anas platyrhynchos	94.32	0.00e+00	1612.00
IUUC-Aca-004873	Anolis carolinensis	93.79	0.00e+00	1610.00
IUUC-Ame-011166	Astyanax mexicanus	86.36	0.00e+00	1449.00
IUUC-Bta-013286	Bos taurus	96.47	0.00e+00	1611.00
IUUC-Cja-019707	Callithrix jacchus	95.98	0.00e+00	1625.00
IUUC-Cfa-020154	Canis familiaris	97.47	0.00e+00	1647.00
IUUC-Cpo-021292	Cavia porcellus	96.61	0.00e+00	1579.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	2.00e-82	298.00
IUUC-Csa-023378	Chlorocebus sabaeus	96.12	0.00e+00	1632.00
IUUC-Cho-025059	Choloepus hoffmanni	93.82	0.00e+00	1509.00
IUUC-Cin-025643	Ciona intestinalis	44.57	0.00e+00	712.00
IUUC-Csv-026282	Ciona savignyi	44.72	0.00e+00	667.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	2.00e-101	363.00
IUUC-Dre-027901	Danio rerio	85.90	0.00e+00	1431.00
IUUC-Dno-029320	Dasypus novemcinctus	97.72	0.00e+00	1640.00
IUUC-Dor-030756	Dipodomys ordii	93.84	0.00e+00	728.00
IUUC-Dme-032035	Drosophila melanogaster	40.00	2.00e-170	593.00
IUUC-Eca-033843	Equus caballus	97.08	0.00e+00	1588.00
IUUC-Eeu-035109	Erinaceus europaeus	95.56	0.00e+00	1543.00
IUUC-Fal-036747	Ficedula albicollis	94.32	0.00e+00	1611.00
IUUC-Gmo-038840	Gadus morhua	63.18	0.00e+00	1100.00
IUUC-Gga-040399	Gallus gallus	94.32	0.00e+00	1611.00
IUUC-Gac-041933	Gasterosteus aculeatus	83.64	0.00e+00	1389.00
IUUC-Ggo-044804	Gorilla gorilla	95.99	0.00e+00	1624.00
IUUC-Hsa-045727	Homo sapiens	95.99	0.00e+00	1624.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	93.92	0.00e+00	1509.00
IUUC-Lch-050197	Latimeria chalumnae	90.60	0.00e+00	1540.00
IUUC-Loc-052743	Lepisosteus oculatus	89.47	0.00e+00	1536.00
IUUC-Lma-053245	Leptosphaeria maculans	33.87	5.00e-57	216.00
IUUC-Laf-053615	Loxodonta africana	95.74	0.00e+00	1587.00
IUUC-Mcc-054934	Macaca mulatta	96.20	0.00e+00	1618.00
IUUC-Meu-056061	Macropus eugenii	95.61	0.00e+00	1351.00
IUUC-Mga-059271	Meleagris gallopavo	92.50	0.00e+00	1568.00
IUUC-Mmr-061288	Microcebus murinus	97.35	0.00e+00	1619.00
IUUC-Mdo-062975	Monodelphis domestica	95.22	0.00e+00	1625.00
IUUC-Mmu-063674	Mus musculus	93.27	0.00e+00	1571.00
IUUC-Mpu-066568	Mustela putorius furo	99.20	0.00e+00	1670.00
IUUC-Mlu-067522	Myotis lucifugus	89.92	0.00e+00	1523.00
IUUC-Nle-069505	Nomascus leucogenys	95.99	0.00e+00	1624.00
IUUC-Opr-070570	Ochotona princeps	90.23	0.00e+00	1470.00
IUUC-Ont-071527	Oreochromis niloticus	85.70	0.00e+00	1464.00
IUUC-Oan-073446	Ornithorhynchus anatinus	91.00	0.00e+00	1051.00
IUUC-Ocu-074922	Oryctolagus cuniculus	96.04	0.00e+00	1638.00
IUUC-Ola-086996	Oryzias latipes	84.66	0.00e+00	1451.00
IUUC-Oga-088261	Otolemur garnettii	97.43	0.00e+00	1597.00
IUUC-Oar-090024	Ovis aries	96.47	0.00e+00	1611.00
IUUC-Ptr-090455	Pan troglodytes	95.99	0.00e+00	1624.00
IUUC-Pan-092509	Papio anubis	95.48	0.00e+00	1451.00
IUUC-Psi-092974	Pelodiscus sinensis	93.86	0.00e+00	1578.00
IUUC-Pma-094643	Petromyzon marinus	71.10	0.00e+00	1249.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.32	9.00e-58	219.00
IUUC-Pfo-096905	Poecilia formosa	83.12	0.00e+00	1454.00
IUUC-Pab-097840	Pongo abelii	95.79	0.00e+00	1558.00
IUUC-Pca-100869	Procavia capensis	96.38	0.00e+00	1571.00
IUUC-Pva-103040	Pteropus vampyrus	97.02	0.00e+00	667.00
IUUC-Rno-105453	Rattus norvegicus	93.16	0.00e+00	1570.00
IUUC-Sha-107651	Sarcophilus harrisii	95.22	0.00e+00	1625.00
IUUC-Smo-108858	Selaginella moellendorffii	49.88	2.00e-116	413.00
IUUC-Sar-113293	Sorex araneus	97.31	0.00e+00	1596.00
IUUC-Ssc-115979	Sus scrofa	98.01	0.00e+00	1602.00
IUUC-Tgu-116901	Taeniopygia guttata	94.32	0.00e+00	1612.00
IUUC-Tru-118368	Takifugu rubripes	85.81	0.00e+00	1467.00
IUUC-Tsy-119516	Tarsius syrichta	93.68	0.00e+00	1488.00
IUUC-Tni-120143	Tetraodon nigroviridis	85.47	0.00e+00	1467.00
IUUC-Tbe-127484	Tupaia belangeri	92.14	0.00e+00	1097.00
IUUC-Ttr-129078	Tursiops truncatus	96.61	0.00e+00	1587.00
IUUC-Vpa-130312	Vicugna pacos	88.83	0.00e+00	1365.00
IUUC-Xtr-132881	Xenopus tropicalis	90.14	0.00e+00	1549.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence