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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106464
UUCD1 version UUC-SaC-00164
Ensembl Protein ID YDL145C
UniProt Accession P53622; D6VRK3; Q07595; COPA_YEAST
Genbank Protein ID CAA86588.1; CAA58712.1; CAA98719.1; CAA98718.1; CAA66346.1; DAA11713.1
Protein Name Coatomer subunit alpha; Alpha-coat protein; Retrieval from endoplasmic reticulum protein 1; Secretory protein 22; Suppressor of osmo-sensitivity 1
Genbank Nucleotide ID Z46617; X83754; Z74193; Z74192; X97751; BK006938
Gene Name COP1; RET1; SEC33; SOO1; YDL145C; D1578
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YDL145C YDL145C YDL145C
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMBioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.60e-39 128.7 52 89
UBD/Beta-Prp 8.40e-92 305.9 4 328
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           H+++v++l+f ++ +++vs++dD tikvW+l+t+++l 
   Q: 52   HEGPVRGLDFhPTqPIFVSAGDDYTIKVWSLDTNKCLY 89
           9**********888*********************986 PP
   

   UBD/Beta-Prp
   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfs 103
            t +++++++ + ++f+p++++++++  ++ti++wd+++g+ll+++++he++v+ ++f+p+++i+v++++D+tikvw+l+t+kc++tl+gh d+v+++ f+
   Q: 4    LTKFESKSTRAKGIAFHPSRPWVLVALFSSTIQLWDYRMGTLLHRFEDHEGPVRGLDFHPTQPIFVSAGDDYTIKVWSLDTNKCLYTLTGHLDYVRTVFFH 104
           678899999******************************************************************************************** PP
   S: 104  psgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............................ktgkllrtl. 175
           ++  +++s+s+d+tir+w++++++++  +l+gh+++v+c+++hp+++l+vs+slD+t+r+Wd+                            + g+++ ++ 
   Q: 105  RELPWIISASDDQTIRIWNWQNRKEIA-CLTGHNHFVMCAQFHPTDDLIVSASLDETIRIWDIsglrkrhsapgtssfeeqmsaqqnlldgSLGDCVVKFi 204
           ***************************.************************************************************************* PP
   S: 176  .tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavl 273
            + ght+ v++ sf+++ + +vsgs+d++vklw +++++   v+t++ght+nv sv f+p++++++s+++D+++r+Wdl++++++k+++++n++++ +a+ 
   Q: 205  lE-GHTRGVNWASFHPTLPLIVSGSDDRQVKLWRMSATKAweVDTCRGHTNNVDSVIFHPHQNLIISVGEDKTLRVWDLDKRTPVKQFKRENDRFWLIAA- 303
           55.5********************************777778**********************************************************. PP
   S: 274  sfgdnvlvlgse..dskvniwklkknep 299
              ++++ l+++  ds ++++kl++++p
   Q: 304  ---HPHINLFGAahDSGIMVFKLDRERP 328
           ...99999999999*********99887 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
Protein Sequence
(Fasta)
MKMLTKFESK STRAKGIAFH PSRPWVLVAL FSSTIQLWDY RMGTLLHRFE DHEGPVRGLD 60
FHPTQPIFVS AGDDYTIKVW SLDTNKCLYT LTGHLDYVRT VFFHRELPWI ISASDDQTIR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106464|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAAGATGT TAACTAAATT TGAATCAAAG TCCACTAGGG CCAAGGGCAT TGCCTTCCAC 60
CCCTCCAGAC CTTGGGTTTT GGTGGCTTTG TTTTCCTCTA CTATTCAATT ATGGGATTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106464|UBD,Beta-Prp;E3,WD_repeat|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011044--Quino_amine_DH_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0043130--F:ubiquitin binding
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER
KEGG sce:YDL145C
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000064 Aegilops tauschii 49.40 0.00e+00 836.00
IUUC-Aml-001758 Ailuropoda melanoleuca 43.14 0.00e+00 1028.00
IUUC-Atr-002493 Amborella trichopoda 48.98 0.00e+00 815.00
IUUC-Apl-003385 Anas platyrhynchos 39.66 0.00e+00 745.00
IUUC-Aca-005154 Anolis carolinensis 59.33 4.00e-79 285.00
IUUC-Aly-006020 Arabidopsis lyrata 42.60 0.00e+00 942.00
IUUC-Ath-007058 Arabidopsis thaliana 49.22 0.00e+00 821.00
IUUC-Ago-007992 Ashbya gossypii 68.85 0.00e+00 1720.00
IUUC-Acl-008027 Aspergillus clavatus 53.35 0.00e+00 1264.00
IUUC-Afl-008644 Aspergillus flavus 53.47 0.00e+00 1266.00
IUUC-Afu-008964 Aspergillus fumigatus 53.34 0.00e+00 1281.00
IUUC-Ani-009379 Aspergillus nidulans 60.02 0.00e+00 1076.00
IUUC-Ang-009756 Aspergillus niger 53.14 0.00e+00 1269.00
IUUC-Aor-010174 Aspergillus oryzae 53.55 0.00e+00 1265.00
IUUC-Ate-010302 Aspergillus terreus 53.68 0.00e+00 1300.00
IUUC-Ame-011229 Astyanax mexicanus 42.71 0.00e+00 1000.00
IUUC-Bgr-012300 Blumeria graminis 49.41 0.00e+00 1163.00
IUUC-Bta-012524 Bos taurus 43.54 0.00e+00 1027.00
IUUC-Bci-013781 Botrytis cinerea 49.39 0.00e+00 1202.00
IUUC-Bdi-014549 Brachypodium distachyon 41.57 0.00e+00 956.00
IUUC-Bol-015925 Brassica oleracea 49.94 0.00e+00 826.00
IUUC-Bra-016978 Brassica rapa 49.76 0.00e+00 823.00
IUUC-Cel-018115 Caenorhabditis elegans 48.27 0.00e+00 798.00
IUUC-Cja-019107 Callithrix jacchus 42.94 0.00e+00 1011.00
IUUC-Cfa-020675 Canis familiaris 42.97 0.00e+00 1000.00
IUUC-Cpo-021813 Cavia porcellus 43.38 0.00e+00 1036.00
IUUC-Cre-022969 Chlamydomonas reinhardtii 49.05 0.00e+00 846.00
IUUC-Csa-023523 Chlorocebus sabaeus 43.79 0.00e+00 1040.00
IUUC-Cho-024704 Choloepus hoffmanni 55.34 1.00e-108 385.00
IUUC-Cin-025572 Ciona intestinalis 42.47 0.00e+00 968.00
IUUC-Csv-025864 Ciona savignyi 48.21 0.00e+00 794.00
IUUC-Cgl-026510 Colletotrichum gloeosporioides 50.59 0.00e+00 1189.00
IUUC-Cne-027053 Cryptococcus neoformans 46.09 0.00e+00 1031.00
IUUC-Cme-027222 Cyanidioschyzon merolae 38.04 5.00e-119 421.00
IUUC-Dre-027421 Danio rerio 43.16 0.00e+00 1017.00
IUUC-Dno-029303 Dasypus novemcinctus 43.38 0.00e+00 1038.00
IUUC-Dor-030290 Dipodomys ordii 40.60 1.00e-124 439.00
IUUC-Dse-031543 Dothistroma septosporum 50.29 0.00e+00 1158.00
IUUC-Dme-031945 Drosophila melanogaster 48.74 0.00e+00 815.00
IUUC-Ete-032873 Echinops telfairi 41.65 0.00e+00 909.00
IUUC-Eca-033773 Equus caballus 42.54 0.00e+00 998.00
IUUC-Eeu-034874 Erinaceus europaeus 34.96 8.00e-136 476.00
IUUC-Fca-035739 Felis catus 42.77 0.00e+00 1009.00
IUUC-Fal-037263 Ficedula albicollis 40.21 0.00e+00 877.00
IUUC-Fox-037738 Fusarium oxysporum 50.33 0.00e+00 1230.00
IUUC-Fso-038153 Fusarium solani 50.82 0.00e+00 1239.00
IUUC-Gmo-039602 Gadus morhua 41.20 0.00e+00 932.00
IUUC-Ggr-039931 Gaeumannomyces graminis 58.54 0.00e+00 1053.00
IUUC-Gga-040590 Gallus gallus 43.53 0.00e+00 1022.00
IUUC-Gac-041318 Gasterosteus aculeatus 43.30 0.00e+00 1013.00
IUUC-Gma-043354 Glycine max 50.58 0.00e+00 811.00
IUUC-Ggo-045029 Gorilla gorilla 43.47 0.00e+00 1031.00
IUUC-Hsa-046078 Homo sapiens 43.55 0.00e+00 1033.00
IUUC-Hvu-047556 Hordeum vulgare 41.94 0.00e+00 953.00
IUUC-Itr-048881 Ictidomys tridecemlineatus 36.62 8.00e-153 532.00
IUUC-Kpa-049256 Komagataella pastoris 59.31 0.00e+00 1476.00
IUUC-Lch-049706 Latimeria chalumnae 43.04 0.00e+00 1001.00
IUUC-Lpe-051316 Leersia perrieri 48.74 0.00e+00 822.00
IUUC-Loc-051867 Lepisosteus oculatus 35.30 0.00e+00 669.00
IUUC-Lma-053138 Leptosphaeria maculans 50.86 0.00e+00 1222.00
IUUC-Laf-053510 Loxodonta africana 43.86 0.00e+00 1038.00
IUUC-Mcc-055836 Macaca mulatta 43.21 0.00e+00 1030.00
IUUC-Meu-056238 Macropus eugenii 46.02 1.00e-176 611.00
IUUC-Mor-057172 Magnaporthe oryzae 50.00 0.00e+00 1212.00
IUUC-Mpo-057300 Magnaporthe poae 50.34 0.00e+00 1202.00
IUUC-Mtr-058248 Medicago truncatula 47.95 0.00e+00 818.00
IUUC-Mla-059019 Melampsora laricipopulina 45.12 0.00e+00 1058.00
IUUC-Mga-059499 Meleagris gallopavo 43.46 0.00e+00 1018.00
IUUC-Mvi-060336 Microbotryum violaceum 53.75 0.00e+00 910.00
IUUC-Mmr-061102 Microcebus murinus 43.08 0.00e+00 1020.00
IUUC-Mdo-062594 Monodelphis domestica 44.29 0.00e+00 1045.00
IUUC-Mmu-063736 Mus musculus 43.39 0.00e+00 1027.00
IUUC-Mac-065272 Musa acuminata 39.25 0.00e+00 833.00
IUUC-Mpu-066701 Mustela putorius furo 43.30 0.00e+00 1026.00
IUUC-Mlu-067392 Myotis lucifugus 43.75 0.00e+00 1023.00
IUUC-Nfi-068270 Neosartorya fischeri 53.39 0.00e+00 1269.00
IUUC-Ncr-068892 Neurospora crassa 49.75 0.00e+00 1202.00
IUUC-Nle-069634 Nomascus leucogenys 52.39 0.00e+00 754.00
IUUC-Opr-070952 Ochotona princeps 32.72 6.00e-127 446.00
IUUC-Ont-072488 Oreochromis niloticus 43.21 0.00e+00 1001.00
IUUC-Oan-073184 Ornithorhynchus anatinus 62.66 2.00e-59 219.00
IUUC-Ocu-074211 Oryctolagus cuniculus 43.38 0.00e+00 1035.00
IUUC-Oba-075761 Oryza barthii 48.50 0.00e+00 818.00
IUUC-Obr-076429 Oryza brachyantha 48.98 0.00e+00 823.00
IUUC-Ogl-077364 Oryza glaberrima 48.50 0.00e+00 819.00
IUUC-Ogu-078257 Oryza glumaepatula 48.38 0.00e+00 817.00
IUUC-Oin-080029 Oryza indica 48.86 0.00e+00 824.00
IUUC-Olo-080895 Oryza longistaminata 49.21 0.00e+00 821.00
IUUC-Ome-081993 Oryza meridionalis 51.00 0.00e+00 800.00
IUUC-Oni-082874 Oryza nivara 48.56 0.00e+00 821.00
IUUC-Opu-083370 Oryza punctata 48.62 0.00e+00 821.00
IUUC-Oru-084274 Oryza rufipogon 48.50 0.00e+00 819.00
IUUC-Osa-085841 Oryza sativa 48.62 0.00e+00 820.00
IUUC-Ola-086921 Oryzias latipes 43.55 0.00e+00 1015.00
IUUC-Olu-087639 Ostreococcus lucimarinus 43.11 0.00e+00 1011.00
IUUC-Oga-087991 Otolemur garnettii 41.79 0.00e+00 976.00
IUUC-Oar-089590 Ovis aries 43.54 0.00e+00 1036.00
IUUC-Ptr-090808 Pan troglodytes 43.47 0.00e+00 1031.00
IUUC-Pan-092475 Papio anubis 43.59 0.00e+00 1029.00
IUUC-Psi-093044 Pelodiscus sinensis 44.67 0.00e+00 721.00
IUUC-Pno-094839 Phaeosphaeria nodorum 49.29 0.00e+00 1163.00
IUUC-Ppa-095390 Physcomitrella patens 43.57 0.00e+00 968.00
IUUC-Pfo-097493 Poecilia formosa 43.21 0.00e+00 1005.00
IUUC-Pab-098497 Pongo abelii 43.70 0.00e+00 1040.00
IUUC-Pop-099992 Populus trichocarpa 48.63 0.00e+00 813.00
IUUC-Pca-100413 Procavia capensis 46.22 4.00e-151 527.00
IUUC-Ppe-101392 Prunus persica 42.16 0.00e+00 944.00
IUUC-Pva-102126 Pteropus vampyrus 41.78 0.00e+00 979.00
IUUC-Pgr-103376 Puccinia graminis 45.35 0.00e+00 1077.00
IUUC-Ptt-103978 Puccinia triticina 40.41 0.00e+00 875.00
IUUC-Pte-104126 Pyrenophora teres 49.87 0.00e+00 1168.00
IUUC-Pyt-104778 Pyrenophora triticirepentis 43.65 0.00e+00 836.00
IUUC-Rno-105428 Rattus norvegicus 43.79 0.00e+00 1035.00
IUUC-Sha-107301 Sarcophilus harrisii 43.76 0.00e+00 1014.00
IUUC-Sja-107961 Schizosaccharomyces japonicus 44.50 0.00e+00 1060.00
IUUC-Spo-108217 Schizosaccharomyces pombe 45.94 0.00e+00 1083.00
IUUC-Ssl-108643 Sclerotinia sclerotiorum 49.43 0.00e+00 1203.00
IUUC-Smo-109582 Selaginella moellendorffii 50.36 0.00e+00 859.00
IUUC-Sit-109697 Setaria italica 48.50 0.00e+00 825.00
IUUC-Sly-111447 Solanum lycopersicum 41.25 0.00e+00 952.00
IUUC-Stu-112564 Solanum tuberosum 40.96 0.00e+00 944.00
IUUC-Sar-113313 Sorex araneus 37.06 4.00e-131 460.00
IUUC-Sbi-114388 Sorghum bicolor 48.38 0.00e+00 822.00
IUUC-Sre-115209 Sporisorium reilianum 53.74 0.00e+00 924.00
IUUC-Ssc-115933 Sus scrofa 43.78 0.00e+00 1038.00
IUUC-Tgu-117109 Taeniopygia guttata 37.91 3.00e-73 266.00
IUUC-Tru-117772 Takifugu rubripes 43.12 0.00e+00 995.00
IUUC-Tsy-119105 Tarsius syrichta 41.56 0.00e+00 780.00
IUUC-Tni-120556 Tetraodon nigroviridis 34.03 0.00e+00 627.00
IUUC-Tca-121046 Theobroma cacao 42.59 0.00e+00 971.00
IUUC-Tre-121951 Trichoderma reesei 49.84 0.00e+00 1195.00
IUUC-Tvi-122359 Trichoderma virens 50.08 0.00e+00 1204.00
IUUC-Tae-125527 Triticum aestivum 49.28 0.00e+00 834.00
IUUC-Tur-126754 Triticum urartu 49.16 0.00e+00 832.00
IUUC-Tme-127170 Tuber melanosporum 53.46 0.00e+00 1305.00
IUUC-Tbe-127882 Tupaia belangeri 54.19 4.00e-106 377.00
IUUC-Ttr-128217 Tursiops truncatus 42.12 0.00e+00 976.00
IUUC-Uma-129337 Ustilago maydis 53.01 0.00e+00 926.00
IUUC-Vda-129828 Verticillium dahliae 49.26 0.00e+00 1172.00
IUUC-Vpa-130537 Vicugna pacos 43.05 0.00e+00 1013.00
IUUC-Vvi-130958 Vitis vinifera 41.78 0.00e+00 944.00
IUUC-Xtr-132857 Xenopus tropicalis 42.31 0.00e+00 943.00
IUUC-Xma-133138 Xiphophorus maculatus 43.12 0.00e+00 1004.00
IUUC-Yli-134399 Yarrowia lipolytica 58.05 0.00e+00 1016.00
IUUC-Zma-135612 Zea mays 41.14 0.00e+00 947.00
Created Date 25-Jun-2017

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