iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062088

UUCD1 version

UUC-MoD-00860

Ensembl Protein ID

ENSMODP00000021812.2

UniProt Accession

F7FEZ1; F7FEZ1_MONDO

Protein Name

Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; eIF-3-beta; eIF3 p36

Gene Name

EIF3I; EIF3S2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000017481.2	ENSMODT00000022191.2	ENSMODP00000021812.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-21	75.8	50	87

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcl..afsd.tllvsGsdDgtikvWDlrtgvll 36
           gHt+ v+c+  ++ d +++++Gs D+++++WD  tg++l
   Q: 50   GHTGAVWCVdaDW-DtKHVLTGSADNSCRLWDCETGKQL 87
           8*******98679.55*******************9986 PP

Organism

Monodelphis domestica

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

QKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYTG HTGAVWCVDA 60
DWDTKHVLTG SADNSCRLWD CETGKQLALL KTNSAVRTCG FDFGGNIIMF STDKQMGYQC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAAGCCAA TCCTGCTCCA GGGCCACGAG CGATCCATTA CGCAGATCAA GTACAACCGC 60
GAGGGAGACC TGCTCTTCAC TGTGGCCAAG GACCCGGTGA GCGCGCGCGG CTGGCGGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR027525--eIF3i
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0070062--C:extracellular exosome
GO:0003743--F:translation initiation factor activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000115	Aegilops tauschii	57.52	2.00e-34	139.00
IUUC-Aml-001321	Ailuropoda melanoleuca	97.85	0.00e+00	669.00
IUUC-Atr-002468	Amborella trichopoda	52.22	9.00e-53	199.00
IUUC-Apl-003841	Anas platyrhynchos	93.25	0.00e+00	645.00
IUUC-Aca-005123	Anolis carolinensis	92.00	0.00e+00	635.00
IUUC-Aly-005473	Arabidopsis lyrata	43.60	2.00e-82	299.00
IUUC-Ath-007094	Arabidopsis thaliana	46.04	2.00e-84	305.00
IUUC-Ago-008000	Ashbya gossypii	44.74	1.00e-81	296.00
IUUC-Acl-008098	Aspergillus clavatus	52.11	2.00e-99	355.00
IUUC-Afl-008494	Aspergillus flavus	51.99	3.00e-98	351.00
IUUC-Afu-009080	Aspergillus fumigatus	51.81	6.00e-99	353.00
IUUC-Ani-009230	Aspergillus nidulans	52.74	5.00e-99	353.00
IUUC-Aor-010114	Aspergillus oryzae	51.99	3.00e-98	351.00
IUUC-Ate-010285	Aspergillus terreus	53.96	1.00e-101	363.00
IUUC-Ame-011534	Astyanax mexicanus	80.73	3.00e-166	577.00
IUUC-Bgr-012121	Blumeria graminis	48.63	2.00e-88	318.00
IUUC-Bta-013143	Bos taurus	97.54	0.00e+00	666.00
IUUC-Bci-013950	Botrytis cinerea	51.68	4.00e-97	347.00
IUUC-Bdi-015019	Brachypodium distachyon	46.63	1.00e-86	313.00
IUUC-Bol-015709	Brassica oleracea	45.76	1.00e-81	297.00
IUUC-Bra-017760	Brassica rapa	45.76	5.00e-82	298.00
IUUC-Cel-018226	Caenorhabditis elegans	42.20	1.00e-80	292.00
IUUC-Cja-019741	Callithrix jacchus	97.54	0.00e+00	666.00
IUUC-Cfa-021204	Canis familiaris	97.24	0.00e+00	666.00
IUUC-Cpo-021661	Cavia porcellus	97.55	0.00e+00	669.00
IUUC-Cre-022952	Chlamydomonas reinhardtii	43.38	6.00e-80	290.00
IUUC-Csa-024038	Chlorocebus sabaeus	97.54	0.00e+00	666.00
IUUC-Cin-025597	Ciona intestinalis	59.33	2.00e-117	415.00
IUUC-Cgl-026583	Colletotrichum gloeosporioides	50.61	2.00e-92	332.00
IUUC-Cne-026838	Cryptococcus neoformans	48.62	1.00e-90	326.00
IUUC-Cme-027304	Cyanidioschyzon merolae	45.03	2.00e-78	285.00
IUUC-Dre-028567	Danio rerio	83.38	1.00e-170	591.00
IUUC-Dno-029171	Dasypus novemcinctus	97.85	0.00e+00	667.00
IUUC-Dor-030257	Dipodomys ordii	84.09	7.00e-84	303.00
IUUC-Dse-031191	Dothistroma septosporum	49.09	3.00e-92	332.00
IUUC-Dme-031879	Drosophila melanogaster	60.43	1.00e-118	419.00
IUUC-Ete-032336	Echinops telfairi	95.35	3.00e-122	430.00
IUUC-Eca-033259	Equus caballus	97.55	0.00e+00	667.00
IUUC-Eeu-035153	Erinaceus europaeus	75.84	7.00e-59	220.00
IUUC-Fca-036489	Felis catus	97.55	0.00e+00	667.00
IUUC-Fal-037485	Ficedula albicollis	93.25	0.00e+00	646.00
IUUC-Fox-037860	Fusarium oxysporum	48.93	2.00e-91	328.00
IUUC-Fso-038188	Fusarium solani	49.54	2.00e-90	325.00
IUUC-Gmo-039311	Gadus morhua	83.38	3.00e-170	590.00
IUUC-Ggr-040045	Gaeumannomyces graminis	50.76	3.00e-94	338.00
IUUC-Gga-040645	Gallus gallus	90.99	0.00e+00	637.00
IUUC-Gac-042086	Gasterosteus aculeatus	83.38	3.00e-168	583.00
IUUC-Gma-043246	Glycine max	45.40	4.00e-85	307.00
IUUC-Ggo-045578	Gorilla gorilla	97.54	0.00e+00	666.00
IUUC-Hsa-046734	Homo sapiens	97.54	0.00e+00	666.00
IUUC-Hvu-047553	Hordeum vulgare	45.71	1.00e-85	309.00
IUUC-Itr-048467	Ictidomys tridecemlineatus	97.24	0.00e+00	666.00
IUUC-Kpa-049325	Komagataella pastoris	44.00	5.00e-84	304.00
IUUC-Lch-049620	Latimeria chalumnae	85.91	2.00e-159	554.00
IUUC-Lpe-051338	Leersia perrieri	45.02	2.00e-79	288.00
IUUC-Loc-052094	Lepisosteus oculatus	79.38	8.00e-158	549.00
IUUC-Lma-053047	Leptosphaeria maculans	48.33	2.00e-91	328.00
IUUC-Laf-053801	Loxodonta africana	97.81	0.00e+00	655.00
IUUC-Mcc-055498	Macaca mulatta	87.08	1.00e-161	561.00
IUUC-Meu-056729	Macropus eugenii	92.92	0.00e+00	625.00
IUUC-Mor-057025	Magnaporthe oryzae	50.46	1.00e-91	329.00
IUUC-Mpo-057511	Magnaporthe poae	51.38	2.00e-94	338.00
IUUC-Mtr-058051	Medicago truncatula	46.48	2.00e-86	311.00
IUUC-Mla-059061	Melampsora laricipopulina	48.45	2.00e-83	302.00
IUUC-Mga-059229	Meleagris gallopavo	92.38	0.00e+00	637.00
IUUC-Mvi-060399	Microbotryum violaceum	47.29	2.00e-81	295.00
IUUC-Mmr-060764	Microcebus murinus	98.15	0.00e+00	669.00
IUUC-Mmu-064304	Mus musculus	97.54	0.00e+00	667.00
IUUC-Mac-065520	Musa acuminata	47.68	2.00e-87	315.00
IUUC-Mpu-066340	Mustela putorius furo	97.55	0.00e+00	667.00
IUUC-Mlu-067111	Myotis lucifugus	98.16	0.00e+00	671.00
IUUC-Nfi-068478	Neosartorya fischeri	51.81	8.00e-99	353.00
IUUC-Ncr-068820	Neurospora crassa	50.91	1.00e-93	336.00
IUUC-Nle-069903	Nomascus leucogenys	97.24	0.00e+00	666.00
IUUC-Opr-070221	Ochotona princeps	95.08	0.00e+00	645.00
IUUC-Ont-071765	Oreochromis niloticus	84.92	1.00e-172	598.00
IUUC-Oan-073660	Ornithorhynchus anatinus	95.93	3.00e-171	593.00
IUUC-Ocu-074039	Oryctolagus cuniculus	97.55	0.00e+00	668.00
IUUC-Oba-075395	Oryza barthii	39.14	2.00e-68	252.00
IUUC-Obr-076334	Oryza brachyantha	42.81	4.00e-78	284.00
IUUC-Ogl-077060	Oryza glaberrima	45.57	5.00e-84	304.00
IUUC-Ogu-078207	Oryza glumaepatula	45.85	2.00e-86	312.00
IUUC-Oin-079878	Oryza indica	45.40	1.00e-85	309.00
IUUC-Olo-080677	Oryza longistaminata	38.85	5.00e-76	278.00
IUUC-Ome-081228	Oryza meridionalis	34.57	2.00e-34	138.00
IUUC-Oni-082411	Oryza nivara	38.97	3.00e-68	251.00
IUUC-Opu-083136	Oryza punctata	45.26	4.00e-85	307.00
IUUC-Oru-084916	Oryza rufipogon	44.18	2.00e-83	302.00
IUUC-Osa-085454	Oryza sativa	45.40	1.00e-85	309.00
IUUC-Ola-087053	Oryzias latipes	84.00	7.00e-171	592.00
IUUC-Olu-087602	Ostreococcus lucimarinus	47.66	6.00e-89	320.00
IUUC-Oga-088154	Otolemur garnettii	97.24	0.00e+00	665.00
IUUC-Oar-089915	Ovis aries	97.55	0.00e+00	667.00
IUUC-Ptr-091124	Pan troglodytes	78.19	1.00e-145	508.00
IUUC-Pan-092035	Papio anubis	97.54	0.00e+00	666.00
IUUC-Psi-094096	Pelodiscus sinensis	89.91	6.00e-119	419.00
IUUC-Pno-094988	Phaeosphaeria nodorum	45.02	6.00e-80	290.00
IUUC-Ppa-095536	Physcomitrella patens	48.62	5.00e-91	327.00
IUUC-Pfo-096101	Poecilia formosa	84.00	4.00e-171	593.00
IUUC-Pab-097726	Pongo abelii	97.54	0.00e+00	666.00
IUUC-Pop-099617	Populus trichocarpa	47.85	5.00e-88	317.00
IUUC-Pca-101014	Procavia capensis	97.85	0.00e+00	667.00
IUUC-Ppe-101320	Prunus persica	47.26	7.00e-85	306.00
IUUC-Pva-102789	Pteropus vampyrus	84.92	8.00e-161	559.00
IUUC-Pgr-103479	Puccinia graminis	47.83	2.00e-83	302.00
IUUC-Ptt-103981	Puccinia triticina	48.14	4.00e-85	308.00
IUUC-Pte-104278	Pyrenophora teres	48.94	2.00e-90	325.00
IUUC-Pyt-104492	Pyrenophora triticirepentis	48.94	2.00e-90	325.00
IUUC-Rno-105867	Rattus norvegicus	75.15	1.00e-136	479.00
IUUC-Sce-106251	Saccharomyces cerevisiae	45.65	6.00e-83	300.00
IUUC-Sha-107039	Sarcophilus harrisii	99.69	0.00e+00	687.00
IUUC-Sja-107758	Schizosaccharomyces japonicus	52.15	3.00e-94	338.00
IUUC-Spo-108314	Schizosaccharomyces pombe	48.00	7.00e-91	327.00
IUUC-Ssl-108478	Sclerotinia sclerotiorum	51.07	3.00e-96	345.00
IUUC-Smo-108728	Selaginella moellendorffii	48.31	3.00e-87	315.00
IUUC-Sit-110801	Setaria italica	45.09	3.00e-84	304.00
IUUC-Sly-111326	Solanum lycopersicum	46.95	5.00e-86	310.00
IUUC-Stu-112458	Solanum tuberosum	47.56	4.00e-86	311.00
IUUC-Sbi-114063	Sorghum bicolor	45.09	7.00e-84	303.00
IUUC-Sre-115096	Sporisorium reilianum	47.27	2.00e-82	299.00
IUUC-Ssc-116080	Sus scrofa	97.85	0.00e+00	667.00
IUUC-Tgu-116988	Taeniopygia guttata	92.92	0.00e+00	642.00
IUUC-Tru-118766	Takifugu rubripes	84.92	3.00e-172	597.00
IUUC-Tni-120197	Tetraodon nigroviridis	84.31	9.00e-172	595.00
IUUC-Tca-121316	Theobroma cacao	46.01	8.00e-85	306.00
IUUC-Tre-122097	Trichoderma reesei	50.00	2.00e-92	332.00
IUUC-Tvi-122442	Trichoderma virens	50.00	7.00e-93	333.00
IUUC-Tae-125800	Triticum aestivum	45.71	1.00e-85	309.00
IUUC-Tur-126334	Triticum urartu	39.57	2.00e-67	249.00
IUUC-Tme-127038	Tuber melanosporum	53.03	2.00e-99	355.00
IUUC-Ttr-128659	Tursiops truncatus	91.08	2.00e-167	581.00
IUUC-Uma-129464	Ustilago maydis	47.73	8.00e-82	296.00
IUUC-Vda-129841	Verticillium dahliae	51.99	2.00e-94	338.00
IUUC-Vvi-131076	Vitis vinifera	47.09	8.00e-86	310.00
IUUC-Xtr-132395	Xenopus tropicalis	90.46	0.00e+00	632.00
IUUC-Xma-133383	Xiphophorus maculatus	83.69	2.00e-170	591.00
IUUC-Yli-134586	Yarrowia lipolytica	49.54	5.00e-82	297.00
IUUC-Zma-135904	Zea mays	45.09	4.00e-84	304.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence