iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.50e-09	37.0	140	188

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C  C+ +++ ++ +v+Ce+C+ewfHp C + ++ee ++ + +++C++C+
   Q: 140  VFC-KCEMPYNPDDLMVQCEECSEWFHPSCIGTTIEEAKKPD-NFYCEECS 188
           578.79****************************77665555.3******7 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Chromatin remodeling factor that binds to methylated histone (e.g. H3K4me2/3) to prevent their acetylation (e.g. H3K9K14Ac), likely by recruiting histone deacetylase (HDAC) complexes, and thus regulate the transcription of target genes (PubMed:25281686). Required during development and for fertility, probably by modulating developmental gene expression (PubMed:11129039, PubMed:15082927, PubMed:25281686). Promotes development speed, but at fitness cost (PubMed:11129039). Involved in the chromatin-mediated repression of floral initiation and controls genes regulating flowering. Negatively regulates the expression of the floral integrator SOC1, by preventing high levels of H3 acetylation, thus maintaining an inactive chromatin conformation (PubMed:25281686).

Protein Sequence
(Fasta)

MPKQKAPRKQ LKSYKLKHIN KSIQEGDAVL MRSSEPGKPS YVARVEAIET DARGSHAKVR 60
VRWYYRPEES IGGRRQFHGA KEVFLSDHFD FQSADTIEGK CKVHSFSSYT KLDSVGNDDF 120

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Nucleotide Sequence
(Fasta)

CCTTTCTTTC CTCTATATTC ACGATCCTGC CATTGTACAC CCAATCATAC GCTCCTGAGA 60
TCCTCATGAC TTGTTCTTAC CGTACTCCGC GAGACATGCG ATTGATGATT CTTGACTGTA 120

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Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0287--Flowering
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001025--BAH_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51038--BAH
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF01426--BAH
PF00628--PHD

SMART

SM00439--BAH
SM00249--PHD

Gene Ontology

GO:0000785--C:chromatin
GO:0005677--C:chromatin silencing complex
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0035064--F:methylated histone binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006325--P:chromatin organization
GO:0006342--P:chromatin silencing
GO:0016569--P:covalent chromatin modification
GO:0009908--P:flower development
GO:0031507--P:heterochromatin assembly
GO:0035067--P:negative regulation of histone acetylation
GO:0009791--P:post-embryonic development
GO:2000028--P:regulation of photoperiodism, flowering
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

ath:AT4G39100

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-005443	Arabidopsis lyrata	96.93	7.00e-134	468.00
IUUC-Ago-007912	Ashbya gossypii	43.33	3.00e-02	32.70
IUUC-Bol-015574	Brassica oleracea	87.34	2.00e-120	424.00
IUUC-Bra-017900	Brassica rapa	87.77	2.00e-120	424.00
IUUC-Cme-027118	Cyanidioschyzon merolae	34.55	1.00e-03	38.10
IUUC-Gma-043965	Glycine max	71.83	7.00e-95	338.00
IUUC-Kpa-049165	Komagataella pastoris	38.03	2.00e-07	49.70
IUUC-Mtr-058621	Medicago truncatula	70.23	1.00e-91	328.00
IUUC-Mdo-062097	Monodelphis domestica	34.33	3.00e-09	57.00
IUUC-Ogl-077547	Oryza glaberrima	66.84	4.00e-77	279.00
IUUC-Olu-087802	Ostreococcus lucimarinus	45.18	7.00e-42	162.00
IUUC-Pop-098853	Populus trichocarpa	70.42	3.00e-90	323.00
IUUC-Pca-100779	Procavia capensis	34.48	1.00e-10	61.60
IUUC-Ppe-101818	Prunus persica	70.42	5.00e-91	326.00
IUUC-Sce-106421	Saccharomyces cerevisiae	33.33	4.00e-07	48.10
IUUC-Sha-106728	Sarcophilus harrisii	38.00	1.00e-09	54.30
IUUC-Sja-107734	Schizosaccharomyces japonicus	40.38	8.00e-07	49.70
IUUC-Tca-121689	Theobroma cacao	73.21	4.00e-93	333.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence