iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-092974

Ensembl Protein ID

ENSPSIP00000018266.1

UniProt Accession

K7GDA5; K7GDA5_PELSI

Genbank Protein ID

ENSPSIP00000018266

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGCU01191695

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000016196.1	ENSPSIT00000018352.1	ENSPSIP00000018266.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.70e-108	360.8	555	881

Active Site

Position(s)	Description	Evidence
850	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 555  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 638
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfs.vseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+sl  ++++ e ++e+  + +tf+  +++++g+   ++Lk++G++ip+tneN++e+v+l++
   Q: 639  HFPMVVYRKLMGKKGTFRDLADSHPVLYQSLRDLLQY-EGSVEDD-MMITFQiSHTDLFGNPMMHDLKENGDKIPITNENRKEFVNLYA 725
           *************************************.6677775.999999445566******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggy++ds  i+ Fwe++++f++e+++ fLq
   Q: 726  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYSRDSLIIREFWEIVHSFTDEQKRLFLQ 814
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 815  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 881
           *****************...8888866666**************************************97 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

CHRMATACKR SPGEPHSENI ETSRMKRAAA KHLIERYYHQ LTEGCGNEAC TNEFCASCPT 60
FHRMDNNAAA IKALELYKIN AKLCDPHPSK KGTSSAYLEN NSKGAHNNSC TDRKMNKKET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTCAAAAAC AGTGGAAATC CGTTTTATAA TTTGCAAGGA CAAACTTCTG AAGCTGTGAA 60
AAAAATATGG TATGTCTGCT GTTATTTTCA TGTGTTGTAT ATGCAACTTG TCAACTGTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	93.82	0.00e+00	1570.00
IUUC-Atr-003144	Amborella trichopoda	45.00	3.00e-96	345.00
IUUC-Apl-003742	Anas platyrhynchos	98.07	0.00e+00	1677.00
IUUC-Aca-004873	Anolis carolinensis	96.83	0.00e+00	1680.00
IUUC-Ame-011166	Astyanax mexicanus	86.85	0.00e+00	1466.00
IUUC-Bta-013286	Bos taurus	93.29	0.00e+00	1555.00
IUUC-Cja-019707	Callithrix jacchus	91.98	0.00e+00	1582.00
IUUC-Cfa-020154	Canis familiaris	93.47	0.00e+00	1580.00
IUUC-Cpo-021292	Cavia porcellus	92.88	0.00e+00	1547.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.37	4.00e-82	297.00
IUUC-Csa-023378	Chlorocebus sabaeus	91.70	0.00e+00	1586.00
IUUC-Cho-025059	Choloepus hoffmanni	90.68	0.00e+00	1487.00
IUUC-Cin-025643	Ciona intestinalis	44.83	0.00e+00	716.00
IUUC-Csv-026282	Ciona savignyi	43.67	0.00e+00	666.00
IUUC-Cme-027151	Cyanidioschyzon merolae	44.02	1.00e-101	364.00
IUUC-Dre-027901	Danio rerio	85.10	0.00e+00	1441.00
IUUC-Dno-029320	Dasypus novemcinctus	93.74	0.00e+00	1604.00
IUUC-Dor-030756	Dipodomys ordii	88.64	0.00e+00	700.00
IUUC-Dme-032035	Drosophila melanogaster	43.95	1.00e-166	580.00
IUUC-Eca-033843	Equus caballus	93.47	0.00e+00	1527.00
IUUC-Eeu-035109	Erinaceus europaeus	92.07	0.00e+00	1510.00
IUUC-Fca-036344	Felis catus	93.63	0.00e+00	1594.00
IUUC-Fal-036747	Ficedula albicollis	97.95	0.00e+00	1667.00
IUUC-Gmo-038840	Gadus morhua	63.72	0.00e+00	1108.00
IUUC-Gga-040399	Gallus gallus	97.95	0.00e+00	1667.00
IUUC-Gac-041933	Gasterosteus aculeatus	86.87	0.00e+00	1423.00
IUUC-Ggo-044804	Gorilla gorilla	91.43	0.00e+00	1577.00
IUUC-Hsa-045727	Homo sapiens	91.43	0.00e+00	1577.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	90.20	0.00e+00	1466.00
IUUC-Lch-050197	Latimeria chalumnae	91.87	0.00e+00	1575.00
IUUC-Loc-052743	Lepisosteus oculatus	91.08	0.00e+00	1573.00
IUUC-Lma-053245	Leptosphaeria maculans	34.84	2.00e-57	218.00
IUUC-Laf-053615	Loxodonta africana	91.84	0.00e+00	1587.00
IUUC-Mcc-054934	Macaca mulatta	91.72	0.00e+00	1573.00
IUUC-Meu-056061	Macropus eugenii	96.82	0.00e+00	1363.00
IUUC-Mga-059271	Meleagris gallopavo	95.91	0.00e+00	1620.00
IUUC-Mmr-061288	Microcebus murinus	93.33	0.00e+00	1578.00
IUUC-Mdo-062975	Monodelphis domestica	96.59	0.00e+00	1654.00
IUUC-Mmu-063674	Mus musculus	90.10	0.00e+00	1545.00
IUUC-Mpu-066568	Mustela putorius furo	94.20	0.00e+00	1611.00
IUUC-Mlu-067522	Myotis lucifugus	86.60	0.00e+00	1481.00
IUUC-Nle-069505	Nomascus leucogenys	91.43	0.00e+00	1577.00
IUUC-Opr-070570	Ochotona princeps	86.88	0.00e+00	1424.00
IUUC-Ont-071527	Oreochromis niloticus	87.47	0.00e+00	1491.00
IUUC-Oan-073446	Ornithorhynchus anatinus	90.52	0.00e+00	1074.00
IUUC-Ocu-074922	Oryctolagus cuniculus	92.76	0.00e+00	1597.00
IUUC-Ola-086996	Oryzias latipes	84.55	0.00e+00	1486.00
IUUC-Oga-088261	Otolemur garnettii	93.58	0.00e+00	1557.00
IUUC-Oar-090024	Ovis aries	93.29	0.00e+00	1555.00
IUUC-Ptr-090455	Pan troglodytes	91.43	0.00e+00	1577.00
IUUC-Pan-092509	Papio anubis	89.10	0.00e+00	1408.00
IUUC-Pma-094643	Petromyzon marinus	71.17	0.00e+00	1257.00
IUUC-Pno-094886	Phaeosphaeria nodorum	36.10	2.00e-59	224.00
IUUC-Pfo-096905	Poecilia formosa	86.01	0.00e+00	1483.00
IUUC-Pab-097840	Pongo abelii	91.49	0.00e+00	1518.00
IUUC-Pca-100869	Procavia capensis	93.59	0.00e+00	1568.00
IUUC-Pva-103040	Pteropus vampyrus	95.83	0.00e+00	661.00
IUUC-Rno-105453	Rattus norvegicus	89.65	0.00e+00	1538.00
IUUC-Sha-107651	Sarcophilus harrisii	96.59	0.00e+00	1655.00
IUUC-Smo-108858	Selaginella moellendorffii	49.65	2.00e-115	409.00
IUUC-Sar-113293	Sorex araneus	93.82	0.00e+00	1558.00
IUUC-Ssc-115979	Sus scrofa	94.05	0.00e+00	1560.00
IUUC-Tgu-116901	Taeniopygia guttata	97.96	0.00e+00	1675.00
IUUC-Tru-118368	Takifugu rubripes	86.31	0.00e+00	1479.00
IUUC-Tsy-119516	Tarsius syrichta	89.96	0.00e+00	1451.00
IUUC-Tni-120143	Tetraodon nigroviridis	85.96	0.00e+00	1474.00
IUUC-Tbe-127484	Tupaia belangeri	87.15	0.00e+00	1064.00
IUUC-Ttr-129078	Tursiops truncatus	93.36	0.00e+00	1534.00
IUUC-Vpa-130312	Vicugna pacos	85.56	0.00e+00	1308.00
IUUC-Xtr-132881	Xenopus tropicalis	90.84	0.00e+00	1589.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence