iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ncr-068822

Ensembl Protein ID

EAA29459

UniProt Accession

P51599; Q7RV90; Q9C2R6; GCH1_NEUCR

Genbank Protein ID

CAC28574.1; EAA29459.3; CAA89828.1

Protein Name

GTP cyclohydrolase 1; GTP cyclohydrolase I

Genbank Nucleotide ID

AL513410; CM002240; Z49758

Gene Name

gch-1; 104H10.80; NCU07774

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
NCU07774	EAA29459	EAA29459

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	55.94	9.00e-66	248.00	IUUC-Hsa-046907

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Neurospora crassa

Functional Description
(View)

GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity.

Protein Sequence
(Fasta)

MAQETTRDGS DSPSGSVSPP IANGTNNKKD KKSSKKRAHS SGERRSSVSK PARDPSDKPE 60
ESPSKKKKRK TTSSTAAAAV PSTITEEVSP STSVTRSPSP VIDFDGLSRP SRGTRERLEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAACTCCA AAAGTGAAAC AAAACCGAAT CGATTCCACA CAGAATTGAA CCCCGAACAA 60
GCCCGCCCCA TTTCGTCCCC AGAATCAGTC CAGAACGCAG GCTTTGCCCT TGCAGAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0021--Allosteric enzyme
KW-0181--Complete proteome
KW-0289--Folate biosynthesis
KW-0342--GTP-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR001474--GTP_CycHdrlase_I
IPR018234--GTP_CycHdrlase_I_CS
IPR020602--GTP_CycHdrlase_I_dom

PROSITE

PS00859--GTP_CYCLOHYDROL_1_1
PS00860--GTP_CYCLOHYDROL_1_2

Pfam

PF01227--GTP_cyclohydroI

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005525--F:GTP binding
GO:0003934--F:GTP cyclohydrolase I activity
GO:0046872--F:metal ion binding
GO:0035998--P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process
GO:0046656--P:folic acid biosynthetic process
GO:0046654--P:tetrahydrofolate biosynthetic process

KEGG

ncr:NCU07774

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002530	Amborella trichopoda	44.44	1.00e-31	129.00
IUUC-Apl-004135	Anas platyrhynchos	64.15	2.00e-61	226.00
IUUC-Aca-005252	Anolis carolinensis	62.98	1.00e-66	243.00
IUUC-Aly-006454	Arabidopsis lyrata	37.57	2.00e-27	115.00
IUUC-Ath-006744	Arabidopsis thaliana	37.04	6.00e-27	113.00
IUUC-Ago-007744	Ashbya gossypii	58.41	4.00e-71	259.00
IUUC-Acl-008058	Aspergillus clavatus	72.51	2.00e-93	333.00
IUUC-Afl-008668	Aspergillus flavus	71.90	9.00e-92	328.00
IUUC-Afu-008935	Aspergillus fumigatus	72.51	4.00e-93	332.00
IUUC-Ani-009207	Aspergillus nidulans	60.58	2.00e-93	333.00
IUUC-Ang-009686	Aspergillus niger	59.15	2.00e-89	320.00
IUUC-Aor-010202	Aspergillus oryzae	64.40	2.00e-92	329.00
IUUC-Ate-010518	Aspergillus terreus	56.86	3.00e-95	339.00
IUUC-Ame-010958	Astyanax mexicanus	61.17	3.00e-68	249.00
IUUC-Bgr-012060	Blumeria graminis	64.36	1.00e-99	354.00
IUUC-Bta-012416	Bos taurus	56.44	5.00e-68	248.00
IUUC-Bci-013811	Botrytis cinerea	69.86	2.00e-112	396.00
IUUC-Bdi-014794	Brachypodium distachyon	39.50	7.00e-28	116.00
IUUC-Bol-015182	Brassica oleracea	36.41	3.00e-30	124.00
IUUC-Bra-016764	Brassica rapa	35.32	1.00e-27	115.00
IUUC-Cel-018345	Caenorhabditis elegans	59.14	9.00e-68	247.00
IUUC-Cja-019848	Callithrix jacchus	63.97	4.00e-52	194.00
IUUC-Cfa-020630	Canis familiaris	56.44	3.00e-68	249.00
IUUC-Cpo-021420	Cavia porcellus	64.46	3.00e-65	239.00
IUUC-Cre-022618	Chlamydomonas reinhardtii	40.20	1.00e-37	147.00
IUUC-Csa-023403	Chlorocebus sabaeus	57.83	2.00e-54	203.00
IUUC-Cho-024907	Choloepus hoffmanni	57.43	3.00e-69	252.00
IUUC-Cin-025120	Ciona intestinalis	56.31	3.00e-61	226.00
IUUC-Csv-026259	Ciona savignyi	60.67	1.00e-65	239.00
IUUC-Cgl-026508	Colletotrichum gloeosporioides	71.53	4.00e-113	399.00
IUUC-Cne-026810	Cryptococcus neoformans	62.09	7.00e-80	289.00
IUUC-Cme-027139	Cyanidioschyzon merolae	45.11	3.00e-48	183.00
IUUC-Dre-028815	Danio rerio	60.77	1.00e-65	241.00
IUUC-Dno-029017	Dasypus novemcinctus	63.07	4.00e-67	245.00
IUUC-Dor-030417	Dipodomys ordii	63.91	8.00e-51	190.00
IUUC-Dse-031187	Dothistroma septosporum	69.47	1.00e-91	327.00
IUUC-Dme-031615	Drosophila melanogaster	60.22	2.00e-59	220.00
IUUC-Ete-032727	Echinops telfairi	37.04	4.00e-28	115.00
IUUC-Eca-033487	Equus caballus	63.24	3.00e-51	191.00
IUUC-Eeu-034696	Erinaceus europaeus	65.06	7.00e-66	241.00
IUUC-Fca-035975	Felis catus	61.84	3.00e-24	100.00
IUUC-Fal-037439	Ficedula albicollis	63.95	8.00e-57	210.00
IUUC-Fox-037781	Fusarium oxysporum	71.32	1.00e-104	370.00
IUUC-Fso-038377	Fusarium solani	71.32	3.00e-106	376.00
IUUC-Gmo-038945	Gadus morhua	59.36	1.00e-63	233.00
IUUC-Ggr-039834	Gaeumannomyces graminis	73.33	3.00e-115	406.00
IUUC-Gga-040495	Gallus gallus	59.26	3.00e-67	246.00
IUUC-Gac-042306	Gasterosteus aculeatus	54.93	3.00e-66	243.00
IUUC-Gma-043539	Glycine max	36.02	9.00e-34	135.00
IUUC-Ggo-045597	Gorilla gorilla	51.81	6.00e-50	188.00
IUUC-Hsa-046907	Homo sapiens	64.46	5.00e-65	238.00
IUUC-Hvu-047298	Hordeum vulgare	39.41	7.00e-35	139.00
IUUC-Itr-048997	Ictidomys tridecemlineatus	59.67	7.00e-66	241.00
IUUC-Kpa-049319	Komagataella pastoris	62.09	2.00e-81	293.00
IUUC-Lch-049771	Latimeria chalumnae	58.05	9.00e-70	254.00
IUUC-Lpe-050904	Leersia perrieri	42.35	1.00e-32	132.00
IUUC-Loc-052063	Lepisosteus oculatus	50.40	4.00e-68	248.00
IUUC-Lma-053280	Leptosphaeria maculans	53.94	3.00e-69	254.00
IUUC-Laf-054214	Loxodonta africana	56.44	3.00e-68	249.00
IUUC-Mcc-054778	Macaca mulatta	64.46	5.00e-65	238.00
IUUC-Meu-056598	Macropus eugenii	61.19	8.00e-20	88.60
IUUC-Mor-056989	Magnaporthe oryzae	86.30	1.00e-115	407.00
IUUC-Mpo-057591	Magnaporthe poae	84.93	1.00e-114	403.00
IUUC-Mtr-057924	Medicago truncatula	43.64	1.00e-34	138.00
IUUC-Mla-058931	Melampsora laricipopulina	61.70	4.00e-73	266.00
IUUC-Mga-060001	Meleagris gallopavo	63.24	1.00e-51	193.00
IUUC-Mvi-060513	Microbotryum violaceum	60.27	6.00e-77	278.00
IUUC-Mmr-061725	Microcebus murinus	58.59	8.00e-68	248.00
IUUC-Mdo-062715	Monodelphis domestica	56.62	3.00e-68	250.00
IUUC-Mmu-063203	Mus musculus	55.94	3.00e-65	239.00
IUUC-Mac-065392	Musa acuminata	44.85	1.00e-38	150.00
IUUC-Mpu-066174	Mustela putorius furo	56.72	5.00e-68	248.00
IUUC-Mlu-067883	Myotis lucifugus	63.97	5.00e-52	194.00
IUUC-Nfi-068317	Neosartorya fischeri	72.51	2.00e-93	333.00
IUUC-Nle-069231	Nomascus leucogenys	64.46	6.00e-65	238.00
IUUC-Opr-070417	Ochotona princeps	64.66	7.00e-51	190.00
IUUC-Ont-072168	Oreochromis niloticus	54.55	3.00e-65	239.00
IUUC-Oan-072690	Ornithorhynchus anatinus	63.16	1.00e-24	101.00
IUUC-Ocu-074537	Oryctolagus cuniculus	58.59	3.00e-67	246.00
IUUC-Oba-075333	Oryza barthii	42.53	2.00e-34	138.00
IUUC-Obr-076255	Oryza brachyantha	33.90	1.00e-23	101.00
IUUC-Ogl-077792	Oryza glaberrima	42.35	2.00e-34	137.00
IUUC-Ogu-078354	Oryza glumaepatula	42.35	2.00e-33	135.00
IUUC-Oin-079934	Oryza indica	42.35	2.00e-33	135.00
IUUC-Olo-080643	Oryza longistaminata	38.89	5.00e-25	107.00
IUUC-Ome-081632	Oryza meridionalis	45.21	8.00e-32	129.00
IUUC-Oni-083004	Oryza nivara	42.35	2.00e-33	135.00
IUUC-Opu-083899	Oryza punctata	42.35	5.00e-33	133.00
IUUC-Oru-084386	Oryza rufipogon	42.35	1.00e-33	135.00
IUUC-Osa-085665	Oryza sativa	33.90	2.00e-23	101.00
IUUC-Ola-086577	Oryzias latipes	62.03	5.00e-68	248.00
IUUC-Olu-087867	Ostreococcus lucimarinus	43.08	5.00e-39	152.00
IUUC-Oga-088652	Otolemur garnettii	63.86	3.00e-64	236.00
IUUC-Oar-089965	Ovis aries	55.94	4.00e-68	248.00
IUUC-Ptr-090833	Pan troglodytes	64.46	5.00e-65	238.00
IUUC-Psi-093542	Pelodiscus sinensis	60.22	3.00e-61	226.00
IUUC-Pma-094423	Petromyzon marinus	63.50	2.00e-50	188.00
IUUC-Pno-095091	Phaeosphaeria nodorum	71.49	1.00e-86	310.00
IUUC-Ppa-096013	Physcomitrella patens	44.94	2.00e-33	135.00
IUUC-Pfo-097146	Poecilia formosa	57.58	5.00e-66	242.00
IUUC-Pab-098744	Pongo abelii	64.46	5.00e-65	238.00
IUUC-Pop-099917	Populus trichocarpa	43.79	4.00e-31	127.00
IUUC-Pca-100111	Procavia capensis	56.44	1.00e-67	247.00
IUUC-Ppe-101984	Prunus persica	41.83	2.00e-29	121.00
IUUC-Pva-103078	Pteropus vampyrus	54.55	1.00e-66	244.00
IUUC-Pgr-103438	Puccinia graminis	63.24	4.00e-72	262.00
IUUC-Ptt-103875	Puccinia triticina	63.64	1.00e-72	264.00
IUUC-Pte-104180	Pyrenophora teres	69.33	7.00e-91	325.00
IUUC-Pyt-104552	Pyrenophora triticirepentis	69.33	4.00e-91	326.00
IUUC-Rno-105506	Rattus norvegicus	55.45	5.00e-67	245.00
IUUC-Sce-106375	Saccharomyces cerevisiae	60.27	5.00e-77	278.00
IUUC-Sha-107585	Sarcophilus harrisii	63.24	9.00e-52	193.00
IUUC-Sja-107871	Schizosaccharomyces japonicus	61.61	9.00e-82	294.00
IUUC-Spo-108282	Schizosaccharomyces pombe	61.01	4.00e-82	295.00
IUUC-Smo-109561	Selaginella moellendorffii	40.67	6.00e-37	146.00
IUUC-Sit-110577	Setaria italica	38.86	3.00e-29	121.00
IUUC-Sly-111719	Solanum lycopersicum	45.75	8.00e-33	132.00
IUUC-Stu-112752	Solanum tuberosum	45.81	6.00e-34	136.00
IUUC-Sar-113701	Sorex araneus	60.22	3.00e-66	242.00
IUUC-Sbi-114308	Sorghum bicolor	41.03	6.00e-35	140.00
IUUC-Sre-115125	Sporisorium reilianum	59.91	5.00e-81	292.00
IUUC-Tgu-117039	Taeniopygia guttata	63.24	1.00e-51	192.00
IUUC-Tru-117939	Takifugu rubripes	56.25	7.00e-66	241.00
IUUC-Tsy-118852	Tarsius syrichta	56.39	2.00e-40	155.00
IUUC-Tni-120356	Tetraodon nigroviridis	56.10	1.00e-65	240.00
IUUC-Tca-121422	Theobroma cacao	41.86	9.00e-34	135.00
IUUC-Tre-122035	Trichoderma reesei	78.48	5.00e-108	381.00
IUUC-Tvi-122649	Trichoderma virens	71.85	2.00e-113	400.00
IUUC-Tae-124146	Triticum aestivum	39.60	6.00e-36	142.00
IUUC-Tme-127015	Tuber melanosporum	66.67	2.00e-87	313.00
IUUC-Tbe-128024	Tupaia belangeri	56.39	1.00e-40	156.00
IUUC-Ttr-128474	Tursiops truncatus	54.91	4.00e-68	249.00
IUUC-Uma-129655	Ustilago maydis	59.91	5.00e-81	293.00
IUUC-Vda-129970	Verticillium dahliae	71.16	1.00e-111	394.00
IUUC-Vpa-130564	Vicugna pacos	64.66	4.00e-51	191.00
IUUC-Vvi-131597	Vitis vinifera	41.00	9.00e-32	129.00
IUUC-Xtr-132201	Xenopus tropicalis	57.56	1.00e-67	247.00
IUUC-Xma-133679	Xiphophorus maculatus	57.58	6.00e-66	241.00
IUUC-Yli-134489	Yarrowia lipolytica	62.72	2.00e-85	306.00
IUUC-Zma-135058	Zea mays	40.91	2.00e-35	141.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence