iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013128

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 15; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15

Genbank Nucleotide ID

DAAA02013374

Gene Name

USP15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010428.5	ENSBTAT00000037574.4	ENSBTAP00000037402.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-119	399.7	260	904
ULD/UDP/UBQ/UBQ_Other	6.30e-10	38.9	147	217

Active Site

Position(s)	Description	Evidence
269	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
862	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl+NlgNtC+mNS+ QcLsn+p+l+e++l+ k++e+ln +np ++ ge++ks+++l++++w++k ++v+pr+++++++++a++fsgy+
   Q: 260  CGLSNLGNTCFMNSAFQCLSNTPPLTEYFLNdKYQEELNFDNPLGMRGEIAKSYAELIKQMWSGKYSYVTPRAFKTQVGRFAPQFSGYQ 348
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ ++kp+ +++++d   ++d+     a+e++ k+n+s+i+d+F+g +ks+++c+ec+++s++++pf++l
   Q: 349  QQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDAD--GRPDKvvaeeAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYL 435
           ******************************9999..5555555777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p+k+e+ +e                                                                            
   Q: 436  TLPLPMKKERTLEvylvrmdpltkpmqykvvvpkignildlctalsllsgvpadkmivtdiynhrfhrifamdenlssimerddiyvfe 524
           *********9999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 525  ininrtedtehviipvclrekfrhssythhtgsslfgqpflmavprnntedklynlllvrmcryvkistdtedtegslhcckdqningn 613
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 614  gpngiheegspsemetdepddessqdqelpsenensqsedsvggdndsenglcteetcrgqltghkkrlftfqfnnlgntdinyikddt 702
           ***************************************************************************************** PP
   S: 186  .......................................................slqdcLesftkeeelegenkyycekckkkqeaek 219
                                                                  +l+dc+e ft++e+l  e+ +yc++ck++q+a+k
   Q: 703  rhirfddrqlrldersflaldwdpdlkkryfdenaaedfekhesveykppkkpfvKLKDCIELFTTKEKLGAEDPWYCPNCKEHQQATK 791
           ***************************************************************************************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.W 306
           kl+l++lP+vL++hLkRfs+s+  ++r k+++ v+fp++ Ld+s+f+++p+ +   +++Y+Liav +H+G++++GHY+a++kn++++ W
   Q: 792  KLDLWSLPPVLVVHLKRFSYSR--YMRDKLDTLVDFPINdLDMSEFLINPNAG---PCRYNLIAVSNHYGGMGGGHYTAFAKNKDDGkW 875
           ******************9977..6999*********************9988...8**************************65555* PP
   S: 307  llfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++fdDs+V++ +e+++++   + aYvlfY+r+
   Q: 876  YYFDDSSVSTASEDQIVS---KAAYVLFYQRQ 904
           ******************...*********96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk.....GkiL.eddktLadyglkdgstihllekksg 75
           + t++++++dt+ ++ ++i+k ++ip + + rL++k      ++L ++d t++d gl++g+++++++k+++
   Q: 147  VVTRRFSKADTIDTIEKEIRKIFNIPdEKETRLWNKymsntFEPLnKPDSTIQDAGLYQGQVLVIEQKNED 217
           77899*********************999*****998875544569*********************9986 PP

Organism

Bos taurus

Functional Description
(View)

Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling and NF-kappa-B pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates as well as 'Lys-48'-linked polyubiquitin chains, protecting them against proteasomal degradation. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP.

Protein Sequence
(Fasta)

MAEGGAADLD IQRSDIATLL KTSLRKGDTW YLVDSRWFKQ WKKYVGFDSW DKYQMGDQNV 60
YPGPIDNSGL LRDGDAQSLK EHLIDELDYI LLPTEGWNKL VSWYTLMEGQ EPIARKVVEQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATGCTCTGG GGCGTGCCGC CGCCGTCGCT GCCGCCTCCG CTACCGCTAG TGGAAGAAGA 60
TGGCGGAAGG CGGAGCGGCA GATCTGGACA TCCAGCGTTC TGACATCGCG ACGCTGCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR013792--RNA3'P_cycl/enolpyr_Trfase_a/b
IPR028135--Ub_USP-typ
IPR029071--Ubiquitin-rel_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
PF14533--USP7_C2

SMART

SM00695--DUSP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0030509--P:BMP signaling pathway
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:0060389--P:pathway-restricted SMAD protein phosphorylation
GO:0016579--P:protein deubiquitination
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

bta:538284

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000058	Aegilops tauschii	36.95	4.00e-119	422.00
IUUC-Aml-001852	Ailuropoda melanoleuca	95.11	0.00e+00	1854.00
IUUC-Apl-003249	Anas platyrhynchos	92.65	0.00e+00	1689.00
IUUC-Aca-004261	Anolis carolinensis	90.97	0.00e+00	1701.00
IUUC-Aly-005644	Arabidopsis lyrata	35.35	7.00e-139	488.00
IUUC-Ath-006782	Arabidopsis thaliana	35.04	3.00e-138	486.00
IUUC-Acl-008284	Aspergillus clavatus	33.66	4.00e-55	210.00
IUUC-Afl-008507	Aspergillus flavus	38.57	1.00e-54	209.00
IUUC-Aor-009949	Aspergillus oryzae	38.29	1.00e-53	205.00
IUUC-Ame-010757	Astyanax mexicanus	77.80	0.00e+00	1237.00
IUUC-Bgr-012277	Blumeria graminis	42.76	4.00e-63	237.00
IUUC-Bci-013993	Botrytis cinerea	43.15	6.00e-64	239.00
IUUC-Bol-015570	Brassica oleracea	37.63	3.00e-154	538.00
IUUC-Bra-017029	Brassica rapa	36.98	1.00e-139	490.00
IUUC-Cel-018203	Caenorhabditis elegans	59.90	4.00e-70	259.00
IUUC-Cja-019222	Callithrix jacchus	95.01	0.00e+00	1853.00
IUUC-Cfa-020035	Canis familiaris	95.11	0.00e+00	1853.00
IUUC-Cpo-022071	Cavia porcellus	94.57	0.00e+00	1765.00
IUUC-Csa-023882	Chlorocebus sabaeus	95.31	0.00e+00	1858.00
IUUC-Cin-025292	Ciona intestinalis	44.68	0.00e+00	748.00
IUUC-Csv-026109	Ciona savignyi	43.31	0.00e+00	691.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	36.42	1.00e-60	229.00
IUUC-Cme-027338	Cyanidioschyzon merolae	55.91	1.00e-67	251.00
IUUC-Dno-029025	Dasypus novemcinctus	95.14	0.00e+00	1790.00
IUUC-Dor-030956	Dipodomys ordii	85.90	0.00e+00	1587.00
IUUC-Eca-034340	Equus caballus	95.06	0.00e+00	1797.00
IUUC-Eeu-034488	Erinaceus europaeus	83.79	0.00e+00	1224.00
IUUC-Fca-035552	Felis catus	98.42	0.00e+00	1873.00
IUUC-Fal-036618	Ficedula albicollis	92.44	0.00e+00	1680.00
IUUC-Gga-041146	Gallus gallus	91.24	0.00e+00	1721.00
IUUC-Gac-041679	Gasterosteus aculeatus	76.21	0.00e+00	1437.00
IUUC-Ggo-045002	Gorilla gorilla	95.06	0.00e+00	1793.00
IUUC-Hsa-046052	Homo sapiens	95.21	0.00e+00	1857.00
IUUC-Hvu-047108	Hordeum vulgare	39.73	6.00e-122	431.00
IUUC-Itr-048306	Ictidomys tridecemlineatus	98.32	0.00e+00	1874.00
IUUC-Kpa-049332	Komagataella pastoris	33.98	2.00e-74	274.00
IUUC-Lch-050107	Latimeria chalumnae	83.83	0.00e+00	1697.00
IUUC-Loc-052105	Lepisosteus oculatus	81.09	0.00e+00	1480.00
IUUC-Lma-052981	Leptosphaeria maculans	37.79	3.00e-67	251.00
IUUC-Laf-053645	Loxodonta africana	94.60	0.00e+00	1846.00
IUUC-Mcc-055586	Macaca mulatta	95.21	0.00e+00	1857.00
IUUC-Meu-056764	Macropus eugenii	89.81	0.00e+00	1001.00
IUUC-Mga-060162	Meleagris gallopavo	91.55	0.00e+00	1725.00
IUUC-Mmr-061105	Microcebus murinus	95.41	0.00e+00	1858.00
IUUC-Mdo-062107	Monodelphis domestica	93.39	0.00e+00	1804.00
IUUC-Mmu-063662	Mus musculus	93.58	0.00e+00	1831.00
IUUC-Mac-065239	Musa acuminata	32.99	2.00e-131	463.00
IUUC-Mpu-065868	Mustela putorius furo	93.21	0.00e+00	1844.00
IUUC-Mlu-068000	Myotis lucifugus	89.99	0.00e+00	1673.00
IUUC-Nfi-068330	Neosartorya fischeri	28.36	5.00e-58	220.00
IUUC-Nle-069874	Nomascus leucogenys	95.05	0.00e+00	1832.00
IUUC-Opr-071212	Ochotona princeps	89.24	0.00e+00	1733.00
IUUC-Ont-071834	Oreochromis niloticus	77.89	0.00e+00	1430.00
IUUC-Ocu-074573	Oryctolagus cuniculus	95.11	0.00e+00	1854.00
IUUC-Obr-076416	Oryza brachyantha	39.78	3.00e-120	426.00
IUUC-Oga-089022	Otolemur garnettii	98.11	0.00e+00	1872.00
IUUC-Oar-089767	Ovis aries	96.23	0.00e+00	1872.00
IUUC-Ptr-091319	Pan troglodytes	98.84	0.00e+00	1885.00
IUUC-Pan-091968	Papio anubis	95.31	0.00e+00	1858.00
IUUC-Psi-093849	Pelodiscus sinensis	91.28	0.00e+00	1681.00
IUUC-Pma-094533	Petromyzon marinus	60.58	0.00e+00	1120.00
IUUC-Pno-094890	Phaeosphaeria nodorum	37.68	3.00e-61	231.00
IUUC-Pfo-097110	Poecilia formosa	76.39	0.00e+00	1429.00
IUUC-Pab-098664	Pongo abelii	95.31	0.00e+00	1858.00
IUUC-Pop-099801	Populus trichocarpa	37.06	1.00e-151	530.00
IUUC-Pca-100359	Procavia capensis	85.58	0.00e+00	1095.00
IUUC-Ppe-101587	Prunus persica	37.30	9.00e-149	521.00
IUUC-Pva-102394	Pteropus vampyrus	93.68	0.00e+00	1815.00
IUUC-Pgr-103546	Puccinia graminis	29.73	8.00e-68	253.00
IUUC-Pte-104102	Pyrenophora teres	37.61	6.00e-59	223.00
IUUC-Pyt-104812	Pyrenophora triticirepentis	41.47	8.00e-58	219.00
IUUC-Rno-105383	Rattus norvegicus	97.48	0.00e+00	1865.00
IUUC-Sha-107393	Sarcophilus harrisii	93.49	0.00e+00	1810.00
IUUC-Sja-107752	Schizosaccharomyces japonicus	36.67	1.00e-83	305.00
IUUC-Spo-108291	Schizosaccharomyces pombe	33.05	3.00e-77	283.00
IUUC-Ssl-108461	Sclerotinia sclerotiorum	30.56	2.00e-13	71.20
IUUC-Sar-113498	Sorex araneus	94.50	0.00e+00	1843.00
IUUC-Ssc-115285	Sus scrofa	95.62	0.00e+00	1858.00
IUUC-Tgu-116529	Taeniopygia guttata	91.96	0.00e+00	1737.00
IUUC-Tru-118298	Takifugu rubripes	77.17	0.00e+00	1445.00
IUUC-Tsy-119117	Tarsius syrichta	89.20	0.00e+00	1151.00
IUUC-Tni-120093	Tetraodon nigroviridis	73.81	0.00e+00	1374.00
IUUC-Tca-121670	Theobroma cacao	43.03	7.00e-75	275.00
IUUC-Tae-125811	Triticum aestivum	37.48	6.00e-126	445.00
IUUC-Tur-126149	Triticum urartu	37.04	1.00e-106	381.00
IUUC-Tbe-127672	Tupaia belangeri	86.26	0.00e+00	1210.00
IUUC-Ttr-128441	Tursiops truncatus	88.93	0.00e+00	1120.00
IUUC-Vpa-130469	Vicugna pacos	94.95	0.00e+00	1785.00
IUUC-Xtr-132729	Xenopus tropicalis	80.96	0.00e+00	1589.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence