iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.00e-46	158.2	7	136

Active Site

Position(s)	Description	Evidence
87	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekWspalsv 98
           R+ ke+++l +dp++gisa+p++  +   ++vl++Gp+d+p+egg Fkle+ +pedYP+k+Pkv+fltkifhPn+++ G++Cl+ilk  +kWspal++
   Q: 7    RIIKETQRLLEDPVPGISATPDEC-NARYFHVLVTGPKDSPFEGGNFKLELFLPEDYPMKAPKVRFLTKIFHPNIDRVGRICLDILK--DKWSPALQI 101
           899********************9.9************************************************************9..********* PP
   S: 99   esvllsiqsllaepnpesplneeaaellkknreey 133
           ++vllsiq+ll+ pnp++pl +++ael+k n+++ 
   Q: 102  RTVLLSIQALLSAPNPDDPLANDVAELWKVNERRA 136
           *****************************998755 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MAALTPRIIK ETQRLLEDPV PGISATPDEC NARYFHVLVT GPKDSPFEGG NFKLELFLPE 60
DYPMKAPKVR FLTKIFHPNI DRVGRICLDI LKDKWSPALQ IRTVLLSIQA LLSAPNPDDP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTAGAAAAA CCAAGTAACC GACAGTGTAA TTCAGAAATT TTATTCAAAT TAAATCTACT 60
TAAAATCTAC TTAAACACAT CAAATTTAAC AGCGTTTTTT TGGAGGAAAC GGATCAAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006301--P:postreplication repair
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination

KEGG

dme:Dmel_CG3473

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence