iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	20004458

Classification

Family	E-value	Score	Start	End
DUB/USP	2.60e-66	222.5	205	536

Active Site

Position(s)	Description	Evidence
214	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
465	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldq 102
           +G++N+g+tCY+NS+LQ+ ++++ +r+l+ e     ++ e +++p++++  +lq+ f +l + ++   ++ el++++++   e  ++ q+D+qE+ ++l+d+
   Q: 205  VGFRNQGATCYLNSLLQSYFFTKYFRKLVYE-----IPTE-HESPNNSVPLALQRAFYQL-QVSDIPLDTLELTRSFGWDTAE--SFTQHDVQELNRILMDR 297
           69*****************************.....5444.368899*************.77778999*********98877..99*************** PP
   S: 103  leeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegen 204
           le+++                          k +  +  ++++F g++ks ikc + d +s r e+f+dl+l+v++ +     +lq++++++ + e ++gen
   Q: 298  LENNM--------------------------KGTPVEGKLNEIFVGKMKSYIKCINVDYESARVEDFWDLQLNVKNFK-----NLQESFDNYIEMELMNGEN 368
           *****..........................78899999***************************************.....9****************** PP
   S: 205  kyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........peekqkekkkYeLiavvvHsGslssGHYvay 298
           +y  +   ++q+a+k + ++++P+vL+l+LkRf+++ + ++  k+n+k+efp+++dlspf+ +        +e+k+k+++ Y+L++v+vHsG +s GHY+++
   Q: 369  QYAAQDY-GLQDAQKGVIFESFPPVLHLQLKRFEYDFNYDQMVKVNDKYEFPETIDLSPFVDKdvlkktldSENKDKNPYVYNLHGVLVHSGDISTGHYYTL 469
           9998886.69*****************************************************999999997777888************************ PP
   S: 299  vkn.ekgkWllfdDskVtevkeeevleetg..........................staYvlfYkrr 338
           +k   +++W++fdD++V  v++++v +e+                           ++aY+l+Y r+
   Q: 470  IKPgVEDQWYRFDDERVWRVTKKQVFQENFgcdrlpdekvrtmtrgeyqnyiiqrhTSAYMLVYIRQ 536
           **956777*****************997779*********************************875 PP

Organism

Saccharomyces cerevisiae

Protein Sequence
(Fasta)

MSSEDELGSI GTVFPGSPID KSIGSILPQF DEEVETLLED SFTWNIPDWN ELTNPKYNSP 60
RFRIGDFEWD ILLFPQGNHN KGVAVYLEPH PEEKLDETTG EMVPVDPDWY CCAQFAIGIS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCTCTG AAGACGAATT GGGAAGTATC GGTACTGTGT TTCCCGGAAG TCCCATAGAT 60
AAGAGCATTG GGAGTATTCT CCCACAATTT GATGAAGAAG TGGAGACTTT GCTGGAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR002083--MATH/TRAF_dom
IPR001394--Peptidase_C19_UCH
IPR008974--TRAF-like
IPR024729--USP7_ICP0-binding_dom
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50144--MATH
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF14533--USP7_C2
PF12436--USP7_ICP0_bdg

SMART

SM00061--MATH

Gene Ontology

GO:0005829--C:cytosol
GO:0005777--C:peroxisome
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0010995--P:free ubiquitin chain depolymerization
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YMR304W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000791	Aegilops tauschii	40.72	6.00e-116	409.00
IUUC-Aml-002408	Ailuropoda melanoleuca	30.10	1.00e-125	442.00
IUUC-Atr-003067	Amborella trichopoda	33.46	3.00e-82	297.00
IUUC-Apl-003558	Anas platyrhynchos	29.97	6.00e-133	466.00
IUUC-Aca-004518	Anolis carolinensis	29.00	1.00e-120	425.00
IUUC-Aly-006427	Arabidopsis lyrata	33.75	2.00e-122	431.00
IUUC-Ath-006591	Arabidopsis thaliana	33.54	7.00e-122	429.00
IUUC-Ago-007849	Ashbya gossypii	52.05	0.00e+00	1255.00
IUUC-Acl-008327	Aspergillus clavatus	33.88	2.00e-178	617.00
IUUC-Afl-008491	Aspergillus flavus	33.42	2.00e-173	601.00
IUUC-Afu-008804	Aspergillus fumigatus	33.05	6.00e-164	569.00
IUUC-Ani-009257	Aspergillus nidulans	28.45	4.00e-32	132.00
IUUC-Ang-009776	Aspergillus niger	33.65	2.00e-171	594.00
IUUC-Aor-009998	Aspergillus oryzae	32.76	4.00e-165	573.00
IUUC-Ate-010428	Aspergillus terreus	33.36	1.00e-172	598.00
IUUC-Ame-010903	Astyanax mexicanus	39.29	1.00e-123	435.00
IUUC-Bgr-012132	Blumeria graminis	32.79	2.00e-167	581.00
IUUC-Bta-013192	Bos taurus	30.10	4.00e-125	440.00
IUUC-Bci-013924	Botrytis cinerea	33.64	4.00e-165	573.00
IUUC-Bdi-015069	Brachypodium distachyon	34.57	1.00e-120	426.00
IUUC-Bol-015424	Brassica oleracea	34.05	4.00e-123	434.00
IUUC-Bra-016686	Brassica rapa	34.16	4.00e-123	434.00
IUUC-Cel-018219	Caenorhabditis elegans	38.56	1.00e-87	316.00
IUUC-Cja-019006	Callithrix jacchus	30.10	2.00e-125	441.00
IUUC-Cfa-020361	Canis familiaris	30.10	1.00e-125	442.00
IUUC-Cpo-022320	Cavia porcellus	30.10	9.00e-126	442.00
IUUC-Cre-022708	Chlamydomonas reinhardtii	40.22	4.00e-94	336.00
IUUC-Csa-024050	Chlorocebus sabaeus	30.19	5.00e-126	443.00
IUUC-Cho-025006	Choloepus hoffmanni	36.49	2.00e-58	219.00
IUUC-Cin-025689	Ciona intestinalis	37.90	6.00e-116	410.00
IUUC-Csv-025963	Ciona savignyi	38.08	2.00e-116	411.00
IUUC-Cgl-026650	Colletotrichum gloeosporioides	35.35	1.00e-160	558.00
IUUC-Cne-026968	Cryptococcus neoformans	46.08	2.00e-161	561.00
IUUC-Cme-027103	Cyanidioschyzon merolae	39.20	2.00e-100	358.00
IUUC-Dre-028510	Danio rerio	38.36	2.00e-123	435.00
IUUC-Dno-029696	Dasypus novemcinctus	30.28	5.00e-125	440.00
IUUC-Dor-030611	Dipodomys ordii	44.63	6.00e-75	273.00
IUUC-Dse-031433	Dothistroma septosporum	32.89	3.00e-168	584.00
IUUC-Dme-031583	Drosophila melanogaster	38.14	1.00e-102	366.00
IUUC-Ete-033191	Echinops telfairi	32.62	2.00e-124	438.00
IUUC-Eca-034122	Equus caballus	30.10	1.00e-125	442.00
IUUC-Eeu-035292	Erinaceus europaeus	34.93	4.00e-58	218.00
IUUC-Fca-036377	Felis catus	30.19	8.00e-126	442.00
IUUC-Fal-036964	Ficedula albicollis	30.19	3.00e-134	471.00
IUUC-Fox-037695	Fusarium oxysporum	33.25	1.00e-161	561.00
IUUC-Fso-038084	Fusarium solani	33.88	1.00e-167	582.00
IUUC-Gmo-038644	Gadus morhua	39.31	4.00e-125	440.00
IUUC-Ggr-040029	Gaeumannomyces graminis	34.21	2.00e-158	551.00
IUUC-Gga-040944	Gallus gallus	30.19	8.00e-134	469.00
IUUC-Gac-041740	Gasterosteus aculeatus	38.98	2.00e-124	438.00
IUUC-Gma-044078	Glycine max	33.07	1.00e-117	415.00
IUUC-Ggo-044947	Gorilla gorilla	30.19	8.00e-126	442.00
IUUC-Hsa-046278	Homo sapiens	30.19	5.00e-126	443.00
IUUC-Hvu-047749	Hordeum vulgare	32.25	3.00e-119	420.00
IUUC-Itr-047904	Ictidomys tridecemlineatus	31.10	7.00e-118	416.00
IUUC-Kpa-049121	Komagataella pastoris	40.26	0.00e+00	841.00
IUUC-Lch-049847	Latimeria chalumnae	29.70	5.00e-132	463.00
IUUC-Lpe-051543	Leersia perrieri	32.11	6.00e-114	403.00
IUUC-Loc-052234	Lepisosteus oculatus	38.68	8.00e-124	436.00
IUUC-Lma-053169	Leptosphaeria maculans	35.00	0.00e+00	634.00
IUUC-Laf-053566	Loxodonta africana	30.02	2.00e-125	441.00
IUUC-Mcc-055549	Macaca mulatta	30.16	9.00e-126	442.00
IUUC-Meu-056904	Macropus eugenii	34.10	6.00e-48	184.00
IUUC-Mor-057149	Magnaporthe oryzae	34.90	2.00e-171	594.00
IUUC-Mpo-057536	Magnaporthe poae	45.95	3.00e-151	527.00
IUUC-Mtr-058585	Medicago truncatula	33.33	1.00e-119	422.00
IUUC-Mla-058899	Melampsora laricipopulina	33.99	5.00e-179	619.00
IUUC-Mga-060148	Meleagris gallopavo	30.19	5.00e-134	470.00
IUUC-Mvi-060207	Microbotryum violaceum	35.44	0.00e+00	645.00
IUUC-Mmr-060946	Microcebus murinus	30.10	4.00e-126	443.00
IUUC-Mdo-062079	Monodelphis domestica	30.33	9.00e-111	392.00
IUUC-Mmu-063678	Mus musculus	30.24	5.00e-126	443.00
IUUC-Mac-064796	Musa acuminata	33.88	3.00e-119	421.00
IUUC-Mpu-066744	Mustela putorius furo	30.02	3.00e-125	441.00
IUUC-Mlu-067949	Myotis lucifugus	30.07	1.00e-125	442.00
IUUC-Nfi-068342	Neosartorya fischeri	32.79	3.00e-163	567.00
IUUC-Ncr-068818	Neurospora crassa	34.17	1.00e-169	588.00
IUUC-Nle-070064	Nomascus leucogenys	30.19	5.00e-126	443.00
IUUC-Opr-071001	Ochotona princeps	31.90	1.00e-117	416.00
IUUC-Ont-072095	Oreochromis niloticus	39.19	8.00e-123	432.00
IUUC-Oan-073483	Ornithorhynchus anatinus	30.10	2.00e-124	438.00
IUUC-Ocu-073967	Oryctolagus cuniculus	29.93	5.00e-124	437.00
IUUC-Oba-075312	Oryza barthii	33.48	6.00e-113	400.00
IUUC-Obr-076857	Oryza brachyantha	29.98	2.00e-117	415.00
IUUC-Ogl-077038	Oryza glaberrima	39.19	2.00e-114	405.00
IUUC-Ogu-078265	Oryza glumaepatula	36.76	5.00e-100	357.00
IUUC-Oin-079513	Oryza indica	30.01	3.00e-112	397.00
IUUC-Olo-081067	Oryza longistaminata	28.71	1.00e-106	379.00
IUUC-Ome-081879	Oryza meridionalis	32.99	3.00e-108	384.00
IUUC-Oni-082978	Oryza nivara	29.38	2.00e-108	385.00
IUUC-Opu-083199	Oryza punctata	30.04	1.00e-111	395.00
IUUC-Oru-085109	Oryza rufipogon	32.82	3.00e-105	374.00
IUUC-Osa-085318	Oryza sativa	43.63	1.00e-109	388.00
IUUC-Ola-086640	Oryzias latipes	38.98	6.00e-124	436.00
IUUC-Olu-087874	Ostreococcus lucimarinus	36.79	1.00e-100	359.00
IUUC-Oga-089059	Otolemur garnettii	35.18	2.00e-93	335.00
IUUC-Oar-089710	Ovis aries	30.07	2.00e-125	441.00
IUUC-Ptr-091334	Pan troglodytes	30.19	8.00e-126	442.00
IUUC-Pan-091717	Papio anubis	30.19	5.00e-126	443.00
IUUC-Psi-093933	Pelodiscus sinensis	30.06	9.00e-132	462.00
IUUC-Pma-094648	Petromyzon marinus	31.86	1.00e-130	458.00
IUUC-Pno-095020	Phaeosphaeria nodorum	33.74	2.00e-164	571.00
IUUC-Ppa-095954	Physcomitrella patens	31.77	1.00e-126	445.00
IUUC-Pfo-096181	Poecilia formosa	38.70	1.00e-122	432.00
IUUC-Pab-098231	Pongo abelii	29.12	1.00e-113	402.00
IUUC-Pop-098967	Populus trichocarpa	34.15	9.00e-121	426.00
IUUC-Pca-100543	Procavia capensis	32.80	5.00e-84	304.00
IUUC-Ppe-101523	Prunus persica	33.61	8.00e-118	416.00
IUUC-Pva-102472	Pteropus vampyrus	29.90	8.00e-120	422.00
IUUC-Pgr-103463	Puccinia graminis	33.61	3.00e-177	613.00
IUUC-Ptt-103716	Puccinia triticina	33.56	1.00e-167	581.00
IUUC-Pte-104360	Pyrenophora teres	33.86	2.00e-169	587.00
IUUC-Pyt-104581	Pyrenophora triticirepentis	33.94	2.00e-170	591.00
IUUC-Rno-105816	Rattus norvegicus	30.19	2.00e-126	444.00
IUUC-Sha-107439	Sarcophilus harrisii	30.02	1.00e-124	439.00
IUUC-Sja-107690	Schizosaccharomyces japonicus	45.74	1.00e-149	522.00
IUUC-Spo-108019	Schizosaccharomyces pombe	43.91	1.00e-139	488.00
IUUC-Smo-109308	Selaginella moellendorffii	31.48	5.00e-122	430.00
IUUC-Sit-109868	Setaria italica	33.68	7.00e-123	433.00
IUUC-Sly-111008	Solanum lycopersicum	31.69	2.00e-119	421.00
IUUC-Stu-112387	Solanum tuberosum	32.01	1.00e-118	419.00
IUUC-Sar-113685	Sorex araneus	30.02	6.00e-123	433.00
IUUC-Sbi-114424	Sorghum bicolor	30.76	5.00e-116	410.00
IUUC-Sre-115156	Sporisorium reilianum	33.56	1.00e-164	571.00
IUUC-Ssc-116297	Sus scrofa	30.28	3.00e-126	444.00
IUUC-Tgu-116767	Taeniopygia guttata	29.97	6.00e-133	466.00
IUUC-Tru-118208	Takifugu rubripes	32.43	1.00e-128	452.00
IUUC-Tsy-119277	Tarsius syrichta	39.63	1.00e-64	239.00
IUUC-Tni-119890	Tetraodon nigroviridis	39.41	9.00e-124	436.00
IUUC-Tca-121630	Theobroma cacao	40.34	6.00e-114	403.00
IUUC-Tre-122169	Trichoderma reesei	45.58	2.00e-148	517.00
IUUC-Tvi-122600	Trichoderma virens	45.27	2.00e-151	528.00
IUUC-Tae-125233	Triticum aestivum	31.63	2.00e-120	425.00
IUUC-Tur-126287	Triticum urartu	31.04	7.00e-115	406.00
IUUC-Tme-127045	Tuber melanosporum	35.68	2.00e-177	614.00
IUUC-Tbe-127861	Tupaia belangeri	35.63	1.00e-57	216.00
IUUC-Ttr-129161	Tursiops truncatus	29.93	1.00e-123	436.00
IUUC-Uma-129535	Ustilago maydis	34.46	7.00e-180	622.00
IUUC-Vda-129708	Verticillium dahliae	34.59	0.00e+00	625.00
IUUC-Vpa-130141	Vicugna pacos	36.21	1.00e-59	223.00
IUUC-Vvi-130882	Vitis vinifera	34.44	1.00e-118	419.00
IUUC-Xtr-132073	Xenopus tropicalis	38.95	4.00e-118	417.00
IUUC-Xma-133949	Xiphophorus maculatus	38.70	1.00e-122	432.00
IUUC-Yli-134527	Yarrowia lipolytica	45.51	4.00e-168	583.00
IUUC-Zma-135855	Zea mays	32.51	6.00e-118	416.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence