iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108048

UUCD1 version

UUC-ScP-00040

Ensembl Protein ID

SPBC3D6.11c.1:pep

UniProt Accession

P87176; Q9US65; SLX8_SCHPO

Genbank Protein ID

CAB09120.1; BAA87320.1

Protein Name

E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8; RING finger protein slx8; RING-dependent E3 ubiquitin-protein ligase slx8; RING-type E3 ubiquitin transferase slx8; Synthetic lethal of unknown function protein 8

Genbank Nucleotide ID

CU329671; AB028016

Gene Name

slx8; SPBC3D6.11c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC3D6.11c	SPBC3D6.11c.1	SPBC3D6.11c.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17762865

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.40e-07	30.1	206	247

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C iCl+++++ + ++pCgH+f+  C+  ++      +  +++CP+Cr
   Q: 206  CVICLDSPEN-LSCTPCGHIFCNFCIlSAL----GTTAATQKCPVCR 247
           **********.888***********96666....77999999****8 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression (By similarity).

Protein Sequence
(Fasta)

MPPAHKRDTN VRNLSAPYNI PSQSARVAAG NAAINRRRSS PVENSPGNGF PVSEDATDYP 60
SGTTSENESL PLNRAPRSLR EVASELAQEE TLPVETSDLN IDVESEVFDL EDINFQNDAD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATTGAATGT GCTCATGAAA AAGGTCATAA ATATTAATTA GACTAGCATC TTACAACATT 60
GTGGTAGTGA GCCAATTTTT CCATGTAGAC TTCAAAAATC ATAGGTCTAC TAAATTTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0033768--C:SUMO-targeted ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006310--P:DNA recombination
GO:0033234--P:negative regulation of protein sumoylation
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

spo:SPBC3D6.11c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007769	Ashbya gossypii	37.74	4.00e-09	52.80
IUUC-Afl-008526	Aspergillus flavus	31.00	5.00e-10	55.50
IUUC-Ani-009314	Aspergillus nidulans	37.29	1.00e-08	50.80
IUUC-Ang-009772	Aspergillus niger	29.41	1.00e-08	50.80
IUUC-Ate-010384	Aspergillus terreus	25.60	1.00e-09	53.90
IUUC-Bgr-012018	Blumeria graminis	36.97	8.00e-14	68.90
IUUC-Bci-013671	Botrytis cinerea	44.23	5.00e-11	60.10
IUUC-Bdi-014670	Brachypodium distachyon	30.43	1.00e-06	48.90
IUUC-Cel-018228	Caenorhabditis elegans	40.00	1.00e-08	51.20
IUUC-Csv-026190	Ciona savignyi	35.19	1.00e-07	48.50
IUUC-Cgl-026743	Colletotrichum gloeosporioides	49.02	3.00e-12	64.70
IUUC-Cme-027215	Cyanidioschyzon merolae	40.30	6.00e-11	60.10
IUUC-Dse-031337	Dothistroma septosporum	34.21	5.00e-08	50.10
IUUC-Fso-038195	Fusarium solani	41.18	6.00e-11	60.10
IUUC-Kpa-049242	Komagataella pastoris	34.41	3.00e-09	52.80
IUUC-Lma-053230	Leptosphaeria maculans	45.83	7.00e-12	63.90
IUUC-Mor-057077	Magnaporthe oryzae	35.29	5.00e-11	60.50
IUUC-Mpo-057431	Magnaporthe poae	42.59	4.00e-11	60.80
IUUC-Mla-058962	Melampsora laricipopulina	40.00	6.00e-07	44.70
IUUC-Mac-064442	Musa acuminata	24.69	3.00e-09	54.30
IUUC-Ncr-068628	Neurospora crassa	45.10	3.00e-11	61.20
IUUC-Osa-085816	Oryza sativa	21.56	6.00e-08	49.30
IUUC-Pno-094942	Phaeosphaeria nodorum	33.33	2.00e-11	61.20
IUUC-Ppa-095718	Physcomitrella patens	46.81	2.00e-09	54.30
IUUC-Pte-104163	Pyrenophora teres	33.70	9.00e-11	58.50
IUUC-Pyt-104640	Pyrenophora triticirepentis	38.03	1.00e-10	58.20
IUUC-Sja-107944	Schizosaccharomyces japonicus	75.00	7.00e-31	125.00
IUUC-Smo-109339	Selaginella moellendorffii	51.11	2.00e-09	53.50
IUUC-Sit-110764	Setaria italica	23.83	8.00e-07	49.70
IUUC-Stu-112419	Solanum tuberosum	35.62	1.00e-07	48.90
IUUC-Sbi-114108	Sorghum bicolor	23.81	3.00e-06	48.10
IUUC-Sre-115213	Sporisorium reilianum	55.26	9.00e-10	56.60
IUUC-Tca-120945	Theobroma cacao	23.04	2.00e-06	48.50
IUUC-Tre-122215	Trichoderma reesei	41.67	1.00e-10	59.70
IUUC-Tme-127178	Tuber melanosporum	42.67	2.00e-13	67.40
IUUC-Uma-129386	Ustilago maydis	55.26	1.00e-09	56.20
IUUC-Vda-129983	Verticillium dahliae	42.31	3.00e-09	52.80
IUUC-Yli-134480	Yarrowia lipolytica	47.76	9.00e-13	64.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence