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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106312
UUCD1 version UUC-SaC-00018
Ensembl Protein ID YER068W
UniProt Accession P34909; D3DLX3; NOT4_YEAST
Genbank Protein ID AAC37413.1; AAB00326.1; AAB64604.1; DAA07727.1
Protein Name General negative regulator of transcription subunit 4; Modulator of transcription 2
Genbank Nucleotide ID M96736; L26309; U18813; BK006939
Gene Name MOT2; CCL1; NOT4; SIG1; SSF1; YER068W
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YER068W YER068W YER068W
Annotation
mRNA Expression
GEOFFGED
DNA & RNA Element
JASPARTRANSFAC
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
PHOSIDABioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19556875; 16926149; 20660159
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.15 11.0 33 78
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf...kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C e++   ++  +  pCg ++++ C +++    ++   + rCP Cr
   Q: 33   CPLCIEPMditDKNFFPCPCGYQICQFCYNNI---RQNPELNGRCPACR 78
           ********87733355569*********8888...666777889****8 PP
   
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
 Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.
Protein Sequence
(Fasta)
MMNPHVQENL QAIHNALSNF DTSFLSEDEE DYCPLCIEPM DITDKNFFPC PCGYQICQFC 60
YNNIRQNPEL NGRCPACRRK YDDENVRYVT LSPEELKMER AKLARKEKER KHREKERKEN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sce-106312|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGATGAATC CACACGTTCA AGAAAATTTG CAAGCAATCC ACAACGCCTT AAGCAATTTT 60
GATACGTCAT TTTTATCGGA GGATGAAGAA GATTATTGCC CTCTTTGTAT TGAACCAATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sce-106312|E3,RING|Saccharomyces cerevisiae
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0694--RNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR034261--CNOT4_RRM
IPR012677--Nucleotide-bd_a/b_plait
IPR000504--RRM_dom
IPR003954--RRM_dom_euk
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50102--RRM
PS50103--ZF_C3H1
PS50089--ZF_RING_2
SMART

SM00361--RRM_1
Gene Ontology

GO:0030015--C:CCR4-NOT core complex
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0031087--P:deadenylation-independent decapping of nuclear-transcribed mRNA
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0010498--P:proteasomal protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0006351--P:transcription, DNA-templated
KEGG sce:YER068W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000464 Aegilops tauschii 34.70 6.00e-50 191.00
IUUC-Aml-002384 Ailuropoda melanoleuca 44.90 4.00e-56 210.00
IUUC-Atr-002462 Amborella trichopoda 41.31 2.00e-56 212.00
IUUC-Apl-003756 Anas platyrhynchos 44.90 1.00e-56 212.00
IUUC-Aca-004643 Anolis carolinensis 44.90 2.00e-56 212.00
IUUC-Aly-006093 Arabidopsis lyrata 40.00 5.00e-53 201.00
IUUC-Ath-007371 Arabidopsis thaliana 38.95 3.00e-52 198.00
IUUC-Ago-007799 Ashbya gossypii 79.03 3.00e-120 423.00
IUUC-Acl-008077 Aspergillus clavatus 50.83 6.00e-62 231.00
IUUC-Afl-008720 Aspergillus flavus 49.59 7.00e-66 244.00
IUUC-Afu-008905 Aspergillus fumigatus 48.35 9.00e-59 220.00
IUUC-Ani-009264 Aspergillus nidulans 46.89 3.00e-40 158.00
IUUC-Ang-009537 Aspergillus niger 50.41 2.00e-66 246.00
IUUC-Aor-010123 Aspergillus oryzae 48.63 6.00e-38 151.00
IUUC-Ate-010409 Aspergillus terreus 50.83 4.00e-66 245.00
IUUC-Ame-011538 Astyanax mexicanus 44.90 9.00e-50 189.00
IUUC-Bgr-012062 Blumeria graminis 51.61 5.00e-74 271.00
IUUC-Bta-012419 Bos taurus 44.90 2.00e-56 211.00
IUUC-Bci-013633 Botrytis cinerea 50.81 5.00e-73 268.00
IUUC-Bdi-014913 Brachypodium distachyon 35.59 4.00e-51 194.00
IUUC-Bol-016407 Brassica oleracea 39.70 1.00e-53 203.00
IUUC-Bra-017755 Brassica rapa 39.13 3.00e-54 204.00
IUUC-Cel-018123 Caenorhabditis elegans 40.08 3.00e-48 184.00
IUUC-Cja-019705 Callithrix jacchus 44.90 1.00e-56 212.00
IUUC-Cfa-020440 Canis familiaris 44.90 1.00e-56 213.00
IUUC-Cpo-022091 Cavia porcellus 42.86 4.00e-55 206.00
IUUC-Cre-022872 Chlamydomonas reinhardtii 38.96 7.00e-15 73.20
IUUC-Csa-024202 Chlorocebus sabaeus 44.90 2.00e-56 211.00
IUUC-Cho-024410 Choloepus hoffmanni 42.78 5.00e-39 154.00
IUUC-Cin-025558 Ciona intestinalis 39.83 6.00e-55 206.00
IUUC-Cgl-026687 Colletotrichum gloeosporioides 45.63 6.00e-63 233.00
IUUC-Cne-027084 Cryptococcus neoformans 38.28 2.00e-49 188.00
IUUC-Cme-027148 Cyanidioschyzon merolae 28.18 5.00e-21 94.40
IUUC-Dre-028377 Danio rerio 44.90 1.00e-49 189.00
IUUC-Dno-029100 Dasypus novemcinctus 44.90 1.00e-56 213.00
IUUC-Dor-030310 Dipodomys ordii 45.34 2.00e-51 195.00
IUUC-Dse-031514 Dothistroma septosporum 47.94 8.00e-72 263.00
IUUC-Dme-031735 Drosophila melanogaster 41.15 1.00e-52 199.00
IUUC-Ete-033091 Echinops telfairi 42.04 1.00e-50 192.00
IUUC-Eca-033506 Equus caballus 44.90 2.00e-56 211.00
IUUC-Eeu-034506 Erinaceus europaeus 39.59 7.00e-45 173.00
IUUC-Fca-036033 Felis catus 44.90 2.00e-56 211.00
IUUC-Fal-037540 Ficedula albicollis 44.90 1.00e-56 213.00
IUUC-Fox-037944 Fusarium oxysporum 46.99 1.00e-69 255.00
IUUC-Fso-038172 Fusarium solani 42.97 5.00e-56 211.00
IUUC-Gmo-039211 Gadus morhua 43.82 5.00e-50 190.00
IUUC-Ggr-040096 Gaeumannomyces graminis 48.00 3.00e-70 259.00
IUUC-Gga-040487 Gallus gallus 44.90 9.00e-57 213.00
IUUC-Gac-042294 Gasterosteus aculeatus 43.03 3.00e-47 181.00
IUUC-Gma-043229 Glycine max 39.70 3.00e-52 198.00
IUUC-Ggo-044950 Gorilla gorilla 40.10 2.00e-35 142.00
IUUC-Hsa-046666 Homo sapiens 44.90 3.00e-56 210.00
IUUC-Hvu-047405 Hordeum vulgare 35.07 2.00e-50 192.00
IUUC-Itr-047888 Ictidomys tridecemlineatus 41.70 4.00e-55 206.00
IUUC-Kpa-049260 Komagataella pastoris 65.10 6.00e-92 329.00
IUUC-Lch-050203 Latimeria chalumnae 44.90 1.00e-56 212.00
IUUC-Lpe-051195 Leersia perrieri 35.82 2.00e-48 185.00
IUUC-Loc-052886 Lepisosteus oculatus 44.49 3.00e-49 188.00
IUUC-Lma-053073 Leptosphaeria maculans 49.80 1.00e-68 252.00
IUUC-Laf-053490 Loxodonta africana 44.90 8.00e-57 213.00
IUUC-Mcc-055724 Macaca mulatta 44.90 2.00e-56 211.00
IUUC-Meu-056787 Macropus eugenii 50.44 5.00e-27 114.00
IUUC-Mor-056921 Magnaporthe oryzae 46.40 3.00e-68 251.00
IUUC-Mpo-057616 Magnaporthe poae 47.60 5.00e-69 253.00
IUUC-Mtr-058426 Medicago truncatula 39.16 2.00e-49 189.00
IUUC-Mla-059146 Melampsora laricipopulina 43.10 1.00e-50 192.00
IUUC-Mga-059372 Meleagris gallopavo 44.90 9.00e-57 213.00
IUUC-Mvi-060479 Microbotryum violaceum 42.36 3.00e-41 162.00
IUUC-Mmr-061012 Microcebus murinus 44.90 1.00e-56 212.00
IUUC-Mdo-062330 Monodelphis domestica 44.90 1.00e-56 212.00
IUUC-Mmu-063894 Mus musculus 44.90 2.00e-56 212.00
IUUC-Mac-064805 Musa acuminata 39.45 5.00e-53 199.00
IUUC-Mpu-066894 Mustela putorius furo 44.90 1.00e-56 213.00
IUUC-Mlu-067321 Myotis lucifugus 44.90 3.00e-56 211.00
IUUC-Nfi-068451 Neosartorya fischeri 42.99 3.00e-61 229.00
IUUC-Ncr-068667 Neurospora crassa 40.35 8.00e-63 234.00
IUUC-Nle-070058 Nomascus leucogenys 44.90 7.00e-53 200.00
IUUC-Opr-071108 Ochotona princeps 42.48 1.00e-24 106.00
IUUC-Ont-071541 Oreochromis niloticus 43.03 3.00e-47 181.00
IUUC-Oan-073232 Ornithorhynchus anatinus 44.90 1.00e-56 212.00
IUUC-Ocu-074893 Oryctolagus cuniculus 44.90 1.00e-56 212.00
IUUC-Oba-075623 Oryza barthii 35.67 1.00e-26 111.00
IUUC-Obr-076653 Oryza brachyantha 34.70 1.00e-49 190.00
IUUC-Ogl-077946 Oryza glaberrima 34.36 3.00e-38 149.00
IUUC-Ogu-078775 Oryza glumaepatula 33.33 2.00e-48 183.00
IUUC-Oin-079214 Oryza indica 33.66 2.00e-49 188.00
IUUC-Olo-080799 Oryza longistaminata 27.07 1.00e-22 97.40
IUUC-Ome-081843 Oryza meridionalis 33.70 4.00e-48 183.00
IUUC-Oni-082944 Oryza nivara 35.67 1.00e-26 110.00
IUUC-Opu-083668 Oryza punctata 34.31 6.00e-50 191.00
IUUC-Oru-084249 Oryza rufipogon 31.75 4.00e-34 137.00
IUUC-Osa-086233 Oryza sativa 33.66 2.00e-49 189.00
IUUC-Ola-087121 Oryzias latipes 43.03 6.00e-47 180.00
IUUC-Olu-087772 Ostreococcus lucimarinus 36.19 9.00e-37 144.00
IUUC-Oga-088556 Otolemur garnettii 44.90 1.00e-56 212.00
IUUC-Oar-089768 Ovis aries 44.90 2.00e-56 212.00
IUUC-Ptr-090585 Pan troglodytes 44.90 2.00e-56 211.00
IUUC-Pan-092625 Papio anubis 44.90 2.00e-56 212.00
IUUC-Psi-093462 Pelodiscus sinensis 44.90 9.00e-57 213.00
IUUC-Pma-094468 Petromyzon marinus 42.91 1.00e-52 199.00
IUUC-Pno-094812 Phaeosphaeria nodorum 43.01 9.00e-39 154.00
IUUC-Ppa-095589 Physcomitrella patens 45.90 1.00e-15 75.90
IUUC-Pfo-096762 Poecilia formosa 43.03 8.00e-47 180.00
IUUC-Pab-097890 Pongo abelii 44.90 2.00e-56 211.00
IUUC-Pop-099764 Populus trichocarpa 39.27 2.00e-53 202.00
IUUC-Pca-101121 Procavia capensis 40.10 6.00e-32 130.00
IUUC-Ppe-102076 Prunus persica 40.00 1.00e-52 199.00
IUUC-Pva-102489 Pteropus vampyrus 44.90 5.00e-56 210.00
IUUC-Pgr-103568 Puccinia graminis 41.49 7.00e-52 197.00
IUUC-Ptt-103721 Puccinia triticina 37.31 7.00e-33 134.00
IUUC-Pte-104118 Pyrenophora teres 50.61 3.00e-74 271.00
IUUC-Pyt-104612 Pyrenophora triticirepentis 50.61 2.00e-74 271.00
IUUC-Rno-105627 Rattus norvegicus 44.90 2.00e-56 211.00
IUUC-Sha-106619 Sarcophilus harrisii 44.90 1.00e-56 212.00
IUUC-Sja-107765 Schizosaccharomyces japonicus 50.94 1.00e-61 228.00
IUUC-Spo-108328 Schizosaccharomyces pombe 53.17 4.00e-64 236.00
IUUC-Ssl-108577 Sclerotinia sclerotiorum 50.81 9.00e-68 249.00
IUUC-Smo-108760 Selaginella moellendorffii 43.21 9.00e-53 197.00
IUUC-Sit-109923 Setaria italica 36.65 8.00e-51 193.00
IUUC-Sly-110900 Solanum lycopersicum 37.41 4.00e-50 191.00
IUUC-Stu-112226 Solanum tuberosum 37.68 1.00e-49 189.00
IUUC-Sar-113620 Sorex araneus 44.90 1.00e-54 205.00
IUUC-Sbi-114318 Sorghum bicolor 37.50 4.00e-51 194.00
IUUC-Sre-114956 Sporisorium reilianum 51.16 3.00e-73 268.00
IUUC-Ssc-116116 Sus scrofa 41.70 5.00e-55 205.00
IUUC-Tgu-117357 Taeniopygia guttata 44.90 1.00e-56 213.00
IUUC-Tru-118759 Takifugu rubripes 43.03 3.00e-48 184.00
IUUC-Tsy-119387 Tarsius syrichta 44.90 5.00e-56 210.00
IUUC-Tni-120536 Tetraodon nigroviridis 41.43 1.00e-47 182.00
IUUC-Tca-121035 Theobroma cacao 40.75 5.00e-55 207.00
IUUC-Tre-121996 Trichoderma reesei 43.37 1.00e-56 213.00
IUUC-Tvi-122371 Trichoderma virens 46.18 8.00e-66 244.00
IUUC-Tae-124373 Triticum aestivum 35.07 7.00e-51 193.00
IUUC-Tur-126324 Triticum urartu 35.07 2.00e-50 192.00
IUUC-Tme-127072 Tuber melanosporum 44.62 6.00e-60 224.00
IUUC-Tbe-128107 Tupaia belangeri 44.08 2.00e-53 202.00
IUUC-Ttr-128846 Tursiops truncatus 44.90 7.00e-56 210.00
IUUC-Uma-129607 Ustilago maydis 51.16 3.00e-73 268.00
IUUC-Vda-129971 Verticillium dahliae 44.34 3.00e-54 205.00
IUUC-Vpa-130298 Vicugna pacos 39.18 5.00e-43 167.00
IUUC-Vvi-131651 Vitis vinifera 38.87 6.00e-52 197.00
IUUC-Xtr-132728 Xenopus tropicalis 44.90 3.00e-56 211.00
IUUC-Xma-133789 Xiphophorus maculatus 43.03 8.00e-47 179.00
IUUC-Yli-134461 Yarrowia lipolytica 63.75 3.00e-84 303.00
IUUC-Zma-135031 Zea mays 36.69 4.00e-52 197.00
Created Date 25-Jun-2017

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