iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004763

UUCD1 version

UUC-AnC-00971

Ensembl Protein ID

ENSACAP00000008181.3

UniProt Accession

H9GDT0; H9GDT0_ANOCA

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Gene Name

UCHL5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000008306.3	ENSACAT00000008357.3	ENSACAP00000008181.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.00e-99	332.6	7	324

Active Site

Position(s)	Description	Evidence
90	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
166	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 5    vkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktiffakq 93
           + ew+ +esdPg+ft+l++ fg+++  qvee++sL+pen++++ +pv+gl++lFk+++ +e +          +vv+++ ++tiffakq
   Q: 7    AGEWCLMESDPGVFTELIKGFGCRGA-QVEEIWSLEPENFEKL-KPVHGLIFLFKWQPGEEPAG---------SVVQDSRLDTIFFAKQ 84
           579***********************.****************.********************.........899************* PP
   S: 94   vigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeafhfvs 182
           vi+N+Cat+A++svllnc+++ ++lG+tls+++e+++++++ +k+lal+n++v++++hns+ar+++++ + +  ++    +++afhfvs
   Q: 85   VINNACATQAIVSVLLNCTHQDVHLGETLSEFREFSQSFDAAMKGLALSNSEVIRQVHNSFARQQMFEFDAKSTAK----EEDAFHFVS 169
           **********************************************************************988776....89******* PP
   S: 183  yvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid.........keL 262
           yv++ngrlyeldgl++ P+dlg  ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +          + 
   Q: 170  YVPVNGRLYELDGLREGPIDLGV-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEQKIVELQAQlaeeepmdtDQS 255
           **********************9.78999*********..******************************9766666888888887566 PP
   S: 263  lkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveetisevrefgv 334
            ++l+ i+se++k+++ +++e++k k++ki++irR++ny  fi++++k+la++++l  lve+    + ++++
   Q: 256  SNILSSIQSEVAKYQMLIEEENQKLKRYKIENIRRKHNYLPFIMELLKTLAEHQQLIPLVEKA---KEKQNA 324
           78***********************************************************93...333554 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MAGGGSAGEW CLMESDPGVF TELIKGFGCR GAQVEEIWSL EPENFEKLKP VHGLIFLFKW 60
QPGEEPAGSV VQDSRLDTIF FAKQVINNAC ATQAIVSVLL NCTHQDVHLG ETLSEFREFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGGAG GAGGCAGTGC CGGCGAGTGG TGCCTCATGG AGAGCGACCC GGGCGTCTTC 60
ACGGAGCTCA TCAAAGGGTT CGGTGAGGCT TGGGTTGCCC TTTTTTTTTT TTTTTACCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031011--C:Ino80 complex
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004866--F:endopeptidase inhibitor activity
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0048853--P:forebrain morphogenesis
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0016579--P:protein deubiquitination
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

acs:100561706

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	46.39	7.00e-83	300.00
IUUC-Aml-001866	Ailuropoda melanoleuca	95.50	7.00e-180	622.00
IUUC-Atr-002966	Amborella trichopoda	47.11	2.00e-80	292.00
IUUC-Apl-003306	Anas platyrhynchos	87.32	1.00e-178	618.00
IUUC-Aly-005581	Arabidopsis lyrata	48.02	6.00e-79	287.00
IUUC-Ath-007283	Arabidopsis thaliana	47.42	8.00e-81	293.00
IUUC-Ago-007999	Ashbya gossypii	37.71	2.00e-32	132.00
IUUC-Acl-008231	Aspergillus clavatus	43.27	4.00e-52	197.00
IUUC-Afl-008557	Aspergillus flavus	38.69	5.00e-55	207.00
IUUC-Afu-008988	Aspergillus fumigatus	44.90	2.00e-54	205.00
IUUC-Ani-009420	Aspergillus nidulans	37.66	7.00e-53	200.00
IUUC-Ang-009859	Aspergillus niger	41.20	5.00e-49	187.00
IUUC-Aor-010145	Aspergillus oryzae	38.69	5.00e-55	207.00
IUUC-Ate-010347	Aspergillus terreus	41.70	8.00e-53	200.00
IUUC-Ame-010791	Astyanax mexicanus	92.35	0.00e+00	638.00
IUUC-Bgr-012298	Blumeria graminis	37.50	2.00e-49	189.00
IUUC-Bta-013251	Bos taurus	95.50	3.00e-178	617.00
IUUC-Bci-013786	Botrytis cinerea	36.58	3.00e-56	211.00
IUUC-Bdi-014132	Brachypodium distachyon	47.55	8.00e-80	290.00
IUUC-Bol-015611	Brassica oleracea	49.08	6.00e-83	300.00
IUUC-Bra-017769	Brassica rapa	49.08	7.00e-83	300.00
IUUC-Cel-018604	Caenorhabditis elegans	47.13	2.00e-82	298.00
IUUC-Cja-019768	Callithrix jacchus	85.96	1.00e-172	598.00
IUUC-Cfa-020207	Canis familiaris	95.50	7.00e-180	622.00
IUUC-Cpo-021925	Cavia porcellus	91.32	1.00e-170	591.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	46.08	7.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	93.95	2.00e-176	611.00
IUUC-Cho-024928	Choloepus hoffmanni	98.70	2.00e-42	165.00
IUUC-Cin-025771	Ciona intestinalis	55.11	3.00e-101	361.00
IUUC-Csv-026149	Ciona savignyi	57.37	1.00e-103	369.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	38.60	3.00e-52	198.00
IUUC-Cne-026955	Cryptococcus neoformans	36.56	3.00e-53	202.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.42	4.00e-50	191.00
IUUC-Dre-027409	Danio rerio	92.68	0.00e+00	637.00
IUUC-Dno-028921	Dasypus novemcinctus	95.50	8.00e-180	622.00
IUUC-Dse-031170	Dothistroma septosporum	37.97	2.00e-56	212.00
IUUC-Dme-031677	Drosophila melanogaster	60.82	5.00e-114	403.00
IUUC-Ete-032707	Echinops telfairi	66.67	4.00e-115	407.00
IUUC-Eca-033776	Equus caballus	95.14	7.00e-165	572.00
IUUC-Eeu-035305	Erinaceus europaeus	77.30	2.00e-80	292.00
IUUC-Fca-035846	Felis catus	87.39	1.00e-174	605.00
IUUC-Fal-037597	Ficedula albicollis	96.53	7.00e-162	562.00
IUUC-Fox-037670	Fusarium oxysporum	49.35	3.00e-54	205.00
IUUC-Fso-038243	Fusarium solani	49.35	1.00e-53	203.00
IUUC-Gmo-038499	Gadus morhua	86.54	1.00e-165	575.00
IUUC-Ggr-039975	Gaeumannomyces graminis	42.97	1.00e-48	186.00
IUUC-Gga-040904	Gallus gallus	96.07	0.00e+00	663.00
IUUC-Gac-042058	Gasterosteus aculeatus	91.03	3.00e-174	603.00
IUUC-Gma-043030	Glycine max	48.66	1.00e-84	305.00
IUUC-Ggo-044699	Gorilla gorilla	88.85	8.00e-162	562.00
IUUC-Hsa-046227	Homo sapiens	94.86	8.00e-179	619.00
IUUC-Hvu-047359	Hordeum vulgare	46.50	1.00e-81	296.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	86.38	2.00e-174	604.00
IUUC-Lch-049829	Latimeria chalumnae	93.27	1.00e-176	612.00
IUUC-Lpe-050899	Leersia perrieri	47.63	6.00e-77	280.00
IUUC-Loc-052264	Lepisosteus oculatus	92.97	1.00e-176	612.00
IUUC-Lma-053110	Leptosphaeria maculans	38.41	1.00e-47	183.00
IUUC-Laf-053639	Loxodonta africana	95.50	7.00e-180	622.00
IUUC-Mcc-055506	Macaca mulatta	93.95	2.00e-176	611.00
IUUC-Mor-057001	Magnaporthe oryzae	45.38	9.00e-55	206.00
IUUC-Mpo-057608	Magnaporthe poae	41.71	2.00e-33	135.00
IUUC-Mtr-057731	Medicago truncatula	48.66	5.00e-84	303.00
IUUC-Mla-059016	Melampsora laricipopulina	42.79	2.00e-43	168.00
IUUC-Mga-060178	Meleagris gallopavo	96.38	9.00e-176	608.00
IUUC-Mvi-060353	Microbotryum violaceum	38.55	3.00e-54	204.00
IUUC-Mmr-060738	Microcebus murinus	95.18	2.00e-179	620.00
IUUC-Mdo-062266	Monodelphis domestica	96.57	2.00e-119	421.00
IUUC-Mmu-063619	Mus musculus	93.27	1.00e-176	611.00
IUUC-Mac-065301	Musa acuminata	51.10	1.00e-87	316.00
IUUC-Mpu-066058	Mustela putorius furo	95.82	3.00e-180	624.00
IUUC-Mlu-067292	Myotis lucifugus	94.21	1.00e-175	608.00
IUUC-Nfi-068275	Neosartorya fischeri	39.31	1.00e-55	209.00
IUUC-Ncr-068713	Neurospora crassa	38.80	7.00e-58	217.00
IUUC-Nle-069013	Nomascus leucogenys	94.21	5.00e-176	610.00
IUUC-Opr-070628	Ochotona princeps	82.99	3.00e-163	567.00
IUUC-Ont-072688	Oreochromis niloticus	91.72	1.00e-174	605.00
IUUC-Oan-073004	Ornithorhynchus anatinus	95.12	7.00e-140	489.00
IUUC-Ocu-074303	Oryctolagus cuniculus	95.82	0.00e+00	626.00
IUUC-Oba-075002	Oryza barthii	47.89	5.00e-81	293.00
IUUC-Obr-076392	Oryza brachyantha	48.58	2.00e-78	285.00
IUUC-Ogl-077271	Oryza glaberrima	47.89	5.00e-81	293.00
IUUC-Ogu-078493	Oryza glumaepatula	47.89	1.00e-81	296.00
IUUC-Oin-080084	Oryza indica	47.89	1.00e-81	296.00
IUUC-Olo-080803	Oryza longistaminata	47.59	2.00e-81	295.00
IUUC-Ome-081146	Oryza meridionalis	46.99	3.00e-80	291.00
IUUC-Oni-082146	Oryza nivara	47.89	1.00e-81	296.00
IUUC-Opu-083633	Oryza punctata	48.26	4.00e-77	281.00
IUUC-Oru-084789	Oryza rufipogon	47.89	1.00e-81	296.00
IUUC-Osa-086196	Oryza sativa	47.89	1.00e-81	296.00
IUUC-Ola-087126	Oryzias latipes	91.96	3.00e-170	590.00
IUUC-Olu-087665	Ostreococcus lucimarinus	41.67	4.00e-69	254.00
IUUC-Oga-089140	Otolemur garnettii	86.98	6.00e-174	602.00
IUUC-Oar-090296	Ovis aries	95.18	2.00e-178	617.00
IUUC-Ptr-090566	Pan troglodytes	94.86	8.00e-179	619.00
IUUC-Pan-092052	Papio anubis	93.95	3.00e-176	610.00
IUUC-Psi-093723	Pelodiscus sinensis	96.53	8.00e-168	582.00
IUUC-Pma-094568	Petromyzon marinus	61.11	1.00e-107	382.00
IUUC-Pno-095120	Phaeosphaeria nodorum	38.94	8.00e-49	186.00
IUUC-Ppa-095761	Physcomitrella patens	47.66	9.00e-85	306.00
IUUC-Pfo-096210	Poecilia formosa	91.32	1.00e-174	605.00
IUUC-Pab-098463	Pongo abelii	94.86	1.00e-178	618.00
IUUC-Pop-099109	Populus trichocarpa	48.07	9.00e-84	303.00
IUUC-Pca-100108	Procavia capensis	94.65	9.00e-138	482.00
IUUC-Ppe-101176	Prunus persica	50.30	5.00e-84	303.00
IUUC-Pva-102629	Pteropus vampyrus	93.08	2.00e-143	501.00
IUUC-Pgr-103419	Puccinia graminis	40.85	4.00e-57	214.00
IUUC-Pte-104207	Pyrenophora teres	44.38	2.00e-32	131.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	39.34	2.00e-56	212.00
IUUC-Rno-105579	Rattus norvegicus	83.59	5.00e-157	546.00
IUUC-Sha-106894	Sarcophilus harrisii	92.75	2.00e-153	534.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	38.87	5.00e-59	221.00
IUUC-Spo-108371	Schizosaccharomyces pombe	40.26	6.00e-60	223.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	37.68	6.00e-47	180.00
IUUC-Smo-109396	Selaginella moellendorffii	51.08	4.00e-88	317.00
IUUC-Sit-110630	Setaria italica	49.24	3.00e-85	308.00
IUUC-Sly-110972	Solanum lycopersicum	49.52	4.00e-80	290.00
IUUC-Stu-112185	Solanum tuberosum	50.00	1.00e-88	319.00
IUUC-Sar-113294	Sorex araneus	78.93	4.00e-159	553.00
IUUC-Sbi-113951	Sorghum bicolor	49.54	2.00e-85	308.00
IUUC-Ssc-115501	Sus scrofa	94.61	9.00e-169	585.00
IUUC-Tgu-117152	Taeniopygia guttata	96.18	7.00e-162	562.00
IUUC-Tru-118388	Takifugu rubripes	91.03	6.00e-175	606.00
IUUC-Tsy-119109	Tarsius syrichta	94.59	3.00e-179	620.00
IUUC-Tni-120048	Tetraodon nigroviridis	91.03	2.00e-175	608.00
IUUC-Tca-121750	Theobroma cacao	50.00	1.00e-87	316.00
IUUC-Tre-122130	Trichoderma reesei	39.33	2.00e-55	209.00
IUUC-Tvi-122284	Trichoderma virens	40.07	7.00e-53	200.00
IUUC-Tae-124082	Triticum aestivum	47.09	5.00e-81	293.00
IUUC-Tur-126366	Triticum urartu	42.43	4.00e-66	244.00
IUUC-Tme-127187	Tuber melanosporum	40.59	1.00e-58	219.00
IUUC-Tbe-127619	Tupaia belangeri	86.06	3.00e-138	484.00
IUUC-Ttr-128867	Tursiops truncatus	85.31	8.00e-121	426.00
IUUC-Vda-129912	Verticillium dahliae	37.71	1.00e-53	202.00
IUUC-Vpa-130552	Vicugna pacos	97.10	1.00e-122	432.00
IUUC-Vvi-130881	Vitis vinifera	50.74	2.00e-84	305.00
IUUC-Xtr-131934	Xenopus tropicalis	87.50	3.00e-176	610.00
IUUC-Xma-133312	Xiphophorus maculatus	91.00	2.00e-173	601.00
IUUC-Yli-134487	Yarrowia lipolytica	39.48	3.00e-47	181.00
IUUC-Zma-135462	Zea mays	43.08	1.00e-70	259.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence