iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074007

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02039185

Gene Name

NLE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000014310.3	ENSOCUT00000014310.3	ENSOCUP00000012300.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.20e-67	219.1	197	240
UBD/Beta-Prp	2.50e-78	263.3	106	304

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf......sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH+ ++t+l++      ++ ++++s+s Dg+++vWD++ g++++
   Q: 197  GHSKWITGLSWeplhvnPEcRYVASSSKDGSVRVWDTTAGRCER 240
           8***************9889**********************86 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           + +sl+gh+++v +v fsp+gk+l++gs D t++ wdlst ++  t kgh + vls+++sp+g+kl+sG +   i +wd +tg+ +   
   Q: 106  CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSIAWSPDGKKLASGCKNGQILLWDPSTGKQVGRA 194
           6789************************************************************************************* PP
   S: 133  lsghdgvvncvvv.....hpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l gh+++++++++     +p++++++s+s+D+ vr+Wd   g++ r ltg ht+sv++l +  +g  l s+s+d+t+k+w  + g   r
   Q: 195  LVGHSKWITGLSWeplhvNPECRYVASSSKDGSVRVWDTTAGRCERILTG-HTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCR 281
           *********98652222278899**************************9.************98.*********************** PP
   S: 217  tlnghtdnvksvrfspnderlvsg 240
           tl+gh  +v+ +++s  d  l +g
   Q: 282  TLQGHGHWVNTMALS-TDYALRTG 304
           **************9.44444444 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MAAAAAEEAA AHDVQRLLVQ FQDESGQLLG APFDVPVDIT PDRLQLVCNA LLAQEEPLPL 60
AFYVHDAEIV SSLGKTLESQ AVETEKVLDI IYQPQAIFRV RAVTRCTSSL EGHSEAVISV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCGCTCTG GCCCGCGGCA GTCAGTCTCC TCCACGTGCG GACGCAGGAT GGCGGCGGCG 60
GCGGCGGTGG GTGTGCGCGC TCGGGGGTCC CCCCGAGCCC GAGGGAGGAG GTCAAGTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR012972--NLE
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0061484--P:hematopoietic stem cell homeostasis
GO:0001826--P:inner cell mass cell differentiation
GO:0001822--P:kidney development
GO:2001268--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0007219--P:Notch signaling pathway
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0042273--P:ribosomal large subunit biogenesis
GO:0048705--P:skeletal system morphogenesis
GO:0001756--P:somitogenesis

KEGG

ocu:100357680

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000437	Aegilops tauschii	59.01	2.00e-170	591.00
IUUC-Aml-001793	Ailuropoda melanoleuca	96.19	0.00e+00	939.00
IUUC-Atr-002507	Amborella trichopoda	59.49	2.00e-169	588.00
IUUC-Apl-003964	Anas platyrhynchos	83.92	0.00e+00	808.00
IUUC-Aly-006396	Arabidopsis lyrata	55.32	8.00e-163	566.00
IUUC-Ath-007278	Arabidopsis thaliana	55.53	1.00e-162	566.00
IUUC-Ago-007951	Ashbya gossypii	48.26	1.00e-130	460.00
IUUC-Acl-008298	Aspergillus clavatus	47.29	5.00e-120	424.00
IUUC-Afl-008581	Aspergillus flavus	52.22	6.00e-109	387.00
IUUC-Afu-008906	Aspergillus fumigatus	46.68	5.00e-119	421.00
IUUC-Ani-009189	Aspergillus nidulans	44.62	1.00e-116	412.00
IUUC-Ang-009630	Aspergillus niger	47.61	3.00e-123	435.00
IUUC-Aor-010038	Aspergillus oryzae	47.20	8.00e-127	447.00
IUUC-Ate-010278	Aspergillus terreus	47.20	3.00e-122	432.00
IUUC-Ame-011890	Astyanax mexicanus	80.97	0.00e+00	822.00
IUUC-Bgr-012011	Blumeria graminis	47.83	1.00e-129	456.00
IUUC-Bta-012964	Bos taurus	95.98	0.00e+00	937.00
IUUC-Bci-013592	Botrytis cinerea	45.62	6.00e-120	424.00
IUUC-Bdi-015035	Brachypodium distachyon	59.53	1.00e-172	599.00
IUUC-Bol-015501	Brassica oleracea	56.20	6.00e-163	566.00
IUUC-Bra-017642	Brassica rapa	55.98	4.00e-162	564.00
IUUC-Cel-018430	Caenorhabditis elegans	57.51	1.00e-165	575.00
IUUC-Cja-019125	Callithrix jacchus	96.19	0.00e+00	937.00
IUUC-Cfa-021013	Canis familiaris	94.92	0.00e+00	853.00
IUUC-Cpo-021743	Cavia porcellus	95.99	0.00e+00	943.00
IUUC-Cre-022973	Chlamydomonas reinhardtii	47.77	3.00e-123	434.00
IUUC-Csa-024270	Chlorocebus sabaeus	96.19	0.00e+00	939.00
IUUC-Cin-025795	Ciona intestinalis	66.52	0.00e+00	687.00
IUUC-Csv-025953	Ciona savignyi	67.38	0.00e+00	686.00
IUUC-Cgl-026517	Colletotrichum gloeosporioides	51.99	7.00e-109	387.00
IUUC-Cne-026901	Cryptococcus neoformans	49.20	1.00e-138	486.00
IUUC-Cme-027281	Cyanidioschyzon merolae	48.01	1.00e-113	403.00
IUUC-Dre-028515	Danio rerio	77.80	0.00e+00	799.00
IUUC-Dno-029596	Dasypus novemcinctus	96.41	0.00e+00	940.00
IUUC-Dor-030494	Dipodomys ordii	95.97	0.00e+00	931.00
IUUC-Dse-031538	Dothistroma septosporum	47.83	1.00e-128	453.00
IUUC-Dme-031974	Drosophila melanogaster	58.26	2.00e-168	585.00
IUUC-Ete-032948	Echinops telfairi	97.61	6.00e-118	417.00
IUUC-Eca-033399	Equus caballus	96.82	0.00e+00	941.00
IUUC-Eeu-035013	Erinaceus europaeus	94.74	5.00e-116	411.00
IUUC-Fca-035860	Felis catus	95.56	0.00e+00	933.00
IUUC-Fal-037069	Ficedula albicollis	87.20	2.00e-131	461.00
IUUC-Fox-038059	Fusarium oxysporum	46.56	1.00e-125	442.00
IUUC-Fso-038445	Fusarium solani	46.76	5.00e-126	444.00
IUUC-Gmo-039319	Gadus morhua	76.81	0.00e+00	739.00
IUUC-Ggr-040095	Gaeumannomyces graminis	47.29	2.00e-122	432.00
IUUC-Gga-040303	Gallus gallus	84.80	8.00e-129	452.00
IUUC-Gac-042267	Gasterosteus aculeatus	78.32	0.00e+00	765.00
IUUC-Gma-043974	Glycine max	58.30	4.00e-172	597.00
IUUC-Ggo-044637	Gorilla gorilla	96.39	0.00e+00	932.00
IUUC-Hsa-046128	Homo sapiens	96.41	0.00e+00	941.00
IUUC-Hvu-047373	Hordeum vulgare	58.46	1.00e-169	589.00
IUUC-Itr-048070	Ictidomys tridecemlineatus	95.61	0.00e+00	937.00
IUUC-Kpa-049274	Komagataella pastoris	44.97	4.00e-127	447.00
IUUC-Lch-049907	Latimeria chalumnae	81.97	0.00e+00	818.00
IUUC-Lpe-050778	Leersia perrieri	54.82	2.00e-153	535.00
IUUC-Loc-051889	Lepisosteus oculatus	80.34	0.00e+00	823.00
IUUC-Lma-053041	Leptosphaeria maculans	49.41	3.00e-116	412.00
IUUC-Laf-053598	Loxodonta africana	96.62	0.00e+00	943.00
IUUC-Mcc-055660	Macaca mulatta	95.98	0.00e+00	937.00
IUUC-Meu-056197	Macropus eugenii	79.10	0.00e+00	768.00
IUUC-Mor-056949	Magnaporthe oryzae	46.38	3.00e-120	425.00
IUUC-Mpo-057571	Magnaporthe poae	45.08	1.00e-63	236.00
IUUC-Mtr-058530	Medicago truncatula	58.94	5.00e-168	583.00
IUUC-Mla-059133	Melampsora laricipopulina	46.28	2.00e-125	442.00
IUUC-Mga-059252	Meleagris gallopavo	84.11	0.00e+00	658.00
IUUC-Mvi-060522	Microbotryum violaceum	50.00	2.00e-136	479.00
IUUC-Mmr-061117	Microcebus murinus	96.20	0.00e+00	931.00
IUUC-Mdo-062892	Monodelphis domestica	88.58	0.00e+00	885.00
IUUC-Mmu-064108	Mus musculus	96.19	0.00e+00	912.00
IUUC-Mac-064430	Musa acuminata	60.39	3.00e-175	608.00
IUUC-Mpu-065882	Mustela putorius furo	95.35	0.00e+00	929.00
IUUC-Mlu-068123	Myotis lucifugus	95.98	0.00e+00	939.00
IUUC-Nfi-068484	Neosartorya fischeri	47.60	4.00e-120	424.00
IUUC-Ncr-068649	Neurospora crassa	44.07	3.00e-116	411.00
IUUC-Nle-069140	Nomascus leucogenys	95.97	0.00e+00	931.00
IUUC-Opr-070220	Ochotona princeps	90.43	0.00e+00	830.00
IUUC-Ont-072643	Oreochromis niloticus	80.21	0.00e+00	818.00
IUUC-Oba-075904	Oryza barthii	59.53	3.00e-173	601.00
IUUC-Obr-076280	Oryza brachyantha	59.10	5.00e-172	597.00
IUUC-Ogl-077425	Oryza glaberrima	59.53	4.00e-173	600.00
IUUC-Ogu-078586	Oryza glumaepatula	59.53	4.00e-173	600.00
IUUC-Oin-079489	Oryza indica	57.39	3.00e-164	571.00
IUUC-Olo-080766	Oryza longistaminata	59.40	6.00e-173	600.00
IUUC-Ome-081905	Oryza meridionalis	59.53	4.00e-173	600.00
IUUC-Oni-083022	Oryza nivara	59.53	2.00e-173	601.00
IUUC-Opu-083615	Oryza punctata	59.53	3.00e-173	601.00
IUUC-Oru-085076	Oryza rufipogon	59.53	2.00e-173	601.00
IUUC-Osa-085744	Oryza sativa	59.74	1.00e-173	602.00
IUUC-Ola-087290	Oryzias latipes	78.48	0.00e+00	802.00
IUUC-Olu-087898	Ostreococcus lucimarinus	52.41	1.00e-144	506.00
IUUC-Oga-088980	Otolemur garnettii	95.33	0.00e+00	928.00
IUUC-Oar-089580	Ovis aries	95.35	0.00e+00	812.00
IUUC-Ptr-090845	Pan troglodytes	95.54	0.00e+00	926.00
IUUC-Pan-092836	Papio anubis	96.19	0.00e+00	941.00
IUUC-Psi-093965	Pelodiscus sinensis	83.33	9.00e-57	211.00
IUUC-Pno-095052	Phaeosphaeria nodorum	46.80	1.00e-121	430.00
IUUC-Ppa-095432	Physcomitrella patens	59.49	3.00e-172	597.00
IUUC-Pfo-096963	Poecilia formosa	71.79	0.00e+00	701.00
IUUC-Pab-097716	Pongo abelii	92.14	0.00e+00	886.00
IUUC-Pop-099224	Populus trichocarpa	60.00	6.00e-174	603.00
IUUC-Pca-100682	Procavia capensis	92.11	0.00e+00	674.00
IUUC-Ppe-101819	Prunus persica	58.64	7.00e-170	590.00
IUUC-Pva-102338	Pteropus vampyrus	95.52	0.00e+00	710.00
IUUC-Pgr-103583	Puccinia graminis	55.12	5.00e-132	464.00
IUUC-Ptt-103737	Puccinia triticina	44.57	6.00e-99	354.00
IUUC-Pte-104150	Pyrenophora teres	52.21	3.00e-121	428.00
IUUC-Pyt-104606	Pyrenophora triticirepentis	51.96	6.00e-121	427.00
IUUC-Rno-105987	Rattus norvegicus	95.97	0.00e+00	935.00
IUUC-Sce-106315	Saccharomyces cerevisiae	47.36	2.00e-130	459.00
IUUC-Sha-107273	Sarcophilus harrisii	89.85	0.00e+00	896.00
IUUC-Sja-107677	Schizosaccharomyces japonicus	46.12	3.00e-117	415.00
IUUC-Spo-108092	Schizosaccharomyces pombe	48.97	1.00e-123	436.00
IUUC-Ssl-108442	Sclerotinia sclerotiorum	44.81	1.00e-116	413.00
IUUC-Smo-108855	Selaginella moellendorffii	57.29	3.00e-165	574.00
IUUC-Sit-110329	Setaria italica	59.53	2.00e-172	599.00
IUUC-Sly-111830	Solanum lycopersicum	60.39	2.00e-175	608.00
IUUC-Stu-112603	Solanum tuberosum	60.39	2.00e-175	608.00
IUUC-Sar-113504	Sorex araneus	90.78	8.00e-73	267.00
IUUC-Sbi-114560	Sorghum bicolor	59.31	4.00e-171	594.00
IUUC-Sre-115133	Sporisorium reilianum	41.46	2.00e-123	436.00
IUUC-Ssc-115903	Sus scrofa	95.77	0.00e+00	936.00
IUUC-Tgu-116798	Taeniopygia guttata	84.99	0.00e+00	856.00
IUUC-Tru-118361	Takifugu rubripes	78.53	0.00e+00	803.00
IUUC-Tsy-118849	Tarsius syrichta	96.59	0.00e+00	933.00
IUUC-Tni-120094	Tetraodon nigroviridis	78.74	0.00e+00	803.00
IUUC-Tca-121634	Theobroma cacao	58.72	2.00e-169	588.00
IUUC-Tre-122051	Trichoderma reesei	47.08	3.00e-120	425.00
IUUC-Tvi-122322	Trichoderma virens	47.71	9.00e-124	436.00
IUUC-Tae-125822	Triticum aestivum	58.89	2.00e-170	592.00
IUUC-Tur-126766	Triticum urartu	52.57	3.00e-162	565.00
IUUC-Tme-127175	Tuber melanosporum	51.05	6.00e-132	464.00
IUUC-Tbe-127779	Tupaia belangeri	95.08	0.00e+00	826.00
IUUC-Ttr-128224	Tursiops truncatus	91.59	0.00e+00	807.00
IUUC-Uma-129537	Ustilago maydis	41.99	3.00e-125	442.00
IUUC-Vda-129927	Verticillium dahliae	46.03	3.00e-111	395.00
IUUC-Vpa-130658	Vicugna pacos	83.62	0.00e+00	787.00
IUUC-Vvi-131659	Vitis vinifera	59.06	2.00e-172	598.00
IUUC-Xtr-132918	Xenopus tropicalis	76.42	0.00e+00	783.00
IUUC-Xma-133700	Xiphophorus maculatus	80.21	0.00e+00	814.00
IUUC-Yli-134478	Yarrowia lipolytica	50.00	1.00e-138	486.00
IUUC-Zma-135835	Zea mays	56.39	2.00e-167	581.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence