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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046024
Ensembl Protein ID ENSP00000478877.1
UniProt Accession Q16186; A0PKB1; Q96FJ7; Q9H1P2; ADRM1_HUMAN
Genbank Protein ID BAA11023.1; FAA00246.1; AAH10733.1; AAH17245.1
Protein Name Proteasomal ubiquitin receptor ADRM1; 110 kDa cell membrane glycoprotein; Adhesion-regulating molecule 1; Proteasome regulatory particle non-ATPase 13; Rpn13 homolog
Genbank Nucleotide ID D64154; AL354836; BC010733; BC017245
Gene Name ADRM1; GP110
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000130706.12 ENST00000491935.5 ENSP00000478877.1
ENSG00000130706.12 ENST00000620230.4 ENSP00000480756.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/PRU 26.53 1.90e-02 35.00 IUUC-Sce-106377
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex.
Protein Sequence
(Fasta)
MTTSGALFPS LVPGSRGASN KYLVEFRAGK MSLKGTTVTP DKRKGLVYIQ QTDDSLIHFC 60
WKDRTSGNVE DDLIIFPDDC EFKRVPQCPS GRVYVLKFKA GSKRLFFWMQ EPKTDQDEEH 120
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Protein Fasta Sequence



>IUUC-Hsa-046024|UBD,PRU|Homo sapiens
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Nucleotide Sequence
(Fasta)
CGACTGCCGC CTTTTTACCC TGTGGCCTTT CCCATCCAGG CGTCCAGAGG GTGAGCCCCT 60
GCCCTCCAGG ACCCCTCCCT TCCAGGACCC TACCCGTCTG GGACTCAGGC CTTCCCTGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046024|UBD,PRU|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR006773--26S_Psome_Ubiquitin-recp_Rpn13
IPR032368--RPN13_C

Pfam

PF04683--Proteasom_Rpn13
PF16550--RPN13_C

Gene Ontology

GO:0005829--C:cytosol
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0000502--C:proteasome complex
GO:0008541--C:proteasome regulatory particle, lid subcomplex
GO:0061133--F:endopeptidase activator activity
GO:0002020--F:protease binding
GO:0070628--F:proteasome binding
GO:0043130--F:ubiquitin binding
GO:0043248--P:proteasome assembly
GO:0016579--P:protein deubiquitination
GO:0006368--P:transcription elongation from RNA polymerase II promoter
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG hsa:11047
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000735 Aegilops tauschii 40.43 8.00e-25 107.00
IUUC-Aml-002306 Ailuropoda melanoleuca 98.84 2.00e-85 309.00
IUUC-Atr-002494 Amborella trichopoda 53.15 1.00e-33 137.00
IUUC-Apl-003608 Anas platyrhynchos 88.68 6.00e-65 241.00
IUUC-Aca-004810 Anolis carolinensis 92.94 3.00e-80 291.00
IUUC-Aly-006501 Arabidopsis lyrata 48.30 2.00e-35 142.00
IUUC-Ath-007220 Arabidopsis thaliana 50.00 1.00e-36 147.00
IUUC-Ago-007904 Ashbya gossypii 32.35 1.00e-08 52.80
IUUC-Acl-008240 Aspergillus clavatus 36.63 3.00e-13 69.30
IUUC-Afl-008673 Aspergillus flavus 36.63 1.00e-13 70.90
IUUC-Afu-009026 Aspergillus fumigatus 52.38 5.00e-03 35.40
IUUC-Ani-009170 Aspergillus nidulans 37.11 5.00e-13 68.60
IUUC-Ang-009696 Aspergillus niger 34.26 8.00e-13 68.20
IUUC-Aor-009975 Aspergillus oryzae 36.63 1.00e-13 70.90
IUUC-Ate-010404 Aspergillus terreus 36.63 3.00e-13 69.70
IUUC-Ame-011726 Astyanax mexicanus 87.88 6.00e-67 248.00
IUUC-Bgr-012116 Blumeria graminis 37.37 4.00e-13 68.90
IUUC-Bta-012686 Bos taurus 98.84 2.00e-85 309.00
IUUC-Bci-013772 Botrytis cinerea 35.92 1.00e-10 60.80
IUUC-Bdi-014600 Brachypodium distachyon 52.34 2.00e-30 126.00
IUUC-Bol-015418 Brassica oleracea 53.15 3.00e-32 132.00
IUUC-Bra-018022 Brassica rapa 53.15 1.00e-32 133.00
IUUC-Cja-019223 Callithrix jacchus 97.67 1.00e-83 303.00
IUUC-Cfa-020426 Canis familiaris 97.67 5.00e-88 318.00
IUUC-Cpo-021820 Cavia porcellus 97.67 9.00e-88 317.00
IUUC-Csa-023622 Chlorocebus sabaeus 100.00 7.00e-86 310.00
IUUC-Cin-025475 Ciona intestinalis 64.94 3.00e-57 215.00
IUUC-Csv-026094 Ciona savignyi 73.83 5.00e-49 188.00
IUUC-Cgl-026557 Colletotrichum gloeosporioides 39.22 7.00e-14 71.60
IUUC-Cne-026937 Cryptococcus neoformans 36.61 2.00e-18 86.30
IUUC-Cme-027138 Cyanidioschyzon merolae 41.23 4.00e-25 108.00
IUUC-Dre-027576 Danio rerio 88.82 4.00e-71 261.00
IUUC-Dno-029119 Dasypus novemcinctus 97.67 1.00e-83 303.00
IUUC-Dor-030837 Dipodomys ordii 96.27 6.00e-73 268.00
IUUC-Dse-031557 Dothistroma septosporum 40.40 1.00e-16 80.90
IUUC-Dme-031872 Drosophila melanogaster 67.50 1.00e-50 193.00
IUUC-Ete-032654 Echinops telfairi 91.82 1.00e-69 256.00
IUUC-Eca-034182 Equus caballus 97.67 4.00e-83 301.00
IUUC-Eeu-035242 Erinaceus europaeus 98.26 6.00e-85 307.00
IUUC-Fca-036448 Felis catus 98.84 1.00e-85 310.00
IUUC-Fal-036857 Ficedula albicollis 92.94 6.00e-84 304.00
IUUC-Fox-037975 Fusarium oxysporum 34.31 2.00e-12 66.60
IUUC-Fso-038361 Fusarium solani 35.29 3.00e-12 66.20
IUUC-Gmo-038621 Gadus morhua 88.17 2.00e-70 259.00
IUUC-Ggr-039789 Gaeumannomyces graminis 34.29 3.00e-10 59.70
IUUC-Gga-040784 Gallus gallus 92.44 2.00e-84 305.00
IUUC-Gac-041531 Gasterosteus aculeatus 83.33 9.00e-78 283.00
IUUC-Gma-044281 Glycine max 46.09 4.00e-31 128.00
IUUC-Ggo-044790 Gorilla gorilla 99.42 2.00e-85 309.00
IUUC-Hvu-047480 Hordeum vulgare 46.81 7.00e-34 137.00
IUUC-Itr-048195 Ictidomys tridecemlineatus 98.26 6.00e-85 308.00
IUUC-Kpa-049226 Komagataella pastoris 26.92 5.00e-08 49.70
IUUC-Lch-049418 Latimeria chalumnae 89.41 1.00e-76 280.00
IUUC-Lpe-050742 Leersia perrieri 48.94 1.00e-35 143.00
IUUC-Loc-052496 Lepisosteus oculatus 89.29 3.00e-70 259.00
IUUC-Lma-053330 Leptosphaeria maculans 36.45 2.00e-13 68.90
IUUC-Laf-053604 Loxodonta africana 97.67 4.00e-86 311.00
IUUC-Mcc-055359 Macaca mulatta 100.00 7.00e-86 310.00
IUUC-Meu-056243 Macropus eugenii 90.85 8.00e-66 243.00
IUUC-Mor-057247 Magnaporthe oryzae 36.19 2.00e-09 57.00
IUUC-Mpo-057457 Magnaporthe poae 35.24 1.00e-10 61.20
IUUC-Mtr-058738 Medicago truncatula 54.39 4.00e-33 135.00
IUUC-Mla-059042 Melampsora laricipopulina 35.29 5.00e-15 75.10
IUUC-Mga-059762 Meleagris gallopavo 87.42 7.00e-65 239.00
IUUC-Mvi-060526 Microbotryum violaceum 42.59 8.00e-20 91.30
IUUC-Mmr-061152 Microcebus murinus 98.26 3.00e-88 318.00
IUUC-Mdo-062086 Monodelphis domestica 94.71 2.00e-81 295.00
IUUC-Mmu-064131 Mus musculus 97.09 3.00e-83 301.00
IUUC-Mpu-066924 Mustela putorius furo 96.45 1.00e-73 269.00
IUUC-Mlu-068064 Myotis lucifugus 98.26 5.00e-85 308.00
IUUC-Nfi-068545 Neosartorya fischeri 35.64 6.00e-12 65.50
IUUC-Ncr-068847 Neurospora crassa 35.29 6.00e-12 65.50
IUUC-Nle-069563 Nomascus leucogenys 97.67 8.00e-84 303.00
IUUC-Ont-072472 Oreochromis niloticus 84.71 4.00e-72 265.00
IUUC-Oan-072770 Ornithorhynchus anatinus 94.12 5.00e-81 294.00
IUUC-Oba-075129 Oryza barthii 47.52 5.00e-34 138.00
IUUC-Obr-076216 Oryza brachyantha 48.23 2.00e-35 142.00
IUUC-Ogl-077663 Oryza glaberrima 47.52 5.00e-34 137.00
IUUC-Oin-079928 Oryza indica 47.52 5.00e-34 137.00
IUUC-Ome-081406 Oryza meridionalis 40.43 2.00e-24 105.00
IUUC-Oni-083080 Oryza nivara 47.52 5.00e-34 138.00
IUUC-Opu-083569 Oryza punctata 46.81 3.00e-33 135.00
IUUC-Osa-085922 Oryza sativa 47.52 5.00e-34 137.00
IUUC-Ola-087324 Oryzias latipes 84.71 3.00e-74 272.00
IUUC-Oga-089045 Otolemur garnettii 99.42 1.00e-85 310.00
IUUC-Oar-090402 Ovis aries 98.84 2.00e-85 309.00
IUUC-Ptr-090578 Pan troglodytes 100.00 3.00e-79 288.00
IUUC-Pan-092872 Papio anubis 100.00 7.00e-86 310.00
IUUC-Psi-093198 Pelodiscus sinensis 92.94 1.00e-79 290.00
IUUC-Pno-095051 Phaeosphaeria nodorum 33.94 4.00e-12 64.70
IUUC-Ppa-095547 Physcomitrella patens 53.21 6.00e-32 131.00
IUUC-Pfo-096879 Poecilia formosa 87.50 1.00e-66 246.00
IUUC-Pab-098731 Pongo abelii 98.84 8.00e-82 297.00
IUUC-Pca-100816 Procavia capensis 93.24 8.00e-67 247.00
IUUC-Ppe-101400 Prunus persica 54.05 9.00e-33 134.00
IUUC-Pva-103198 Pteropus vampyrus 95.60 3.00e-73 268.00
IUUC-Pgr-103494 Puccinia graminis 38.39 7.00e-19 87.80
IUUC-Ptt-103732 Puccinia triticina 30.59 1.00e-04 38.50
IUUC-Pte-104034 Pyrenophora teres 37.38 1.00e-13 70.90
IUUC-Pyt-104724 Pyrenophora triticirepentis 36.45 5.00e-13 68.90
IUUC-Rno-105937 Rattus norvegicus 97.09 6.00e-84 304.00
IUUC-Sce-106377 Saccharomyces cerevisiae 35.90 1.10e-02 32.70
IUUC-Sha-106986 Sarcophilus harrisii 95.29 2.00e-81 296.00
IUUC-Sja-107713 Schizosaccharomyces japonicus 48.67 6.00e-28 118.00
IUUC-Spo-108172 Schizosaccharomyces pombe 45.69 5.00e-26 112.00
IUUC-Ssl-108639 Sclerotinia sclerotiorum 33.98 5.00e-10 57.80
IUUC-Smo-109349 Selaginella moellendorffii 25.00 3.00e-03 37.40
IUUC-Sly-111320 Solanum lycopersicum 55.05 1.00e-31 130.00
IUUC-Sbi-114588 Sorghum bicolor 55.05 1.00e-33 136.00
IUUC-Tgu-116881 Taeniopygia guttata 89.24 4.00e-83 299.00
IUUC-Tru-118602 Takifugu rubripes 84.12 3.00e-66 245.00
IUUC-Tni-119694 Tetraodon nigroviridis 85.29 6.00e-67 248.00
IUUC-Tca-121244 Theobroma cacao 34.72 2.00e-26 112.00
IUUC-Tre-122090 Trichoderma reesei 37.25 4.00e-12 65.90
IUUC-Tvi-122267 Trichoderma virens 36.54 2.00e-12 66.60
IUUC-Tae-124010 Triticum aestivum 47.52 3.00e-34 138.00
IUUC-Tur-126552 Triticum urartu 39.72 3.00e-24 105.00
IUUC-Tme-126941 Tuber melanosporum 35.83 2.00e-18 86.30
IUUC-Tbe-127777 Tupaia belangeri 95.49 2.00e-65 241.00
IUUC-Ttr-128473 Tursiops truncatus 98.26 2.00e-101 362.00
IUUC-Vda-129665 Verticillium dahliae 36.00 5.00e-13 68.90
IUUC-Vvi-131383 Vitis vinifera 51.35 1.00e-32 134.00
IUUC-Xma-133590 Xiphophorus maculatus 87.43 5.00e-68 251.00
IUUC-Yli-134627 Yarrowia lipolytica 31.36 5.00e-13 68.20
IUUC-Zma-134939 Zea mays 54.63 5.00e-33 134.00
Created Date 25-Jun-2017

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