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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046244
UUCD1 version UUC-HoS-00202
Ensembl Protein ID ENSP00000384823.3
UniProt Accession Q86XK2; A1L491; Q52ZP1; Q53EP7; Q53RT5; Q8IXG3; Q96E90; Q9H6V8; Q9H9L1; Q9NR14; Q9UFK1; Q9UHI1; Q9UKC2; FBX11_HUMAN
Genbank Protein ID AAV87312.1; AAN76518.1; BAD97312.1; BAB14214.1; BAB15143.1; BAF85566.1; AAY24083.1; EAX00205.1; AAH12728.2; AAH43258.2; AAI30446.1; AAI36481.1; AAF04520.1; AAF17611.1; CAB56019.1; AAF76888.1
Protein Name F-box only protein 11; Protein arginine N-methyltransferase 9; Vitiligo-associated protein 1
Genbank Nucleotide ID AY827075; AF351618; AK223592; AK022735; AK025477; AK292877; AC006509; CH471053; BC012728; BC043258; BC130445; BC136480; AF174599; AF176706; AL117620; AF264714
Gene Name FBXO11; FBX11; PRMT9; VIT1; UG063H01
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138081.20 ENST00000403359.7 ENSP00000384823.3
ENSG00000138081.20 ENST00000493962.6 ENSP00000428118.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Drug and target
TTDGRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 19580641
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 3.30e-06 28.9 147 200
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 91   tptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktvt 147
           + +p    ++ l+++lp+e++++i+++l +++l+raa+vc+r++ela+++ lwk+++
   Q: 147  SAAPA---EQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLY 200
           44443...467889***************************************9876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
Protein Sequence
(Fasta)
MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PQQQPPPPPQ QQQQQQPPPP 60
PPPPPPLPQE RNNVGERDDD VPADMVAEES GPGAQNSPYQ LRRKTLLPKR TACPTKNSME 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046244|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCCTGCCCC GAAGCTCGCT GTGCGTGTGC GTGTGTGTGT CCCTCCGCCA ACGCCGCCAC 60
CTCAGCCCGG CAAATGAACT CCGTCCGAGC CGCCAACCGG AGACCCAGGC GAGTGTCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046244|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006633--Carb-bd_sugar_hydrolysis-dom
IPR001810--F-box_dom
IPR029799--FBX11/DRE-1
IPR007742--NosD_dom
IPR022441--Para_beta_helix_rpt-2
IPR006626--PbH1
IPR012334--Pectin_lyas_fold
IPR011050--Pectin_lyase_fold/virulence
IPR003126--Znf_UBR
PROSITE

PS50181--FBOX
PS51157--ZF_UBR
Pfam

PF12937--F-box-like
PF05048--NosD
PF02207--zf-UBR
SMART

SM00722--CASH
SM00256--FBOX
SM00710--PbH1
SM00396--ZnF_UBR1
Gene Ontology

GO:0005694--C:chromosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0016274--F:protein-arginine N-methyltransferase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006464--P:cellular protein modification process
GO:0016567--P:protein ubiquitination
GO:0007605--P:sensory perception of sound
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:80204
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002291 Ailuropoda melanoleuca 99.53 0.00e+00 1770.00
IUUC-Apl-003412 Anas platyrhynchos 99.41 0.00e+00 1768.00
IUUC-Aca-004842 Anolis carolinensis 99.06 0.00e+00 1763.00
IUUC-Ate-010540 Aspergillus terreus 27.27 7.00e-06 45.40
IUUC-Ame-011539 Astyanax mexicanus 98.36 0.00e+00 1761.00
IUUC-Bta-013526 Bos taurus 99.21 0.00e+00 1301.00
IUUC-Bci-013908 Botrytis cinerea 43.90 2.00e-04 41.20
IUUC-Cel-018135 Caenorhabditis elegans 59.18 0.00e+00 950.00
IUUC-Cja-019156 Callithrix jacchus 100.00 0.00e+00 1792.00
IUUC-Cfa-020503 Canis familiaris 99.76 0.00e+00 1774.00
IUUC-Cpo-022148 Cavia porcellus 99.53 0.00e+00 1769.00
IUUC-Csa-023799 Chlorocebus sabaeus 100.00 0.00e+00 1792.00
IUUC-Cho-024925 Choloepus hoffmanni 91.87 0.00e+00 1580.00
IUUC-Cin-025649 Ciona intestinalis 68.57 0.00e+00 1233.00
IUUC-Csv-026010 Ciona savignyi 74.10 0.00e+00 1199.00
IUUC-Cgl-026674 Colletotrichum gloeosporioides 35.37 5.00e-07 49.70
IUUC-Cne-027052 Cryptococcus neoformans 33.90 2.00e-05 44.70
IUUC-Dre-027855 Danio rerio 97.90 0.00e+00 1756.00
IUUC-Dno-029555 Dasypus novemcinctus 99.06 0.00e+00 1761.00
IUUC-Dor-030610 Dipodomys ordii 86.95 0.00e+00 1517.00
IUUC-Dme-031852 Drosophila melanogaster 69.21 0.00e+00 1117.00
IUUC-Ete-032999 Echinops telfairi 94.66 0.00e+00 1645.00
IUUC-Eca-033942 Equus caballus 99.53 0.00e+00 1786.00
IUUC-Eeu-034872 Erinaceus europaeus 99.64 0.00e+00 1752.00
IUUC-Fca-035904 Felis catus 98.36 0.00e+00 1740.00
IUUC-Fal-036742 Ficedula albicollis 99.41 0.00e+00 1753.00
IUUC-Gmo-039082 Gadus morhua 96.47 0.00e+00 1719.00
IUUC-Gga-040292 Gallus gallus 99.40 0.00e+00 1747.00
IUUC-Gac-042106 Gasterosteus aculeatus 97.53 0.00e+00 1728.00
IUUC-Ggo-045283 Gorilla gorilla 100.00 0.00e+00 1792.00
IUUC-Itr-047990 Ictidomys tridecemlineatus 99.65 0.00e+00 1770.00
IUUC-Lch-049831 Latimeria chalumnae 97.44 0.00e+00 1744.00
IUUC-Loc-051875 Lepisosteus oculatus 98.71 0.00e+00 1765.00
IUUC-Laf-053642 Loxodonta africana 99.30 0.00e+00 1774.00
IUUC-Mcc-055761 Macaca mulatta 99.88 0.00e+00 1774.00
IUUC-Meu-056886 Macropus eugenii 99.81 0.00e+00 1088.00
IUUC-Mga-059470 Meleagris gallopavo 99.41 0.00e+00 1768.00
IUUC-Mmr-060959 Microcebus murinus 99.64 0.00e+00 1759.00
IUUC-Mdo-062165 Monodelphis domestica 99.65 0.00e+00 1773.00
IUUC-Mmu-063590 Mus musculus 99.42 0.00e+00 1780.00
IUUC-Mpu-066702 Mustela putorius furo 99.76 0.00e+00 1761.00
IUUC-Mlu-067906 Myotis lucifugus 98.95 0.00e+00 1761.00
IUUC-Nle-069878 Nomascus leucogenys 100.00 0.00e+00 1792.00
IUUC-Opr-070211 Ochotona princeps 92.67 0.00e+00 747.00
IUUC-Ont-072305 Oreochromis niloticus 96.84 0.00e+00 1723.00
IUUC-Oan-073077 Ornithorhynchus anatinus 93.09 0.00e+00 1298.00
IUUC-Ocu-074419 Oryctolagus cuniculus 99.76 0.00e+00 1769.00
IUUC-Ola-087393 Oryzias latipes 96.59 0.00e+00 1717.00
IUUC-Oga-088010 Otolemur garnettii 100.00 0.00e+00 1631.00
IUUC-Oar-089660 Ovis aries 99.65 0.00e+00 1769.00
IUUC-Ptr-091220 Pan troglodytes 100.00 0.00e+00 1763.00
IUUC-Pan-092606 Papio anubis 99.85 0.00e+00 1353.00
IUUC-Psi-093950 Pelodiscus sinensis 99.29 0.00e+00 1751.00
IUUC-Pma-094248 Petromyzon marinus 86.47 0.00e+00 1523.00
IUUC-Pfo-097361 Poecilia formosa 96.95 0.00e+00 1724.00
IUUC-Pab-097736 Pongo abelii 100.00 0.00e+00 1792.00
IUUC-Pca-100204 Procavia capensis 93.78 0.00e+00 1616.00
IUUC-Pva-102248 Pteropus vampyrus 94.92 0.00e+00 1390.00
IUUC-Pgr-103283 Puccinia graminis 41.82 6.00e-07 49.30
IUUC-Rno-106009 Rattus norvegicus 99.88 0.00e+00 1763.00
IUUC-Sha-107330 Sarcophilus harrisii 99.65 0.00e+00 1773.00
IUUC-Ssl-108666 Sclerotinia sclerotiorum 41.46 2.00e-04 41.20
IUUC-Stu-111936 Solanum tuberosum 43.48 7.00e-06 43.10
IUUC-Sar-112927 Sorex araneus 99.70 0.00e+00 688.00
IUUC-Sre-115181 Sporisorium reilianum 45.45 7.00e-08 52.80
IUUC-Ssc-115330 Sus scrofa 99.07 0.00e+00 1773.00
IUUC-Tgu-116883 Taeniopygia guttata 99.41 0.00e+00 1769.00
IUUC-Tru-118225 Takifugu rubripes 95.82 0.00e+00 1714.00
IUUC-Tsy-119194 Tarsius syrichta 95.58 0.00e+00 1380.00
IUUC-Tni-119690 Tetraodon nigroviridis 95.55 0.00e+00 1688.00
IUUC-Tae-123166 Triticum aestivum 38.03 3.00e-06 46.20
IUUC-Tme-127013 Tuber melanosporum 38.98 9.00e-05 42.00
IUUC-Tbe-127560 Tupaia belangeri 100.00 1.00e-158 553.00
IUUC-Ttr-129186 Tursiops truncatus 96.04 0.00e+00 1711.00
IUUC-Uma-129621 Ustilago maydis 41.07 4.00e-07 50.40
IUUC-Vda-129883 Verticillium dahliae 34.18 4.00e-06 47.00
IUUC-Vpa-130098 Vicugna pacos 97.18 0.00e+00 1709.00
IUUC-Xtr-132162 Xenopus tropicalis 97.67 0.00e+00 1749.00
Created Date 25-Jun-2017

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