iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033773

Ensembl Protein ID

ENSECAP00000019949.1

UniProt Accession

F7B497; F7B497_HORSE

Protein Name

Coatomer subunit alpha

Gene Name

COPA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000021818.1	ENSECAT00000024039.1	ENSECAP00000019949.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-36	121.9	50	80
UBD/Beta-Prp	3.80e-76	256.3	3	324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDl 30
           H ++v++++f  + +l+vsG+dD +ikvW++
   Q: 50   HDGPVRGIDFhkQQPLFVSGGDDYKIKVWNY 80
           99********97449**************96 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           t +++++++++ + f+p++++++t+  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl g
   Q: 3    TKFETKSARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLG 91
           67889999********************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
           h d+++++ f+ +  +++s+s+d+tirvw++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+               
   Q: 92   HLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDIsglrkknlspgaves 179
           **************************************.************************************************** PP
   S: 167  ............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                        t+ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   v+t++gh +nv++  f+p++e+++s s
   Q: 180  dvrgitgvdlfgTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAweVDTCRGHYNNVSCAVFHPRQELILSNS 268
           ************888888888777********************************888888*************************** PP
   S: 242  sDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D+sir+Wd+ +++ ++t+ + +++++  a+ +++ n +++g  d+   ++kl++++p
   Q: 269  EDKSIRVWDMSKRTGVQTFRRDHDRFWVLAA-HPNLNLFAAG-HDGGMIVFKLERERP 324
           *******************************.5554444444.589999999988765 PP

Organism

Equus caballus

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSA RVKGLSFHPK RPWILTSLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRVW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTAACCA AATTCGAGAC CAAGAGCGCG CGGGTTAAAG GTAGTGGAGA AGAAAAGGGG 60
CCCTATGGAG GCTGGATGTC AGGGGTGGCG CAGTCACGGG GGAAGAGAGA GAGAGGGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006888--P:ER to Golgi vesicle-mediated transport
GO:0006891--P:intra-Golgi vesicle-mediated transport
GO:0006886--P:intracellular protein transport
GO:0030157--P:pancreatic juice secretion
GO:0006890--P:retrograde vesicle-mediated transport, Golgi to ER

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	53.02	0.00e+00	1285.00
IUUC-Aml-001758	Ailuropoda melanoleuca	96.44	0.00e+00	2421.00
IUUC-Atr-002493	Amborella trichopoda	53.28	0.00e+00	1281.00
IUUC-Apl-003385	Anas platyrhynchos	93.42	0.00e+00	1988.00
IUUC-Aca-005154	Anolis carolinensis	97.10	1.00e-121	427.00
IUUC-Aly-006020	Arabidopsis lyrata	61.71	0.00e+00	1097.00
IUUC-Ath-007058	Arabidopsis thaliana	61.99	0.00e+00	1091.00
IUUC-Ago-007992	Ashbya gossypii	43.83	0.00e+00	996.00
IUUC-Acl-008027	Aspergillus clavatus	57.21	0.00e+00	1006.00
IUUC-Afl-008644	Aspergillus flavus	48.83	0.00e+00	1152.00
IUUC-Afu-008964	Aspergillus fumigatus	48.23	0.00e+00	1153.00
IUUC-Ani-009379	Aspergillus nidulans	56.60	0.00e+00	1013.00
IUUC-Ang-009756	Aspergillus niger	48.79	0.00e+00	1171.00
IUUC-Aor-010174	Aspergillus oryzae	48.83	0.00e+00	1151.00
IUUC-Ate-010302	Aspergillus terreus	48.43	0.00e+00	1185.00
IUUC-Ame-011229	Astyanax mexicanus	84.91	0.00e+00	2132.00
IUUC-Bgr-012300	Blumeria graminis	47.53	0.00e+00	1095.00
IUUC-Bta-012524	Bos taurus	96.90	0.00e+00	2406.00
IUUC-Bci-013781	Botrytis cinerea	47.54	0.00e+00	1149.00
IUUC-Bdi-014549	Brachypodium distachyon	53.87	0.00e+00	1313.00
IUUC-Bol-015925	Brassica oleracea	61.63	0.00e+00	1083.00
IUUC-Bra-016978	Brassica rapa	60.93	0.00e+00	1080.00
IUUC-Cel-018115	Caenorhabditis elegans	64.27	0.00e+00	1129.00
IUUC-Cja-019107	Callithrix jacchus	93.68	0.00e+00	2350.00
IUUC-Cfa-020675	Canis familiaris	96.30	0.00e+00	2385.00
IUUC-Cpo-021813	Cavia porcellus	96.57	0.00e+00	2417.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	64.57	0.00e+00	1112.00
IUUC-Csa-023523	Chlorocebus sabaeus	96.90	0.00e+00	2435.00
IUUC-Cho-024704	Choloepus hoffmanni	81.97	0.00e+00	1817.00
IUUC-Cin-025572	Ciona intestinalis	70.69	0.00e+00	1808.00
IUUC-Csv-025864	Ciona savignyi	75.85	0.00e+00	1298.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	57.35	0.00e+00	1023.00
IUUC-Cne-027053	Cryptococcus neoformans	50.88	0.00e+00	1204.00
IUUC-Cme-027222	Cyanidioschyzon merolae	39.62	7.00e-143	501.00
IUUC-Dre-027421	Danio rerio	84.76	0.00e+00	2167.00
IUUC-Dno-029303	Dasypus novemcinctus	96.42	0.00e+00	2416.00
IUUC-Dor-030290	Dipodomys ordii	92.95	0.00e+00	1041.00
IUUC-Dse-031543	Dothistroma septosporum	44.89	0.00e+00	1081.00
IUUC-Dme-031945	Drosophila melanogaster	76.17	0.00e+00	1298.00
IUUC-Ete-032873	Echinops telfairi	92.78	0.00e+00	2156.00
IUUC-Eeu-034874	Erinaceus europaeus	82.31	0.00e+00	1430.00
IUUC-Fca-035739	Felis catus	95.62	0.00e+00	2333.00
IUUC-Fal-037263	Ficedula albicollis	85.91	0.00e+00	2062.00
IUUC-Fox-037738	Fusarium oxysporum	47.86	0.00e+00	1171.00
IUUC-Fso-038153	Fusarium solani	47.96	0.00e+00	1163.00
IUUC-Gmo-039602	Gadus morhua	80.39	0.00e+00	1988.00
IUUC-Ggr-039931	Gaeumannomyces graminis	56.43	0.00e+00	1017.00
IUUC-Gga-040590	Gallus gallus	94.62	0.00e+00	2348.00
IUUC-Gac-041318	Gasterosteus aculeatus	84.43	0.00e+00	2150.00
IUUC-Gma-043894	Glycine max	54.10	0.00e+00	1315.00
IUUC-Ggo-045029	Gorilla gorilla	96.03	0.00e+00	2424.00
IUUC-Hsa-046078	Homo sapiens	96.03	0.00e+00	2424.00
IUUC-Hvu-047556	Hordeum vulgare	54.60	0.00e+00	1326.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	94.21	0.00e+00	1660.00
IUUC-Kpa-049256	Komagataella pastoris	44.66	0.00e+00	1055.00
IUUC-Lch-049706	Latimeria chalumnae	90.95	0.00e+00	2244.00
IUUC-Lpe-051316	Leersia perrieri	62.87	0.00e+00	1110.00
IUUC-Loc-051867	Lepisosteus oculatus	71.93	0.00e+00	1219.00
IUUC-Lma-053138	Leptosphaeria maculans	56.55	0.00e+00	1025.00
IUUC-Laf-053510	Loxodonta africana	95.92	0.00e+00	2407.00
IUUC-Mcc-055836	Macaca mulatta	95.71	0.00e+00	2406.00
IUUC-Meu-056238	Macropus eugenii	87.13	0.00e+00	1178.00
IUUC-Mor-057172	Magnaporthe oryzae	47.99	0.00e+00	1156.00
IUUC-Mpo-057300	Magnaporthe poae	48.06	0.00e+00	1150.00
IUUC-Mtr-058248	Medicago truncatula	54.31	0.00e+00	1328.00
IUUC-Mla-059019	Melampsora laricipopulina	51.41	0.00e+00	1251.00
IUUC-Mga-059499	Meleagris gallopavo	94.46	0.00e+00	2341.00
IUUC-Mvi-060336	Microbotryum violaceum	52.46	0.00e+00	1240.00
IUUC-Mmr-061102	Microcebus murinus	95.87	0.00e+00	2375.00
IUUC-Mdo-062594	Monodelphis domestica	95.76	0.00e+00	2442.00
IUUC-Mmu-063736	Mus musculus	95.30	0.00e+00	2398.00
IUUC-Mac-065398	Musa acuminata	51.33	0.00e+00	1203.00
IUUC-Mpu-066701	Mustela putorius furo	96.59	0.00e+00	2375.00
IUUC-Mlu-067392	Myotis lucifugus	95.20	0.00e+00	2383.00
IUUC-Nfi-068270	Neosartorya fischeri	57.57	0.00e+00	1009.00
IUUC-Ncr-068892	Neurospora crassa	49.41	0.00e+00	1145.00
IUUC-Nle-069634	Nomascus leucogenys	99.24	0.00e+00	1378.00
IUUC-Opr-070952	Ochotona princeps	83.35	0.00e+00	1721.00
IUUC-Ont-072488	Oreochromis niloticus	86.43	0.00e+00	2162.00
IUUC-Ocu-074211	Oryctolagus cuniculus	96.82	0.00e+00	2423.00
IUUC-Oba-075761	Oryza barthii	62.75	0.00e+00	1108.00
IUUC-Obr-076429	Oryza brachyantha	62.75	0.00e+00	1108.00
IUUC-Ogl-077364	Oryza glaberrima	62.75	0.00e+00	1109.00
IUUC-Ogu-078257	Oryza glumaepatula	63.01	0.00e+00	1109.00
IUUC-Oin-079274	Oryza indica	62.63	0.00e+00	1107.00
IUUC-Olo-080466	Oryza longistaminata	62.67	0.00e+00	1095.00
IUUC-Ome-081993	Oryza meridionalis	64.79	0.00e+00	1034.00
IUUC-Oni-082874	Oryza nivara	63.01	0.00e+00	1108.00
IUUC-Opu-083697	Oryza punctata	53.13	0.00e+00	1295.00
IUUC-Oru-084274	Oryza rufipogon	62.75	0.00e+00	1108.00
IUUC-Osa-085565	Oryza sativa	62.75	0.00e+00	1108.00
IUUC-Ola-086921	Oryzias latipes	84.94	0.00e+00	2139.00
IUUC-Olu-087639	Ostreococcus lucimarinus	55.41	0.00e+00	1335.00
IUUC-Oga-087991	Otolemur garnettii	91.30	0.00e+00	2275.00
IUUC-Oar-089590	Ovis aries	96.98	0.00e+00	2430.00
IUUC-Ptr-090808	Pan troglodytes	96.11	0.00e+00	2426.00
IUUC-Pan-092475	Papio anubis	96.41	0.00e+00	2422.00
IUUC-Psi-093044	Pelodiscus sinensis	80.15	0.00e+00	1696.00
IUUC-Pno-094839	Phaeosphaeria nodorum	46.78	0.00e+00	1070.00
IUUC-Ppa-095254	Physcomitrella patens	56.09	0.00e+00	1373.00
IUUC-Pfo-097493	Poecilia formosa	86.03	0.00e+00	2135.00
IUUC-Pab-098497	Pongo abelii	96.98	0.00e+00	2437.00
IUUC-Pop-099992	Populus trichocarpa	55.66	0.00e+00	1311.00
IUUC-Pca-100413	Procavia capensis	89.47	0.00e+00	1012.00
IUUC-Ppe-101899	Prunus persica	53.73	0.00e+00	1296.00
IUUC-Pva-102126	Pteropus vampyrus	92.26	0.00e+00	2305.00
IUUC-Pgr-103376	Puccinia graminis	51.96	0.00e+00	1266.00
IUUC-Ptt-103978	Puccinia triticina	46.27	0.00e+00	1053.00
IUUC-Pte-104126	Pyrenophora teres	56.95	0.00e+00	983.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	47.08	1.00e-179	623.00
IUUC-Rno-105428	Rattus norvegicus	96.00	0.00e+00	2406.00
IUUC-Sce-106464	Saccharomyces cerevisiae	42.78	0.00e+00	979.00
IUUC-Sha-107301	Sarcophilus harrisii	95.63	0.00e+00	2383.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	45.34	0.00e+00	1071.00
IUUC-Spo-108217	Schizosaccharomyces pombe	46.40	0.00e+00	1111.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	47.63	0.00e+00	1157.00
IUUC-Smo-109582	Selaginella moellendorffii	65.87	0.00e+00	1159.00
IUUC-Sit-109697	Setaria italica	62.28	0.00e+00	1102.00
IUUC-Sly-111447	Solanum lycopersicum	54.42	0.00e+00	1331.00
IUUC-Stu-112564	Solanum tuberosum	54.07	0.00e+00	1327.00
IUUC-Sar-113313	Sorex araneus	84.89	0.00e+00	1406.00
IUUC-Sbi-114388	Sorghum bicolor	62.87	0.00e+00	1109.00
IUUC-Sre-115209	Sporisorium reilianum	57.71	0.00e+00	1048.00
IUUC-Ssc-115933	Sus scrofa	97.06	0.00e+00	2429.00
IUUC-Tgu-117109	Taeniopygia guttata	81.32	0.00e+00	747.00
IUUC-Tru-117772	Takifugu rubripes	84.75	0.00e+00	2121.00
IUUC-Tsy-119105	Tarsius syrichta	81.70	0.00e+00	2018.00
IUUC-Tni-120556	Tetraodon nigroviridis	68.76	0.00e+00	1460.00
IUUC-Tca-121046	Theobroma cacao	53.74	0.00e+00	1338.00
IUUC-Tre-121951	Trichoderma reesei	57.18	0.00e+00	1020.00
IUUC-Tvi-122359	Trichoderma virens	57.45	0.00e+00	1026.00
IUUC-Tae-125527	Triticum aestivum	53.14	0.00e+00	1291.00
IUUC-Tur-126754	Triticum urartu	62.04	0.00e+00	1101.00
IUUC-Tme-127170	Tuber melanosporum	49.08	0.00e+00	1186.00
IUUC-Tbe-127882	Tupaia belangeri	71.68	0.00e+00	798.00
IUUC-Ttr-128217	Tursiops truncatus	94.17	0.00e+00	2349.00
IUUC-Uma-129337	Ustilago maydis	57.01	0.00e+00	1045.00
IUUC-Vda-129828	Verticillium dahliae	47.71	0.00e+00	1144.00
IUUC-Vpa-130537	Vicugna pacos	95.95	0.00e+00	2382.00
IUUC-Vvi-130958	Vitis vinifera	63.23	0.00e+00	1116.00
IUUC-Xtr-132857	Xenopus tropicalis	87.62	0.00e+00	2195.00
IUUC-Xma-133138	Xiphophorus maculatus	85.78	0.00e+00	2133.00
IUUC-Yli-134399	Yarrowia lipolytica	50.82	0.00e+00	868.00
IUUC-Zma-135612	Zea mays	53.62	0.00e+00	1305.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence