iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053608

Ensembl Protein ID

ENSLAFP00000021669.1

UniProt Accession

G3U1G1; G3U1G1_LOXAF

Protein Name

Uncharacterized protein

Gene Name

ITSN1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000001327.4	ENSLAFT00000032415.1	ENSLAFP00000021669.1
ENSLAFG00000001327.4	ENSLAFT00000030248.1	ENSLAFP00000026350.1
ENSLAFG00000001327.4	ENSLAFT00000035533.1	ENSLAFP00000024517.1
ENSLAFG00000001327.4	ENSLAFT00000032498.1	ENSLAFP00000028982.1
ENSLAFG00000001327.4	ENSLAFT00000001330.4	ENSLAFP00000001121.4
ENSLAFG00000001327.4	ENSLAFT00000035724.1	ENSLAFP00000018055.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.80e-68	225.7	1157	1208

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           +v+ +ydy+aqnddeL + kG ++ v+  +++d +W+kg  e +g+ GlfP+n+v+
   Q: 1157 QVIGMYDYTAQNDDELAFSKGQIINVL--NKEDPDWWKG--EVSGQVGLFPSNYVK 1208
           56779**********************..8889******..9*************8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MDQFPTRFGG NLDIWAITVE ERAKHDQQFH SLKPTSGFIT GDQARNFFFQ SGLPQPVLAQ 60
IWALADMNND GRMDQVEFSI AMKLIKLKLQ GYQLPSALPS VMKQQPVTIS SAPVFRFGGI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCAGT TTCCAACGCG TTTTGGTGGT AAGTTTTAGA AAAAAATCTT TGCTTAATGT 60
ATTTTGGGAG CATATTAAAA AAAAAAATAG TGTTATGGCA AATTTCAAAT ATCCACGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000008--C2_dom
IPR000219--DH-domain
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR000261--EH_dom
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS00741--DH_1
PS50010--DH_2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50031--EH
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00168--C2
PF12763--EF-hand_4
PF16652--PH_13
PF00621--RhoGEF
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00054--EFh
SM00027--EH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005905--C:clathrin-coated pit
GO:0030139--C:endocytic vesicle
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0019209--F:kinase activator activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0051897--P:positive regulation of protein kinase B signaling
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000722	Aegilops tauschii	41.67	3.00e-14	75.10
IUUC-Aml-001218	Ailuropoda melanoleuca	94.21	0.00e+00	2357.00
IUUC-Apl-003335	Anas platyrhynchos	90.41	0.00e+00	2249.00
IUUC-Aca-005130	Anolis carolinensis	87.88	0.00e+00	2218.00
IUUC-Ago-007935	Ashbya gossypii	34.33	8.00e-14	72.00
IUUC-Ani-009403	Aspergillus nidulans	40.52	4.00e-15	73.20
IUUC-Ate-010587	Aspergillus terreus	33.55	1.00e-16	81.60
IUUC-Ame-011878	Astyanax mexicanus	75.73	0.00e+00	1932.00
IUUC-Bta-012863	Bos taurus	93.02	0.00e+00	2310.00
IUUC-Bdi-014016	Brachypodium distachyon	40.00	4.00e-14	73.90
IUUC-Cja-019012	Callithrix jacchus	95.56	0.00e+00	2360.00
IUUC-Cfa-020272	Canis familiaris	94.52	0.00e+00	2372.00
IUUC-Cpo-021352	Cavia porcellus	87.02	0.00e+00	2814.00
IUUC-Cho-024969	Choloepus hoffmanni	83.02	0.00e+00	1877.00
IUUC-Cin-025435	Ciona intestinalis	45.11	0.00e+00	973.00
IUUC-Csv-026290	Ciona savignyi	57.59	0.00e+00	780.00
IUUC-Cne-026918	Cryptococcus neoformans	32.31	4.00e-38	154.00
IUUC-Dre-028623	Danio rerio	75.95	0.00e+00	1939.00
IUUC-Dno-030044	Dasypus novemcinctus	93.13	0.00e+00	2353.00
IUUC-Dor-030272	Dipodomys ordii	87.68	0.00e+00	2077.00
IUUC-Ete-032927	Echinops telfairi	97.80	0.00e+00	1038.00
IUUC-Eca-033469	Equus caballus	93.97	0.00e+00	2337.00
IUUC-Eeu-034977	Erinaceus europaeus	89.67	0.00e+00	1087.00
IUUC-Fca-036419	Felis catus	93.97	0.00e+00	2342.00
IUUC-Fal-037236	Ficedula albicollis	88.28	0.00e+00	2234.00
IUUC-Gmo-039632	Gadus morhua	70.04	0.00e+00	1684.00
IUUC-Gga-040835	Gallus gallus	87.61	0.00e+00	2202.00
IUUC-Gac-041948	Gasterosteus aculeatus	71.82	0.00e+00	1800.00
IUUC-Gma-043381	Glycine max	35.64	2.00e-11	65.10
IUUC-Hsa-045699	Homo sapiens	95.87	0.00e+00	2415.00
IUUC-Hvu-047530	Hordeum vulgare	40.00	1.00e-13	72.00
IUUC-Itr-048773	Ictidomys tridecemlineatus	91.53	0.00e+00	2305.00
IUUC-Kpa-049215	Komagataella pastoris	40.00	6.00e-15	75.50
IUUC-Lch-050502	Latimeria chalumnae	77.83	0.00e+00	1631.00
IUUC-Lpe-051250	Leersia perrieri	41.67	3.00e-14	74.30
IUUC-Loc-052613	Lepisosteus oculatus	80.98	0.00e+00	1970.00
IUUC-Mcc-055720	Macaca mulatta	95.87	0.00e+00	2392.00
IUUC-Meu-056445	Macropus eugenii	84.21	0.00e+00	1683.00
IUUC-Mla-059128	Melampsora laricipopulina	29.62	2.00e-40	162.00
IUUC-Mga-059997	Meleagris gallopavo	57.89	0.00e+00	1454.00
IUUC-Mvi-060268	Microbotryum violaceum	29.40	2.00e-43	172.00
IUUC-Mmr-061258	Microcebus murinus	94.76	0.00e+00	2363.00
IUUC-Mdo-062019	Monodelphis domestica	90.32	0.00e+00	2201.00
IUUC-Mmu-063885	Mus musculus	92.78	0.00e+00	2359.00
IUUC-Mac-065649	Musa acuminata	33.90	5.00e-12	67.00
IUUC-Mlu-067025	Myotis lucifugus	66.67	0.00e+00	1457.00
IUUC-Nle-069448	Nomascus leucogenys	84.20	0.00e+00	1187.00
IUUC-Opr-070441	Ochotona princeps	87.92	0.00e+00	2046.00
IUUC-Ont-071752	Oreochromis niloticus	69.71	0.00e+00	1702.00
IUUC-Oan-073390	Ornithorhynchus anatinus	84.79	0.00e+00	2130.00
IUUC-Ocu-073753	Oryctolagus cuniculus	91.17	0.00e+00	2972.00
IUUC-Ogu-078849	Oryza glumaepatula	41.67	3.00e-14	74.30
IUUC-Olo-080259	Oryza longistaminata	41.67	2.00e-14	75.10
IUUC-Ome-081199	Oryza meridionalis	41.67	2.00e-14	74.70
IUUC-Oni-082167	Oryza nivara	41.67	5.00e-14	73.60
IUUC-Oru-084541	Oryza rufipogon	41.67	5.00e-14	73.60
IUUC-Ola-086482	Oryzias latipes	55.02	0.00e+00	1120.00
IUUC-Olu-087698	Ostreococcus lucimarinus	27.62	2.00e-17	84.00
IUUC-Oga-088602	Otolemur garnettii	95.56	0.00e+00	2383.00
IUUC-Oar-090195	Ovis aries	93.10	0.00e+00	2315.00
IUUC-Ptr-091363	Pan troglodytes	95.95	0.00e+00	2416.00
IUUC-Pan-092385	Papio anubis	95.57	0.00e+00	2382.00
IUUC-Psi-093136	Pelodiscus sinensis	56.18	0.00e+00	1360.00
IUUC-Pfo-097486	Poecilia formosa	73.74	0.00e+00	1837.00
IUUC-Pab-098281	Pongo abelii	84.85	0.00e+00	2029.00
IUUC-Pop-098963	Populus trichocarpa	40.24	3.00e-11	64.70
IUUC-Pca-100270	Procavia capensis	79.60	0.00e+00	1328.00
IUUC-Pva-102335	Pteropus vampyrus	91.67	0.00e+00	2298.00
IUUC-Pgr-103473	Puccinia graminis	28.53	8.00e-36	147.00
IUUC-Ptt-103973	Puccinia triticina	24.27	1.00e-25	113.00
IUUC-Rno-106122	Rattus norvegicus	91.77	0.00e+00	2330.00
IUUC-Sha-106851	Sarcophilus harrisii	90.00	0.00e+00	2214.00
IUUC-Spo-108101	Schizosaccharomyces pombe	42.57	8.00e-16	79.30
IUUC-Sit-110414	Setaria italica	40.48	3.00e-14	74.30
IUUC-Sbi-114170	Sorghum bicolor	38.89	3.00e-14	74.70
IUUC-Sre-115028	Sporisorium reilianum	34.45	2.00e-32	135.00
IUUC-Tgu-117028	Taeniopygia guttata	88.84	0.00e+00	2260.00
IUUC-Tru-117789	Takifugu rubripes	75.22	0.00e+00	1845.00
IUUC-Tsy-119039	Tarsius syrichta	93.85	0.00e+00	1405.00
IUUC-Tni-119952	Tetraodon nigroviridis	73.55	0.00e+00	1717.00
IUUC-Tae-123242	Triticum aestivum	41.67	4.00e-14	73.90
IUUC-Tur-126623	Triticum urartu	40.00	3.00e-14	74.30
IUUC-Tbe-127754	Tupaia belangeri	83.41	0.00e+00	1704.00
IUUC-Ttr-129178	Tursiops truncatus	94.92	0.00e+00	2355.00
IUUC-Uma-129456	Ustilago maydis	31.27	9.00e-32	133.00
IUUC-Vpa-130687	Vicugna pacos	90.79	0.00e+00	1170.00
IUUC-Xtr-132905	Xenopus tropicalis	85.57	0.00e+00	2160.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence