iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	miRNAMap	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.20e-56	190.8	102	457

Active Site

Position(s)	Description	Evidence
111	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
409	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw......kskkkavsprellkalkkeaeefsgyeqqDaqEfl 96
           +Gl NlgNtCY+NS +Q+L  ++el   +l+   e+++ +   e++ +l+++l++lf++l        sk + ++p + + +l++  ++f++++qqDa+E+l
   Q: 102  CGLANLGNTCYFNSCVQMLKEVNEL---VLK-PAEEMRIR---EHNDRLCHNLATLFNSLRdkdralRSKGEPIKPFAAILTLSDSFPQFEKFKQQDANECL 196
           7****************99777766...566.45555554...56889************655556688889****************************** PP
   S: 97   aflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkkeslqdcLesftke 197
             +++++ +                                +   i+ lF++q+++++kcle d+vs ++ e +++l++ v+++       lq  +++ ++e
   Q: 197  VSIMSNVTRIY----------------------------GLSGWNIESLFRIQTETTMKCLESDEVSeKKVERNNQLTCYVNQDVR----FLQTGIKAGFEE 266
           *********99............................456789**********************9999*************96....6*********** PP
   S: 198  eelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts................................ 267
           e+ +     ++e+ +++ + +k +++++lP++L+++++Rf ++e++k + ki k+v+fp +Ld    c++                                
   Q: 267  EMTR-----NSEELNRDAKWQKNTQISRLPKYLTVNINRFFYKESTKTNAKILKSVQFPMQLDTYDLCSQelkdklvarradikleedaklerelrkkvldk 363
           ***9.....58999********************************************************77777777777777777766666666666666 PP
   S: 268  ..................peekqkekkkYeLiavvvHsG.slssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg....staYvlfYkr 337
                             ++ +++++  Y+L +++ H+G s++ GHYva++++ e+gkW lfdD++Vt+v+ee +l+++g    ++aYvl+Y+ 
   Q: 364  eqgdkifddgvalptafeDDAGSNNSGFYDLKGIITHKGrSSQDGHYVAWMRSsEDGKWRLFDDEHVTVVDEEAILKTSGggdwHSAYVLLYEA 457
           66666666666666666544444459**************************945566*******************888************96 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity).

Protein Sequence
(Fasta)

MPIVNVKWQK EKYVVEVDTS APPMVFKAQL FALTQVVPER QKVVIMGRTL GDDDWEGITI 60
KENMTIMMMG SVGEIPKPPT VLEKKQANRD KQAEEISALY PCGLANLGNT CYFNSCVQML 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAATAATGC CTATTGTCAA TGTTAAATGG CAAAAGGAGA AATATGTTGT GGAAGTCGAC 60
ACCTCAGCAC CTCCGATGGT GTTCAAAGCG CAACTTTTCG CTTTAACACA GGTGGTACCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0000502--C:proteasome complex
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_C13B4.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	28.08	5.00e-30	124.00
IUUC-Aml-002053	Ailuropoda melanoleuca	40.96	3.00e-94	337.00
IUUC-Atr-002725	Amborella trichopoda	37.50	4.00e-76	277.00
IUUC-Apl-004031	Anas platyrhynchos	41.43	5.00e-96	343.00
IUUC-Aca-004361	Anolis carolinensis	41.43	1.00e-101	362.00
IUUC-Aly-006078	Arabidopsis lyrata	35.99	2.00e-79	288.00
IUUC-Ath-007623	Arabidopsis thaliana	36.38	8.00e-79	286.00
IUUC-Ago-007796	Ashbya gossypii	29.51	4.00e-51	194.00
IUUC-Acl-008258	Aspergillus clavatus	31.11	2.00e-41	162.00
IUUC-Afl-008732	Aspergillus flavus	30.92	2.00e-61	228.00
IUUC-Afu-008755	Aspergillus fumigatus	30.86	3.00e-59	221.00
IUUC-Ani-009148	Aspergillus nidulans	31.63	1.00e-61	229.00
IUUC-Ang-009878	Aspergillus niger	31.86	4.00e-60	224.00
IUUC-Aor-010239	Aspergillus oryzae	30.92	3.00e-61	228.00
IUUC-Ate-010243	Aspergillus terreus	31.35	6.00e-60	223.00
IUUC-Ame-011327	Astyanax mexicanus	30.84	4.00e-47	181.00
IUUC-Bgr-012231	Blumeria graminis	29.08	2.00e-54	205.00
IUUC-Bta-012553	Bos taurus	41.19	3.00e-94	337.00
IUUC-Bci-013606	Botrytis cinerea	30.02	3.00e-60	224.00
IUUC-Bdi-014567	Brachypodium distachyon	37.47	4.00e-80	290.00
IUUC-Bol-015565	Brassica oleracea	36.86	4.00e-82	297.00
IUUC-Bra-017501	Brassica rapa	37.01	9.00e-82	296.00
IUUC-Cja-019516	Callithrix jacchus	40.32	3.00e-97	347.00
IUUC-Cfa-020808	Canis familiaris	41.58	6.00e-95	340.00
IUUC-Cpo-021688	Cavia porcellus	41.53	4.00e-93	333.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	35.62	1.00e-72	265.00
IUUC-Csa-023429	Chlorocebus sabaeus	40.76	9.00e-94	335.00
IUUC-Cho-024347	Choloepus hoffmanni	39.68	2.00e-94	338.00
IUUC-Cin-025198	Ciona intestinalis	37.43	1.00e-82	298.00
IUUC-Csv-026007	Ciona savignyi	39.13	1.00e-85	308.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	32.59	2.00e-42	166.00
IUUC-Cne-026963	Cryptococcus neoformans	30.17	5.00e-50	190.00
IUUC-Cme-027240	Cyanidioschyzon merolae	28.49	3.00e-50	191.00
IUUC-Dre-027647	Danio rerio	42.83	1.00e-105	375.00
IUUC-Dno-029967	Dasypus novemcinctus	40.63	9.00e-94	335.00
IUUC-Dor-030886	Dipodomys ordii	36.53	1.00e-69	256.00
IUUC-Dse-031466	Dothistroma septosporum	27.42	3.00e-33	135.00
IUUC-Dme-032079	Drosophila melanogaster	37.68	4.00e-85	306.00
IUUC-Ete-032351	Echinops telfairi	41.81	1.00e-95	342.00
IUUC-Eca-033461	Equus caballus	41.40	4.00e-101	360.00
IUUC-Eeu-035220	Erinaceus europaeus	55.29	2.00e-26	112.00
IUUC-Fca-036210	Felis catus	41.78	3.00e-95	341.00
IUUC-Fal-037528	Ficedula albicollis	41.43	1.00e-95	342.00
IUUC-Fox-037805	Fusarium oxysporum	33.78	2.00e-46	179.00
IUUC-Fso-038177	Fusarium solani	32.61	1.00e-45	176.00
IUUC-Gmo-038953	Gadus morhua	41.22	3.00e-95	340.00
IUUC-Ggr-039972	Gaeumannomyces graminis	31.30	6.00e-39	154.00
IUUC-Gga-040462	Gallus gallus	42.02	3.00e-96	343.00
IUUC-Gac-041312	Gasterosteus aculeatus	41.82	2.00e-102	365.00
IUUC-Gma-043255	Glycine max	36.57	9.00e-79	286.00
IUUC-Ggo-045458	Gorilla gorilla	33.86	6.00e-67	246.00
IUUC-Hsa-045706	Homo sapiens	40.95	4.00e-94	337.00
IUUC-Hvu-047821	Hordeum vulgare	34.72	7.00e-29	119.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	40.71	6.00e-101	359.00
IUUC-Lch-050464	Latimeria chalumnae	41.19	2.00e-98	351.00
IUUC-Lpe-051419	Leersia perrieri	38.20	3.00e-81	294.00
IUUC-Loc-052732	Lepisosteus oculatus	43.50	6.00e-104	369.00
IUUC-Lma-053177	Leptosphaeria maculans	30.59	4.00e-43	168.00
IUUC-Laf-053822	Loxodonta africana	41.80	8.00e-95	339.00
IUUC-Mcc-055893	Macaca mulatta	40.95	4.00e-94	337.00
IUUC-Meu-056307	Macropus eugenii	38.18	3.00e-89	320.00
IUUC-Mor-057171	Magnaporthe oryzae	33.77	5.00e-48	184.00
IUUC-Mpo-057415	Magnaporthe poae	31.04	3.00e-39	155.00
IUUC-Mtr-057901	Medicago truncatula	37.60	6.00e-80	290.00
IUUC-Mla-058897	Melampsora laricipopulina	32.93	6.00e-48	183.00
IUUC-Mga-060016	Meleagris gallopavo	42.24	1.00e-96	345.00
IUUC-Mvi-060562	Microbotryum violaceum	31.84	2.00e-38	152.00
IUUC-Mmr-060624	Microcebus murinus	42.60	8.00e-102	362.00
IUUC-Mdo-061809	Monodelphis domestica	42.28	2.00e-97	348.00
IUUC-Mmu-063869	Mus musculus	41.15	7.00e-95	339.00
IUUC-Mac-064876	Musa acuminata	35.66	4.00e-72	264.00
IUUC-Mpu-066480	Mustela putorius furo	41.35	4.00e-95	340.00
IUUC-Mlu-067866	Myotis lucifugus	41.85	1.00e-95	342.00
IUUC-Nfi-068393	Neosartorya fischeri	30.16	4.00e-57	214.00
IUUC-Ncr-068815	Neurospora crassa	33.25	3.00e-46	178.00
IUUC-Nle-069741	Nomascus leucogenys	47.83	3.00e-40	155.00
IUUC-Opr-070712	Ochotona princeps	46.79	2.00e-58	218.00
IUUC-Ont-071544	Oreochromis niloticus	41.82	2.00e-91	328.00
IUUC-Oan-073635	Ornithorhynchus anatinus	37.84	8.00e-72	263.00
IUUC-Ocu-074926	Oryctolagus cuniculus	41.04	3.00e-94	337.00
IUUC-Oba-075633	Oryza barthii	37.58	3.00e-81	294.00
IUUC-Obr-076423	Oryza brachyantha	38.22	4.00e-84	303.00
IUUC-Ogl-077913	Oryza glaberrima	38.22	3.00e-84	304.00
IUUC-Ogu-078435	Oryza glumaepatula	37.58	3.00e-81	294.00
IUUC-Oin-080072	Oryza indica	37.16	7.00e-80	289.00
IUUC-Olo-080535	Oryza longistaminata	36.12	4.00e-72	264.00
IUUC-Ome-081309	Oryza meridionalis	37.58	3.00e-81	294.00
IUUC-Oni-083113	Oryza nivara	37.58	3.00e-81	294.00
IUUC-Opu-083168	Oryza punctata	36.61	4.00e-76	276.00
IUUC-Oru-084253	Oryza rufipogon	37.58	3.00e-81	294.00
IUUC-Osa-085554	Oryza sativa	38.22	3.00e-84	304.00
IUUC-Ola-086998	Oryzias latipes	42.05	2.00e-97	348.00
IUUC-Olu-087818	Ostreococcus lucimarinus	32.02	8.00e-56	209.00
IUUC-Oga-088571	Otolemur garnettii	42.06	2.00e-95	341.00
IUUC-Oar-089526	Ovis aries	41.60	1.00e-93	335.00
IUUC-Ptr-091433	Pan troglodytes	40.95	4.00e-94	337.00
IUUC-Pan-091966	Papio anubis	40.76	9.00e-94	335.00
IUUC-Psi-093458	Pelodiscus sinensis	41.15	2.00e-95	341.00
IUUC-Pma-094343	Petromyzon marinus	38.36	1.00e-42	165.00
IUUC-Pno-095109	Phaeosphaeria nodorum	32.21	3.00e-42	165.00
IUUC-Ppa-095756	Physcomitrella patens	36.79	3.00e-80	291.00
IUUC-Pfo-096514	Poecilia formosa	41.41	4.00e-91	327.00
IUUC-Pab-098477	Pongo abelii	36.52	6.00e-67	246.00
IUUC-Pop-099221	Populus trichocarpa	35.83	3.00e-75	274.00
IUUC-Pca-100791	Procavia capensis	33.80	7.00e-53	199.00
IUUC-Ppe-101812	Prunus persica	37.17	5.00e-78	283.00
IUUC-Pva-102462	Pteropus vampyrus	39.03	2.00e-72	265.00
IUUC-Pgr-103623	Puccinia graminis	33.53	7.00e-48	183.00
IUUC-Ptt-103767	Puccinia triticina	32.38	6.00e-42	164.00
IUUC-Pte-104109	Pyrenophora teres	31.27	3.00e-45	175.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	32.99	1.00e-44	173.00
IUUC-Rno-105351	Rattus norvegicus	40.36	5.00e-94	337.00
IUUC-Sce-106168	Saccharomyces cerevisiae	28.71	3.00e-49	187.00
IUUC-Sha-107491	Sarcophilus harrisii	41.27	3.00e-96	344.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	33.89	2.00e-70	258.00
IUUC-Spo-108174	Schizosaccharomyces pombe	34.50	2.00e-69	255.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	33.09	8.00e-44	170.00
IUUC-Smo-108805	Selaginella moellendorffii	39.29	7.00e-80	289.00
IUUC-Sit-110361	Setaria italica	37.47	2.00e-82	298.00
IUUC-Sly-110965	Solanum lycopersicum	37.83	2.00e-79	288.00
IUUC-Sar-113355	Sorex araneus	35.15	4.00e-43	167.00
IUUC-Sbi-114778	Sorghum bicolor	38.07	4.00e-81	294.00
IUUC-Sre-115011	Sporisorium reilianum	28.77	1.00e-34	139.00
IUUC-Ssc-116273	Sus scrofa	41.40	1.00e-91	328.00
IUUC-Tgu-117063	Taeniopygia guttata	41.43	2.00e-95	342.00
IUUC-Tru-118381	Takifugu rubripes	42.77	3.00e-100	357.00
IUUC-Tsy-119076	Tarsius syrichta	43.06	1.00e-49	189.00
IUUC-Tni-119941	Tetraodon nigroviridis	42.42	3.00e-94	337.00
IUUC-Tca-121246	Theobroma cacao	36.92	6.00e-80	290.00
IUUC-Tre-121969	Trichoderma reesei	33.91	1.00e-46	179.00
IUUC-Tvi-122543	Trichoderma virens	30.73	2.00e-61	228.00
IUUC-Tae-125484	Triticum aestivum	36.36	1.00e-78	285.00
IUUC-Tur-126128	Triticum urartu	30.43	5.00e-31	127.00
IUUC-Tbe-128030	Tupaia belangeri	38.48	7.00e-78	283.00
IUUC-Ttr-128701	Tursiops truncatus	37.85	4.00e-70	257.00
IUUC-Uma-129657	Ustilago maydis	28.90	4.00e-35	141.00
IUUC-Vda-129723	Verticillium dahliae	31.00	1.00e-59	222.00
IUUC-Vpa-130284	Vicugna pacos	55.29	1.00e-26	112.00
IUUC-Vvi-131037	Vitis vinifera	38.02	2.00e-80	291.00
IUUC-Xtr-132235	Xenopus tropicalis	42.66	2.00e-100	357.00
IUUC-Xma-133840	Xiphophorus maculatus	41.82	2.00e-96	345.00
IUUC-Yli-134453	Yarrowia lipolytica	35.11	4.00e-67	247.00
IUUC-Zma-135669	Zea mays	30.98	5.00e-64	237.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence