iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013168

Ensembl Protein ID

ENSBTAP00000051462.1

UniProt Accession

Q92176; Q3SZF9; COR1A_BOVIN

Genbank Protein ID

BAA07939.1; ABF57419.1; AAI02877.1

Protein Name

Coronin-1A; Coronin-like protein A; Coronin-like protein p57; Tryptophan aspartate-containing coat protein

Genbank Nucleotide ID

D44496; BT025463; BC102876

Gene Name

CORO1A; CORO1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000008631.5	ENSBTAT00000051969.1	ENSBTAP00000051462.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.40e-20	70.1	79	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvl 35
           gHt++v ++a+   +d+ ++sGs D++++vW++ +g l
   Q: 79   GHTAPVLDIAWcphNDNVIASGSEDCSVMVWEIPDGGL 116
           8***********9877****************998875 PP

Organism

Bos taurus

Functional Description
(View)

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected macrophages, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes (By similarity).

Protein Sequence
(Fasta)

MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQNTWDSGFC AVNPKFVALI CEASGGGAFL 60
VLPLGKTGRV DKNVPMVCGH TAPVLDIAWC PHNDNVIASG SEDCSVMVWE IPDGGLTLPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCGCGGAC GGTCTCAGGC TCCGCCGGCT CCTTCCTCCT CCTCCTCCTC GCCCTCCTCC 60
GTCTGGGGGG TCGCTCATCT CTCAGCCGCA GGTAAGGCTG GAGCCCGGCG ACCCGGGCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0009--Actin-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0903--Direct protein sequencing
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR029508--CORO1A
IPR015505--Coronin
IPR015048--DUF1899
IPR015049--Trimer_CC
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF08954--Trimer_CC
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005884--C:actin filament
GO:0030424--C:axon
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0030027--C:lamellipodium
GO:0001891--C:phagocytic cup
GO:0030670--C:phagocytic vesicle membrane
GO:0043234--C:protein complex
GO:0051015--F:actin filament binding
GO:0003723--F:RNA binding
GO:0030036--P:actin cytoskeleton organization
GO:0007015--P:actin filament organization
GO:0006816--P:calcium ion transport
GO:0031589--P:cell-substrate adhesion
GO:0071353--P:cellular response to interleukin-4
GO:0061502--P:early endosome to recycling endosome transport
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0030595--P:leukocyte chemotaxis
GO:0043320--P:natural killer cell degranulation
GO:0051126--P:negative regulation of actin nucleation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0031339--P:negative regulation of vesicle fusion
GO:0038180--P:nerve growth factor signaling pathway
GO:0001845--P:phagolysosome assembly
GO:0050918--P:positive chemotaxis
GO:0030335--P:positive regulation of cell migration
GO:0042102--P:positive regulation of T cell proliferation
GO:0008360--P:regulation of cell shape
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0043029--P:T cell homeostasis
GO:0032796--P:uropod organization

KEGG

bta:282196

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002012	Ailuropoda melanoleuca	97.18	0.00e+00	933.00
IUUC-Aca-005048	Anolis carolinensis	66.81	0.00e+00	676.00
IUUC-Ago-007901	Ashbya gossypii	40.73	9.00e-89	321.00
IUUC-Ame-011101	Astyanax mexicanus	69.08	0.00e+00	685.00
IUUC-Cja-019660	Callithrix jacchus	96.10	0.00e+00	924.00
IUUC-Cfa-020938	Canis familiaris	97.40	0.00e+00	933.00
IUUC-Cpo-022056	Cavia porcellus	94.36	0.00e+00	908.00
IUUC-Csa-023193	Chlorocebus sabaeus	95.66	0.00e+00	917.00
IUUC-Cne-026773	Cryptococcus neoformans	38.94	3.00e-87	316.00
IUUC-Dre-028167	Danio rerio	68.64	0.00e+00	674.00
IUUC-Dno-029363	Dasypus novemcinctus	96.10	0.00e+00	917.00
IUUC-Dor-030426	Dipodomys ordii	95.23	0.00e+00	912.00
IUUC-Eca-034229	Equus caballus	95.44	0.00e+00	920.00
IUUC-Eeu-034499	Erinaceus europaeus	94.81	0.00e+00	793.00
IUUC-Fca-036472	Felis catus	95.66	0.00e+00	919.00
IUUC-Gmo-039519	Gadus morhua	66.23	0.00e+00	655.00
IUUC-Gac-042545	Gasterosteus aculeatus	69.00	0.00e+00	684.00
IUUC-Ggo-045162	Gorilla gorilla	95.44	0.00e+00	916.00
IUUC-Hsa-046874	Homo sapiens	95.44	0.00e+00	916.00
IUUC-Itr-048911	Ictidomys tridecemlineatus	95.23	0.00e+00	917.00
IUUC-Lch-050582	Latimeria chalumnae	67.37	0.00e+00	692.00
IUUC-Laf-053427	Loxodonta africana	95.66	0.00e+00	910.00
IUUC-Mcc-055750	Macaca mulatta	95.55	0.00e+00	852.00
IUUC-Meu-056083	Macropus eugenii	89.37	0.00e+00	856.00
IUUC-Mla-058883	Melampsora laricipopulina	43.07	5.00e-87	315.00
IUUC-Mvi-060569	Microbotryum violaceum	40.99	3.00e-89	322.00
IUUC-Mmr-060858	Microcebus murinus	96.10	0.00e+00	923.00
IUUC-Mdo-062469	Monodelphis domestica	91.05	0.00e+00	860.00
IUUC-Mmu-063583	Mus musculus	93.93	0.00e+00	906.00
IUUC-Mpu-066451	Mustela putorius furo	96.83	0.00e+00	897.00
IUUC-Mlu-066978	Myotis lucifugus	95.66	0.00e+00	920.00
IUUC-Nle-069815	Nomascus leucogenys	95.88	0.00e+00	918.00
IUUC-Opr-070911	Ochotona princeps	94.14	0.00e+00	898.00
IUUC-Ont-072391	Oreochromis niloticus	69.70	0.00e+00	692.00
IUUC-Ocu-074429	Oryctolagus cuniculus	85.90	0.00e+00	792.00
IUUC-Oga-089072	Otolemur garnettii	95.03	0.00e+00	909.00
IUUC-Oar-089676	Ovis aries	99.35	0.00e+00	947.00
IUUC-Ptr-091647	Pan troglodytes	95.44	0.00e+00	916.00
IUUC-Pan-092672	Papio anubis	95.66	0.00e+00	917.00
IUUC-Pfo-096735	Poecilia formosa	70.02	0.00e+00	682.00
IUUC-Pab-098348	Pongo abelii	90.46	0.00e+00	850.00
IUUC-Pva-102668	Pteropus vampyrus	96.96	0.00e+00	930.00
IUUC-Pgr-103354	Puccinia graminis	41.73	5.00e-91	328.00
IUUC-Rno-105604	Rattus norvegicus	93.28	0.00e+00	898.00
IUUC-Sha-107210	Sarcophilus harrisii	91.11	0.00e+00	884.00
IUUC-Sar-113292	Sorex araneus	95.68	0.00e+00	737.00
IUUC-Sre-114911	Sporisorium reilianum	39.37	1.00e-81	296.00
IUUC-Tme-126924	Tuber melanosporum	42.36	4.00e-95	342.00
IUUC-Tbe-128025	Tupaia belangeri	96.65	2.00e-153	534.00
IUUC-Ttr-128689	Tursiops truncatus	97.40	0.00e+00	934.00
IUUC-Uma-129489	Ustilago maydis	39.32	8.00e-86	311.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence