iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013151

Ensembl Protein ID

ENSBTAP00000013845.2

UniProt Accession

Q32KW2; UBXN1_BOVIN

Genbank Protein ID

AAI09899.1

Protein Name

UBX domain-containing protein 1; SAPK substrate protein 1

Genbank Nucleotide ID

BC109898

Gene Name

UBXN1; SAKS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010481.3	ENSBTAT00000013845.2	ENSBTAP00000013845.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	1.90e-08	34.3	4	42
ULD/UDP/UFD/UBX	8.60e-21	74.4	210	291

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
             +le l+eMGF++ +a +aL+ + n  +eaA+++L+++
   Q: 4    LTALESLIEMGFPKGRAEKALALTgNQGIEAAMDWLMEH 42
           5689********************************987 PP

ULD/UDP/UFD/UBX

   S: 2    tteqatlqiRlpdGkrlvrkFpssttleqiyqfve....yllvessdpFeLvspfPrrtlkpeehmstlqeagLvpsgsllv 79
           +++q+++q+RlpdG  l+++F+++++l +++ +ve    ++l+  +dp +L+s+fPrr +++ ++++ lqe+gLvps++l+v
   Q: 210  EYDQCRIQVRLPDGTSLTQTFRAREQLAAVRLYVElhrgEELGGAQDPVQLLSGFPRRAFSEADMERPLQELGLVPSAVLIV 291
           578*****************************************************************************98 PP

Organism

Bos taurus

Functional Description
(View)

Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol (By similarity).

Protein Sequence
(Fasta)

MAELTALESL IEMGFPKGRA EKALALTGNQ GIEAAMDWLM EHEDDPDVDE PLATPLGHVL 60
GREPTPSEQG GPKGPGSAVG EGKPVLTEEE RQEQTKRMLE LVAQKQRERE EREEREALER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATTCGGGC ACTTCCGTCT CGCCTAGGCT TTCTTCTCGT AGGTGTCCGC GGCTGGTCCG 60
CAGCCGGTGA GTGAGCAAGC ACCCGGCTGG GGCGGTCGCG GGCAAGGTTG GGCGCTGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR001012--UBX_dom

PROSITE

PS50030--UBA
PS50033--UBX

Pfam

PF00627--UBA
PF00789--UBX

SMART

SM00165--UBA
SM00166--UBX

Gene Ontology

GO:0005829--C:cytosol
GO:0000502--C:proteasome complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0071796--F:K6-linked polyubiquitin binding
GO:1904293--P:negative regulation of ERAD pathway
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:1903094--P:negative regulation of protein K48-linked deubiquitination
GO:0031397--P:negative regulation of protein ubiquitination
GO:2000157--P:negative regulation of ubiquitin-specific protease activity

KEGG

bta:506676

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001103	Aegilops tauschii	38.75	9.00e-10	58.20
IUUC-Aml-002325	Ailuropoda melanoleuca	93.17	3.00e-110	391.00
IUUC-Atr-002907	Amborella trichopoda	43.75	1.00e-09	57.40
IUUC-Aca-004329	Anolis carolinensis	71.69	2.00e-46	178.00
IUUC-Aly-005639	Arabidopsis lyrata	45.88	2.00e-12	67.00
IUUC-Ath-006887	Arabidopsis thaliana	45.88	2.00e-12	66.60
IUUC-Ame-011399	Astyanax mexicanus	53.75	4.00e-60	224.00
IUUC-Bdi-014311	Brachypodium distachyon	54.55	1.00e-09	57.80
IUUC-Bol-016537	Brassica oleracea	45.88	1.00e-11	64.70
IUUC-Bra-017906	Brassica rapa	61.36	1.00e-11	64.70
IUUC-Cel-018300	Caenorhabditis elegans	34.85	3.00e-13	68.90
IUUC-Cja-019084	Callithrix jacchus	93.31	9.00e-101	359.00
IUUC-Cfa-020997	Canis familiaris	90.49	2.00e-89	322.00
IUUC-Cpo-021736	Cavia porcellus	79.05	1.00e-83	302.00
IUUC-Csa-024040	Chlorocebus sabaeus	93.60	7.00e-100	356.00
IUUC-Cho-024543	Choloepus hoffmanni	94.06	1.00e-70	259.00
IUUC-Cin-025719	Ciona intestinalis	39.20	3.00e-36	145.00
IUUC-Csv-025854	Ciona savignyi	38.67	3.00e-35	141.00
IUUC-Cne-027046	Cryptococcus neoformans	39.51	5.00e-09	55.10
IUUC-Cme-027235	Cyanidioschyzon merolae	45.45	9.00e-08	51.60
IUUC-Dre-027745	Danio rerio	50.83	3.00e-57	214.00
IUUC-Dno-029598	Dasypus novemcinctus	90.91	2.00e-100	358.00
IUUC-Dor-030917	Dipodomys ordii	79.93	4.00e-87	314.00
IUUC-Dme-032055	Drosophila melanogaster	42.42	4.00e-22	98.60
IUUC-Ete-032960	Echinops telfairi	75.89	7.00e-77	280.00
IUUC-Eca-034294	Equus caballus	94.93	1.00e-112	399.00
IUUC-Eeu-034906	Erinaceus europaeus	89.12	6.00e-105	373.00
IUUC-Fca-035653	Felis catus	91.20	1.00e-93	335.00
IUUC-Gmo-038755	Gadus morhua	50.64	7.00e-54	204.00
IUUC-Gac-042481	Gasterosteus aculeatus	53.23	8.00e-55	207.00
IUUC-Gma-042684	Glycine max	52.27	2.00e-10	60.10
IUUC-Ggo-044821	Gorilla gorilla	92.96	2.00e-93	335.00
IUUC-Hsa-046797	Homo sapiens	93.92	3.00e-103	367.00
IUUC-Itr-048850	Ictidomys tridecemlineatus	94.59	3.00e-113	400.00
IUUC-Lch-049508	Latimeria chalumnae	52.76	9.00e-57	213.00
IUUC-Laf-053932	Loxodonta africana	94.26	2.00e-129	455.00
IUUC-Mcc-055300	Macaca mulatta	93.94	5.00e-100	357.00
IUUC-Mtr-058774	Medicago truncatula	50.00	8.00e-10	57.80
IUUC-Mla-059083	Melampsora laricipopulina	30.67	2.00e-06	47.00
IUUC-Mvi-060245	Microbotryum violaceum	42.17	1.00e-10	60.50
IUUC-Mmr-060979	Microcebus murinus	87.50	3.00e-106	377.00
IUUC-Mdo-062299	Monodelphis domestica	85.46	1.00e-96	345.00
IUUC-Mmu-063212	Mus musculus	91.92	2.00e-116	411.00
IUUC-Mac-065072	Musa acuminata	58.54	1.00e-10	60.50
IUUC-Mpu-066540	Mustela putorius furo	92.91	1.00e-111	395.00
IUUC-Mlu-067589	Myotis lucifugus	92.59	3.00e-105	374.00
IUUC-Nle-069045	Nomascus leucogenys	93.95	7.00e-76	276.00
IUUC-Opr-070772	Ochotona princeps	86.62	3.00e-92	331.00
IUUC-Ont-072006	Oreochromis niloticus	53.82	1.00e-55	209.00
IUUC-Oan-073244	Ornithorhynchus anatinus	61.43	3.00e-44	171.00
IUUC-Ocu-074333	Oryctolagus cuniculus	92.91	2.00e-102	365.00
IUUC-Oba-075451	Oryza barthii	49.06	5.00e-11	62.40
IUUC-Obr-076923	Oryza brachyantha	55.10	1.00e-11	64.30
IUUC-Ogl-077259	Oryza glaberrima	38.36	1.00e-09	58.20
IUUC-Ogu-078589	Oryza glumaepatula	49.06	5.00e-11	62.40
IUUC-Oin-079151	Oryza indica	49.06	5.00e-11	62.40
IUUC-Olo-080934	Oryza longistaminata	45.90	1.00e-10	60.50
IUUC-Ome-081253	Oryza meridionalis	49.06	4.00e-11	62.40
IUUC-Oni-082110	Oryza nivara	38.36	3.00e-10	59.30
IUUC-Opu-083336	Oryza punctata	49.06	5.00e-11	62.00
IUUC-Oru-085235	Oryza rufipogon	49.06	5.00e-11	62.00
IUUC-Osa-085611	Oryza sativa	49.06	5.00e-11	62.00
IUUC-Ola-086781	Oryzias latipes	54.69	5.00e-53	201.00
IUUC-Oga-088429	Otolemur garnettii	93.58	2.00e-101	362.00
IUUC-Oar-089885	Ovis aries	98.32	1.00e-133	468.00
IUUC-Ptr-091315	Pan troglodytes	93.64	1.00e-95	342.00
IUUC-Pan-092885	Papio anubis	93.60	7.00e-100	356.00
IUUC-Psi-093299	Pelodiscus sinensis	70.37	3.00e-63	234.00
IUUC-Pma-094221	Petromyzon marinus	64.37	3.00e-28	116.00
IUUC-Ppa-095484	Physcomitrella patens	51.11	2.00e-10	60.10
IUUC-Pfo-096188	Poecilia formosa	53.75	3.00e-53	201.00
IUUC-Pab-097881	Pongo abelii	86.53	3.00e-98	351.00
IUUC-Pop-098863	Populus trichocarpa	52.94	9.00e-12	64.70
IUUC-Pca-100977	Procavia capensis	92.33	4.00e-107	380.00
IUUC-Ppe-101243	Prunus persica	47.06	4.00e-10	58.50
IUUC-Pva-102169	Pteropus vampyrus	94.01	5.00e-99	353.00
IUUC-Rno-105459	Rattus norvegicus	91.58	4.00e-116	410.00
IUUC-Sha-107526	Sarcophilus harrisii	87.12	4.00e-97	347.00
IUUC-Ssl-108389	Sclerotinia sclerotiorum	27.54	2.00e-06	47.00
IUUC-Sit-110434	Setaria italica	35.23	2.00e-09	56.20
IUUC-Sly-111766	Solanum lycopersicum	47.54	5.00e-11	62.40
IUUC-Stu-112122	Solanum tuberosum	47.54	5.00e-11	62.00
IUUC-Sar-112945	Sorex araneus	91.34	6.00e-69	253.00
IUUC-Sbi-114159	Sorghum bicolor	31.89	2.00e-10	60.10
IUUC-Ssc-116114	Sus scrofa	94.59	4.00e-101	360.00
IUUC-Tru-117839	Takifugu rubripes	53.99	8.00e-55	207.00
IUUC-Tsy-118813	Tarsius syrichta	91.87	2.00e-60	225.00
IUUC-Tni-120504	Tetraodon nigroviridis	55.52	4.00e-55	207.00
IUUC-Tae-124974	Triticum aestivum	38.75	1.00e-09	57.40
IUUC-Tur-126615	Triticum urartu	38.75	1.00e-09	57.40
IUUC-Tbe-128034	Tupaia belangeri	92.61	6.00e-104	370.00
IUUC-Ttr-128468	Tursiops truncatus	89.53	3.00e-107	381.00
IUUC-Uma-129569	Ustilago maydis	33.33	1.00e-04	40.40
IUUC-Vpa-130179	Vicugna pacos	90.04	7.00e-80	289.00
IUUC-Vvi-131064	Vitis vinifera	49.02	3.00e-10	59.70
IUUC-Xtr-132119	Xenopus tropicalis	62.42	2.00e-66	245.00
IUUC-Xma-134067	Xiphophorus maculatus	52.90	3.00e-54	205.00
IUUC-Zma-134709	Zea mays	54.05	1.00e-09	57.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence