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Tag Content
iUUCD ID IUUC-Cne-026830
Ensembl Protein ID AAW45760
UniProt Accession P0CP90; Q55KK3; Q5KAW8; PPIL2_CRYNJ
Genbank Protein ID AAW45760.1
Protein Name Peptidyl-prolyl cis-trans isomerase-like 2; Cyclophilin-60; Cyclophilin-like protein Cyp-60; RING-type E3 ubiquitin transferase isomerase-like 2; Rotamase
Genbank Nucleotide ID AE017350
Gene Name CYP8; CNJ00200
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
CNJ00200 AAW45760 AAW45760
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/U-box 5.70e-06 24.8 40 108
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 4    eeflCpIslelMrdPvvlpsGi.........tydrssIekwlasggktcPvtrqplteedlvPnltlrrl 64
           ++ +C++sl+++++Pv + s           ++d  +I  ++++ ++ +Pvt++pl+ ++l+  ++ r+ 
   Q: 40   PFDCCALSLQPFKNPVAVISETkageapradVFDLLNIVPYIRKFKS-NPVTGKPLETSQLIKLNFSRNA 108
           5679***********98876543344444459************999.***************9999986 PP
   
Organism Cryptococcus neoformans
Functional Description
(View)

Functional Description


     May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
 May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.
Protein Sequence
(Fasta)
MGHNSDKLYV THSEHAAGSH TASSFGKRQE TGKSEFQRLP FDCCALSLQP FKNPVAVISE 60
TKAGEAPRAD VFDLLNIVPY IRKFKSNPVT GKPLETSQLI KLNFSRNAEG NLHDPITYKV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cne-026830|E3,U-box|Cryptococcus neoformans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAACACTTTC TCCGCAAAAA TATGGGACAC AACTCGGACA AGCTATACGT GACGCACTCG 60
GAACATGCGG CGGGGAGCCA CACTGCTTCA AGTTTTGGGA AAAGACAAGA GACGGGCAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cne-026830|E3,U-box|Cryptococcus neoformans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0413--Isomerase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0697--Rotamase
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR029000--Cyclophilin-like_dom
IPR024936--Cyclophilin-type_PPIase
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR003613--Ubox_domain
PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS51698--U_BOX
Pfam

PF00160--Pro_isomerase
PRINTS

PR00153--CSAPPISMRASE
SMART

SM00504--Ubox
Gene Ontology

GO:0005634--C:nucleus
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006457--P:protein folding
KEGG cne:CNJ00200
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000982 Aegilops tauschii 42.61 3.00e-36 144.00
IUUC-Aml-002351 Ailuropoda melanoleuca 36.66 6.00e-100 355.00
IUUC-Atr-002724 Amborella trichopoda 36.89 8.00e-82 296.00
IUUC-Apl-003515 Anas platyrhynchos 44.17 1.00e-93 335.00
IUUC-Aca-004802 Anolis carolinensis 41.45 4.00e-104 370.00
IUUC-Aly-005928 Arabidopsis lyrata 40.38 4.00e-43 167.00
IUUC-Ath-007574 Arabidopsis thaliana 40.38 6.00e-43 166.00
IUUC-Acl-008183 Aspergillus clavatus 42.94 8.00e-107 379.00
IUUC-Afl-008382 Aspergillus flavus 43.57 4.00e-110 389.00
IUUC-Afu-008952 Aspergillus fumigatus 42.64 1.00e-108 385.00
IUUC-Ani-009146 Aspergillus nidulans 43.16 1.00e-112 398.00
IUUC-Ang-009743 Aspergillus niger 41.95 2.00e-112 397.00
IUUC-Aor-010027 Aspergillus oryzae 44.73 5.00e-108 382.00
IUUC-Ate-010569 Aspergillus terreus 42.58 8.00e-106 375.00
IUUC-Ame-010783 Astyanax mexicanus 39.18 3.00e-100 357.00
IUUC-Bgr-012172 Blumeria graminis 37.37 1.00e-80 291.00
IUUC-Bta-012459 Bos taurus 37.36 3.00e-94 337.00
IUUC-Bci-013693 Botrytis cinerea 41.03 4.00e-107 379.00
IUUC-Bdi-014623 Brachypodium distachyon 37.74 2.00e-85 307.00
IUUC-Bol-015781 Brassica oleracea 39.91 2.00e-43 168.00
IUUC-Bra-016624 Brassica rapa 39.45 3.00e-43 167.00
IUUC-Cel-018328 Caenorhabditis elegans 37.11 3.00e-88 317.00
IUUC-Cja-019427 Callithrix jacchus 38.06 2.00e-97 347.00
IUUC-Cfa-020829 Canis familiaris 40.14 4.00e-101 359.00
IUUC-Cpo-022189 Cavia porcellus 39.11 9.00e-99 352.00
IUUC-Cre-022723 Chlamydomonas reinhardtii 47.95 2.00e-45 174.00
IUUC-Csa-024212 Chlorocebus sabaeus 39.76 6.00e-98 349.00
IUUC-Cin-025720 Ciona intestinalis 43.01 1.00e-107 381.00
IUUC-Csv-026137 Ciona savignyi 44.07 5.00e-101 359.00
IUUC-Cgl-026532 Colletotrichum gloeosporioides 39.83 4.00e-103 366.00
IUUC-Dre-028561 Danio rerio 38.21 1.00e-96 345.00
IUUC-Dno-029029 Dasypus novemcinctus 35.90 7.00e-85 306.00
IUUC-Dor-030544 Dipodomys ordii 44.86 5.00e-40 157.00
IUUC-Dse-031506 Dothistroma septosporum 42.76 2.00e-110 390.00
IUUC-Dme-032058 Drosophila melanogaster 37.37 1.00e-92 332.00
IUUC-Ete-033157 Echinops telfairi 34.71 6.00e-64 236.00
IUUC-Eca-034176 Equus caballus 44.86 3.00e-40 158.00
IUUC-Eeu-034470 Erinaceus europaeus 36.04 2.00e-54 204.00
IUUC-Fca-036571 Felis catus 39.45 1.00e-98 352.00
IUUC-Fal-037613 Ficedula albicollis 41.19 2.00e-97 347.00
IUUC-Fox-037795 Fusarium oxysporum 39.22 5.00e-106 376.00
IUUC-Fso-038213 Fusarium solani 40.35 3.00e-100 357.00
IUUC-Gmo-039609 Gadus morhua 42.53 2.00e-91 327.00
IUUC-Ggr-039825 Gaeumannomyces graminis 39.24 5.00e-97 346.00
IUUC-Gga-041191 Gallus gallus 39.93 4.00e-99 353.00
IUUC-Gac-041524 Gasterosteus aculeatus 41.84 2.00e-94 337.00
IUUC-Gma-042936 Glycine max 39.82 6.00e-45 173.00
IUUC-Ggo-045352 Gorilla gorilla 38.58 2.00e-98 350.00
IUUC-Hsa-045709 Homo sapiens 38.58 3.00e-98 350.00
IUUC-Hvu-047058 Hordeum vulgare 40.97 2.00e-45 174.00
IUUC-Itr-048483 Ictidomys tridecemlineatus 43.18 2.00e-99 354.00
IUUC-Lch-049681 Latimeria chalumnae 44.00 2.00e-95 341.00
IUUC-Lpe-050799 Leersia perrieri 42.79 1.00e-46 178.00
IUUC-Loc-052566 Lepisosteus oculatus 38.03 5.00e-83 300.00
IUUC-Lma-053028 Leptosphaeria maculans 42.23 4.00e-108 383.00
IUUC-Laf-054547 Loxodonta africana 39.14 9.00e-100 355.00
IUUC-Mcc-054753 Macaca mulatta 39.75 3.00e-98 350.00
IUUC-Meu-056855 Macropus eugenii 36.80 4.00e-36 142.00
IUUC-Mor-056941 Magnaporthe oryzae 41.44 8.00e-97 345.00
IUUC-Mpo-057306 Magnaporthe poae 39.71 1.00e-104 372.00
IUUC-Mtr-058349 Medicago truncatula 39.27 2.00e-44 171.00
IUUC-Mla-058842 Melampsora laricipopulina 46.01 4.00e-135 473.00
IUUC-Mga-060099 Meleagris gallopavo 38.10 5.00e-86 309.00
IUUC-Mvi-060413 Microbotryum violaceum 45.95 1.00e-128 451.00
IUUC-Mmr-061530 Microcebus murinus 39.62 2.00e-101 360.00
IUUC-Mdo-062668 Monodelphis domestica 41.60 2.00e-96 344.00
IUUC-Mmu-063871 Mus musculus 39.03 3.00e-101 360.00
IUUC-Mac-064559 Musa acuminata 37.44 5.00e-42 163.00
IUUC-Mpu-065919 Mustela putorius furo 38.93 3.00e-100 356.00
IUUC-Mlu-067846 Myotis lucifugus 35.98 1.00e-84 305.00
IUUC-Nfi-068507 Neosartorya fischeri 43.39 3.00e-105 373.00
IUUC-Ncr-068805 Neurospora crassa 37.66 2.00e-85 307.00
IUUC-Nle-070125 Nomascus leucogenys 36.10 9.00e-87 312.00
IUUC-Opr-070486 Ochotona princeps 37.93 6.00e-74 269.00
IUUC-Ont-071597 Oreochromis niloticus 42.71 1.00e-96 344.00
IUUC-Oan-073117 Ornithorhynchus anatinus 42.16 7.00e-33 133.00
IUUC-Ocu-074411 Oryctolagus cuniculus 39.24 4.00e-99 353.00
IUUC-Oba-075040 Oryza barthii 42.31 2.00e-46 178.00
IUUC-Obr-076727 Oryza brachyantha 41.35 4.00e-45 174.00
IUUC-Ogl-077605 Oryza glaberrima 42.31 2.00e-46 178.00
IUUC-Ogu-078177 Oryza glumaepatula 42.31 2.00e-46 178.00
IUUC-Oin-079549 Oryza indica 42.31 1.00e-46 179.00
IUUC-Olo-081090 Oryza longistaminata 42.31 2.00e-46 178.00
IUUC-Ome-081979 Oryza meridionalis 42.31 2.00e-46 178.00
IUUC-Oni-082819 Oryza nivara 42.31 2.00e-46 178.00
IUUC-Opu-083212 Oryza punctata 42.31 3.00e-46 177.00
IUUC-Oru-084412 Oryza rufipogon 42.31 2.00e-46 178.00
IUUC-Osa-085431 Oryza sativa 40.00 4.00e-27 111.00
IUUC-Ola-086602 Oryzias latipes 41.68 1.00e-89 321.00
IUUC-Olu-087682 Ostreococcus lucimarinus 40.41 3.00e-82 296.00
IUUC-Oga-088999 Otolemur garnettii 37.60 7.00e-89 319.00
IUUC-Oar-089338 Ovis aries 34.66 2.00e-69 254.00
IUUC-Ptr-091185 Pan troglodytes 38.58 2.00e-98 350.00
IUUC-Pan-092321 Papio anubis 39.69 7.00e-100 355.00
IUUC-Psi-094018 Pelodiscus sinensis 41.46 1.00e-54 204.00
IUUC-Pma-094111 Petromyzon marinus 38.06 2.00e-67 247.00
IUUC-Pno-094782 Phaeosphaeria nodorum 40.74 7.00e-105 372.00
IUUC-Ppa-095335 Physcomitrella patens 43.84 2.00e-49 188.00
IUUC-Pfo-097393 Poecilia formosa 39.83 3.00e-97 347.00
IUUC-Pab-098263 Pongo abelii 35.64 2.00e-83 301.00
IUUC-Pop-099316 Populus trichocarpa 40.47 9.00e-76 275.00
IUUC-Pca-100456 Procavia capensis 44.32 5.00e-40 157.00
IUUC-Ppe-101275 Prunus persica 37.48 3.00e-82 297.00
IUUC-Pva-102150 Pteropus vampyrus 40.14 3.00e-81 293.00
IUUC-Pgr-103378 Puccinia graminis 47.99 2.00e-137 480.00
IUUC-Ptt-103908 Puccinia triticina 45.24 6.00e-125 439.00
IUUC-Pte-104248 Pyrenophora teres 41.39 6.00e-107 379.00
IUUC-Pyt-104645 Pyrenophora triticirepentis 41.29 3.00e-107 380.00
IUUC-Rno-105162 Rattus norvegicus 39.38 2.00e-101 360.00
IUUC-Sha-107123 Sarcophilus harrisii 43.40 4.00e-43 167.00
IUUC-Sja-107828 Schizosaccharomyces japonicus 40.52 5.00e-104 369.00
IUUC-Spo-108368 Schizosaccharomyces pombe 40.35 1.00e-107 381.00
IUUC-Smo-109102 Selaginella moellendorffii 36.96 4.00e-91 327.00
IUUC-Sit-110821 Setaria italica 35.80 1.00e-76 278.00
IUUC-Sly-111803 Solanum lycopersicum 36.62 4.00e-87 313.00
IUUC-Stu-112730 Solanum tuberosum 38.95 4.00e-85 306.00
IUUC-Sar-113618 Sorex araneus 39.89 3.00e-94 336.00
IUUC-Sbi-114487 Sorghum bicolor 35.42 1.00e-67 249.00
IUUC-Sre-115009 Sporisorium reilianum 43.10 4.00e-116 409.00
IUUC-Ssc-115984 Sus scrofa 41.56 1.00e-97 348.00
IUUC-Tgu-117410 Taeniopygia guttata 41.42 1.00e-100 358.00
IUUC-Tru-118537 Takifugu rubripes 41.51 6.00e-94 335.00
IUUC-Tsy-119318 Tarsius syrichta 30.06 6.00e-33 133.00
IUUC-Tni-120514 Tetraodon nigroviridis 42.37 6.00e-68 249.00
IUUC-Tca-121620 Theobroma cacao 43.50 7.00e-48 183.00
IUUC-Tre-121904 Trichoderma reesei 38.06 7.00e-85 306.00
IUUC-Tvi-122585 Trichoderma virens 39.38 3.00e-87 313.00
IUUC-Tae-125342 Triticum aestivum 40.53 6.00e-45 173.00
IUUC-Tur-126759 Triticum urartu 49.33 5.00e-38 150.00
IUUC-Tme-126960 Tuber melanosporum 46.68 1.00e-118 417.00
IUUC-Tbe-128038 Tupaia belangeri 43.78 2.00e-38 152.00
IUUC-Ttr-129173 Tursiops truncatus 30.34 3.00e-65 240.00
IUUC-Uma-129595 Ustilago maydis 41.19 2.00e-108 384.00
IUUC-Vda-130012 Verticillium dahliae 42.21 2.00e-106 377.00
IUUC-Vpa-130129 Vicugna pacos 44.86 3.00e-40 157.00
IUUC-Vvi-131156 Vitis vinifera 35.05 3.00e-84 303.00
IUUC-Xtr-132807 Xenopus tropicalis 39.23 6.00e-92 329.00
IUUC-Xma-133563 Xiphophorus maculatus 43.78 5.00e-39 154.00
IUUC-Yli-134361 Yarrowia lipolytica 44.34 3.00e-38 150.00
IUUC-Zma-135759 Zea mays 48.11 4.00e-42 164.00
Created Date 25-Jun-2017

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