iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052400

Ensembl Protein ID

ENSLOCP00000003256.1

UniProt Accession

W5M4E8; W5M4E8_LEPOC

Genbank Protein ID

ENSLOCP00000003256

Protein Name

Ubiquitin-related modifier 1

Genbank Nucleotide ID

AHAT01021517

Gene Name

urm1; URM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000002768.1	ENSLOCT00000003263.1	ENSLOCP00000003256.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	37.37	1.00e-14	72.40	IUUC-Sce-106366

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Lepisosteus oculatus

Functional Description
(View)

Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Protein Sequence
(Fasta)

MAAPISLHLE FGGGAELLFD GVKNHHVTLP SQSEPWNMKQ LLLWIKGNLL KERPELFIQG 60
DTVRPGILVL INDADWELMG EMDYRLQHQD NVVFISTLHG G 101

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Nucleotide Sequence
(Fasta)

ATGGCGGCGC CCATATCCTT ACATCTGGAA TTCGGGTGAG TCTTAATATG AGTTTTTAAA 60
CCCGGTCTTG CTCATAGGAA GTGTGTGCTC TGTGGTGCCT GATTTATAAG TCTGGTGCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway

Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1

Pfam

PF09138--Urm1

Gene Ontology

GO:0005829--C:cytosol
GO:0032447--P:protein urmylation
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002254	Ailuropoda melanoleuca	77.23	6.00e-45	171.00
IUUC-Atr-003089	Amborella trichopoda	59.60	3.00e-31	125.00
IUUC-Apl-003382	Anas platyrhynchos	81.32	1.00e-40	157.00
IUUC-Aca-004981	Anolis carolinensis	81.19	5.00e-47	178.00
IUUC-Aly-005517	Arabidopsis lyrata	57.61	3.00e-28	115.00
IUUC-Ath-006718	Arabidopsis thaliana	58.33	9.00e-25	104.00
IUUC-Ago-007917	Ashbya gossypii	38.38	1.00e-17	80.90
IUUC-Acl-008054	Aspergillus clavatus	70.00	8.00e-16	74.30
IUUC-Afl-008704	Aspergillus flavus	54.44	4.00e-20	89.00
IUUC-Aor-009890	Aspergillus oryzae	53.92	1.00e-23	101.00
IUUC-Bta-012448	Bos taurus	78.22	3.00e-45	172.00
IUUC-Bci-013865	Botrytis cinerea	45.54	3.00e-21	92.80
IUUC-Bdi-014980	Brachypodium distachyon	64.79	1.00e-23	100.00
IUUC-Bol-016055	Brassica oleracea	57.89	5.00e-24	102.00
IUUC-Bra-016845	Brassica rapa	57.89	5.00e-24	102.00
IUUC-Cel-018485	Caenorhabditis elegans	33.01	6.00e-11	58.50
IUUC-Cja-019587	Callithrix jacchus	79.21	3.00e-45	172.00
IUUC-Cfa-020653	Canis familiaris	77.23	5.00e-45	171.00
IUUC-Cpo-021622	Cavia porcellus	79.21	3.00e-45	172.00
IUUC-Cre-023015	Chlamydomonas reinhardtii	52.04	2.00e-24	103.00
IUUC-Csa-023756	Chlorocebus sabaeus	78.48	1.00e-33	135.00
IUUC-Cgl-026518	Colletotrichum gloeosporioides	46.53	5.00e-21	92.40
IUUC-Cne-026953	Cryptococcus neoformans	54.37	2.00e-26	111.00
IUUC-Cme-027314	Cyanidioschyzon merolae	43.30	4.00e-18	82.00
IUUC-Dre-027884	Danio rerio	87.13	2.00e-49	186.00
IUUC-Dno-029262	Dasypus novemcinctus	78.75	1.00e-34	139.00
IUUC-Dor-030601	Dipodomys ordii	50.50	2.00e-21	92.80
IUUC-Dme-031893	Drosophila melanogaster	59.80	3.00e-30	122.00
IUUC-Ete-032773	Echinops telfairi	75.25	1.00e-41	160.00
IUUC-Eca-034187	Equus caballus	78.22	4.00e-45	172.00
IUUC-Eeu-034808	Erinaceus europaeus	74.26	6.00e-44	168.00
IUUC-Fca-036107	Felis catus	77.23	3.00e-45	172.00
IUUC-Fal-036607	Ficedula albicollis	79.12	9.00e-40	154.00
IUUC-Fox-037698	Fusarium oxysporum	43.27	2.00e-20	90.50
IUUC-Gmo-039492	Gadus morhua	87.13	1.00e-48	183.00
IUUC-Ggr-039965	Gaeumannomyces graminis	44.23	3.00e-18	84.00
IUUC-Gga-041268	Gallus gallus	81.19	5.00e-46	175.00
IUUC-Gac-042111	Gasterosteus aculeatus	84.16	4.00e-48	182.00
IUUC-Gma-043240	Glycine max	54.76	1.00e-22	97.40
IUUC-Ggo-045176	Gorilla gorilla	78.48	4.00e-27	113.00
IUUC-Hsa-046077	Homo sapiens	78.22	1.00e-38	150.00
IUUC-Itr-048111	Ictidomys tridecemlineatus	79.78	6.00e-33	131.00
IUUC-Kpa-049157	Komagataella pastoris	44.44	5.00e-18	82.00
IUUC-Lch-049889	Latimeria chalumnae	80.20	2.00e-46	176.00
IUUC-Lpe-050783	Leersia perrieri	68.25	3.00e-22	96.30
IUUC-Lma-053259	Leptosphaeria maculans	47.52	5.00e-21	92.00
IUUC-Laf-053596	Loxodonta africana	76.70	3.00e-43	166.00
IUUC-Mcc-054845	Macaca mulatta	74.49	8.00e-40	154.00
IUUC-Meu-055968	Macropus eugenii	79.21	4.00e-46	175.00
IUUC-Mor-057126	Magnaporthe oryzae	42.31	3.00e-17	80.50
IUUC-Mpo-057311	Magnaporthe poae	47.52	2.00e-20	91.30
IUUC-Mtr-058266	Medicago truncatula	53.49	6.00e-23	98.60
IUUC-Mla-058847	Melampsora laricipopulina	38.83	5.00e-11	59.30
IUUC-Mga-059468	Meleagris gallopavo	81.32	1.00e-40	156.00
IUUC-Mvi-060235	Microbotryum violaceum	33.11	2.00e-17	81.60
IUUC-Mdo-061948	Monodelphis domestica	78.22	2.00e-45	173.00
IUUC-Mmu-063946	Mus musculus	76.24	4.00e-44	168.00
IUUC-Mac-064812	Musa acuminata	66.15	3.00e-24	102.00
IUUC-Mpu-066763	Mustela putorius furo	78.22	1.00e-44	170.00
IUUC-Mlu-066970	Myotis lucifugus	79.75	2.00e-34	136.00
IUUC-Ncr-068824	Neurospora crassa	45.54	1.00e-19	87.40
IUUC-Nle-069849	Nomascus leucogenys	78.48	1.00e-33	135.00
IUUC-Opr-070227	Ochotona princeps	79.21	3.00e-45	172.00
IUUC-Ont-072530	Oreochromis niloticus	85.15	7.00e-48	181.00
IUUC-Oan-073191	Ornithorhynchus anatinus	73.20	1.00e-39	153.00
IUUC-Ocu-074460	Oryctolagus cuniculus	77.55	1.00e-43	166.00
IUUC-Oba-075499	Oryza barthii	68.75	2.00e-22	98.60
IUUC-Obr-076896	Oryza brachyantha	67.19	8.00e-22	96.70
IUUC-Ogl-077834	Oryza glaberrima	68.75	5.00e-23	98.60
IUUC-Ogu-078622	Oryza glumaepatula	68.75	5.00e-23	98.60
IUUC-Oin-079358	Oryza indica	68.75	1.00e-22	99.40
IUUC-Olo-081035	Oryza longistaminata	55.67	1.00e-23	102.00
IUUC-Oni-082425	Oryza nivara	68.75	5.00e-23	98.60
IUUC-Opu-083461	Oryza punctata	68.25	3.00e-22	97.40
IUUC-Oru-084875	Oryza rufipogon	61.97	5.00e-21	92.00
IUUC-Oga-089128	Otolemur garnettii	78.22	5.00e-45	171.00
IUUC-Oar-089896	Ovis aries	78.22	3.00e-45	172.00
IUUC-Ptr-091618	Pan troglodytes	78.48	5.00e-27	113.00
IUUC-Pan-092238	Papio anubis	78.48	9.00e-34	135.00
IUUC-Psi-093879	Pelodiscus sinensis	83.17	1.00e-46	177.00
IUUC-Pma-094484	Petromyzon marinus	76.24	6.00e-34	134.00
IUUC-Ppa-095801	Physcomitrella patens	56.58	4.00e-22	95.90
IUUC-Pfo-097192	Poecilia formosa	86.14	3.00e-49	185.00
IUUC-Pab-098203	Pongo abelii	78.22	2.00e-38	149.00
IUUC-Pop-099614	Populus trichocarpa	55.95	2.00e-24	103.00
IUUC-Pca-100507	Procavia capensis	78.48	3.00e-34	135.00
IUUC-Ppe-101174	Prunus persica	59.60	4.00e-30	122.00
IUUC-Pva-102735	Pteropus vampyrus	78.22	7.00e-42	161.00
IUUC-Pgr-103510	Puccinia graminis	40.78	1.00e-12	64.70
IUUC-Ptt-103918	Puccinia triticina	38.83	6.00e-12	62.40
IUUC-Pte-104173	Pyrenophora teres	47.57	8.00e-23	98.20
IUUC-Pyt-104806	Pyrenophora triticirepentis	47.57	5.00e-23	99.00
IUUC-Rno-105820	Rattus norvegicus	77.23	1.00e-44	170.00
IUUC-Sce-106366	Saccharomyces cerevisiae	37.37	4.00e-15	72.40
IUUC-Sja-107727	Schizosaccharomyces japonicus	40.62	1.00e-16	77.80
IUUC-Spo-108074	Schizosaccharomyces pombe	40.82	1.00e-09	53.90
IUUC-Smo-108944	Selaginella moellendorffii	58.43	7.00e-25	104.00
IUUC-Sit-110277	Setaria italica	57.14	3.00e-23	99.40
IUUC-Sly-111505	Solanum lycopersicum	54.76	1.00e-24	103.00
IUUC-Stu-112076	Solanum tuberosum	55.95	5.00e-25	105.00
IUUC-Sbi-114274	Sorghum bicolor	60.53	7.00e-24	101.00
IUUC-Sre-114953	Sporisorium reilianum	55.88	8.00e-26	108.00
IUUC-Ssc-115418	Sus scrofa	78.22	5.00e-45	171.00
IUUC-Tgu-117311	Taeniopygia guttata	79.12	9.00e-40	154.00
IUUC-Tru-118598	Takifugu rubripes	82.02	8.00e-40	154.00
IUUC-Tni-120109	Tetraodon nigroviridis	80.39	2.00e-44	169.00
IUUC-Tca-120942	Theobroma cacao	53.75	1.00e-23	100.00
IUUC-Tre-122099	Trichoderma reesei	46.81	8.00e-15	71.20
IUUC-Tvi-122285	Trichoderma virens	50.00	6.00e-19	85.50
IUUC-Tae-125193	Triticum aestivum	67.69	2.00e-22	97.10
IUUC-Tur-126677	Triticum urartu	57.14	7.00e-20	88.60
IUUC-Tme-127120	Tuber melanosporum	48.08	3.00e-24	103.00
IUUC-Tbe-128050	Tupaia belangeri	58.42	3.00e-28	115.00
IUUC-Ttr-129019	Tursiops truncatus	75.25	9.00e-42	160.00
IUUC-Uma-129483	Ustilago maydis	53.92	1.00e-23	100.00
IUUC-Vda-129690	Verticillium dahliae	40.18	5.00e-16	75.90
IUUC-Vvi-131174	Vitis vinifera	56.63	3.00e-24	102.00
IUUC-Xma-133862	Xiphophorus maculatus	86.14	3.00e-49	185.00
IUUC-Yli-134398	Yarrowia lipolytica	43.43	3.00e-17	79.70
IUUC-Zma-134964	Zea mays	59.74	2.00e-22	96.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence