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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063909
Ensembl Protein ID ENSMUSP00000040765.6
UniProt Accession Q80TJ7; A2ABU8; A2ABV0; A2ABV2; Q8BLX8; Q8BLY0; Q8BZ61; Q8CG26; PHF8_MOUSE
Genbank Protein ID BAC29505.1; BAC30755.2; BAC30763.1; CAM17161.1; CAM15464.1; CAM15464.1; CAM17159.1; CAM17159.1; CAM17163.1; BAC65729.1; AAO17385.1
Protein Name Histone lysine demethylase PHF8; PHD finger protein 8
Genbank Nucleotide ID AK036609; AK040943; AK040969; AL662922; AL840642; AL662922; AL662922; AL840642; AL662922; AK122447; AF528164
Gene Name Phf8; Kiaa1111
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000041229.15 ENSMUST00000112666.7 ENSMUSP00000108285.1
ENSMUSG00000041229.15 ENSMUST00000112670.7 ENSMUSP00000108289.1
ENSMUSG00000041229.15 ENSMUST00000046962.10 ENSMUSP00000041312.4
ENSMUSG00000041229.15 ENSMUST00000112668.8 ENSMUSP00000108287.2
ENSMUSG00000041229.15 ENSMUST00000046950.12 ENSMUSP00000040765.6
ENSMUSG00000041229.15 ENSMUST00000151941.1 ENSMUSP00000116792.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IID
Protein 3D Structure
PDBMMDB
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 9.00e-09 36.5 6 54
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C+ +++ ++ ++eC+ C++wfH  C++ + ee+  + + + Cp+C+
   Q: 6    VYC-LCRLPYDVTRFMIECDMCQDWFHGSCVGVE-EEKAADIDLYHCPNCE 54
           69*.******************************.*******99******6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3 (By similarity).
 Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3 (By similarity).
Protein Sequence
(Fasta)
MASVPVYCLC RLPYDVTRFM IECDMCQDWF HGSCVGVEEE KAADIDLYHC PNCEVLHGPS 60
IMKKRRGSSK GHDNHKGKPL KTGSSMFIRE LRGRTFDSSD EVILKPTGSQ LTVEFLEENS 120
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Protein Fasta Sequence


>IUUC-Mmu-063909|E3,PHD|Mus musculus
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Nucleotide Sequence
(Fasta)
GTGCCCGAGC CTCGTAAGAT GGCGGCGGGC TCGTCTCTTT CCCAGAACGC CGCCACTCTC 60
AATATGGTAG CTGTTTACCA TATCTCTCCA CCCCTCTCCG CCTCAACTGC CTCGCGATTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063909|E3,PHD|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF02373--JmjC
PF00628--PHD
SMART

SM00558--JmjC
SM00249--PHD
Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0032452--F:histone demethylase activity
GO:0071558--F:histone demethylase activity (H3-K27 specific)
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0035575--F:histone demethylase activity (H4-K20 specific)
GO:0005506--F:iron ion binding
GO:0035064--F:methylated histone binding
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0007420--P:brain development
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0071557--P:histone H3-K27 demethylation
GO:0070544--P:histone H3-K36 demethylation
GO:0033169--P:histone H3-K9 demethylation
GO:0035574--P:histone H4-K20 demethylation
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0045943--P:positive regulation of transcription from RNA polymerase I promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:320595; mmu:74042
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002427 Ailuropoda melanoleuca 94.10 0.00e+00 1467.00
IUUC-Aca-004346 Anolis carolinensis 69.39 0.00e+00 1122.00
IUUC-Acl-008303 Aspergillus clavatus 31.94 3.00e-67 251.00
IUUC-Afl-008579 Aspergillus flavus 27.59 2.00e-28 121.00
IUUC-Afu-008903 Aspergillus fumigatus 31.98 4.00e-67 250.00
IUUC-Ani-009279 Aspergillus nidulans 31.60 3.00e-65 244.00
IUUC-Ang-009645 Aspergillus niger 30.68 3.00e-64 240.00
IUUC-Aor-010233 Aspergillus oryzae 31.14 1.00e-66 248.00
IUUC-Ate-010345 Aspergillus terreus 32.39 4.00e-69 257.00
IUUC-Ame-010945 Astyanax mexicanus 79.63 0.00e+00 835.00
IUUC-Cfa-021156 Canis familiaris 93.47 0.00e+00 1662.00
IUUC-Cpo-022284 Cavia porcellus 94.24 0.00e+00 1684.00
IUUC-Cre-022934 Chlamydomonas reinhardtii 41.54 3.00e-10 58.20
IUUC-Csa-023515 Chlorocebus sabaeus 94.43 0.00e+00 1737.00
IUUC-Dre-028423 Danio rerio 63.45 0.00e+00 1040.00
IUUC-Dno-029446 Dasypus novemcinctus 92.93 0.00e+00 1172.00
IUUC-Dse-031402 Dothistroma septosporum 34.88 2.00e-64 241.00
IUUC-Ete-032380 Echinops telfairi 93.58 0.00e+00 1093.00
IUUC-Eca-034302 Equus caballus 94.04 0.00e+00 1662.00
IUUC-Fca-035578 Felis catus 94.24 0.00e+00 1687.00
IUUC-Gmo-038789 Gadus morhua 61.18 0.00e+00 1082.00
IUUC-Gac-041666 Gasterosteus aculeatus 79.22 0.00e+00 808.00
IUUC-Ggo-044712 Gorilla gorilla 94.05 0.00e+00 1732.00
IUUC-Hsa-045724 Homo sapiens 94.53 0.00e+00 1744.00
IUUC-Kpa-049384 Komagataella pastoris 32.94 2.00e-57 216.00
IUUC-Lch-049793 Latimeria chalumnae 64.79 0.00e+00 1169.00
IUUC-Lma-053190 Leptosphaeria maculans 34.65 2.00e-66 248.00
IUUC-Laf-053656 Loxodonta africana 93.99 0.00e+00 1545.00
IUUC-Mcc-055658 Macaca mulatta 94.43 0.00e+00 1737.00
IUUC-Mtr-057679 Medicago truncatula 41.54 1.00e-11 62.80
IUUC-Mla-058890 Melampsora laricipopulina 48.92 3.00e-75 274.00
IUUC-Mvi-060481 Microbotryum violaceum 38.93 8.00e-78 285.00
IUUC-Mmr-060993 Microcebus murinus 94.72 0.00e+00 1654.00
IUUC-Mdo-062097 Monodelphis domestica 69.54 0.00e+00 1211.00
IUUC-Mpu-066429 Mustela putorius furo 94.04 0.00e+00 1689.00
IUUC-Mlu-067746 Myotis lucifugus 91.42 0.00e+00 1649.00
IUUC-Nfi-068537 Neosartorya fischeri 32.39 9.00e-68 252.00
IUUC-Nle-070143 Nomascus leucogenys 93.95 0.00e+00 1757.00
IUUC-Ont-072257 Oreochromis niloticus 78.42 0.00e+00 815.00
IUUC-Oan-073654 Ornithorhynchus anatinus 84.27 0.00e+00 857.00
IUUC-Ocu-074417 Oryctolagus cuniculus 93.07 0.00e+00 1668.00
IUUC-Ola-087502 Oryzias latipes 76.14 0.00e+00 802.00
IUUC-Oga-088662 Otolemur garnettii 94.71 0.00e+00 1388.00
IUUC-Oar-090332 Ovis aries 93.87 0.00e+00 1661.00
IUUC-Ptr-091646 Pan troglodytes 94.10 0.00e+00 1418.00
IUUC-Pan-092122 Papio anubis 94.34 0.00e+00 1736.00
IUUC-Pma-094621 Petromyzon marinus 67.41 0.00e+00 644.00
IUUC-Pno-094984 Phaeosphaeria nodorum 35.22 5.00e-65 243.00
IUUC-Pfo-096107 Poecilia formosa 80.04 0.00e+00 814.00
IUUC-Pab-097635 Pongo abelii 84.88 0.00e+00 1482.00
IUUC-Pca-100779 Procavia capensis 89.57 0.00e+00 929.00
IUUC-Pva-102839 Pteropus vampyrus 80.82 0.00e+00 1345.00
IUUC-Ptt-103859 Puccinia triticina 39.47 6.00e-77 281.00
IUUC-Pte-104241 Pyrenophora teres 33.66 8.00e-64 239.00
IUUC-Pyt-104741 Pyrenophora triticirepentis 33.66 6.00e-63 236.00
IUUC-Rno-105933 Rattus norvegicus 98.24 0.00e+00 1773.00
IUUC-Ssc-115645 Sus scrofa 94.43 0.00e+00 1617.00
IUUC-Tru-118403 Takifugu rubripes 74.60 0.00e+00 795.00
IUUC-Tsy-119214 Tarsius syrichta 87.30 0.00e+00 1221.00
IUUC-Tni-119736 Tetraodon nigroviridis 77.50 0.00e+00 799.00
IUUC-Tme-127054 Tuber melanosporum 30.39 1.00e-54 208.00
IUUC-Tbe-128138 Tupaia belangeri 93.30 0.00e+00 1442.00
IUUC-Vpa-130595 Vicugna pacos 89.38 0.00e+00 1050.00
IUUC-Xtr-132307 Xenopus tropicalis 67.88 0.00e+00 1150.00
IUUC-Xma-134323 Xiphophorus maculatus 80.91 0.00e+00 820.00
IUUC-Yli-134626 Yarrowia lipolytica 35.73 5.00e-60 225.00
Created Date 25-Jun-2017

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