iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004341

UUCD1 version

UUC-AnC-00832

Ensembl Protein ID

ENSACAP00000015533.3

UniProt Accession

G1KRM4; G1KRM4_ANOCA

Protein Name

Uncharacterized protein

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000015716.3	ENSACAT00000015847.3	ENSACAP00000015533.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.10e-58	190.1	343	377
UBD/Beta-Prp	1.10e-69	234.8	257	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 343  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 377
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 44   llrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleet 132
           l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +
   Q: 257  LRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-V 340
           445569************99..8**************************************..************************.* PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 341  LEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 421
           **************9..***********************************99.************..99**************7 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MCHYQHGHIN SYLKPMLQRD FITALPEQGL DHIAENILSY LDARSLCAAE LVCKEWQRVI 60
SEGMLWKKLI ERMVRTDPLW KGLSERRGWD QYLFKNRPTD GPPNSFYRSL YPKIIQDIET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACACTTCAG TAATGGAGGA TCAGAATGAA GATGAGTCTC CAAAGAAGAG CACACTATGG 60
CAGGTAGGTT CAGTTATCTT CCCAAAATTC CCAGTAAGGG GATTTTGAAA TGCATTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ang-009766	Aspergillus niger	31.41	1.00e-51	197.00
IUUC-Ame-011393	Astyanax mexicanus	94.37	0.00e+00	874.00
IUUC-Bta-012920	Bos taurus	99.10	0.00e+00	912.00
IUUC-Cpo-022151	Cavia porcellus	98.65	0.00e+00	905.00
IUUC-Csa-024095	Chlorocebus sabaeus	99.10	0.00e+00	912.00
IUUC-Dre-028160	Danio rerio	94.82	0.00e+00	877.00
IUUC-Dse-031287	Dothistroma septosporum	29.36	1.00e-52	201.00
IUUC-Eca-033804	Equus caballus	99.10	0.00e+00	911.00
IUUC-Fca-035887	Felis catus	99.10	0.00e+00	914.00
IUUC-Gmo-038590	Gadus morhua	93.24	0.00e+00	859.00
IUUC-Itr-048436	Ictidomys tridecemlineatus	98.92	0.00e+00	758.00
IUUC-Mdo-062005	Monodelphis domestica	98.87	0.00e+00	913.00
IUUC-Mpu-065716	Mustela putorius furo	99.10	0.00e+00	913.00
IUUC-Mlu-067001	Myotis lucifugus	99.10	0.00e+00	912.00
IUUC-Nle-069788	Nomascus leucogenys	99.10	0.00e+00	913.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	1.00e-44	174.00
IUUC-Sha-107339	Sarcophilus harrisii	98.87	0.00e+00	913.00
IUUC-Xma-133187	Xiphophorus maculatus	96.07	1.00e-158	551.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence