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Tag Content
UUCD2 ID IUUC-Bta-013070
UUCD1 version UUC-BoT-00134
Ensembl Protein ID ENSBTAP00000037967.3
UniProt Accession E1B7Q7; Q0P5M6; TRIPC_BOVIN
Genbank Protein ID AAI19852.1
Protein Name E3 ubiquitin-protein ligase TRIP12; HECT-type E3 ubiquitin transferase TRIP12; Thyroid receptor-interacting protein 12
Genbank Nucleotide ID DAAA02006173
Gene Name TRIP12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000021653.5 ENSBTAT00000038151.3 ENSBTAP00000037967.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.20e-96 324.2 1613 1992
Active Site
Position(s) Description Evidence
1959 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 6    kkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlq..pnpdsglknp.....................ehlk 69
           ++ le+++++E g++l G+t+ef+al+s+elq++dlgl++ +e   ++ +   + +++                         ++  
   Q: 1613 RAMLEIQYENEVGTGL-GPTLEFYALVSQELQRADLGLWRGEEVTLSNPKgsQEGTKY---IqnlqglfalpfgrtakpahiaKVKM 1695
           56899***********.**********************6665533332200222333...14458888999**********9999* PP
   S: 70   lFeflGrllgkalqdgrlldlplsksfyklllgkklsl..edleevdpelykslkeikena......es.................. 130
            F+flG+l++ka++d rl+dlpl  +fyk +l+++ sl  +dl ++dp +++s+  +++ +      e+                  
   Q: 1696 KFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLtsHDLFDIDPVVARSVYHLEDIVrqkkrlEQdksqtkeslqyaletltm 1782
           **********************************654444**************999999855555511555666666554444444 PP
   S: 131  ...dieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslF 209
              ++e+            +     l+   + eLk gG++ipVt+ N+eeY +lv+ + l+eg+ +q+++fr+Gf++v+pl++l++F
   Q: 1783 ngcSVED------------LgldftLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQYF 1857
           4444444............25555578999********************************************************* PP
   S: 210  teeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk... 291
            +eel++l+cG+  +++d+++l + ++ ++gyt+ds+a+++++e+l++f++e+++ fLqFvTgs+rlP+gGf++l+p l+++rk   
   Q: 1858 YPEELDQLLCGSkaDTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKtfe 1944
           ************7778999999999999*********************************************************** PP
   S: 292  ..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
             ++ dd lPs++TC+nyLkLP+Yss ei++ekLl+A +e+ ++F+ls
   Q: 1945 stENPDDFLPSVMTCVNYLKLPDYSSLEIMREKLLMAAREGqQSFHLS 1992
           988888***************************************985 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
 E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Protein Sequence
(Fasta)
MSNRPNNNPG GSLRRSQRNT AGAQPQDDSI GGRSCSSSSV VIVPQPEDPD RANTSEKQKT 60
GQVPKKDNSR GVKRSASPDY NRTNSPSSAK KPKALQHTES PSETSKPHSK SKKRHLDQEP 120
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Protein Fasta Sequence


>IUUC-Bta-013070|E3,HECT|Bos taurus
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Nucleotide Sequence
(Fasta)
ATGTCCAACC GGCCTAATAA CAATCCAGGG GGGTCACTGC GACGTTCACA GAGGAACACT 60
GCCGGGGCCC AACCACAAGA CGACTCGATA GGAGGAAGGT ATGTATTTAA TGGTAATTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013070|E3,HECT|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom
IPR004170--WWE-dom
PROSITE

PS50237--HECT
PS50918--WWE
Pfam

PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0009790--P:embryo development
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG bta:514387
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000750 Aegilops tauschii 38.69 1.00e-126 448.00
IUUC-Aml-001502 Ailuropoda melanoleuca 94.71 0.00e+00 3551.00
IUUC-Atr-002821 Amborella trichopoda 37.45 4.00e-117 417.00
IUUC-Apl-003531 Anas platyrhynchos 91.22 0.00e+00 3321.00
IUUC-Aly-005962 Arabidopsis lyrata 38.80 4.00e-114 407.00
IUUC-Ath-006636 Arabidopsis thaliana 38.66 4.00e-114 407.00
IUUC-Ago-007875 Ashbya gossypii 36.20 5.00e-82 300.00
IUUC-Acl-008242 Aspergillus clavatus 35.85 9.00e-114 405.00
IUUC-Afl-008736 Aspergillus flavus 39.01 2.00e-110 394.00
IUUC-Afu-008812 Aspergillus fumigatus 35.25 3.00e-114 407.00
IUUC-Ani-009407 Aspergillus nidulans 37.58 1.00e-110 395.00
IUUC-Ang-009763 Aspergillus niger 40.18 3.00e-106 380.00
IUUC-Aor-009941 Aspergillus oryzae 30.77 1.00e-112 401.00
IUUC-Ate-010459 Aspergillus terreus 36.42 1.00e-85 312.00
IUUC-Ame-011761 Astyanax mexicanus 85.09 0.00e+00 2907.00
IUUC-Bgr-012265 Blumeria graminis 35.01 1.00e-104 375.00
IUUC-Bci-013890 Botrytis cinerea 39.92 6.00e-103 369.00
IUUC-Bdi-014046 Brachypodium distachyon 38.47 6.00e-122 432.00
IUUC-Bol-015942 Brassica oleracea 44.23 1.00e-114 408.00
IUUC-Bra-016849 Brassica rapa 44.23 4.00e-114 407.00
IUUC-Cja-019046 Callithrix jacchus 94.32 0.00e+00 3501.00
IUUC-Cfa-020521 Canis familiaris 96.42 0.00e+00 3397.00
IUUC-Cpo-021639 Cavia porcellus 91.53 0.00e+00 3437.00
IUUC-Cre-022767 Chlamydomonas reinhardtii 39.88 1.00e-89 323.00
IUUC-Csa-023231 Chlorocebus sabaeus 95.86 0.00e+00 3487.00
IUUC-Cho-024380 Choloepus hoffmanni 87.70 0.00e+00 3202.00
IUUC-Cin-025482 Ciona intestinalis 51.21 6.00e-160 557.00
IUUC-Csv-026121 Ciona savignyi 49.13 0.00e+00 1557.00
IUUC-Cgl-026716 Colletotrichum gloeosporioides 34.79 2.00e-110 394.00
IUUC-Cne-026857 Cryptococcus neoformans 39.89 2.00e-94 342.00
IUUC-Cme-027226 Cyanidioschyzon merolae 35.14 3.00e-74 274.00
IUUC-Dre-028174 Danio rerio 85.12 0.00e+00 2954.00
IUUC-Dor-030939 Dipodomys ordii 88.10 0.00e+00 2784.00
IUUC-Dse-031444 Dothistroma septosporum 39.52 2.00e-105 378.00
IUUC-Dme-032162 Drosophila melanogaster 63.41 5.00e-158 553.00
IUUC-Ete-032345 Echinops telfairi 92.22 0.00e+00 2303.00
IUUC-Eca-033229 Equus caballus 97.08 0.00e+00 3474.00
IUUC-Eeu-035205 Erinaceus europaeus 88.40 0.00e+00 3110.00
IUUC-Fca-036444 Felis catus 94.07 0.00e+00 3497.00
IUUC-Fal-037131 Ficedula albicollis 89.50 0.00e+00 3362.00
IUUC-Fox-038035 Fusarium oxysporum 35.91 2.00e-109 390.00
IUUC-Fso-038320 Fusarium solani 37.07 3.00e-109 390.00
IUUC-Gmo-039497 Gadus morhua 82.75 0.00e+00 3083.00
IUUC-Ggr-040057 Gaeumannomyces graminis 34.75 7.00e-108 386.00
IUUC-Gga-041021 Gallus gallus 89.55 0.00e+00 3380.00
IUUC-Gac-042474 Gasterosteus aculeatus 83.97 0.00e+00 3063.00
IUUC-Gma-043060 Glycine max 38.92 6.00e-122 432.00
IUUC-Ggo-044855 Gorilla gorilla 97.14 0.00e+00 3496.00
IUUC-Hsa-046147 Homo sapiens 98.34 0.00e+00 3574.00
IUUC-Hvu-047775 Hordeum vulgare 38.69 5.00e-125 442.00
IUUC-Itr-048131 Ictidomys tridecemlineatus 95.71 0.00e+00 3460.00
IUUC-Kpa-049098 Komagataella pastoris 38.10 3.00e-86 314.00
IUUC-Lch-049818 Latimeria chalumnae 83.90 0.00e+00 3038.00
IUUC-Lpe-051017 Leersia perrieri 38.44 2.00e-118 421.00
IUUC-Loc-051777 Lepisosteus oculatus 83.42 0.00e+00 3184.00
IUUC-Lma-052990 Leptosphaeria maculans 39.74 2.00e-111 397.00
IUUC-Laf-053727 Loxodonta africana 97.19 0.00e+00 3496.00
IUUC-Mcc-055799 Macaca mulatta 94.35 0.00e+00 3394.00
IUUC-Meu-056065 Macropus eugenii 93.88 0.00e+00 2098.00
IUUC-Mor-057054 Magnaporthe oryzae 38.67 6.00e-107 383.00
IUUC-Mpo-057417 Magnaporthe poae 39.36 4.00e-109 390.00
IUUC-Mtr-057849 Medicago truncatula 37.36 8.00e-114 405.00
IUUC-Mla-058870 Melampsora laricipopulina 42.37 3.00e-106 380.00
IUUC-Mga-059580 Meleagris gallopavo 89.98 0.00e+00 2927.00
IUUC-Mvi-060507 Microbotryum violaceum 40.19 7.00e-113 403.00
IUUC-Mmr-060816 Microcebus murinus 95.76 0.00e+00 3477.00
IUUC-Mdo-062866 Monodelphis domestica 89.28 0.00e+00 3204.00
IUUC-Mmu-063906 Mus musculus 94.91 0.00e+00 3519.00
IUUC-Mac-064675 Musa acuminata 38.76 2.00e-111 396.00
IUUC-Mpu-066199 Mustela putorius furo 94.45 0.00e+00 3381.00
IUUC-Mlu-067110 Myotis lucifugus 95.65 0.00e+00 3519.00
IUUC-Nfi-068482 Neosartorya fischeri 35.40 2.00e-114 407.00
IUUC-Ncr-068906 Neurospora crassa 38.94 1.00e-108 389.00
IUUC-Nle-069410 Nomascus leucogenys 94.02 0.00e+00 3491.00
IUUC-Opr-070401 Ochotona princeps 86.04 0.00e+00 2978.00
IUUC-Ont-072100 Oreochromis niloticus 79.53 0.00e+00 3021.00
IUUC-Oan-073121 Ornithorhynchus anatinus 89.66 0.00e+00 3463.00
IUUC-Ocu-074623 Oryctolagus cuniculus 91.92 0.00e+00 3435.00
IUUC-Oba-075380 Oryza barthii 36.51 1.00e-113 405.00
IUUC-Obr-076915 Oryza brachyantha 37.77 5.00e-119 423.00
IUUC-Ogl-077055 Oryza glaberrima 38.42 3.00e-118 421.00
IUUC-Ogu-078892 Oryza glumaepatula 40.36 1.00e-112 401.00
IUUC-Oin-079256 Oryza indica 38.38 2.00e-117 417.00
IUUC-Olo-080343 Oryza longistaminata 38.38 8.00e-118 419.00
IUUC-Ome-081422 Oryza meridionalis 38.10 2.00e-117 417.00
IUUC-Oni-083047 Oryza nivara 36.66 1.00e-114 408.00
IUUC-Opu-083641 Oryza punctata 36.44 3.00e-111 397.00
IUUC-Oru-084439 Oryza rufipogon 40.36 3.00e-113 403.00
IUUC-Osa-085972 Oryza sativa 38.16 1.00e-116 413.00
IUUC-Ola-087173 Oryzias latipes 80.24 0.00e+00 3003.00
IUUC-Olu-087871 Ostreococcus lucimarinus 36.89 5.00e-89 321.00
IUUC-Oga-087908 Otolemur garnettii 94.18 0.00e+00 3505.00
IUUC-Oar-090277 Ovis aries 96.69 0.00e+00 3650.00
IUUC-Ptr-091543 Pan troglodytes 98.39 0.00e+00 3578.00
IUUC-Pan-092243 Papio anubis 94.30 0.00e+00 3395.00
IUUC-Psi-093150 Pelodiscus sinensis 91.47 0.00e+00 3477.00
IUUC-Pno-094891 Phaeosphaeria nodorum 41.13 1.00e-112 401.00
IUUC-Ppa-095181 Physcomitrella patens 42.14 3.00e-107 382.00
IUUC-Pfo-096267 Poecilia formosa 81.08 0.00e+00 2976.00
IUUC-Pab-098072 Pongo abelii 97.08 0.00e+00 3493.00
IUUC-Pop-099190 Populus trichocarpa 41.34 4.00e-116 413.00
IUUC-Pca-100311 Procavia capensis 90.78 0.00e+00 3274.00
IUUC-Ppe-101284 Prunus persica 37.37 1.00e-115 412.00
IUUC-Pva-102215 Pteropus vampyrus 89.47 0.00e+00 1252.00
IUUC-Pgr-103694 Puccinia graminis 40.48 5.00e-104 373.00
IUUC-Ptt-103916 Puccinia triticina 38.80 4.00e-98 353.00
IUUC-Pte-104346 Pyrenophora teres 39.41 1.00e-109 391.00
IUUC-Pyt-104508 Pyrenophora triticirepentis 39.48 1.00e-109 392.00
IUUC-Rno-105315 Rattus norvegicus 93.74 0.00e+00 3338.00
IUUC-Sce-106273 Saccharomyces cerevisiae 35.00 2.00e-71 265.00
IUUC-Sha-106835 Sarcophilus harrisii 90.96 0.00e+00 3482.00
IUUC-Sja-107943 Schizosaccharomyces japonicus 37.58 1.00e-94 342.00
IUUC-Spo-108081 Schizosaccharomyces pombe 37.26 8.00e-95 342.00
IUUC-Ssl-108560 Sclerotinia sclerotiorum 40.12 2.00e-106 381.00
IUUC-Smo-108776 Selaginella moellendorffii 43.28 2.00e-112 401.00
IUUC-Sit-110717 Setaria italica 37.94 3.00e-120 427.00
IUUC-Sly-111469 Solanum lycopersicum 38.97 5.00e-122 433.00
IUUC-Stu-112896 Solanum tuberosum 38.22 7.00e-106 378.00
IUUC-Sar-113224 Sorex araneus 92.38 0.00e+00 1924.00
IUUC-Sbi-114313 Sorghum bicolor 38.02 9.00e-124 439.00
IUUC-Sre-114993 Sporisorium reilianum 34.09 2.00e-100 362.00
IUUC-Ssc-115535 Sus scrofa 93.11 0.00e+00 3422.00
IUUC-Tgu-117493 Taeniopygia guttata 89.72 0.00e+00 2648.00
IUUC-Tru-118669 Takifugu rubripes 79.67 0.00e+00 2985.00
IUUC-Tsy-119373 Tarsius syrichta 94.47 0.00e+00 1860.00
IUUC-Tni-120049 Tetraodon nigroviridis 77.25 0.00e+00 860.00
IUUC-Tca-121779 Theobroma cacao 38.76 8.00e-116 412.00
IUUC-Tre-122195 Trichoderma reesei 35.95 1.00e-105 379.00
IUUC-Tvi-122650 Trichoderma virens 36.17 5.00e-109 390.00
IUUC-Tae-123580 Triticum aestivum 38.58 1.00e-124 440.00
IUUC-Tur-126295 Triticum urartu 38.54 2.00e-125 444.00
IUUC-Tme-126964 Tuber melanosporum 40.28 2.00e-105 377.00
IUUC-Tbe-128149 Tupaia belangeri 81.85 0.00e+00 1462.00
IUUC-Ttr-128165 Tursiops truncatus 95.29 0.00e+00 3072.00
IUUC-Uma-129365 Ustilago maydis 36.07 5.00e-89 323.00
IUUC-Vda-129725 Verticillium dahliae 41.48 9.00e-110 392.00
IUUC-Vpa-130678 Vicugna pacos 99.20 0.00e+00 2695.00
IUUC-Vvi-131147 Vitis vinifera 39.09 1.00e-121 431.00
IUUC-Xtr-132636 Xenopus tropicalis 86.98 0.00e+00 3231.00
IUUC-Xma-133458 Xiphophorus maculatus 81.59 0.00e+00 3011.00
IUUC-Yli-134481 Yarrowia lipolytica 39.56 4.00e-98 353.00
IUUC-Zma-135782 Zea mays 37.87 5.00e-118 419.00
Created Date 25-Jun-2017

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