iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ago-007890

Ensembl Protein ID

AAS54512

UniProt Accession

Q750D2; Q750D2_ASHGO

Genbank Protein ID

AAS54512.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AE016820

Gene Name

AGOS_AGR023C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AGOS_AGR023C	AAS54512	AAS54512

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.10e-52	175.8	318	776
UBD/Alpha-Helix/UBA	1.80e-14	51.3	584	622

Active Site

Position(s)	Description	Evidence
327	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
730	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsn..ipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgyeqqDaqEfl 96
           +Gl NlgN+CY+NSv+Q+L+n  +++   ++l  +++++       p+++l ++l kl ++l    ++ ++ v+p +++k++++ +eefs+ +qqDa Efl
   Q: 318  CGLINLGNSCYLNSVVQVLFNggVKDWNLDMLGDFPRDVVF-----PSTNLKCQLIKLRNALKihpEKYQHGVKPASVKKCIGEDNEEFSSGRQQDAMEFL 413
           7*******************988889999999989998865.....6789999999999999888899999****************************** PP
   S: 97   aflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftke 197
           ++++d+l++++                            k ++s  +dl+++ +++++ c +c++v+ + +    l++p+ ++++  ++ l d L+s+++ 
   Q: 414  TYFIDKLDRKV--------------------------FSKASSSNPNDLMRFMVEDRLECTKCEHVKYSSQVCEILQIPLLDSND--PQFLMDRLHSYFNG 486
           ***********..........................568899999***********************************9995..579*********** PP
   S: 198  eelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefp.....leLdlspfcts.......................... 267
           e+l+    ++c++c + + a+k  +lk+ P +L ++  R+  + +++ ++k ++++ +p     ++L+ls+f ++                          
   Q: 487  ESLD----IHCPQCSEITVATKNSMLKTAPATLLINPIRI--KLQNWTPIKTSNQLFVPglrdeKRLKLSQFKAHgrqpgekifedspddnsnvpasaisf 581
           ***9....9*******************************..6677*************9999666*****999988888888887777666666666666 PP
   S: 268  ............................................peekqke.................................................. 274
                                                       p     e                                                  
   Q: 582  npdedkvisiismgfsknaalralyntgseveralnwifehmedP-----Elnaefsvpgtkkqaavvdqgaldsmvsmglaerhcrkalilndgdvtrsv 677
           666666666666666666666666555555555555555555550.....055555555555556666777777777777777777777777777777777 PP
   S: 275  ................................kkkYeLiavvvHsG.slssGHYvayvkn...ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
                                              Y L+av++H+G s++sGHYva++k+    + kW+l++D+k  +v  +e l+e ++++Y+++++r
   Q: 678  ewvfnnadnlddddtqesidppvsrdygypgdIPDYALSAVICHKGnSVQSGHYVAFIKKavdGEPKWVLYNDEKLMAVGGNENLQEIEKNGYIFIFNR 776
           777777777788888888999999999999999***************************5444555************9999999899******9976 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           dedk+  +++MGF++++al+aL +++  +e+A+++++++
   Q: 584  DEDKVISIISMGFSKNAALRALYNTGSEVERALNWIFEH 622
           799**********************************87 PP

Organism

Ashbya gossypii

Protein Sequence
(Fasta)

MCEVVKQLKI PSTIYKDDCG YCFETMINPN FGDGGPAEPE HQLNICLGCF QSFCHEHVNL 60
HQQVVRRVQQ ATHDLYLNVY KIERPKATES AEKRLKLEVQ DLSEEELYET VWSLVRINNA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGTGAGG TAGTGAAGCA ACTAAAGATC CCTAGTACCA TATATAAGGA TGATTGTGGT 60
TACTGTTTTG AAACGATGAT TAACCCCAAC TTTGGCGATG GTGGCCCTGC GGAACCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR033864--UBA2_scUBP14-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0045721--P:negative regulation of gluconeogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination

KEGG

ago:AGOS_AGR023C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	26.84	3.00e-60	224.00
IUUC-Aml-002104	Ailuropoda melanoleuca	28.65	3.00e-77	281.00
IUUC-Atr-002580	Amborella trichopoda	29.20	9.00e-39	153.00
IUUC-Apl-003774	Anas platyrhynchos	28.81	2.00e-75	275.00
IUUC-Aca-005368	Anolis carolinensis	28.36	2.00e-76	278.00
IUUC-Aly-005727	Arabidopsis lyrata	27.44	9.00e-67	246.00
IUUC-Ath-006974	Arabidopsis thaliana	26.83	4.00e-66	244.00
IUUC-Acl-008057	Aspergillus clavatus	33.50	5.00e-104	370.00
IUUC-Afl-008547	Aspergillus flavus	35.82	3.00e-99	353.00
IUUC-Afu-008805	Aspergillus fumigatus	34.44	2.00e-87	314.00
IUUC-Ani-009441	Aspergillus nidulans	33.12	4.00e-77	280.00
IUUC-Ang-009720	Aspergillus niger	32.18	3.00e-106	377.00
IUUC-Aor-010111	Aspergillus oryzae	32.69	1.00e-108	385.00
IUUC-Ate-010531	Aspergillus terreus	31.41	3.00e-91	327.00
IUUC-Ame-011470	Astyanax mexicanus	24.69	5.00e-59	220.00
IUUC-Bgr-012183	Blumeria graminis	31.17	5.00e-96	343.00
IUUC-Bta-013179	Bos taurus	28.91	2.00e-77	281.00
IUUC-Bci-013858	Botrytis cinerea	31.52	1.00e-100	358.00
IUUC-Bdi-014904	Brachypodium distachyon	26.75	1.00e-65	242.00
IUUC-Bol-015536	Brassica oleracea	27.85	1.00e-66	245.00
IUUC-Bra-017939	Brassica rapa	27.14	2.00e-66	244.00
IUUC-Cel-018625	Caenorhabditis elegans	25.45	1.00e-55	208.00
IUUC-Cja-019063	Callithrix jacchus	28.67	4.00e-76	277.00
IUUC-Cfa-020976	Canis familiaris	29.34	1.00e-79	288.00
IUUC-Cpo-022265	Cavia porcellus	29.19	8.00e-79	286.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	32.99	1.00e-36	145.00
IUUC-Csa-024177	Chlorocebus sabaeus	28.89	4.00e-69	254.00
IUUC-Cho-024702	Choloepus hoffmanni	28.73	3.00e-38	151.00
IUUC-Cin-025411	Ciona intestinalis	26.84	6.00e-62	230.00
IUUC-Csv-026347	Ciona savignyi	26.42	6.00e-57	213.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	31.10	2.00e-95	340.00
IUUC-Cne-026831	Cryptococcus neoformans	31.04	1.00e-91	328.00
IUUC-Cme-027335	Cyanidioschyzon merolae	27.41	1.00e-32	133.00
IUUC-Dre-027651	Danio rerio	25.79	1.00e-62	232.00
IUUC-Dno-029034	Dasypus novemcinctus	28.79	1.00e-77	282.00
IUUC-Dor-030130	Dipodomys ordii	26.88	9.00e-31	126.00
IUUC-Dse-031467	Dothistroma septosporum	30.02	3.00e-94	337.00
IUUC-Dme-032075	Drosophila melanogaster	28.19	2.00e-59	222.00
IUUC-Ete-032865	Echinops telfairi	26.19	4.00e-63	234.00
IUUC-Eca-034059	Equus caballus	28.87	7.00e-78	283.00
IUUC-Eeu-035304	Erinaceus europaeus	30.55	1.00e-69	255.00
IUUC-Fca-035515	Felis catus	28.97	4.00e-79	287.00
IUUC-Fal-037271	Ficedula albicollis	29.08	2.00e-71	261.00
IUUC-Fox-037745	Fusarium oxysporum	31.93	8.00e-107	379.00
IUUC-Fso-038158	Fusarium solani	31.60	9.00e-104	369.00
IUUC-Gmo-039071	Gadus morhua	27.88	4.00e-44	171.00
IUUC-Ggr-040098	Gaeumannomyces graminis	30.88	3.00e-92	330.00
IUUC-Gga-040635	Gallus gallus	28.30	1.00e-78	285.00
IUUC-Gac-042528	Gasterosteus aculeatus	26.95	2.00e-61	228.00
IUUC-Gma-043614	Glycine max	28.15	7.00e-62	229.00
IUUC-Ggo-044602	Gorilla gorilla	29.13	4.00e-79	287.00
IUUC-Hsa-045959	Homo sapiens	29.13	4.00e-79	287.00
IUUC-Hvu-047563	Hordeum vulgare	30.57	8.00e-64	235.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	28.65	2.00e-77	281.00
IUUC-Kpa-049156	Komagataella pastoris	35.46	6.00e-133	466.00
IUUC-Lch-049648	Latimeria chalumnae	27.73	5.00e-69	253.00
IUUC-Lpe-051523	Leersia perrieri	26.93	6.00e-67	246.00
IUUC-Loc-052072	Lepisosteus oculatus	26.21	1.00e-66	246.00
IUUC-Lma-053216	Leptosphaeria maculans	30.80	1.00e-90	326.00
IUUC-Laf-054327	Loxodonta africana	28.33	4.00e-78	284.00
IUUC-Mcc-055443	Macaca mulatta	29.02	9.00e-78	282.00
IUUC-Meu-056298	Macropus eugenii	30.41	3.00e-50	191.00
IUUC-Mor-057106	Magnaporthe oryzae	31.58	5.00e-103	366.00
IUUC-Mpo-057589	Magnaporthe poae	30.46	3.00e-92	330.00
IUUC-Mtr-058680	Medicago truncatula	26.69	2.00e-65	241.00
IUUC-Mla-058903	Melampsora laricipopulina	29.27	1.00e-86	312.00
IUUC-Mga-059669	Meleagris gallopavo	28.31	4.00e-73	267.00
IUUC-Mvi-060476	Microbotryum violaceum	28.30	3.00e-83	300.00
IUUC-Mmr-060575	Microcebus murinus	28.41	3.00e-77	280.00
IUUC-Mdo-062183	Monodelphis domestica	28.60	7.00e-76	276.00
IUUC-Mmu-063592	Mus musculus	28.60	4.00e-77	280.00
IUUC-Mac-065634	Musa acuminata	26.72	2.00e-31	129.00
IUUC-Mpu-066082	Mustela putorius furo	29.00	8.00e-77	279.00
IUUC-Mlu-067345	Myotis lucifugus	28.38	2.00e-75	275.00
IUUC-Nfi-068558	Neosartorya fischeri	32.81	1.00e-98	351.00
IUUC-Ncr-068960	Neurospora crassa	31.10	2.00e-92	331.00
IUUC-Nle-070173	Nomascus leucogenys	29.34	3.00e-79	287.00
IUUC-Opr-070556	Ochotona princeps	28.91	3.00e-77	281.00
IUUC-Ont-071502	Oreochromis niloticus	26.38	2.00e-63	234.00
IUUC-Oan-072959	Ornithorhynchus anatinus	30.22	2.00e-23	99.80
IUUC-Ocu-074861	Oryctolagus cuniculus	28.77	4.00e-77	280.00
IUUC-Oba-075109	Oryza barthii	27.37	1.00e-67	249.00
IUUC-Obr-076292	Oryza brachyantha	27.92	6.00e-62	229.00
IUUC-Ogl-077065	Oryza glaberrima	27.95	1.00e-71	262.00
IUUC-Ogu-078776	Oryza glumaepatula	27.61	2.00e-68	251.00
IUUC-Oin-080048	Oryza indica	27.83	7.00e-69	253.00
IUUC-Olo-080711	Oryza longistaminata	26.59	4.00e-62	230.00
IUUC-Ome-081506	Oryza meridionalis	27.41	2.00e-64	238.00
IUUC-Oni-082320	Oryza nivara	26.77	1.00e-65	242.00
IUUC-Opu-083801	Oryza punctata	27.01	3.00e-64	237.00
IUUC-Oru-085139	Oryza rufipogon	26.88	3.00e-65	241.00
IUUC-Osa-085713	Oryza sativa	27.95	9.00e-72	262.00
IUUC-Ola-086951	Oryzias latipes	26.29	2.00e-55	208.00
IUUC-Olu-087822	Ostreococcus lucimarinus	29.22	5.00e-59	220.00
IUUC-Oga-088625	Otolemur garnettii	28.89	2.00e-76	278.00
IUUC-Oar-089995	Ovis aries	28.87	6.00e-77	280.00
IUUC-Ptr-090640	Pan troglodytes	29.79	5.00e-81	293.00
IUUC-Pan-091974	Papio anubis	28.89	6.00e-77	280.00
IUUC-Psi-093957	Pelodiscus sinensis	27.41	2.00e-75	275.00
IUUC-Pma-094242	Petromyzon marinus	30.61	1.00e-35	141.00
IUUC-Pno-094835	Phaeosphaeria nodorum	33.12	2.00e-78	285.00
IUUC-Ppa-095901	Physcomitrella patens	27.68	2.00e-65	241.00
IUUC-Pfo-097148	Poecilia formosa	26.79	1.00e-59	222.00
IUUC-Pab-098068	Pongo abelii	27.37	2.00e-63	234.00
IUUC-Pop-098943	Populus trichocarpa	26.64	9.00e-63	233.00
IUUC-Pca-100738	Procavia capensis	28.91	3.00e-52	197.00
IUUC-Ppe-101315	Prunus persica	27.99	4.00e-65	240.00
IUUC-Pva-102154	Pteropus vampyrus	28.35	1.00e-74	272.00
IUUC-Pgr-103343	Puccinia graminis	29.45	6.00e-70	256.00
IUUC-Ptt-103928	Puccinia triticina	25.83	3.00e-64	237.00
IUUC-Pte-104306	Pyrenophora teres	30.88	3.00e-81	294.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	30.98	5.00e-84	303.00
IUUC-Rno-105801	Rattus norvegicus	28.72	4.00e-77	280.00
IUUC-Sce-106304	Saccharomyces cerevisiae	48.93	0.00e+00	723.00
IUUC-Sha-107635	Sarcophilus harrisii	28.93	4.00e-78	283.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.53	1.00e-94	338.00
IUUC-Spo-108144	Schizosaccharomyces pombe	31.20	4.00e-95	340.00
IUUC-Smo-108703	Selaginella moellendorffii	28.43	1.00e-64	239.00
IUUC-Sit-110728	Setaria italica	26.75	3.00e-68	251.00
IUUC-Sly-111523	Solanum lycopersicum	28.23	1.00e-72	265.00
IUUC-Sar-113733	Sorex araneus	27.85	2.00e-29	121.00
IUUC-Sbi-114419	Sorghum bicolor	26.87	6.00e-65	239.00
IUUC-Sre-115225	Sporisorium reilianum	30.22	2.00e-85	308.00
IUUC-Ssc-115686	Sus scrofa	28.54	7.00e-77	280.00
IUUC-Tgu-117346	Taeniopygia guttata	27.93	3.00e-75	274.00
IUUC-Tru-118350	Takifugu rubripes	27.80	5.00e-44	170.00
IUUC-Tsy-119278	Tarsius syrichta	24.22	1.00e-44	172.00
IUUC-Tni-120658	Tetraodon nigroviridis	28.10	3.00e-39	154.00
IUUC-Tca-121585	Theobroma cacao	26.29	2.00e-61	228.00
IUUC-Tre-122043	Trichoderma reesei	31.55	4.00e-99	353.00
IUUC-Tvi-122303	Trichoderma virens	31.46	4.00e-104	370.00
IUUC-Tae-123798	Triticum aestivum	27.37	1.00e-68	252.00
IUUC-Tur-126732	Triticum urartu	26.70	6.00e-62	229.00
IUUC-Tme-126909	Tuber melanosporum	31.77	2.00e-101	361.00
IUUC-Tbe-127261	Tupaia belangeri	25.75	1.00e-37	149.00
IUUC-Ttr-128295	Tursiops truncatus	23.18	1.00e-43	169.00
IUUC-Uma-129599	Ustilago maydis	30.64	5.00e-92	330.00
IUUC-Vda-129688	Verticillium dahliae	31.98	1.00e-101	362.00
IUUC-Vpa-130170	Vicugna pacos	22.86	2.00e-34	138.00
IUUC-Vvi-131116	Vitis vinifera	26.88	2.00e-60	224.00
IUUC-Xtr-131953	Xenopus tropicalis	28.23	8.00e-65	239.00
IUUC-Xma-133837	Xiphophorus maculatus	27.01	1.00e-59	222.00
IUUC-Yli-134510	Yarrowia lipolytica	30.78	5.00e-96	343.00
IUUC-Zma-135786	Zea mays	26.31	1.00e-58	219.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence