iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tca-121491

Ensembl Protein ID

EOY01476

UniProt Accession

A0A061E937; A0A061E937_THECC

Genbank Protein ID

EOY01476.1

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

CM001880

Gene Name

TCM_011349

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TCM_011349	EOY01476	EOY01476

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	4.20e-115	386.2	8	514

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitele 101
           YDRQ+r+wGe++q++l++a+++l+++g++G+E+lKnLvl+Gvgsit+vD+++ve+ +l+++F++++++ g+sKA++++ +l+eln+ v++++ ee +++l 
   Q: 8    YDRQLRIWGEQGQAALEKASICLLNCGPTGSETLKNLVLGGVGSITIVDGSKVELGDLGNNFMVDESSLGQSKAKCVCSFLQELNDAVKAKFIEEYPEALI 108
           ***************************************************************************************************** PP
   S: 102  eeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfctlketpn.........aaehtiew 189
           ++++ Ff++f++Vv+++  +e++ k++r+c++a+v li ++++Gl G vr+++k++ +++s++d   d++++++P+++l+ + +         +a+++i++
   Q: 109  DTNPsFFSQFTLVVATQLVEESMVKLDRICREANVMLIFARSYGLTGLVRISVKEHAVIESKPDhflDDLRLNNPWPELRGFAEaidlnvqdpVAHKHIPY 209
           **********************************************************************************98899999999******** PP
   S: 190  avlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv............... 274
           +v++ k+++e+ +++ ++ ++++eek+e+k++ k++++++de+n++eai +++k fa++ i+s  +q++ + +c++v +++s+fwv               
   Q: 210  VVILVKMADEWIKSHGGSLPSTREEKREFKELLKARMVAMDEDNYKEAIDASFKVFAPRGISSdLQQIIID-SCAEVASNSSDFWVmvaalkefianeggg 309
           ***************************************************************99999888.9**************************** PP
   S: 275  ............................................................sfcsnaealq...........vpekvekdeevvkasap... 301
                                                                       sfc+na++l+            +++  + +++++++++   
   Q: 310  eaplegsipdmtsstehyvnlqkiyqakseadflviekrvrnilkkigrdpnsipkatikSFCKNARKLKvcryrliedeyNNPSLPELQKYLTDEDYsia 410
           **********************************************************************77777777777669999999999999999** PP
   S: 302  ..lylllralerfekkkgrkpgelsfekdddsavdlvtaaanlraeslgiep.kldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknff 399
             +y+llra++r +++ ++ pg+++  +d+d + +l+t+a  l   ++g+++  l++dli e++++++++++ ++a++gG+a+qEviK+++++f+p+  ++
   Q: 411  vgFYILLRAVDRYAANFNSFPGQFDGGMDED-ISRLKTTAVGLL-NDFGCNGlTLTEDLINEMCRFGAAELHAVAAFIGGIASQEVIKLITKQFVPMSGTY 509
           *******************************.******999998.******************************************************** PP
   S: 400  lfdae 404
           +f+++
   Q: 510  VFNGI 514
           99986 PP

Organism

Theobroma cacao

Functional Description
(View)

Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.

Protein Sequence
(Fasta)

MAEPKTKYDR QLRIWGEQGQ AALEKASICL LNCGPTGSET LKNLVLGGVG SITIVDGSKV 60
ELGDLGNNFM VDESSLGQSK AKCVCSFLQE LNDAVKAKFI EEYPEALIDT NPSFFSQFTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTTGTAAA ACACACCGTT GCACTAATTG ACAGCCTCGG CGTTGTCCTC AAAACGCACA 60
CGGACAGTGC GTGGACTGTA ACTGTGCGTA GTAAGCAAGC GAAGAAGCAA TTAAGTTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	68.06	0.00e+00	759.00
IUUC-Aml-002333	Ailuropoda melanoleuca	40.82	2.00e-124	438.00
IUUC-Atr-002644	Amborella trichopoda	75.91	0.00e+00	811.00
IUUC-Apl-003446	Anas platyrhynchos	39.66	2.00e-114	405.00
IUUC-Aca-004450	Anolis carolinensis	38.97	2.00e-120	425.00
IUUC-Aly-005466	Arabidopsis lyrata	79.77	0.00e+00	897.00
IUUC-Ath-006692	Arabidopsis thaliana	80.53	0.00e+00	907.00
IUUC-Ago-007900	Ashbya gossypii	27.32	1.00e-38	153.00
IUUC-Acl-008333	Aspergillus clavatus	32.54	6.00e-72	264.00
IUUC-Afl-008529	Aspergillus flavus	33.33	7.00e-79	287.00
IUUC-Afu-009071	Aspergillus fumigatus	32.97	3.00e-72	265.00
IUUC-Ani-009443	Aspergillus nidulans	31.08	5.00e-67	248.00
IUUC-Ang-009669	Aspergillus niger	31.72	1.00e-75	276.00
IUUC-Aor-009914	Aspergillus oryzae	32.97	2.00e-77	282.00
IUUC-Ate-010450	Aspergillus terreus	34.12	3.00e-78	285.00
IUUC-Ame-011183	Astyanax mexicanus	38.99	2.00e-120	425.00
IUUC-Bgr-012111	Blumeria graminis	33.40	4.00e-64	238.00
IUUC-Bta-012583	Bos taurus	40.60	7.00e-125	440.00
IUUC-Bci-013892	Botrytis cinerea	31.75	3.00e-60	225.00
IUUC-Bdi-014592	Brachypodium distachyon	68.33	0.00e+00	760.00
IUUC-Bol-016399	Brassica oleracea	81.07	0.00e+00	913.00
IUUC-Bra-018084	Brassica rapa	77.82	0.00e+00	850.00
IUUC-Cel-018456	Caenorhabditis elegans	31.04	3.00e-72	265.00
IUUC-Cja-020007	Callithrix jacchus	40.74	4.00e-124	437.00
IUUC-Cfa-020324	Canis familiaris	40.97	3.00e-126	444.00
IUUC-Cpo-022248	Cavia porcellus	35.55	9.00e-66	243.00
IUUC-Csa-023149	Chlorocebus sabaeus	38.02	3.00e-96	344.00
IUUC-Cho-024537	Choloepus hoffmanni	34.48	9.00e-85	306.00
IUUC-Cin-025763	Ciona intestinalis	40.98	2.00e-114	405.00
IUUC-Csv-026113	Ciona savignyi	40.55	5.00e-110	390.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.27	5.00e-58	218.00
IUUC-Cne-026884	Cryptococcus neoformans	33.08	4.00e-71	261.00
IUUC-Cme-027210	Cyanidioschyzon merolae	23.04	6.00e-13	68.60
IUUC-Dre-028140	Danio rerio	40.49	2.00e-125	441.00
IUUC-Dno-030033	Dasypus novemcinctus	39.74	2.00e-105	375.00
IUUC-Dor-030513	Dipodomys ordii	34.26	2.00e-36	145.00
IUUC-Dse-031536	Dothistroma septosporum	31.35	1.00e-67	250.00
IUUC-Dme-031683	Drosophila melanogaster	38.27	3.00e-101	361.00
IUUC-Ete-032420	Echinops telfairi	36.54	6.00e-108	383.00
IUUC-Eca-033992	Equus caballus	38.57	1.00e-95	342.00
IUUC-Eeu-034713	Erinaceus europaeus	32.52	1.00e-37	150.00
IUUC-Fca-036548	Felis catus	40.41	7.00e-125	439.00
IUUC-Fal-037600	Ficedula albicollis	40.15	7.00e-115	406.00
IUUC-Fox-038037	Fusarium oxysporum	30.63	5.00e-64	238.00
IUUC-Fso-038387	Fusarium solani	32.01	2.00e-66	245.00
IUUC-Gmo-038562	Gadus morhua	38.45	3.00e-117	414.00
IUUC-Ggr-040005	Gaeumannomyces graminis	33.15	2.00e-64	239.00
IUUC-Gga-041129	Gallus gallus	39.59	9.00e-117	413.00
IUUC-Gac-042558	Gasterosteus aculeatus	39.77	2.00e-120	424.00
IUUC-Gma-043610	Glycine max	87.38	0.00e+00	937.00
IUUC-Ggo-045611	Gorilla gorilla	40.83	9.00e-123	432.00
IUUC-Hsa-046563	Homo sapiens	41.06	5.00e-124	437.00
IUUC-Hvu-047790	Hordeum vulgare	65.30	2.00e-155	541.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	40.97	9.00e-125	439.00
IUUC-Kpa-049309	Komagataella pastoris	35.37	8.00e-75	273.00
IUUC-Lch-050038	Latimeria chalumnae	39.47	2.00e-118	418.00
IUUC-Lpe-051535	Leersia perrieri	68.02	0.00e+00	684.00
IUUC-Loc-051917	Lepisosteus oculatus	36.98	2.00e-107	382.00
IUUC-Lma-053112	Leptosphaeria maculans	33.16	6.00e-77	280.00
IUUC-Laf-053690	Loxodonta africana	41.53	6.00e-126	443.00
IUUC-Mcc-055117	Macaca mulatta	39.74	9.00e-120	422.00
IUUC-Meu-056761	Macropus eugenii	32.72	1.00e-87	316.00
IUUC-Mor-057230	Magnaporthe oryzae	33.27	2.00e-66	246.00
IUUC-Mpo-057514	Magnaporthe poae	32.55	8.00e-63	233.00
IUUC-Mtr-058551	Medicago truncatula	80.15	0.00e+00	867.00
IUUC-Mla-059183	Melampsora laricipopulina	35.28	3.00e-88	318.00
IUUC-Mga-060144	Meleagris gallopavo	39.20	2.00e-113	401.00
IUUC-Mvi-060221	Microbotryum violaceum	32.06	9.00e-72	263.00
IUUC-Mmr-061325	Microcebus murinus	39.44	3.00e-120	424.00
IUUC-Mdo-062532	Monodelphis domestica	41.13	4.00e-124	437.00
IUUC-Mmu-063956	Mus musculus	40.41	7.00e-125	440.00
IUUC-Mac-064521	Musa acuminata	73.80	0.00e+00	822.00
IUUC-Mpu-066716	Mustela putorius furo	40.00	6.00e-115	407.00
IUUC-Mlu-067459	Myotis lucifugus	41.35	6.00e-126	443.00
IUUC-Nfi-068245	Neosartorya fischeri	33.03	2.00e-72	265.00
IUUC-Ncr-068910	Neurospora crassa	33.89	1.00e-69	256.00
IUUC-Nle-070034	Nomascus leucogenys	39.62	5.00e-118	417.00
IUUC-Opr-070552	Ochotona princeps	37.30	1.00e-95	343.00
IUUC-Ont-071426	Oreochromis niloticus	39.36	7.00e-123	433.00
IUUC-Oan-073389	Ornithorhynchus anatinus	37.89	8.00e-89	320.00
IUUC-Ocu-074911	Oryctolagus cuniculus	40.97	7.00e-126	443.00
IUUC-Oba-075437	Oryza barthii	70.44	0.00e+00	738.00
IUUC-Obr-076684	Oryza brachyantha	69.94	0.00e+00	696.00
IUUC-Ogl-077170	Oryza glaberrima	70.44	0.00e+00	738.00
IUUC-Ogu-078844	Oryza glumaepatula	69.56	0.00e+00	686.00
IUUC-Oin-079105	Oryza indica	70.25	0.00e+00	735.00
IUUC-Olo-080943	Oryza longistaminata	67.81	0.00e+00	665.00
IUUC-Oni-082891	Oryza nivara	68.14	0.00e+00	710.00
IUUC-Opu-083457	Oryza punctata	70.44	0.00e+00	738.00
IUUC-Oru-084960	Oryza rufipogon	67.74	0.00e+00	667.00
IUUC-Osa-085358	Oryza sativa	70.06	0.00e+00	731.00
IUUC-Ola-086420	Oryzias latipes	36.70	2.00e-77	281.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.16	9.00e-62	230.00
IUUC-Oga-088810	Otolemur garnettii	40.78	4.00e-125	441.00
IUUC-Oar-089196	Ovis aries	40.37	3.00e-123	434.00
IUUC-Ptr-090617	Pan troglodytes	41.06	4.00e-124	437.00
IUUC-Pan-092761	Papio anubis	40.78	3.00e-125	441.00
IUUC-Psi-093191	Pelodiscus sinensis	39.04	1.00e-118	419.00
IUUC-Pma-094380	Petromyzon marinus	40.08	6.00e-110	390.00
IUUC-Pno-095084	Phaeosphaeria nodorum	33.21	5.00e-66	245.00
IUUC-Ppa-095798	Physcomitrella patens	56.58	0.00e+00	646.00
IUUC-Pfo-096467	Poecilia formosa	39.51	2.00e-118	419.00
IUUC-Pab-098255	Pongo abelii	40.27	9.00e-101	359.00
IUUC-Pop-099722	Populus trichocarpa	86.62	0.00e+00	959.00
IUUC-Pca-100807	Procavia capensis	50.27	1.00e-51	196.00
IUUC-Ppe-101280	Prunus persica	88.15	0.00e+00	973.00
IUUC-Pva-102333	Pteropus vampyrus	39.44	2.00e-117	415.00
IUUC-Pgr-103401	Puccinia graminis	28.71	4.00e-72	264.00
IUUC-Ptt-103889	Puccinia triticina	27.37	4.00e-61	228.00
IUUC-Pte-104355	Pyrenophora teres	33.15	4.00e-74	271.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	33.82	7.00e-75	273.00
IUUC-Rno-105810	Rattus norvegicus	40.49	7.00e-124	436.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.74	1.00e-29	123.00
IUUC-Sha-106770	Sarcophilus harrisii	45.76	6.00e-69	253.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.00	1.00e-76	279.00
IUUC-Spo-108276	Schizosaccharomyces pombe	32.44	8.00e-84	303.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	32.11	7.00e-59	220.00
IUUC-Smo-109296	Selaginella moellendorffii	53.18	7.00e-165	572.00
IUUC-Sit-110157	Setaria italica	70.36	0.00e+00	802.00
IUUC-Sly-111105	Solanum lycopersicum	77.47	0.00e+00	884.00
IUUC-Stu-112469	Solanum tuberosum	78.58	0.00e+00	897.00
IUUC-Sar-113083	Sorex araneus	38.65	6.00e-43	167.00
IUUC-Sbi-113813	Sorghum bicolor	69.22	0.00e+00	794.00
IUUC-Sre-115058	Sporisorium reilianum	32.96	4.00e-63	234.00
IUUC-Tgu-116772	Taeniopygia guttata	40.75	3.00e-115	407.00
IUUC-Tru-118686	Takifugu rubripes	38.61	5.00e-122	430.00
IUUC-Tsy-119111	Tarsius syrichta	41.91	5.00e-59	221.00
IUUC-Tni-120231	Tetraodon nigroviridis	36.26	2.00e-105	375.00
IUUC-Tre-122103	Trichoderma reesei	33.08	3.00e-69	255.00
IUUC-Tvi-122672	Trichoderma virens	32.90	1.00e-66	246.00
IUUC-Tae-125316	Triticum aestivum	68.91	0.00e+00	766.00
IUUC-Tur-126487	Triticum urartu	67.31	0.00e+00	737.00
IUUC-Tme-127097	Tuber melanosporum	33.89	1.00e-77	283.00
IUUC-Ttr-128465	Tursiops truncatus	38.33	1.00e-111	396.00
IUUC-Uma-129645	Ustilago maydis	31.57	1.00e-69	256.00
IUUC-Vda-129989	Verticillium dahliae	28.91	7.00e-49	187.00
IUUC-Vpa-130529	Vicugna pacos	38.89	1.00e-114	405.00
IUUC-Vvi-131059	Vitis vinifera	88.91	0.00e+00	969.00
IUUC-Xtr-132002	Xenopus tropicalis	40.68	5.00e-125	440.00
IUUC-Xma-133930	Xiphophorus maculatus	39.43	1.00e-120	426.00
IUUC-Yli-134505	Yarrowia lipolytica	33.59	2.00e-82	298.00
IUUC-Zma-135619	Zea mays	68.83	0.00e+00	752.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence