iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt	PHOSIDA
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-15	55.8	113	170

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++  +lyd+e++nd+eL l +Gd+v++   +++ +gWl++++e   k Gl+Pe Fv  ++
   Q: 113  QRAVALYDFEPENDNELRLAEGDIVFIS--YKHGQGWLVAENESGSKTGLVPEEFVSYIQ 170
           56789**********************7..**************************8775 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Negatively regulates the high-osmolarity glycerol (HOG) pathway through its negative regulation of the HOG1 kinase activity. Mediates the binding between the PTC1 phosphatase and the PBS2 MAP/ERK kinase (MEK). With PTC1, regulates endoplasmic reticulum inheritance through the cell wall integrity (CWI) MAPK pathway by modulating the MAPK, SLT2.

Protein Sequence
(Fasta)

MATMETTTQK DTNILKSGLK KTIGVLNEAV LQNGREVEAV QAGNSDTMED TETTTIGYIS 60
IKDYAYADSN PLHYGYFDGD NEEDEMVSDS SNGEDTYNKR QSITLPDDYI VNQRAVALYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCAACGA TGGAAACGAC CACACAAAAA GATACCAATA TTTTGAAATC TGGTCTCAAA 60
AAAACTATAG GTGTTCTCAA TGAGGCAGTA TTACAGAACG GGAGAGAGGT GGAGGCAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR001452--SH3_domain

PROSITE

PS50002--SH3

Pfam

PF00018--SH3_1

SMART

SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030674--F:protein binding, bridging
GO:0006972--P:hyperosmotic response
GO:0000200--P:inactivation of MAPK activity involved in cell wall organization or biogenesis
GO:0000173--P:inactivation of MAPK activity involved in osmosensory signaling pathway
GO:0006469--P:negative regulation of protein kinase activity
GO:0009408--P:response to heat

KEGG

sce:YDR162C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007885	Ashbya gossypii	48.86	1.00e-41	160.00
IUUC-Acl-008309	Aspergillus clavatus	44.57	4.00e-18	84.00
IUUC-Afl-008685	Aspergillus flavus	32.95	1.00e-18	84.70
IUUC-Afu-008858	Aspergillus fumigatus	50.72	2.00e-17	82.00
IUUC-Ani-009346	Aspergillus nidulans	52.17	7.00e-18	82.80
IUUC-Ang-009589	Aspergillus niger	50.72	2.00e-17	81.60
IUUC-Aor-009976	Aspergillus oryzae	41.28	3.00e-18	84.70
IUUC-Ate-010396	Aspergillus terreus	40.37	4.00e-18	83.60
IUUC-Bgr-012179	Blumeria graminis	53.33	1.00e-16	79.00
IUUC-Bci-013764	Botrytis cinerea	52.17	2.00e-17	82.00
IUUC-Cel-018555	Caenorhabditis elegans	37.29	6.00e-06	42.70
IUUC-Cgl-026608	Colletotrichum gloeosporioides	55.07	3.00e-18	84.00
IUUC-Dse-031484	Dothistroma septosporum	58.93	2.00e-17	77.80
IUUC-Fox-037916	Fusarium oxysporum	55.07	5.00e-18	84.00
IUUC-Fso-038233	Fusarium solani	55.07	5.00e-18	84.00
IUUC-Itr-048265	Ictidomys tridecemlineatus	38.33	2.00e-07	48.50
IUUC-Kpa-049230	Komagataella pastoris	40.52	5.00e-18	81.30
IUUC-Lma-053062	Leptosphaeria maculans	50.72	5.00e-17	80.50
IUUC-Nfi-068582	Neosartorya fischeri	46.91	1.00e-17	82.40
IUUC-Pno-094868	Phaeosphaeria nodorum	50.72	5.00e-17	80.50
IUUC-Pte-104168	Pyrenophora teres	50.72	5.00e-17	80.50
IUUC-Pyt-104443	Pyrenophora triticirepentis	50.72	4.00e-17	80.50
IUUC-Sja-107776	Schizosaccharomyces japonicus	38.89	2.00e-14	69.30
IUUC-Spo-108159	Schizosaccharomyces pombe	31.54	3.00e-11	58.90
IUUC-Ssl-108447	Sclerotinia sclerotiorum	52.17	2.00e-17	82.00
IUUC-Tre-122250	Trichoderma reesei	55.07	2.00e-18	84.30
IUUC-Tvi-122478	Trichoderma virens	55.07	3.00e-18	84.00
IUUC-Vda-129961	Verticillium dahliae	55.07	4.00e-18	84.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence