iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000101332.1	ENSDART00000171801.1	ENSDARP00000139796.1
ENSDARG00000101332.1	ENSDART00000166411.1	ENSDARP00000140060.1
ENSDARG00000101332.1	ENSDART00000169126.1	ENSDARP00000130924.1
ENSDARG00000101332.1	ENSDART00000168044.1	ENSDARP00000133087.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.90e-126	422.5	13	426

Active Site

Position(s)	Description	Evidence
174	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 13   qeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnveaheesitele 101
            ++l+s++vl+vGagg+GcEllKnLvl+G+++i+v+D dt++vsnlnrqFLf++++vgksKA+va+e++ +++p+ n++a+++si++++
   Q: 13   ADSLSSCRVLVVGAGGIGCELLKNLVLTGFKNIEVIDLDTIDVSNLNRQFLFQKKHVGKSKAQVAKESVLRFCPSANITAYHDSIMNPD 101
           6899************************************************************************************* PP
   S: 102  eeivFfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaaehtiewa 190
           ++++Ff++f++V++aldnr+ar++vnr+cl+a++pliesgt G+lGqv+vi kg tecy+c+++p+qkt+P+ct+++tp+++ h+i+wa
   Q: 102  YNVEFFRNFQLVMNALDNRAARNHVNRMCLAADIPLIESGTAGYLGQVTVIKKGQTECYECQPKPTQKTFPGCTIRNTPSEPIHCIVWA 190
           ***************************************************************************************** PP
   S: 191  .vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttins.ikqllksfecdivtkskspfwv... 274
            +lfn+l++ee++++ev+++  ++++e+++++  +++++++++++ +++++++k++a++t ++ ik + k  +     +++sp +    
   Q: 191  kYLFNQLFGEEDADQEVSPD--TADPEAAWNPADAAARATASDQDGDIKRVSTKEWARSTGYDpIKLFNKVSAL----SQTSPYLFkdd 273
           *******************5..68******************************************99987333....33444444555 PP
   S: 275  .......................sfcsnaealqvpekvekdeevvkasap...lylllralerfekkkgrkpgelsfekdddsavdlvt 337
                                  +  ++ ++ qv  +++kd++v+ ++ +   ++  +++l++  k+kg   +el ++kdd+ a+d+vt
   Q: 274  imylltmdklwkkrkaplpleweEINQLGSQEQVIGSGLKDQQVLGVQGYaqlFQHSVETLRSQLKEKGDG-AELVWDKDDPPAMDFVT 361
           55555555555*********999999999999999*************99777666666666666666665.499************** PP
   S: 338  aaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfda 403
           aa+nlr+  +++++  +++++k++agniipaiattnav++Gl+++E++K+++ +fe+++++fl+++
   Q: 362  AASNLRMNVFSMNM-KSRFDVKSMAGNIIPAIATTNAVIAGLIVLEALKILNSDFEQCRTIFLNKQ 426
           **************.***********************************************9965 PP

Organism

Danio rerio

Functional Description
(View)

The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

Protein Sequence
(Fasta)

MAELVGPLRK QLADSLSSCR VLVVGAGGIG CELLKNLVLT GFKNIEVIDL DTIDVSNLNR 60
QFLFQKKHVG KSKAQVAKES VLRFCPSANI TAYHDSIMNP DYNVEFFRNF QLVMNALDNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCCTCGCG CTTTTTAGCA GTCTCTGCGC ATGCGCACCC ACTTCCCTCC CCGCAGGATC 60
AAACCGCTGC TCGTCCGCGC GCCGCCGAAA CGCTGAGCCG ACAATGGCAG AACTAGTCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR016040--NAD(P)-bd_dom
IPR030661--SAE2/Uba2
IPR000594--ThiF_NAD_FAD-bd
IPR028077--UAE_UbL_dom
IPR032426--UBA2_C
IPR033127--UBQ-activ_enz_E1_Cys_AS

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF00899--ThiF
PF14732--UAE_UbL
PF16195--UBA2_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0019948--F:SUMO activating enzyme activity
GO:0016925--P:protein sumoylation

KEGG

dre:406672

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000112	Aegilops tauschii	39.78	3.00e-108	385.00
IUUC-Aml-001662	Ailuropoda melanoleuca	75.94	0.00e+00	914.00
IUUC-Atr-002636	Amborella trichopoda	40.85	7.00e-114	404.00
IUUC-Apl-003369	Anas platyrhynchos	77.10	0.00e+00	850.00
IUUC-Aca-004490	Anolis carolinensis	75.00	0.00e+00	804.00
IUUC-Aly-006359	Arabidopsis lyrata	40.18	3.00e-103	369.00
IUUC-Ath-007667	Arabidopsis thaliana	40.00	6.00e-106	378.00
IUUC-Ago-007844	Ashbya gossypii	37.15	1.00e-81	297.00
IUUC-Acl-008270	Aspergillus clavatus	43.53	4.00e-109	388.00
IUUC-Afl-008674	Aspergillus flavus	42.34	8.00e-112	397.00
IUUC-Afu-008883	Aspergillus fumigatus	42.29	8.00e-108	384.00
IUUC-Ani-009500	Aspergillus nidulans	45.14	2.00e-113	402.00
IUUC-Ang-009535	Aspergillus niger	41.27	4.00e-107	382.00
IUUC-Aor-010223	Aspergillus oryzae	43.11	3.00e-113	402.00
IUUC-Ate-010282	Aspergillus terreus	38.64	3.00e-91	329.00
IUUC-Ame-011736	Astyanax mexicanus	88.68	0.00e+00	1090.00
IUUC-Bgr-012166	Blumeria graminis	41.84	8.00e-99	354.00
IUUC-Bta-012589	Bos taurus	76.14	0.00e+00	918.00
IUUC-Bci-013802	Botrytis cinerea	42.29	3.00e-99	356.00
IUUC-Bdi-014697	Brachypodium distachyon	39.56	3.00e-111	395.00
IUUC-Bol-016315	Brassica oleracea	38.41	3.00e-109	389.00
IUUC-Bra-017009	Brassica rapa	38.19	2.00e-109	389.00
IUUC-Cel-018708	Caenorhabditis elegans	43.56	9.00e-131	460.00
IUUC-Cja-019120	Callithrix jacchus	74.88	0.00e+00	911.00
IUUC-Cfa-021061	Canis familiaris	75.65	0.00e+00	913.00
IUUC-Cpo-021842	Cavia porcellus	75.86	0.00e+00	908.00
IUUC-Csa-024104	Chlorocebus sabaeus	76.35	0.00e+00	904.00
IUUC-Cho-024332	Choloepus hoffmanni	70.68	0.00e+00	707.00
IUUC-Cin-025363	Ciona intestinalis	60.76	0.00e+00	687.00
IUUC-Cgl-026419	Colletotrichum gloeosporioides	39.13	1.00e-94	340.00
IUUC-Cne-026888	Cryptococcus neoformans	48.67	5.00e-70	259.00
IUUC-Cme-027315	Cyanidioschyzon merolae	46.50	1.00e-51	198.00
IUUC-Dno-030041	Dasypus novemcinctus	75.82	0.00e+00	907.00
IUUC-Dor-031039	Dipodomys ordii	65.36	3.00e-131	462.00
IUUC-Dse-031504	Dothistroma septosporum	38.12	2.00e-95	343.00
IUUC-Dme-031771	Drosophila melanogaster	49.19	2.00e-146	513.00
IUUC-Ete-033037	Echinops telfairi	70.28	0.00e+00	799.00
IUUC-Eca-033774	Equus caballus	75.97	0.00e+00	892.00
IUUC-Eeu-035074	Erinaceus europaeus	73.16	0.00e+00	691.00
IUUC-Fca-036508	Felis catus	76.13	0.00e+00	894.00
IUUC-Fal-036813	Ficedula albicollis	75.97	0.00e+00	872.00
IUUC-Fox-038056	Fusarium oxysporum	42.41	5.00e-102	365.00
IUUC-Fso-038223	Fusarium solani	43.25	8.00e-103	367.00
IUUC-Gmo-038526	Gadus morhua	80.06	0.00e+00	956.00
IUUC-Ggr-039767	Gaeumannomyces graminis	42.61	5.00e-96	345.00
IUUC-Gga-040981	Gallus gallus	76.73	0.00e+00	876.00
IUUC-Gac-041437	Gasterosteus aculeatus	80.31	0.00e+00	984.00
IUUC-Gma-044072	Glycine max	38.88	5.00e-112	398.00
IUUC-Ggo-045358	Gorilla gorilla	73.26	0.00e+00	853.00
IUUC-Hsa-046068	Homo sapiens	76.35	0.00e+00	903.00
IUUC-Hvu-047646	Hordeum vulgare	39.29	7.00e-110	391.00
IUUC-Itr-047887	Ictidomys tridecemlineatus	75.82	0.00e+00	909.00
IUUC-Lch-049565	Latimeria chalumnae	77.86	0.00e+00	967.00
IUUC-Lpe-050884	Leersia perrieri	41.13	4.00e-110	392.00
IUUC-Loc-052493	Lepisosteus oculatus	78.93	0.00e+00	977.00
IUUC-Lma-053117	Leptosphaeria maculans	46.14	2.00e-98	353.00
IUUC-Laf-054518	Loxodonta africana	73.28	0.00e+00	896.00
IUUC-Mcc-055334	Macaca mulatta	76.35	0.00e+00	904.00
IUUC-Mor-057137	Magnaporthe oryzae	41.70	4.00e-87	315.00
IUUC-Mpo-057449	Magnaporthe poae	39.59	1.00e-96	347.00
IUUC-Mtr-058045	Medicago truncatula	39.57	7.00e-115	407.00
IUUC-Mla-058864	Melampsora laricipopulina	44.65	4.00e-92	332.00
IUUC-Mga-059422	Meleagris gallopavo	73.60	0.00e+00	787.00
IUUC-Mvi-060536	Microbotryum violaceum	39.53	3.00e-85	309.00
IUUC-Mmr-061161	Microcebus murinus	75.32	0.00e+00	907.00
IUUC-Mdo-061802	Monodelphis domestica	76.80	0.00e+00	910.00
IUUC-Mmu-064357	Mus musculus	76.30	0.00e+00	942.00
IUUC-Mac-065475	Musa acuminata	39.76	1.00e-111	397.00
IUUC-Mpu-066895	Mustela putorius furo	75.98	0.00e+00	915.00
IUUC-Mlu-067862	Myotis lucifugus	74.92	0.00e+00	927.00
IUUC-Nfi-068385	Neosartorya fischeri	44.22	5.00e-112	398.00
IUUC-Ncr-068885	Neurospora crassa	40.88	1.00e-102	367.00
IUUC-Nle-069524	Nomascus leucogenys	75.98	0.00e+00	892.00
IUUC-Opr-071038	Ochotona princeps	75.43	0.00e+00	934.00
IUUC-Ont-071719	Oreochromis niloticus	82.03	0.00e+00	1035.00
IUUC-Oan-072877	Ornithorhynchus anatinus	80.26	0.00e+00	835.00
IUUC-Ocu-074080	Oryctolagus cuniculus	76.52	0.00e+00	905.00
IUUC-Oba-075936	Oryza barthii	39.87	2.00e-112	400.00
IUUC-Obr-076841	Oryza brachyantha	39.83	6.00e-113	401.00
IUUC-Ogl-077686	Oryza glaberrima	39.64	2.00e-113	403.00
IUUC-Ogu-078597	Oryza glumaepatula	38.89	3.00e-109	389.00
IUUC-Oin-079791	Oryza indica	39.87	2.00e-112	400.00
IUUC-Olo-081009	Oryza longistaminata	39.87	2.00e-112	400.00
IUUC-Ome-081327	Oryza meridionalis	37.13	6.00e-106	378.00
IUUC-Oni-082334	Oryza nivara	39.08	1.00e-109	390.00
IUUC-Opu-083447	Oryza punctata	39.87	1.00e-113	404.00
IUUC-Oru-084977	Oryza rufipogon	39.87	2.00e-112	399.00
IUUC-Osa-086160	Oryza sativa	44.47	1.00e-96	346.00
IUUC-Ola-087415	Oryzias latipes	80.69	0.00e+00	1007.00
IUUC-Olu-087850	Ostreococcus lucimarinus	38.81	2.00e-98	353.00
IUUC-Oga-088434	Otolemur garnettii	76.80	0.00e+00	917.00
IUUC-Oar-089872	Ovis aries	76.13	0.00e+00	893.00
IUUC-Ptr-091212	Pan troglodytes	76.35	0.00e+00	903.00
IUUC-Pan-092708	Papio anubis	85.23	9.00e-115	407.00
IUUC-Psi-093703	Pelodiscus sinensis	78.28	0.00e+00	895.00
IUUC-Pno-094953	Phaeosphaeria nodorum	45.79	2.00e-102	366.00
IUUC-Ppa-095963	Physcomitrella patens	41.45	6.00e-103	368.00
IUUC-Pfo-097515	Poecilia formosa	82.22	0.00e+00	978.00
IUUC-Pab-097951	Pongo abelii	74.91	0.00e+00	780.00
IUUC-Pop-099703	Populus trichocarpa	36.56	4.00e-97	348.00
IUUC-Pca-100426	Procavia capensis	76.07	0.00e+00	903.00
IUUC-Ppe-101152	Prunus persica	38.44	1.00e-112	400.00
IUUC-Pva-102792	Pteropus vampyrus	70.94	0.00e+00	847.00
IUUC-Pgr-103592	Puccinia graminis	39.71	4.00e-101	362.00
IUUC-Ptt-103805	Puccinia triticina	39.19	2.00e-83	303.00
IUUC-Pte-104215	Pyrenophora teres	44.99	8.00e-111	394.00
IUUC-Pyt-104634	Pyrenophora triticirepentis	43.83	7.00e-109	388.00
IUUC-Rno-106117	Rattus norvegicus	76.34	0.00e+00	945.00
IUUC-Sce-106177	Saccharomyces cerevisiae	36.29	4.00e-70	259.00
IUUC-Sha-107006	Sarcophilus harrisii	77.40	0.00e+00	911.00
IUUC-Sja-107967	Schizosaccharomyces japonicus	42.79	4.00e-91	328.00
IUUC-Spo-108020	Schizosaccharomyces pombe	43.31	4.00e-91	328.00
IUUC-Ssl-108509	Sclerotinia sclerotiorum	42.86	3.00e-99	356.00
IUUC-Smo-109264	Selaginella moellendorffii	42.24	8.00e-105	374.00
IUUC-Sit-110581	Setaria italica	40.36	6.00e-111	395.00
IUUC-Sly-111870	Solanum lycopersicum	39.64	3.00e-111	395.00
IUUC-Stu-112283	Solanum tuberosum	39.53	2.00e-109	389.00
IUUC-Sar-113432	Sorex araneus	52.42	8.00e-102	364.00
IUUC-Sbi-114075	Sorghum bicolor	38.53	1.00e-109	390.00
IUUC-Sre-114926	Sporisorium reilianum	41.71	4.00e-101	362.00
IUUC-Ssc-116281	Sus scrofa	90.81	4.00e-102	363.00
IUUC-Tgu-117247	Taeniopygia guttata	76.13	0.00e+00	876.00
IUUC-Tru-118075	Takifugu rubripes	77.81	0.00e+00	952.00
IUUC-Tsy-119398	Tarsius syrichta	61.44	0.00e+00	652.00
IUUC-Tni-120771	Tetraodon nigroviridis	73.75	0.00e+00	865.00
IUUC-Tca-121651	Theobroma cacao	40.64	4.00e-111	395.00
IUUC-Tre-122224	Trichoderma reesei	41.38	3.00e-94	339.00
IUUC-Tvi-122634	Trichoderma virens	42.10	8.00e-96	344.00
IUUC-Tae-123607	Triticum aestivum	39.96	1.00e-108	387.00
IUUC-Tur-126417	Triticum urartu	39.68	1.00e-107	384.00
IUUC-Tme-127016	Tuber melanosporum	44.64	3.00e-95	342.00
IUUC-Tbe-127678	Tupaia belangeri	72.98	3.00e-112	399.00
IUUC-Ttr-128598	Tursiops truncatus	71.90	0.00e+00	858.00
IUUC-Uma-129612	Ustilago maydis	41.62	8.00e-92	331.00
IUUC-Vda-129811	Verticillium dahliae	42.88	4.00e-99	355.00
IUUC-Vpa-130732	Vicugna pacos	61.60	0.00e+00	696.00
IUUC-Vvi-130832	Vitis vinifera	41.30	1.00e-108	387.00
IUUC-Xtr-132823	Xenopus tropicalis	71.57	0.00e+00	820.00
IUUC-Xma-133552	Xiphophorus maculatus	81.90	0.00e+00	974.00
IUUC-Yli-134666	Yarrowia lipolytica	55.15	8.00e-64	238.00
IUUC-Zma-135547	Zea mays	38.53	8.00e-110	391.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence