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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046929
UUCD1 version UUC-HoS-01159
Ensembl Protein ID ENSP00000264689.6
UniProt Accession Q9NUQ7; Q6IA77; Q96FS3; UFSP2_HUMAN
Genbank Protein ID BAA92064.1; CAG33559.1; AAH10493.1
Protein Name Ufm1-specific protease 2
Genbank Nucleotide ID AK002062; CR457278; AC106897
Gene Name UFSP2; C4orf20
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000109775.10 ENST00000514247.5 ENSP00000423599.1
ENSG00000109775.10 ENST00000264689.10 ENSP00000264689.6
ENSG00000109775.10 ENST00000510755.5 ENSP00000421133.1
ENSG00000109775.10 ENST00000511485.5 ENSP00000425855.1
ENSG00000109775.10 ENST00000509180.1 ENSP00000423657.1
ENSG00000109775.10 ENST00000502428.5 ENSP00000424419.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/ULP ULP 21228277
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.
 Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation.
Protein Sequence
(Fasta)
MVISESMDIL FRIRGGLDLA FQLATPNEIF LKKALKHVLS DLSTKLSSNA LVFRICHSSV 60
YIWPSSDINT IPGELTDASA CKNILRFIQF EPEEDIKRKF MRKKDKKLSD MHQIVNIDLM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046929|DUB,ULP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTTGTAGTT GGTCCGCCCG GGCCCCGCCC CTGGGCCGTG CGGTGACACC ACTTCAGGGC 60
CGGCCCCCGG AACTTTTGGG CAGGCGTCAG CGCCCGTGTC ACCGCCACGT CGCGGACATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046929|DUB,ULP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR012462--Peptidase_C78_UfSP1/2
Pfam

PF07910--Peptidase_C78
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0016790--F:thiolester hydrolase activity
GO:0071567--F:UFM1 hydrolase activity
GO:0006508--P:proteolysis
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
KEGG hsa:55325
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000578 Aegilops tauschii 41.55 6.00e-72 264.00
IUUC-Aml-001757 Ailuropoda melanoleuca 94.44 0.00e+00 911.00
IUUC-Atr-002641 Amborella trichopoda 45.51 2.00e-73 270.00
IUUC-Apl-003911 Anas platyrhynchos 71.09 0.00e+00 667.00
IUUC-Aca-005294 Anolis carolinensis 75.91 0.00e+00 749.00
IUUC-Aly-006185 Arabidopsis lyrata 44.65 2.00e-70 260.00
IUUC-Ath-006919 Arabidopsis thaliana 53.95 4.00e-70 259.00
IUUC-Ame-011931 Astyanax mexicanus 57.14 3.00e-156 545.00
IUUC-Bta-012389 Bos taurus 93.82 0.00e+00 911.00
IUUC-Bdi-014306 Brachypodium distachyon 43.77 4.00e-71 262.00
IUUC-Bol-016591 Brassica oleracea 44.25 8.00e-72 265.00
IUUC-Bra-017122 Brassica rapa 35.62 1.00e-63 238.00
IUUC-Cel-018132 Caenorhabditis elegans 50.71 6.00e-83 301.00
IUUC-Cja-019735 Callithrix jacchus 95.06 0.00e+00 933.00
IUUC-Cfa-020814 Canis familiaris 92.66 0.00e+00 914.00
IUUC-Cpo-021576 Cavia porcellus 92.74 0.00e+00 890.00
IUUC-Cre-022668 Chlamydomonas reinhardtii 57.58 2.00e-64 238.00
IUUC-Csa-023368 Chlorocebus sabaeus 98.51 0.00e+00 942.00
IUUC-Cho-024731 Choloepus hoffmanni 86.17 0.00e+00 769.00
IUUC-Cin-025359 Ciona intestinalis 51.68 9.00e-110 390.00
IUUC-Csv-025886 Ciona savignyi 67.77 7.00e-89 319.00
IUUC-Dre-027673 Danio rerio 57.36 4.00e-166 577.00
IUUC-Dno-030101 Dasypus novemcinctus 89.32 0.00e+00 854.00
IUUC-Dor-030612 Dipodomys ordii 88.91 0.00e+00 854.00
IUUC-Dme-032198 Drosophila melanogaster 47.29 8.00e-80 291.00
IUUC-Ete-032738 Echinops telfairi 78.42 0.00e+00 712.00
IUUC-Eca-034093 Equus caballus 94.60 0.00e+00 905.00
IUUC-Eeu-034624 Erinaceus europaeus 89.55 0.00e+00 904.00
IUUC-Fca-035542 Felis catus 92.31 0.00e+00 886.00
IUUC-Fal-036770 Ficedula albicollis 77.11 0.00e+00 740.00
IUUC-Gmo-039601 Gadus morhua 54.96 1.00e-153 536.00
IUUC-Gga-040670 Gallus gallus 76.50 0.00e+00 736.00
IUUC-Gac-042013 Gasterosteus aculeatus 55.81 2.00e-163 568.00
IUUC-Gma-043320 Glycine max 43.93 4.00e-77 282.00
IUUC-Ggo-045051 Gorilla gorilla 100.00 0.00e+00 952.00
IUUC-Itr-047967 Ictidomys tridecemlineatus 92.95 0.00e+00 892.00
IUUC-Lch-049884 Latimeria chalumnae 63.60 0.00e+00 645.00
IUUC-Lpe-051425 Leersia perrieri 43.48 9.00e-73 268.00
IUUC-Loc-052568 Lepisosteus oculatus 60.51 7.00e-170 590.00
IUUC-Laf-053435 Loxodonta africana 89.63 0.00e+00 865.00
IUUC-Mcc-055106 Macaca mulatta 98.51 0.00e+00 942.00
IUUC-Mtr-057740 Medicago truncatula 43.93 2.00e-78 286.00
IUUC-Mga-060094 Meleagris gallopavo 77.35 0.00e+00 729.00
IUUC-Mmr-061634 Microcebus murinus 90.62 0.00e+00 865.00
IUUC-Mdo-062862 Monodelphis domestica 82.94 0.00e+00 815.00
IUUC-Mmu-063729 Mus musculus 84.45 0.00e+00 808.00
IUUC-Mac-065086 Musa acuminata 43.19 8.00e-74 271.00
IUUC-Mpu-066461 Mustela putorius furo 92.54 0.00e+00 900.00
IUUC-Mlu-067443 Myotis lucifugus 90.43 0.00e+00 880.00
IUUC-Nle-069354 Nomascus leucogenys 100.00 0.00e+00 952.00
IUUC-Opr-070818 Ochotona princeps 93.36 9.00e-141 493.00
IUUC-Ont-072430 Oreochromis niloticus 57.57 9.00e-166 576.00
IUUC-Oan-072972 Ornithorhynchus anatinus 80.00 5.00e-95 340.00
IUUC-Ocu-074052 Oryctolagus cuniculus 93.80 0.00e+00 901.00
IUUC-Oba-075331 Oryza barthii 42.04 1.00e-69 257.00
IUUC-Obr-076810 Oryza brachyantha 42.77 1.00e-72 267.00
IUUC-Ogl-077185 Oryza glaberrima 43.31 4.00e-70 259.00
IUUC-Ogu-078014 Oryza glumaepatula 42.04 1.00e-69 257.00
IUUC-Oin-080170 Oryza indica 43.31 5.00e-70 259.00
IUUC-Olo-080561 Oryza longistaminata 59.16 4.00e-69 256.00
IUUC-Ome-081878 Oryza meridionalis 42.04 1.00e-69 258.00
IUUC-Oni-083106 Oryza nivara 59.16 5.00e-69 255.00
IUUC-Opu-083384 Oryza punctata 41.49 2.00e-72 266.00
IUUC-Oru-085240 Oryza rufipogon 42.04 1.00e-69 257.00
IUUC-Osa-086230 Oryza sativa 43.31 7.00e-70 258.00
IUUC-Ola-087525 Oryzias latipes 64.81 6.00e-140 490.00
IUUC-Oga-088657 Otolemur garnettii 94.44 0.00e+00 908.00
IUUC-Oar-089494 Ovis aries 93.60 0.00e+00 908.00
IUUC-Ptr-091189 Pan troglodytes 100.00 0.00e+00 952.00
IUUC-Pan-092071 Papio anubis 98.93 0.00e+00 945.00
IUUC-Psi-092991 Pelodiscus sinensis 78.25 0.00e+00 776.00
IUUC-Pma-094182 Petromyzon marinus 72.99 1.00e-61 228.00
IUUC-Ppa-095743 Physcomitrella patens 45.07 3.00e-72 266.00
IUUC-Pfo-096271 Poecilia formosa 57.23 3.00e-161 561.00
IUUC-Pab-097928 Pongo abelii 96.82 0.00e+00 912.00
IUUC-Pop-098826 Populus trichocarpa 45.12 8.00e-75 275.00
IUUC-Pca-100279 Procavia capensis 81.84 0.00e+00 838.00
IUUC-Ppe-101401 Prunus persica 45.45 6.00e-70 258.00
IUUC-Pva-102713 Pteropus vampyrus 92.54 0.00e+00 910.00
IUUC-Rno-105697 Rattus norvegicus 84.23 0.00e+00 810.00
IUUC-Sha-106956 Sarcophilus harrisii 82.48 0.00e+00 812.00
IUUC-Smo-109070 Selaginella moellendorffii 44.31 1.00e-78 287.00
IUUC-Sit-109821 Setaria italica 46.11 1.00e-75 276.00
IUUC-Sly-110903 Solanum lycopersicum 45.40 2.00e-75 277.00
IUUC-Stu-111930 Solanum tuberosum 45.03 3.00e-75 276.00
IUUC-Sar-113264 Sorex araneus 92.32 0.00e+00 894.00
IUUC-Sbi-114732 Sorghum bicolor 37.03 2.00e-54 206.00
IUUC-Ssc-115435 Sus scrofa 90.00 0.00e+00 879.00
IUUC-Tgu-116761 Taeniopygia guttata 85.48 4.00e-130 456.00
IUUC-Tru-118435 Takifugu rubripes 55.00 1.00e-156 546.00
IUUC-Tsy-119445 Tarsius syrichta 87.61 0.00e+00 819.00
IUUC-Tni-119948 Tetraodon nigroviridis 72.89 3.00e-103 367.00
IUUC-Tca-121332 Theobroma cacao 45.37 5.00e-75 275.00
IUUC-Tvi-122327 Trichoderma virens 37.66 8.00e-03 35.40
IUUC-Tae-123925 Triticum aestivum 43.48 1.00e-73 271.00
IUUC-Tur-126833 Triticum urartu 42.69 3.00e-69 256.00
IUUC-Tbe-127826 Tupaia belangeri 84.86 0.00e+00 816.00
IUUC-Ttr-129116 Tursiops truncatus 96.50 2.00e-153 535.00
IUUC-Vpa-130588 Vicugna pacos 89.79 0.00e+00 848.00
IUUC-Vvi-130898 Vitis vinifera 41.22 1.00e-75 277.00
IUUC-Xtr-132571 Xenopus tropicalis 65.46 0.00e+00 644.00
IUUC-Xma-133755 Xiphophorus maculatus 56.17 5.00e-160 557.00
Created Date 25-Jun-2017

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