iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-83	279.8	445	948

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           tGl NlgNtCYmNSvLQ+L++ +e+r+++l+ + + +n         +l+k+lq+lf+ l +++++a++pr +++a +   + f+  +q
   Q: 445  TGLINLGNTCYMNSVLQALFMATEFRRQVLSLNLNGCN---------SLMKKLQHLFAFLAHTQREAYAPRIFFEASR--PPWFTPRSQ 522
           7******************************5555554.........7***************************998..777****** PP
   S: 90   qDaqEflaflldqleeelkk...eknkpkeeeeeedkselsde........aeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           qD++E+l+flld+l+ee k    +++++ +e  + +++ l++         ++ ++  ++k+li+++F+g+l+++i cl+c+++s + e
   Q: 523  QDCSEYLRFLLDRLHEEEKIlriQSSHKPSEGLGCTETCLQEVtnkvavpsESPSTGGSEKTLIEKMFGGKLRTHICCLNCRSTSHKVE 611
           ******************5577766666666666666666666889999888889999999**************************** PP
   S: 168  pfldlslpvpgkeetkke....................................................................... 185
            f+dlsl++  + + + +                                                                       
   Q: 612  AFTDLSLAFCPSPSVEDSsfqdpaslpsaqddglmqtsvtdaeeepvvcnpaaaafvcdsvvnerrlgsppvefpcaknssvpgesaki 700
           *********98876655588999****************************************************************** PP
   S: 186  ................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple 258
                           s++d+L+ f ++e l+gen+yyce+c ++q+aek++++++ Pe+Lil L Rfs++++ ++r+ki ++v++pl 
   Q: 701  lvskdvpqnpggesttSVTDLLNYFLAPEVLTGENQYYCESCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLV 789
           ****************************************************************************************9 PP
   S: 259  Ldlspfcts.....................peekqke..............kkkYeLiavvvHsG.slssGHYvayvkn.......... 301
           L+l    ts                           +               + Y L++vvvHsG s++sGHY++y++n          
   Q: 790  LELPVKRTSlsslsegwsadadftdvnenlA-----KklkpsgteeafcpkLVPYLLSSVVVHSGvSSESGHYYSYARNitgtessyqm 873
           9998666665556666666666665555550.....0555555666666669************************************* PP
   S: 302  ..................................ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
                                              +++W+lf+Ds+Vt ++ ++v++ t+    +taYvlfYk++
   Q: 874  rpqseslsltpsqssllggespntvieqdlenkeMSQEWFLFNDSRVTFTSFQSVQKITSrfpkDTAYVLFYKKQ 948
           ***********999999999999999988865433444*******************999*************86 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDKILEGLVS SSHPLPLKRM IVRKVVESAE HWLDEAQCEA MFDLTTRLIL EGQDPFQRQV 60
GHQVLEAYAR YHRPEFESFF NKTFVLGLLQ QGYHSLDRKD VAILDYIHNG LKLIMSCPSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCAGAATC GCCCGCTCCC GTCCCAGCTC GGATGGGCCT TCCCACTCGA TAAATGTGGC 60
TGCTGAGGCA GCGGTGGCGG TGGCCAGACC TGCTGCTGCT TGGCTTCAAG TTCACCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR033840--USP38
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:307764

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002174	Ailuropoda melanoleuca	88.15	0.00e+00	1769.00
IUUC-Apl-003435	Anas platyrhynchos	74.87	0.00e+00	1249.00
IUUC-Aca-004556	Anolis carolinensis	69.61	0.00e+00	1263.00
IUUC-Ame-010616	Astyanax mexicanus	61.36	0.00e+00	1199.00
IUUC-Bta-013544	Bos taurus	89.05	0.00e+00	1789.00
IUUC-Cja-018745	Callithrix jacchus	87.48	0.00e+00	1763.00
IUUC-Cfa-020434	Canis familiaris	84.55	0.00e+00	1699.00
IUUC-Cpo-021666	Cavia porcellus	88.68	0.00e+00	1731.00
IUUC-Csa-023965	Chlorocebus sabaeus	89.83	0.00e+00	1864.00
IUUC-Cho-024809	Choloepus hoffmanni	79.10	0.00e+00	1194.00
IUUC-Cin-025604	Ciona intestinalis	30.33	4.00e-42	165.00
IUUC-Csv-026333	Ciona savignyi	44.57	2.00e-31	129.00
IUUC-Dre-028338	Danio rerio	62.18	0.00e+00	1206.00
IUUC-Dno-029372	Dasypus novemcinctus	87.52	0.00e+00	1766.00
IUUC-Dor-030752	Dipodomys ordii	86.48	0.00e+00	1213.00
IUUC-Ete-032588	Echinops telfairi	77.40	0.00e+00	1095.00
IUUC-Eca-034416	Equus caballus	88.77	0.00e+00	1820.00
IUUC-Eeu-035132	Erinaceus europaeus	71.02	0.00e+00	1332.00
IUUC-Fca-036137	Felis catus	89.53	0.00e+00	1819.00
IUUC-Fal-037297	Ficedula albicollis	74.45	0.00e+00	1436.00
IUUC-Gmo-038727	Gadus morhua	65.33	0.00e+00	1013.00
IUUC-Gga-041091	Gallus gallus	72.52	0.00e+00	1371.00
IUUC-Gac-042082	Gasterosteus aculeatus	61.50	0.00e+00	1119.00
IUUC-Ggo-045376	Gorilla gorilla	85.09	0.00e+00	1698.00
IUUC-Hsa-046444	Homo sapiens	89.54	0.00e+00	1831.00
IUUC-Itr-047976	Ictidomys tridecemlineatus	89.64	0.00e+00	1809.00
IUUC-Lch-050500	Latimeria chalumnae	71.88	0.00e+00	1399.00
IUUC-Loc-052625	Lepisosteus oculatus	64.37	0.00e+00	1256.00
IUUC-Laf-053689	Loxodonta africana	89.12	0.00e+00	1795.00
IUUC-Mcc-055286	Macaca mulatta	89.92	0.00e+00	1821.00
IUUC-Mga-059905	Meleagris gallopavo	72.59	0.00e+00	1207.00
IUUC-Mmr-061397	Microcebus murinus	89.83	0.00e+00	1805.00
IUUC-Mdo-062833	Monodelphis domestica	83.25	0.00e+00	1718.00
IUUC-Mmu-063157	Mus musculus	95.39	0.00e+00	1935.00
IUUC-Mpu-066434	Mustela putorius furo	89.06	0.00e+00	1809.00
IUUC-Mlu-068178	Myotis lucifugus	87.20	0.00e+00	1732.00
IUUC-Nle-070153	Nomascus leucogenys	88.87	0.00e+00	1768.00
IUUC-Ont-072330	Oreochromis niloticus	62.12	0.00e+00	1207.00
IUUC-Oan-072709	Ornithorhynchus anatinus	77.60	0.00e+00	1224.00
IUUC-Ocu-074832	Oryctolagus cuniculus	89.64	0.00e+00	1800.00
IUUC-Ola-087003	Oryzias latipes	55.15	9.00e-45	172.00
IUUC-Oga-088517	Otolemur garnettii	84.72	0.00e+00	1704.00
IUUC-Oar-089472	Ovis aries	85.78	0.00e+00	1711.00
IUUC-Ptr-090996	Pan troglodytes	89.35	0.00e+00	1827.00
IUUC-Pan-091837	Papio anubis	87.89	0.00e+00	1794.00
IUUC-Psi-093236	Pelodiscus sinensis	74.86	0.00e+00	1150.00
IUUC-Pma-094349	Petromyzon marinus	54.04	0.00e+00	961.00
IUUC-Pfo-097193	Poecilia formosa	60.71	0.00e+00	1141.00
IUUC-Pab-098710	Pongo abelii	89.16	0.00e+00	1827.00
IUUC-Pca-100794	Procavia capensis	79.19	0.00e+00	1571.00
IUUC-Pva-102722	Pteropus vampyrus	88.69	0.00e+00	1802.00
IUUC-Sha-106563	Sarcophilus harrisii	81.80	0.00e+00	1378.00
IUUC-Sar-113533	Sorex araneus	76.37	0.00e+00	1509.00
IUUC-Ssc-116259	Sus scrofa	79.62	0.00e+00	1510.00
IUUC-Tgu-117475	Taeniopygia guttata	73.97	0.00e+00	1300.00
IUUC-Tru-118623	Takifugu rubripes	62.09	0.00e+00	1145.00
IUUC-Tsy-119250	Tarsius syrichta	86.98	0.00e+00	1389.00
IUUC-Tni-120441	Tetraodon nigroviridis	58.07	0.00e+00	1055.00
IUUC-Tbe-127936	Tupaia belangeri	78.39	0.00e+00	1514.00
IUUC-Ttr-128483	Tursiops truncatus	75.03	0.00e+00	1325.00
IUUC-Vpa-130303	Vicugna pacos	96.63	0.00e+00	1066.00
IUUC-Xtr-132773	Xenopus tropicalis	71.67	0.00e+00	1385.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence