iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105483

Ensembl Protein ID

ENSRNOP00000021068.5

UniProt Accession

D4ABZ4; D4ABZ4_RAT

Genbank Protein ID

ENSRNOP00000021068

Protein Name

OTU deubiquitinase 7A

Genbank Nucleotide ID

AABR07004100

Gene Name

Otud7a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000015503.6	ENSRNOT00000021068.6	ENSRNOP00000021068.5

Annotation

mRNA Expression
ArrayExpress
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	7.20e-41	140.2	17	192
UBD/ZnF/ZnF_A20	1.20e-15	57.5	704	738

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek....edekefcqklvepe.....ak.g.. 77
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al++++r+ +++++ k+++++++++++k    e+e++++ kl+++e     +k g  
   Q: 17   LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYTMMRTGAEREALKRRWRWQQTQQNKeeewEREWTELLKLASSEprthfSKnGsg 105
           6899********************************************************999999************88777443377 PP
   S: 78   ................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYdaLval 138
                           ee+h+f+La+iL+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++aLv++
   Q: 106  tgggvdnsedpvyeslEEFHVFVLAHILRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPPNRcHCSPLVLAYDQAHFSALVSM 192
           889*********************************************************************************986 PP

UBD/ZnF/ZnF_A20

   S: 2    pskllCkk.gCgfYGnpetngyCSkCyreelrrrr 35
           p++++C++ +C+fYG++et+++CS+Cyreelrrrr
   Q: 704  PAQRRCQReNCAFYGRAETEHFCSYCYREELRRRR 738
           99*******************************97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

GRLNWWSTVC TSCKRLLPLA TTGDGNCLLH AASLGMWGFH DRDLVLRKAL YTMMRTGAER 60
EALKRRWRWQ QTQQNKEEEW EREWTELLKL ASSEPRTHFS KNGSGTGGGV DNSEDPVYES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCGCCTGA ACTGGTGGTC TACTGTGTGC ACGAGCTGTA AAAGGCTTCT TCCCTTGGCC 60
ACGACAGGGG ATGGGAACTG CCTCTTACAT GCCGCCTCGC TAGGTAAGCA CCCCAGCACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001551	Ailuropoda melanoleuca	95.57	0.00e+00	744.00
IUUC-Aca-004392	Anolis carolinensis	72.50	0.00e+00	863.00
IUUC-Ame-011052	Astyanax mexicanus	67.19	0.00e+00	810.00
IUUC-Bta-013296	Bos taurus	88.05	0.00e+00	973.00
IUUC-Cfa-020447	Canis familiaris	94.58	0.00e+00	732.00
IUUC-Csa-023263	Chlorocebus sabaeus	95.98	0.00e+00	740.00
IUUC-Dre-028617	Danio rerio	65.44	0.00e+00	837.00
IUUC-Ete-033068	Echinops telfairi	67.92	0.00e+00	751.00
IUUC-Fal-037145	Ficedula albicollis	74.74	0.00e+00	882.00
IUUC-Gga-040512	Gallus gallus	73.72	0.00e+00	894.00
IUUC-Gac-041599	Gasterosteus aculeatus	66.58	0.00e+00	778.00
IUUC-Ggo-044819	Gorilla gorilla	87.94	0.00e+00	983.00
IUUC-Hsa-046781	Homo sapiens	89.31	0.00e+00	996.00
IUUC-Itr-047999	Ictidomys tridecemlineatus	86.29	0.00e+00	727.00
IUUC-Lch-050666	Latimeria chalumnae	71.24	0.00e+00	885.00
IUUC-Loc-052841	Lepisosteus oculatus	66.23	0.00e+00	824.00
IUUC-Mcc-055353	Macaca mulatta	88.78	0.00e+00	986.00
IUUC-Mga-059741	Meleagris gallopavo	69.31	0.00e+00	858.00
IUUC-Mmr-061437	Microcebus murinus	97.77	0.00e+00	807.00
IUUC-Mdo-061907	Monodelphis domestica	74.80	0.00e+00	883.00
IUUC-Mmu-064074	Mus musculus	97.40	0.00e+00	1032.00
IUUC-Mpu-066004	Mustela putorius furo	92.15	0.00e+00	724.00
IUUC-Nle-069182	Nomascus leucogenys	93.14	0.00e+00	768.00
IUUC-Opr-070701	Ochotona princeps	84.24	0.00e+00	627.00
IUUC-Oan-073235	Ornithorhynchus anatinus	68.92	0.00e+00	788.00
IUUC-Ocu-073935	Oryctolagus cuniculus	94.20	0.00e+00	673.00
IUUC-Oar-089476	Ovis aries	87.38	0.00e+00	981.00
IUUC-Pan-092616	Papio anubis	85.66	0.00e+00	956.00
IUUC-Psi-093126	Pelodiscus sinensis	73.84	0.00e+00	857.00
IUUC-Pab-098336	Pongo abelii	88.17	0.00e+00	824.00
IUUC-Pca-100206	Procavia capensis	79.69	0.00e+00	766.00
IUUC-Ssc-115415	Sus scrofa	86.40	0.00e+00	882.00
IUUC-Xtr-132158	Xenopus tropicalis	66.01	0.00e+00	863.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence