iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105017

Ensembl Protein ID

ENSRNOP00000014261.3

UniProt Accession

Q5XII5; WAP53_RAT

Genbank Protein ID

AAH83696.1

Protein Name

Telomerase Cajal body protein 1; WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 repeat-containing protein antisense to TP53 gene

Genbank Nucleotide ID

BC083696

Gene Name

Wrap53; Tcab1; Wdr79

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000010520.5	ENSRNOT00000014261.5	ENSRNOP00000014261.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.40e-20	70.6	349	383

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGs.dDgtikvWDlrt 32
           gH++++t l+f +d +l+ sG+  D  + +WDlr+
   Q: 349  GHQGGITHLCFhPDgNLFFSGArKDAELLCWDLRQ 383
           8***********999*******88899*****997 PP

Organism

Rattus norvegicus

Functional Description
(View)

Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes. In the telomerase holoenzyme complex, it controls telomerase localization to Cajal body. Required for delivery of TERC to telomeres during S phase and for telomerase activity. Binds small Cajal body RNAs (scaRNAs). The mRNA encoding this protein plays a critical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basal p53 mRNA levels and in p53 induction upon DNA damage (By similarity).

Protein Sequence
(Fasta)

MKTSEELRLA PDSLPSDLVP APVLQASPAD KNTDSEPVPP PCGGDDQLQV ATDAVASSVV 60
SQELQQGDSA PLEVEFNISS ELSPRIEEQE VPENASLPVE ETNRPELESG EAMEGVSEEP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGGACCT TCGTTTCCTC TGTTTGCTTT TGGTTGCGGG GTTCAGCTTA CTCTTTCCGG 60
AAGAGGAAAG CAGACTCGGG GCTGTGCAGT TCTGCGCCGG GACCCCTGGG AACGGTAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0015030--C:Cajal body
GO:0005829--C:cytosol
GO:0005697--C:telomerase holoenzyme complex
GO:0003723--F:RNA binding
GO:0070034--F:telomerase RNA binding
GO:0070200--P:establishment of protein localization to telomere
GO:1904851--P:positive regulation of establishment of protein localization to telomere
GO:0051973--P:positive regulation of telomerase activity
GO:0032212--P:positive regulation of telomere maintenance via telomerase
GO:0090666--P:scaRNA localization to Cajal body
GO:0090671--P:telomerase RNA localization to Cajal body
GO:0032203--P:telomere formation via telomerase

KEGG

rno:287432

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000305	Aegilops tauschii	43.22	1.00e-65	243.00
IUUC-Aml-001893	Ailuropoda melanoleuca	76.06	0.00e+00	784.00
IUUC-Atr-002472	Amborella trichopoda	40.65	8.00e-73	267.00
IUUC-Aca-004937	Anolis carolinensis	66.57	1.00e-134	473.00
IUUC-Aly-006492	Arabidopsis lyrata	42.90	6.00e-78	284.00
IUUC-Ath-006592	Arabidopsis thaliana	42.57	1.00e-79	290.00
IUUC-Acl-008296	Aspergillus clavatus	27.95	2.00e-16	79.30
IUUC-Ani-009149	Aspergillus nidulans	28.57	3.00e-29	122.00
IUUC-Aor-009938	Aspergillus oryzae	28.06	4.00e-25	109.00
IUUC-Ate-010481	Aspergillus terreus	29.11	1.00e-30	127.00
IUUC-Ame-011296	Astyanax mexicanus	64.59	2.00e-133	469.00
IUUC-Bgr-012232	Blumeria graminis	26.65	6.00e-18	85.10
IUUC-Bta-012362	Bos taurus	78.29	0.00e+00	825.00
IUUC-Bdi-014971	Brachypodium distachyon	43.07	5.00e-78	285.00
IUUC-Bol-016557	Brassica oleracea	42.30	2.00e-77	282.00
IUUC-Bra-016734	Brassica rapa	40.70	2.00e-76	279.00
IUUC-Cja-019681	Callithrix jacchus	76.78	0.00e+00	771.00
IUUC-Cfa-020148	Canis familiaris	81.94	0.00e+00	744.00
IUUC-Cpo-022128	Cavia porcellus	85.32	0.00e+00	718.00
IUUC-Cre-022680	Chlamydomonas reinhardtii	45.02	9.00e-72	263.00
IUUC-Csa-023779	Chlorocebus sabaeus	81.97	0.00e+00	754.00
IUUC-Cin-025318	Ciona intestinalis	42.11	5.00e-67	248.00
IUUC-Cne-026778	Cryptococcus neoformans	33.43	5.00e-40	158.00
IUUC-Dre-027809	Danio rerio	60.90	2.00e-138	485.00
IUUC-Dno-028896	Dasypus novemcinctus	86.73	1.00e-168	585.00
IUUC-Dor-030656	Dipodomys ordii	71.03	0.00e+00	660.00
IUUC-Dme-031828	Drosophila melanogaster	38.35	5.00e-65	242.00
IUUC-Eca-033305	Equus caballus	86.53	0.00e+00	724.00
IUUC-Eeu-034936	Erinaceus europaeus	79.90	7.00e-94	337.00
IUUC-Fca-036371	Felis catus	78.37	0.00e+00	755.00
IUUC-Gmo-039283	Gadus morhua	65.22	6.00e-89	319.00
IUUC-Gac-042297	Gasterosteus aculeatus	69.00	1.00e-93	335.00
IUUC-Gma-044331	Glycine max	41.28	6.00e-74	271.00
IUUC-Ggo-044938	Gorilla gorilla	78.46	0.00e+00	774.00
IUUC-Hsa-046795	Homo sapiens	77.90	0.00e+00	772.00
IUUC-Itr-048964	Ictidomys tridecemlineatus	79.33	0.00e+00	843.00
IUUC-Lch-050551	Latimeria chalumnae	52.37	6.00e-92	330.00
IUUC-Lpe-051458	Leersia perrieri	40.12	3.00e-71	262.00
IUUC-Loc-052833	Lepisosteus oculatus	68.87	9.00e-128	449.00
IUUC-Laf-054404	Loxodonta africana	76.95	0.00e+00	754.00
IUUC-Mcc-055500	Macaca mulatta	82.05	0.00e+00	764.00
IUUC-Meu-056062	Macropus eugenii	75.68	6.00e-37	148.00
IUUC-Mtr-058157	Medicago truncatula	42.90	1.00e-77	283.00
IUUC-Mla-058898	Melampsora laricipopulina	28.71	4.00e-31	128.00
IUUC-Mvi-060351	Microbotryum violaceum	29.94	5.00e-38	151.00
IUUC-Mmr-061204	Microcebus murinus	80.30	0.00e+00	800.00
IUUC-Mdo-062997	Monodelphis domestica	72.66	1.00e-151	529.00
IUUC-Mmu-063379	Mus musculus	91.54	0.00e+00	939.00
IUUC-Mac-065509	Musa acuminata	40.46	7.00e-76	279.00
IUUC-Mpu-066898	Mustela putorius furo	81.33	0.00e+00	731.00
IUUC-Mlu-067405	Myotis lucifugus	85.83	0.00e+00	669.00
IUUC-Nle-069679	Nomascus leucogenys	68.54	0.00e+00	645.00
IUUC-Opr-070544	Ochotona princeps	77.33	2.00e-97	349.00
IUUC-Oan-073233	Ornithorhynchus anatinus	60.98	8.00e-86	309.00
IUUC-Ocu-074700	Oryctolagus cuniculus	85.49	0.00e+00	674.00
IUUC-Oba-075164	Oryza barthii	38.62	2.00e-73	273.00
IUUC-Ogl-077700	Oryza glaberrima	43.40	1.00e-78	290.00
IUUC-Ogu-078612	Oryza glumaepatula	35.33	1.00e-49	193.00
IUUC-Oin-079494	Oryza indica	43.40	1.00e-78	286.00
IUUC-Olo-081051	Oryza longistaminata	43.01	1.00e-68	252.00
IUUC-Ome-081868	Oryza meridionalis	36.36	1.00e-55	213.00
IUUC-Oni-082904	Oryza nivara	43.40	4.00e-79	291.00
IUUC-Opu-084082	Oryza punctata	43.38	3.00e-78	288.00
IUUC-Oru-084683	Oryza rufipogon	43.40	1.00e-78	286.00
IUUC-Osa-085518	Oryza sativa	43.40	2.00e-78	286.00
IUUC-Ola-086492	Oryzias latipes	62.10	1.00e-41	162.00
IUUC-Oga-088207	Otolemur garnettii	78.48	0.00e+00	820.00
IUUC-Oar-089463	Ovis aries	78.29	0.00e+00	800.00
IUUC-Ptr-090994	Pan troglodytes	78.28	0.00e+00	780.00
IUUC-Pan-091793	Papio anubis	81.63	0.00e+00	754.00
IUUC-Psi-093816	Pelodiscus sinensis	59.00	8.00e-128	450.00
IUUC-Ppa-095348	Physcomitrella patens	42.86	1.00e-80	293.00
IUUC-Pfo-096740	Poecilia formosa	65.89	9.00e-136	476.00
IUUC-Pab-098447	Pongo abelii	88.12	5.00e-169	586.00
IUUC-Pop-099065	Populus trichocarpa	39.39	1.00e-77	283.00
IUUC-Pca-101130	Procavia capensis	73.81	0.00e+00	721.00
IUUC-Ppe-101669	Prunus persica	41.06	1.00e-80	293.00
IUUC-Pva-102685	Pteropus vampyrus	70.19	6.00e-98	351.00
IUUC-Pgr-103262	Puccinia graminis	31.42	3.00e-41	162.00
IUUC-Ptt-103932	Puccinia triticina	33.09	1.00e-37	150.00
IUUC-Sha-107405	Sarcophilus harrisii	74.43	0.00e+00	634.00
IUUC-Sja-107997	Schizosaccharomyces japonicus	27.84	6.00e-20	91.70
IUUC-Spo-108316	Schizosaccharomyces pombe	29.93	2.00e-27	116.00
IUUC-Smo-108985	Selaginella moellendorffii	45.10	3.00e-80	291.00
IUUC-Sit-109820	Setaria italica	44.31	6.00e-80	291.00
IUUC-Sly-110899	Solanum lycopersicum	41.90	8.00e-82	297.00
IUUC-Stu-112753	Solanum tuberosum	43.39	2.00e-79	289.00
IUUC-Sar-113155	Sorex araneus	74.65	0.00e+00	737.00
IUUC-Sbi-114408	Sorghum bicolor	41.85	1.00e-84	306.00
IUUC-Sre-115186	Sporisorium reilianum	28.50	1.00e-32	134.00
IUUC-Ssc-116125	Sus scrofa	77.65	0.00e+00	804.00
IUUC-Tru-117888	Takifugu rubripes	61.62	3.00e-138	484.00
IUUC-Tsy-119064	Tarsius syrichta	74.08	0.00e+00	632.00
IUUC-Tni-120323	Tetraodon nigroviridis	65.69	9.00e-134	469.00
IUUC-Tca-121784	Theobroma cacao	42.60	3.00e-76	278.00
IUUC-Tae-123366	Triticum aestivum	43.64	4.00e-77	281.00
IUUC-Tur-126046	Triticum urartu	44.44	2.00e-67	249.00
IUUC-Tbe-127406	Tupaia belangeri	84.69	4.00e-103	368.00
IUUC-Ttr-128268	Tursiops truncatus	80.00	0.00e+00	808.00
IUUC-Vpa-130534	Vicugna pacos	83.50	1.00e-136	478.00
IUUC-Vvi-131612	Vitis vinifera	40.52	6.00e-80	292.00
IUUC-Xtr-132969	Xenopus tropicalis	57.54	5.00e-127	447.00
IUUC-Xma-134075	Xiphophorus maculatus	53.91	3.00e-136	478.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence