iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046734

UUCD1 version

UUC-HoS-00641

Ensembl Protein ID

ENSP00000362688.1

UniProt Accession

Q13347; EIF3I_HUMAN

Genbank Protein ID

AAC97144.1; AAC50224.1; AAH00413.1; AAH03140.1

Protein Name

Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; TGF-beta receptor-interacting protein 1; eIF-3-beta; eIF3 p36

Genbank Nucleotide ID

U39067; U36764; BC000413; BC003140

Gene Name

EIF3I; EIF3S2; TRIP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000084623.11	ENST00000373586.1	ENSP00000362688.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-22	80.4	50	87
UBD/Beta-Prp	6.80e-45	155.2	6	250

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcl..afsd.tllvsGsdDgtikvWDlrtgvll 36
           gHt+ v+c+  ++ d +++++Gs D+++++WD  tg++l
   Q: 50   GHTGAVWCVdaDW-DtKHVLTGSADNSCRLWDCETGKQL 87
           8*******98679.55*******************9986 PP

UBD/Beta-Prp

   S: 48   lsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgv 139
           l+ghe  +t++k++++g++l t+++D +++vw   +g+ + t+ gh+  v++++ + +++++++Gs+d+  r+wd etg+ l  +l+ ++ +
   Q: 6    LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLA-LLKTNS-A 95
           69********************************************************************************8.666655.5 PP
   S: 140  vncvvvhpdgnllvsGslDr.....tvrlWdlktgkllrtl......tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
           v++  ++  gn+++ +++ +     +v ++dl+  + ++           ++++++s  + + g+++++g + g ++ ++ ++ge+++ +++
   Q: 96   VRTCGFDFGGNIIMFSTDKQmgyqcFVSFFDLRDPSQIDNNepymkiP-CNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKE 186
           555556666677776654432222269999998888888887777644.48999************************************** PP
   S: 221  htdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsed 286
           h+++++++++s++ + +v++s+D++ +++d+++ +  kt+  ++   + +a+ls+++ ++vlg++ 
   Q: 187  HSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTER--PVNSAALSPNYDHVVLGGGQ 250
           *****************************************955..78888889999999999875 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Protein Sequence
(Fasta)

MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG HTGAVWCVDA 60
DWDTKHVLTG SADNSCRLWD CETGKQLALL KTNSAVRTCG FDFGGNIIMF STDKQMGYQC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAACCCGCT GCAGGCCGGC GGAGGCCCGC TTCAGCAGCG GCTGCGTGCC ACCCCACAGA 60
GCGGCCACCA GCACCAGAGC CAACACCTGC CCTGAATGCA GACGAGTGAG TCACCCTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0396--Initiation factor
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR027525--eIF3i
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005852--C:eukaryotic translation initiation factor 3 complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0070062--C:extracellular exosome
GO:0003743--F:translation initiation factor activity
GO:0006413--P:translational initiation

KEGG

hsa:8668

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000115	Aegilops tauschii	57.52	3.00e-34	139.00
IUUC-Aml-001321	Ailuropoda melanoleuca	99.38	0.00e+00	679.00
IUUC-Atr-002468	Amborella trichopoda	51.05	3.00e-52	198.00
IUUC-Apl-003841	Anas platyrhynchos	94.14	0.00e+00	646.00
IUUC-Aca-005123	Anolis carolinensis	92.00	0.00e+00	636.00
IUUC-Aly-005473	Arabidopsis lyrata	45.12	3.00e-83	301.00
IUUC-Ath-007094	Arabidopsis thaliana	46.65	2.00e-85	309.00
IUUC-Ago-008000	Ashbya gossypii	45.02	2.00e-81	295.00
IUUC-Acl-008098	Aspergillus clavatus	53.01	1.00e-101	363.00
IUUC-Afl-008494	Aspergillus flavus	52.91	8.00e-101	360.00
IUUC-Afu-009080	Aspergillus fumigatus	53.61	8.00e-102	363.00
IUUC-Ani-009230	Aspergillus nidulans	53.96	3.00e-102	364.00
IUUC-Aor-010114	Aspergillus oryzae	52.91	8.00e-101	360.00
IUUC-Ate-010285	Aspergillus terreus	54.88	3.00e-104	371.00
IUUC-Ame-011534	Astyanax mexicanus	81.04	3.00e-168	584.00
IUUC-Bgr-012121	Blumeria graminis	48.94	9.00e-91	327.00
IUUC-Bta-013143	Bos taurus	99.08	0.00e+00	680.00
IUUC-Bci-013950	Botrytis cinerea	51.99	4.00e-99	354.00
IUUC-Bdi-015019	Brachypodium distachyon	46.93	2.00e-87	315.00
IUUC-Bol-015709	Brassica oleracea	46.06	7.00e-82	298.00
IUUC-Bra-017760	Brassica rapa	46.06	3.00e-82	299.00
IUUC-Cel-018226	Caenorhabditis elegans	43.25	6.00e-83	300.00
IUUC-Cja-019741	Callithrix jacchus	100.00	0.00e+00	685.00
IUUC-Cfa-021204	Canis familiaris	99.38	0.00e+00	680.00
IUUC-Cpo-021661	Cavia porcellus	99.38	0.00e+00	680.00
IUUC-Cre-022952	Chlamydomonas reinhardtii	43.65	2.00e-81	296.00
IUUC-Csa-024038	Chlorocebus sabaeus	100.00	0.00e+00	685.00
IUUC-Cin-025597	Ciona intestinalis	59.76	1.00e-117	416.00
IUUC-Cgl-026583	Colletotrichum gloeosporioides	51.22	6.00e-95	340.00
IUUC-Cne-026838	Cryptococcus neoformans	49.54	6.00e-94	337.00
IUUC-Cme-027304	Cyanidioschyzon merolae	45.03	3.00e-79	288.00
IUUC-Dre-028567	Danio rerio	83.69	3.00e-171	593.00
IUUC-Dno-029171	Dasypus novemcinctus	99.07	0.00e+00	677.00
IUUC-Dor-030257	Dipodomys ordii	86.93	6.00e-88	317.00
IUUC-Dse-031191	Dothistroma septosporum	49.85	3.00e-93	335.00
IUUC-Dme-031879	Drosophila melanogaster	60.74	5.00e-120	423.00
IUUC-Ete-032336	Echinops telfairi	97.66	1.00e-125	442.00
IUUC-Eca-033259	Equus caballus	99.69	0.00e+00	681.00
IUUC-Eeu-035153	Erinaceus europaeus	77.85	8.00e-61	227.00
IUUC-Fca-036489	Felis catus	99.69	0.00e+00	681.00
IUUC-Fal-037485	Ficedula albicollis	93.52	0.00e+00	644.00
IUUC-Fox-037860	Fusarium oxysporum	49.85	3.00e-94	338.00
IUUC-Fso-038188	Fusarium solani	50.15	5.00e-93	334.00
IUUC-Gmo-039311	Gadus morhua	84.26	4.00e-171	593.00
IUUC-Ggr-040045	Gaeumannomyces graminis	51.38	3.00e-97	348.00
IUUC-Gga-040645	Gallus gallus	91.89	0.00e+00	642.00
IUUC-Gac-042086	Gasterosteus aculeatus	83.69	5.00e-170	590.00
IUUC-Gma-043246	Glycine max	46.01	6.00e-86	310.00
IUUC-Ggo-045578	Gorilla gorilla	100.00	0.00e+00	685.00
IUUC-Hvu-047553	Hordeum vulgare	46.32	6.00e-87	314.00
IUUC-Itr-048467	Ictidomys tridecemlineatus	99.69	0.00e+00	681.00
IUUC-Kpa-049325	Komagataella pastoris	44.17	3.00e-83	301.00
IUUC-Lch-049620	Latimeria chalumnae	86.58	2.00e-160	558.00
IUUC-Lpe-051338	Leersia perrieri	45.66	2.00e-79	289.00
IUUC-Loc-052094	Lepisosteus oculatus	79.26	1.00e-156	545.00
IUUC-Lma-053047	Leptosphaeria maculans	48.94	5.00e-93	334.00
IUUC-Laf-053801	Loxodonta africana	99.69	0.00e+00	669.00
IUUC-Mcc-055498	Macaca mulatta	88.62	6.00e-167	579.00
IUUC-Meu-056729	Macropus eugenii	90.49	9.00e-176	609.00
IUUC-Mor-057025	Magnaporthe oryzae	51.68	4.00e-95	341.00
IUUC-Mpo-057511	Magnaporthe poae	52.29	1.00e-97	349.00
IUUC-Mtr-058051	Medicago truncatula	47.40	1.00e-86	313.00
IUUC-Mla-059061	Melampsora laricipopulina	48.29	8.00e-85	306.00
IUUC-Mga-059229	Meleagris gallopavo	93.25	0.00e+00	639.00
IUUC-Mvi-060399	Microbotryum violaceum	47.59	2.00e-83	302.00
IUUC-Mmr-060764	Microcebus murinus	99.38	0.00e+00	682.00
IUUC-Mdo-062088	Monodelphis domestica	97.54	0.00e+00	666.00
IUUC-Mmu-064304	Mus musculus	99.38	0.00e+00	682.00
IUUC-Mac-065520	Musa acuminata	47.83	3.00e-87	315.00
IUUC-Mpu-066340	Mustela putorius furo	99.69	0.00e+00	681.00
IUUC-Mlu-067111	Myotis lucifugus	99.38	0.00e+00	678.00
IUUC-Nfi-068478	Neosartorya fischeri	53.01	1.00e-101	362.00
IUUC-Ncr-068820	Neurospora crassa	51.52	4.00e-96	344.00
IUUC-Nle-069903	Nomascus leucogenys	99.69	0.00e+00	681.00
IUUC-Opr-070221	Ochotona princeps	96.92	0.00e+00	662.00
IUUC-Ont-071765	Oreochromis niloticus	84.62	1.00e-172	598.00
IUUC-Oan-073660	Ornithorhynchus anatinus	95.58	1.00e-170	592.00
IUUC-Ocu-074039	Oryctolagus cuniculus	100.00	0.00e+00	683.00
IUUC-Oba-075395	Oryza barthii	39.26	2.00e-68	252.00
IUUC-Obr-076334	Oryza brachyantha	42.94	4.00e-78	284.00
IUUC-Ogl-077060	Oryza glaberrima	46.18	5.00e-84	304.00
IUUC-Ogu-078207	Oryza glumaepatula	46.46	2.00e-86	312.00
IUUC-Oin-079878	Oryza indica	46.01	2.00e-85	309.00
IUUC-Olo-080677	Oryza longistaminata	38.95	5.00e-76	278.00
IUUC-Ome-081228	Oryza meridionalis	34.98	2.00e-35	142.00
IUUC-Oni-082411	Oryza nivara	39.70	1.00e-68	252.00
IUUC-Opu-083136	Oryza punctata	45.09	2.00e-84	306.00
IUUC-Oru-084916	Oryza rufipogon	44.78	8.00e-84	303.00
IUUC-Osa-085454	Oryza sativa	46.01	2.00e-85	309.00
IUUC-Ola-087053	Oryzias latipes	84.31	3.00e-171	594.00
IUUC-Olu-087602	Ostreococcus lucimarinus	48.14	4.00e-89	321.00
IUUC-Oga-088154	Otolemur garnettii	99.69	0.00e+00	680.00
IUUC-Oar-089915	Ovis aries	99.07	0.00e+00	678.00
IUUC-Ptr-091124	Pan troglodytes	79.69	3.00e-149	520.00
IUUC-Pan-092035	Papio anubis	100.00	0.00e+00	685.00
IUUC-Psi-094096	Pelodiscus sinensis	89.40	4.00e-118	416.00
IUUC-Pno-094988	Phaeosphaeria nodorum	45.87	9.00e-82	296.00
IUUC-Ppa-095536	Physcomitrella patens	48.92	2.00e-91	328.00
IUUC-Pfo-096101	Poecilia formosa	84.00	3.00e-171	593.00
IUUC-Pab-097726	Pongo abelii	100.00	0.00e+00	685.00
IUUC-Pop-099617	Populus trichocarpa	47.85	4.00e-88	318.00
IUUC-Pca-101014	Procavia capensis	99.69	0.00e+00	683.00
IUUC-Ppe-101320	Prunus persica	47.87	1.00e-84	306.00
IUUC-Pva-102789	Pteropus vampyrus	86.46	3.00e-165	574.00
IUUC-Pgr-103479	Puccinia graminis	47.98	3.00e-84	305.00
IUUC-Ptt-103981	Puccinia triticina	48.29	6.00e-86	310.00
IUUC-Pte-104278	Pyrenophora teres	49.54	7.00e-92	330.00
IUUC-Pyt-104492	Pyrenophora triticirepentis	49.54	7.00e-92	330.00
IUUC-Rno-105867	Rattus norvegicus	76.38	4.00e-140	490.00
IUUC-Sce-106251	Saccharomyces cerevisiae	45.05	5.00e-83	301.00
IUUC-Sha-107039	Sarcophilus harrisii	97.23	0.00e+00	665.00
IUUC-Sja-107758	Schizosaccharomyces japonicus	52.45	1.00e-95	342.00
IUUC-Spo-108314	Schizosaccharomyces pombe	49.08	2.00e-91	329.00
IUUC-Ssl-108478	Sclerotinia sclerotiorum	51.38	2.00e-98	352.00
IUUC-Smo-108728	Selaginella moellendorffii	48.31	1.00e-86	313.00
IUUC-Sit-110801	Setaria italica	45.71	1.00e-85	309.00
IUUC-Sly-111326	Solanum lycopersicum	47.09	4.00e-86	311.00
IUUC-Stu-112458	Solanum tuberosum	48.17	4.00e-86	311.00
IUUC-Sbi-114063	Sorghum bicolor	45.40	1.00e-84	306.00
IUUC-Sre-115096	Sporisorium reilianum	48.04	4.00e-84	305.00
IUUC-Ssc-116080	Sus scrofa	99.38	0.00e+00	681.00
IUUC-Tgu-116988	Taeniopygia guttata	93.21	0.00e+00	642.00
IUUC-Tru-118766	Takifugu rubripes	84.62	3.00e-172	597.00
IUUC-Tni-120197	Tetraodon nigroviridis	84.00	1.00e-171	595.00
IUUC-Tca-121316	Theobroma cacao	46.63	1.00e-85	310.00
IUUC-Tre-122097	Trichoderma reesei	50.91	2.00e-95	342.00
IUUC-Tvi-122442	Trichoderma virens	50.91	1.00e-95	343.00
IUUC-Tae-125800	Triticum aestivum	46.32	6.00e-87	314.00
IUUC-Tur-126334	Triticum urartu	40.18	9.00e-69	253.00
IUUC-Tme-127038	Tuber melanosporum	53.64	2.00e-102	365.00
IUUC-Ttr-128659	Tursiops truncatus	93.23	7.00e-173	599.00
IUUC-Uma-129464	Ustilago maydis	48.34	6.00e-84	304.00
IUUC-Vda-129841	Verticillium dahliae	52.60	7.00e-97	347.00
IUUC-Vvi-131076	Vitis vinifera	47.71	1.00e-86	313.00
IUUC-Xtr-132395	Xenopus tropicalis	90.15	0.00e+00	633.00
IUUC-Xma-133383	Xiphophorus maculatus	83.69	2.00e-170	591.00
IUUC-Yli-134586	Yarrowia lipolytica	49.39	3.00e-82	298.00
IUUC-Zma-135904	Zea mays	45.71	3.00e-85	308.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence