iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mla-058903

Ensembl Protein ID

EGG04845

UniProt Accession

F4RS36; F4RS36_MELLP

Genbank Protein ID

EGG04845.1

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

GL883116

Gene Name

MELLADRAFT_37211

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MELLADRAFT_37211	EGG04845	EGG04845

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	7.10e-56	189.5	318	823
UBD/Alpha-Helix/UBA	1.50e-15	56.5	635	674

Active Site

Position(s)	Description	Evidence
327	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
783	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel................................wkskkkavs 69
           tGlkNlgN+CY+ SvLQ+L++++++++++ +++ ++ +    + p+++l ++++k+ + l                                    +k +s
   Q: 318  TGLKNLGNSCYIASVLQMLFSLSPFQSQYYNNFVSHASTCTAPFPSECLDCQMNKIAHGLlsgryaipnndpitpplvdvkaeiepshpptpAAAFQKGIS 418
           7******************************88888888888899***************88888888888877777777777776666644477777*** PP
   S: 70   prellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           p ++++ +++ ++efs+++qqDa+Efl +l+++++ ++kk                   ++ ++++  + +  ++ F++ql+++++c++c+ v+ + e+ +
   Q: 419  PMMFKALVGRGHHEFSTMKQQDAEEFLGYLFETIQGHIKK-------------------IETDQNPDVKLTDPTEPFRFQLEQKLQCENCKGVKYKLEDHM 500
           **************************************33...................345567888889999*************************** PP
   S: 171  dlslpvp.......gkeetkke.................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           +lslpvp       g+e    e                 +l++cLesf++  ++e    y c+kc+ k++a  + ++ ++P++Li+h  Rf  +  +++++
   Q: 501  TLSLPVPaipmmshGEE----EkensgetevgkkayqpvTLEQCLESFMACNSVE----YTCPKCRIKTTALTSSRIGSFPKYLIVHARRF--EVVNWVPK 591
           *******8877655222....133568899999999999***************9....********************************..5577**** PP
   S: 248  kinkkvefple.Ldlspfcts.....................................................peekqke.................... 274
           k++  + +    +dl+p++ +                                                     +     +                    
   Q: 592  KLEVPLMIEGDkIDLEPYLGQgqevgeellpdleeasspavpevneetlsvlmsmgfpkwrclkaihatgnrnlQ-----Vatdwlfermdddlhekdlal 687
           *********888*********777777777666666666666666555555555555555555555555555550.....055555555555555555555 PP
   S: 275  ...........................................................................kkkYeLiavvvHsG.slssGHYvayv 299
                                                                                      + +Y+L + v+H+G s++sGHYva+ 
   Q: 688  aapkvhpegnisglqemgftenqarkalrvskgkmdiavdwlfnhpedegeerlfgpddvlkedrppsvlgdrnlPAQYRLQGFVSHKGpSVHSGHYVAHL 788
           556666666666666666666666667777777777777777777777777889999999999999999999999************************** PP
   S: 300  kn.......ekgk........WllfdDskVtevkeee 321
           +        +  +        W+ f+D+kV e +e +
   Q: 789  RFkksneksN--EngvnvkedWVFFNDEKVMEANEGK 823
           9955655551..044555566***********99876 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraa.nnnleaAveyLld 40
            +e+ l  l++MGF++ ++l+a  a+ n nl++A+++L++
   Q: 635  VNEETLSVLMSMGFPKWRCLKAIHATgNRNLQVATDWLFE 674
           58999*********************************96 PP

Organism

Melampsora laricipopulina

Protein Sequence
(Fasta)

MNQSTQPDRV ECEHAVQLID WISSPTNRSM VYREECTQCF DSQDSPSGID VCLQCFNGGC 60
ASPDHHHAKH HAINQNHSLA LNIKRISKPK SQRTNESEPP LKKLAIREEN PIDQYEFVSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATCAAT CAACCCAGCC AGACCGCGTT GAATGTGAGC ATGCAGTACA ACTGATAGAT 60
TGGATTTCAT CACCTACAAA TCGTTCGATG GTCTATCGAG AAGAATGTAC TCAATGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mlr:MELLADRAFT_37211

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	31.37	7.00e-86	309.00
IUUC-Aml-002104	Ailuropoda melanoleuca	32.30	1.00e-118	419.00
IUUC-Atr-002580	Amborella trichopoda	32.80	4.00e-100	357.00
IUUC-Apl-003774	Anas platyrhynchos	32.70	1.00e-119	422.00
IUUC-Aca-005368	Anolis carolinensis	33.18	1.00e-124	438.00
IUUC-Aly-005727	Arabidopsis lyrata	34.30	2.00e-109	387.00
IUUC-Ath-006974	Arabidopsis thaliana	33.82	3.00e-107	380.00
IUUC-Ago-007890	Ashbya gossypii	29.51	1.00e-89	322.00
IUUC-Acl-008057	Aspergillus clavatus	43.62	1.00e-175	607.00
IUUC-Afl-008547	Aspergillus flavus	44.07	4.00e-161	559.00
IUUC-Afu-008805	Aspergillus fumigatus	41.72	2.00e-152	530.00
IUUC-Ani-009441	Aspergillus nidulans	39.97	3.00e-144	503.00
IUUC-Ang-009720	Aspergillus niger	42.61	3.00e-165	573.00
IUUC-Aor-010111	Aspergillus oryzae	44.22	0.00e+00	643.00
IUUC-Ate-010531	Aspergillus terreus	40.10	8.00e-148	515.00
IUUC-Ame-011893	Astyanax mexicanus	33.59	2.00e-99	355.00
IUUC-Bgr-012183	Blumeria graminis	41.52	1.00e-169	588.00
IUUC-Bta-013179	Bos taurus	31.88	1.00e-117	415.00
IUUC-Bci-013858	Botrytis cinerea	42.27	4.00e-178	616.00
IUUC-Bdi-014904	Brachypodium distachyon	32.89	4.00e-98	350.00
IUUC-Bol-015536	Brassica oleracea	35.71	7.00e-112	396.00
IUUC-Bra-017939	Brassica rapa	35.92	8.00e-114	402.00
IUUC-Cel-018625	Caenorhabditis elegans	29.09	4.00e-81	293.00
IUUC-Cja-019063	Callithrix jacchus	32.84	2.00e-118	417.00
IUUC-Cfa-020976	Canis familiaris	33.10	3.00e-121	427.00
IUUC-Cpo-022265	Cavia porcellus	32.70	7.00e-120	422.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	31.47	1.00e-59	222.00
IUUC-Csa-024177	Chlorocebus sabaeus	33.03	3.00e-111	394.00
IUUC-Cho-024702	Choloepus hoffmanni	30.35	4.00e-72	264.00
IUUC-Cin-025411	Ciona intestinalis	32.38	7.00e-97	346.00
IUUC-Csv-026347	Ciona savignyi	29.32	2.00e-87	315.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	42.89	9.00e-168	581.00
IUUC-Cne-026831	Cryptococcus neoformans	45.82	0.00e+00	657.00
IUUC-Cme-027335	Cyanidioschyzon merolae	26.68	2.00e-81	295.00
IUUC-Dre-027982	Danio rerio	32.30	3.00e-100	357.00
IUUC-Dno-029034	Dasypus novemcinctus	32.22	4.00e-120	423.00
IUUC-Dor-030479	Dipodomys ordii	33.33	1.00e-56	213.00
IUUC-Dse-031467	Dothistroma septosporum	41.90	5.00e-171	592.00
IUUC-Dme-032075	Drosophila melanogaster	31.04	6.00e-99	353.00
IUUC-Ete-032865	Echinops telfairi	29.07	5.00e-99	353.00
IUUC-Eca-034059	Equus caballus	31.89	2.00e-117	414.00
IUUC-Eeu-035304	Erinaceus europaeus	33.33	2.00e-109	388.00
IUUC-Fca-035515	Felis catus	32.22	2.00e-118	417.00
IUUC-Fal-037271	Ficedula albicollis	33.50	2.00e-116	410.00
IUUC-Fox-037745	Fusarium oxysporum	44.69	0.00e+00	632.00
IUUC-Fso-038158	Fusarium solani	44.75	0.00e+00	627.00
IUUC-Gmo-039071	Gadus morhua	33.18	6.00e-103	366.00
IUUC-Ggr-040098	Gaeumannomyces graminis	42.49	8.00e-170	588.00
IUUC-Gga-040635	Gallus gallus	32.31	3.00e-123	434.00
IUUC-Gac-042528	Gasterosteus aculeatus	32.94	9.00e-106	375.00
IUUC-Gma-043614	Glycine max	34.14	1.00e-100	358.00
IUUC-Ggo-044602	Gorilla gorilla	32.22	5.00e-119	419.00
IUUC-Hsa-045959	Homo sapiens	32.22	5.00e-119	419.00
IUUC-Hvu-047563	Hordeum vulgare	34.99	7.00e-94	335.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	32.64	2.00e-119	421.00
IUUC-Kpa-049156	Komagataella pastoris	36.80	2.00e-141	494.00
IUUC-Lch-049648	Latimeria chalumnae	31.64	1.00e-111	395.00
IUUC-Lpe-051523	Leersia perrieri	31.51	8.00e-90	322.00
IUUC-Loc-052072	Lepisosteus oculatus	31.32	4.00e-102	363.00
IUUC-Lma-053216	Leptosphaeria maculans	43.19	3.00e-169	588.00
IUUC-Laf-054327	Loxodonta africana	31.53	3.00e-117	414.00
IUUC-Mcc-055443	Macaca mulatta	32.11	2.00e-117	414.00
IUUC-Meu-056298	Macropus eugenii	33.11	3.00e-85	307.00
IUUC-Mor-057106	Magnaporthe oryzae	43.07	2.00e-180	623.00
IUUC-Mpo-057589	Magnaporthe poae	42.86	2.00e-171	593.00
IUUC-Mtr-058680	Medicago truncatula	34.34	7.00e-108	382.00
IUUC-Mga-059669	Meleagris gallopavo	32.40	2.00e-116	411.00
IUUC-Mvi-060476	Microbotryum violaceum	45.94	0.00e+00	645.00
IUUC-Mmr-060575	Microcebus murinus	31.65	8.00e-118	416.00
IUUC-Mdo-062183	Monodelphis domestica	31.97	3.00e-115	407.00
IUUC-Mmu-063592	Mus musculus	32.22	6.00e-119	419.00
IUUC-Mac-065634	Musa acuminata	29.91	2.00e-91	328.00
IUUC-Mpu-066082	Mustela putorius furo	33.10	4.00e-120	423.00
IUUC-Mlu-067345	Myotis lucifugus	32.61	1.00e-116	412.00
IUUC-Nfi-068558	Neosartorya fischeri	43.58	4.00e-169	586.00
IUUC-Ncr-068960	Neurospora crassa	43.92	1.00e-176	611.00
IUUC-Nle-070173	Nomascus leucogenys	32.98	5.00e-121	426.00
IUUC-Opr-070556	Ochotona princeps	32.22	3.00e-119	421.00
IUUC-Ont-071502	Oreochromis niloticus	33.53	4.00e-106	377.00
IUUC-Oan-072959	Ornithorhynchus anatinus	38.82	6.00e-45	171.00
IUUC-Ocu-074861	Oryctolagus cuniculus	33.06	2.00e-120	424.00
IUUC-Oba-075109	Oryza barthii	32.05	2.00e-94	338.00
IUUC-Obr-076292	Oryza brachyantha	32.45	4.00e-99	353.00
IUUC-Ogl-077065	Oryza glaberrima	33.33	8.00e-103	365.00
IUUC-Ogu-078776	Oryza glumaepatula	32.17	1.00e-99	355.00
IUUC-Oin-080048	Oryza indica	33.09	5.00e-103	366.00
IUUC-Olo-080711	Oryza longistaminata	32.06	5.00e-90	323.00
IUUC-Ome-081506	Oryza meridionalis	32.64	5.00e-92	330.00
IUUC-Oni-082320	Oryza nivara	31.46	8.00e-93	332.00
IUUC-Opu-083801	Oryza punctata	31.48	6.00e-91	326.00
IUUC-Oru-085139	Oryza rufipogon	31.18	8.00e-94	336.00
IUUC-Osa-085713	Oryza sativa	33.45	4.00e-104	370.00
IUUC-Ola-086951	Oryzias latipes	32.22	1.00e-99	355.00
IUUC-Olu-087822	Ostreococcus lucimarinus	30.26	8.00e-80	289.00
IUUC-Oga-088625	Otolemur garnettii	31.88	1.00e-116	412.00
IUUC-Oar-089995	Ovis aries	32.41	2.00e-118	418.00
IUUC-Ptr-090640	Pan troglodytes	32.83	3.00e-121	427.00
IUUC-Pan-091974	Papio anubis	32.61	2.00e-118	417.00
IUUC-Psi-093957	Pelodiscus sinensis	32.35	2.00e-122	431.00
IUUC-Pma-094242	Petromyzon marinus	35.78	1.00e-64	238.00
IUUC-Pno-094835	Phaeosphaeria nodorum	42.47	2.00e-143	500.00
IUUC-Ppa-095901	Physcomitrella patens	33.77	4.00e-109	387.00
IUUC-Pfo-097148	Poecilia formosa	33.53	2.00e-104	371.00
IUUC-Pab-098068	Pongo abelii	29.90	4.00e-95	340.00
IUUC-Pop-098943	Populus trichocarpa	33.41	1.00e-98	352.00
IUUC-Pca-100738	Procavia capensis	31.83	8.00e-83	299.00
IUUC-Ppe-101315	Prunus persica	32.48	5.00e-103	366.00
IUUC-Pva-102154	Pteropus vampyrus	31.76	3.00e-117	414.00
IUUC-Pgr-103343	Puccinia graminis	56.83	0.00e+00	737.00
IUUC-Ptt-103928	Puccinia triticina	48.79	0.00e+00	701.00
IUUC-Pte-104306	Pyrenophora teres	43.14	1.00e-153	535.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	43.18	1.00e-156	544.00
IUUC-Rno-105801	Rattus norvegicus	32.11	1.00e-118	419.00
IUUC-Sce-106304	Saccharomyces cerevisiae	29.48	4.00e-80	290.00
IUUC-Sha-107635	Sarcophilus harrisii	32.62	2.00e-118	417.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	38.65	6.00e-146	509.00
IUUC-Spo-108144	Schizosaccharomyces pombe	38.28	4.00e-152	530.00
IUUC-Smo-108703	Selaginella moellendorffii	33.86	1.00e-105	375.00
IUUC-Sit-110728	Setaria italica	33.29	4.00e-103	367.00
IUUC-Sly-111523	Solanum lycopersicum	33.01	4.00e-107	380.00
IUUC-Sar-113733	Sorex araneus	38.44	4.00e-56	210.00
IUUC-Sbi-114419	Sorghum bicolor	32.65	5.00e-101	360.00
IUUC-Sre-115225	Sporisorium reilianum	42.53	1.00e-180	625.00
IUUC-Ssc-115686	Sus scrofa	32.41	2.00e-118	417.00
IUUC-Tgu-117346	Taeniopygia guttata	32.16	1.00e-117	415.00
IUUC-Tru-118350	Takifugu rubripes	31.73	2.00e-102	364.00
IUUC-Tsy-119278	Tarsius syrichta	31.18	4.00e-84	303.00
IUUC-Tni-120658	Tetraodon nigroviridis	32.42	1.00e-97	348.00
IUUC-Tca-121585	Theobroma cacao	33.09	3.00e-99	354.00
IUUC-Tre-122043	Trichoderma reesei	43.51	2.00e-172	597.00
IUUC-Tvi-122303	Trichoderma virens	43.58	2.00e-169	587.00
IUUC-Tae-123798	Triticum aestivum	33.01	2.00e-102	364.00
IUUC-Tur-126732	Triticum urartu	30.96	6.00e-89	320.00
IUUC-Tme-126909	Tuber melanosporum	42.84	2.00e-167	580.00
IUUC-Tbe-127261	Tupaia belangeri	29.25	2.00e-39	155.00
IUUC-Ttr-129119	Tursiops truncatus	35.53	5.00e-59	220.00
IUUC-Uma-129599	Ustilago maydis	43.40	0.00e+00	650.00
IUUC-Vda-129688	Verticillium dahliae	43.56	6.00e-173	598.00
IUUC-Vpa-130170	Vicugna pacos	38.11	7.00e-47	180.00
IUUC-Vvi-131116	Vitis vinifera	34.13	5.00e-99	353.00
IUUC-Xtr-131953	Xenopus tropicalis	32.57	5.00e-105	373.00
IUUC-Xma-133837	Xiphophorus maculatus	33.06	5.00e-104	370.00
IUUC-Yli-134510	Yarrowia lipolytica	38.94	5.00e-137	479.00
IUUC-Zma-135786	Zea mays	31.68	4.00e-94	337.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence