iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cja-019516

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACFV01020590

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000020464.2	ENSCJAT00000040190.2	ENSCJAP00000038043.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.70e-64	217.4	105	482
ULD/UDP/UBQ/UBQ_Other	5.50e-09	36.7	5	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk...sqikclecdnvssreepf 169
             +y qqDa+E++ +++  l+++l+  ++ +++e+        s++a+  +++k+ksli++ F+++++   +++kc e +++ +++ + 
   Q: 192  qgQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETD-------SSSASAATPSKKKSLIDQFFGVEFEttlQSMKCTESEEEEVTKGKE 273
           999*********************664444444443.......3347889999*************99555566798888888888888 PP
   S: 170  ldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple 258
           ++l+l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+
   Q: 274  NQLQLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLM 355
           8888888777744..58999999999999998.....58899999999***************************************** PP
   S: 259  Ldlspfcts.......................peekqke...........................kkkYeLiavvvHsG.slssGHYv 296
           Ld+ + ct                        p     +                           +  Y+L av+ H+G s+ssGHYv
   Q: 356  LDMYELCTPelqekmvsfrskfkdledkkvnqP-----NtsdkksspqkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYV 439
           *********666666666666666666555551.....0555556666677777777777777777*********************** PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           ++vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 440  SWVKRKQDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 482
           ****************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd ++++ ++k+g+t++++ +
   Q: 5    SVTVKWGKEKFEGVELNTDEPPVVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNIKIKNGMTLLMMGS 74
           69********99*************************************999.9**************965 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MPLYSVTVKW GKEKFEGVEL NTDEPPVVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTGAATGA GACTCTCGTC GCACCGAAGC AGCCGCCACC ACCGCGCTTC TGCCTCGGCC 60
GCCGCCACAG CTGCTTCTGG TCCCAATCCC CTAGCCTCCT GTGCCAGGCC CAGCCCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	43.41	7.00e-38	151.00
IUUC-Aml-002053	Ailuropoda melanoleuca	97.36	0.00e+00	919.00
IUUC-Atr-002725	Amborella trichopoda	41.58	3.00e-100	358.00
IUUC-Apl-004031	Anas platyrhynchos	87.65	0.00e+00	877.00
IUUC-Aca-004361	Anolis carolinensis	89.13	0.00e+00	897.00
IUUC-Aly-006078	Arabidopsis lyrata	42.03	2.00e-110	392.00
IUUC-Ath-007623	Arabidopsis thaliana	42.01	5.00e-111	394.00
IUUC-Ago-007796	Ashbya gossypii	31.19	4.00e-57	215.00
IUUC-Acl-008258	Aspergillus clavatus	36.52	2.00e-63	236.00
IUUC-Afl-008732	Aspergillus flavus	36.52	5.00e-65	242.00
IUUC-Afu-008755	Aspergillus fumigatus	37.47	9.00e-66	244.00
IUUC-Ani-009148	Aspergillus nidulans	37.65	1.00e-68	254.00
IUUC-Ang-009878	Aspergillus niger	37.07	2.00e-64	239.00
IUUC-Aor-010239	Aspergillus oryzae	35.65	4.00e-65	242.00
IUUC-Ate-010243	Aspergillus terreus	34.61	2.00e-77	283.00
IUUC-Ame-011327	Astyanax mexicanus	49.90	1.00e-125	442.00
IUUC-Bgr-012231	Blumeria graminis	33.74	3.00e-78	286.00
IUUC-Bta-012553	Bos taurus	95.97	0.00e+00	933.00
IUUC-Bci-013606	Botrytis cinerea	39.43	2.00e-68	253.00
IUUC-Bdi-014567	Brachypodium distachyon	43.46	5.00e-111	394.00
IUUC-Bol-016127	Brassica oleracea	42.35	1.00e-111	396.00
IUUC-Bra-017501	Brassica rapa	42.15	6.00e-111	394.00
IUUC-Cel-018140	Caenorhabditis elegans	40.91	2.00e-98	352.00
IUUC-Cfa-020808	Canis familiaris	97.58	0.00e+00	947.00
IUUC-Cpo-021688	Cavia porcellus	95.77	0.00e+00	925.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	37.07	8.00e-82	297.00
IUUC-Csa-023429	Chlorocebus sabaeus	98.19	0.00e+00	932.00
IUUC-Cho-024347	Choloepus hoffmanni	93.95	0.00e+00	941.00
IUUC-Cin-025198	Ciona intestinalis	54.99	7.00e-151	526.00
IUUC-Csv-026007	Ciona savignyi	52.91	4.00e-153	534.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	38.44	1.00e-63	237.00
IUUC-Cne-026963	Cryptococcus neoformans	34.67	1.00e-74	273.00
IUUC-Cme-027240	Cyanidioschyzon merolae	30.33	4.00e-58	219.00
IUUC-Dre-027647	Danio rerio	81.74	0.00e+00	823.00
IUUC-Dno-029967	Dasypus novemcinctus	96.37	0.00e+00	922.00
IUUC-Dor-030886	Dipodomys ordii	90.72	0.00e+00	751.00
IUUC-Dse-031466	Dothistroma septosporum	34.75	3.00e-55	209.00
IUUC-Dme-032079	Drosophila melanogaster	54.95	1.00e-157	549.00
IUUC-Ete-032351	Echinops telfairi	95.45	2.00e-136	479.00
IUUC-Eca-033461	Equus caballus	96.98	0.00e+00	979.00
IUUC-Eeu-035220	Erinaceus europaeus	73.21	0.00e+00	679.00
IUUC-Fca-036210	Felis catus	97.78	0.00e+00	947.00
IUUC-Fal-037528	Ficedula albicollis	87.07	0.00e+00	860.00
IUUC-Fox-037805	Fusarium oxysporum	39.59	5.00e-69	255.00
IUUC-Fso-038177	Fusarium solani	37.53	6.00e-66	245.00
IUUC-Gmo-038953	Gadus morhua	77.69	0.00e+00	760.00
IUUC-Ggr-039972	Gaeumannomyces graminis	33.94	7.00e-73	268.00
IUUC-Gga-040462	Gallus gallus	86.69	0.00e+00	870.00
IUUC-Gac-041312	Gasterosteus aculeatus	80.57	0.00e+00	793.00
IUUC-Gma-043255	Glycine max	42.06	3.00e-107	382.00
IUUC-Ggo-045458	Gorilla gorilla	83.20	0.00e+00	801.00
IUUC-Hsa-045706	Homo sapiens	98.39	0.00e+00	934.00
IUUC-Hvu-047821	Hordeum vulgare	47.22	4.00e-58	217.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	96.98	0.00e+00	946.00
IUUC-Lch-050464	Latimeria chalumnae	81.74	0.00e+00	813.00
IUUC-Lpe-051419	Leersia perrieri	42.21	1.00e-107	383.00
IUUC-Loc-052732	Lepisosteus oculatus	80.52	0.00e+00	838.00
IUUC-Lma-053177	Leptosphaeria maculans	40.20	5.00e-69	255.00
IUUC-Laf-053822	Loxodonta africana	96.37	0.00e+00	936.00
IUUC-Mcc-055893	Macaca mulatta	98.39	0.00e+00	934.00
IUUC-Meu-056307	Macropus eugenii	81.67	0.00e+00	780.00
IUUC-Mor-057171	Magnaporthe oryzae	39.69	1.00e-66	247.00
IUUC-Mpo-057415	Magnaporthe poae	40.11	4.00e-68	252.00
IUUC-Mtr-057901	Medicago truncatula	42.66	8.00e-110	390.00
IUUC-Mla-058897	Melampsora laricipopulina	39.31	5.00e-74	271.00
IUUC-Mga-060016	Meleagris gallopavo	87.25	0.00e+00	875.00
IUUC-Mvi-060562	Microbotryum violaceum	38.73	8.00e-66	244.00
IUUC-Mmr-060624	Microcebus murinus	96.98	0.00e+00	984.00
IUUC-Mdo-061809	Monodelphis domestica	89.94	0.00e+00	887.00
IUUC-Mmu-063869	Mus musculus	94.75	0.00e+00	925.00
IUUC-Mac-064876	Musa acuminata	39.24	5.00e-95	341.00
IUUC-Mpu-066480	Mustela putorius furo	97.18	0.00e+00	942.00
IUUC-Mlu-067866	Myotis lucifugus	95.97	0.00e+00	941.00
IUUC-Nfi-068393	Neosartorya fischeri	36.74	3.00e-63	236.00
IUUC-Ncr-068815	Neurospora crassa	35.48	2.00e-82	299.00
IUUC-Nle-070121	Nomascus leucogenys	99.60	1.00e-140	492.00
IUUC-Opr-070712	Ochotona princeps	73.32	1.00e-169	589.00
IUUC-Ont-071544	Oreochromis niloticus	80.57	0.00e+00	759.00
IUUC-Oan-073635	Ornithorhynchus anatinus	90.00	0.00e+00	733.00
IUUC-Ocu-074926	Oryctolagus cuniculus	95.56	0.00e+00	917.00
IUUC-Oba-075633	Oryza barthii	42.01	7.00e-108	384.00
IUUC-Obr-076423	Oryza brachyantha	42.60	4.00e-109	388.00
IUUC-Ogl-077913	Oryza glaberrima	42.37	1.00e-109	390.00
IUUC-Ogu-078435	Oryza glumaepatula	42.01	7.00e-108	384.00
IUUC-Oin-080072	Oryza indica	41.98	4.00e-108	384.00
IUUC-Olo-080535	Oryza longistaminata	38.69	3.00e-92	332.00
IUUC-Ome-081309	Oryza meridionalis	42.01	7.00e-108	384.00
IUUC-Oni-083113	Oryza nivara	42.01	7.00e-108	384.00
IUUC-Opu-083168	Oryza punctata	41.07	3.00e-102	365.00
IUUC-Oru-084253	Oryza rufipogon	42.01	7.00e-108	384.00
IUUC-Osa-085554	Oryza sativa	42.37	1.00e-109	389.00
IUUC-Ola-086998	Oryzias latipes	80.24	0.00e+00	783.00
IUUC-Olu-087818	Ostreococcus lucimarinus	35.96	2.00e-70	259.00
IUUC-Oga-088571	Otolemur garnettii	96.37	0.00e+00	934.00
IUUC-Oar-089526	Ovis aries	93.52	0.00e+00	928.00
IUUC-Ptr-091433	Pan troglodytes	98.39	0.00e+00	934.00
IUUC-Pan-091966	Papio anubis	98.19	0.00e+00	932.00
IUUC-Psi-093458	Pelodiscus sinensis	88.22	0.00e+00	837.00
IUUC-Pma-094343	Petromyzon marinus	68.15	8.00e-120	422.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.36	5.00e-64	238.00
IUUC-Ppa-095756	Physcomitrella patens	43.44	3.00e-110	392.00
IUUC-Pfo-096514	Poecilia formosa	81.38	0.00e+00	775.00
IUUC-Pab-098477	Pongo abelii	85.84	0.00e+00	736.00
IUUC-Pop-099221	Populus trichocarpa	40.72	4.00e-102	365.00
IUUC-Pca-100791	Procavia capensis	80.93	2.00e-178	618.00
IUUC-Ppe-101812	Prunus persica	40.96	8.00e-107	380.00
IUUC-Pva-102462	Pteropus vampyrus	91.65	0.00e+00	755.00
IUUC-Pgr-103623	Puccinia graminis	40.34	2.00e-73	269.00
IUUC-Ptt-103767	Puccinia triticina	39.05	1.00e-66	247.00
IUUC-Pte-104109	Pyrenophora teres	38.65	3.00e-68	252.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	40.25	2.00e-68	253.00
IUUC-Rno-105351	Rattus norvegicus	94.55	0.00e+00	889.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.68	3.00e-61	229.00
IUUC-Sha-107491	Sarcophilus harrisii	89.72	0.00e+00	899.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	34.18	1.00e-77	283.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.60	8.00e-79	287.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	34.04	4.00e-82	298.00
IUUC-Smo-108805	Selaginella moellendorffii	43.24	7.00e-109	387.00
IUUC-Sit-110361	Setaria italica	42.08	9.00e-112	397.00
IUUC-Sly-110965	Solanum lycopersicum	39.92	7.00e-107	380.00
IUUC-Sar-113355	Sorex araneus	83.06	0.00e+00	649.00
IUUC-Sbi-114778	Sorghum bicolor	42.77	6.00e-110	390.00
IUUC-Sre-115011	Sporisorium reilianum	35.75	2.00e-60	226.00
IUUC-Ssc-116273	Sus scrofa	93.72	0.00e+00	920.00
IUUC-Tgu-117063	Taeniopygia guttata	86.44	0.00e+00	858.00
IUUC-Tru-118381	Takifugu rubripes	78.18	0.00e+00	778.00
IUUC-Tsy-119076	Tarsius syrichta	81.18	4.00e-116	411.00
IUUC-Tni-119941	Tetraodon nigroviridis	79.51	0.00e+00	770.00
IUUC-Tca-121246	Theobroma cacao	41.03	7.00e-108	384.00
IUUC-Tre-121969	Trichoderma reesei	37.95	6.00e-67	248.00
IUUC-Tvi-122543	Trichoderma virens	34.50	2.00e-76	280.00
IUUC-Tae-125484	Triticum aestivum	41.52	7.00e-107	380.00
IUUC-Tur-126128	Triticum urartu	41.38	9.00e-39	154.00
IUUC-Tbe-128030	Tupaia belangeri	87.35	0.00e+00	839.00
IUUC-Ttr-128701	Tursiops truncatus	95.31	0.00e+00	756.00
IUUC-Uma-129657	Ustilago maydis	36.49	1.00e-63	237.00
IUUC-Vda-129723	Verticillium dahliae	32.65	4.00e-71	262.00
IUUC-Vpa-130284	Vicugna pacos	70.00	3.00e-179	621.00
IUUC-Vvi-131037	Vitis vinifera	42.58	4.00e-108	384.00
IUUC-Xtr-132235	Xenopus tropicalis	85.86	0.00e+00	872.00
IUUC-Xma-133840	Xiphophorus maculatus	81.38	0.00e+00	800.00
IUUC-Yli-134453	Yarrowia lipolytica	36.56	7.00e-81	294.00
IUUC-Zma-135669	Zea mays	36.33	2.00e-94	339.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence