iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053960

UUCD1 version

UUC-LoA-00749

Ensembl Protein ID

ENSLAFP00000020391.1

UniProt Accession

G3TXT3; G3TXT3_LOXAF

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000026912.1	ENSLAFT00000029010.1	ENSLAFP00000020391.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.30e-81	272.7	600	922

Active Site

Position(s)	Description	Evidence
892	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 17   egldlgGvtreflallskelqnpd..lglf.lysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           e+ + +G++r ++++ ++++ + d  ++lf +  +++ +t +p +++      +l++F+ +Gr+lg++l +++l++++l+++++k llg
   Q: 600  ENRKRHGSSRSVVDMDLDDTDDGDdnAPLFyQPGKRGFYTPRPGKNTE----ARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLG 684
           556778**************9999778888334444777777777775....89*********************************** PP
   S: 103  kklsledleevdpelyks.lkeikena..esdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegike 188
           +k++++d++ +dp +y+s  + i++++  ++d   +++dl+f ++ ++ +   ++eL+p+G nipVt +N +eYv++++e+r+    ++
   Q: 685  RKVNWHDFAFFDPVMYESlRQLILASQssDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQ 773
           ******************5556666655556888999**************************************************** PP
   S: 189  qveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspai....qwFwevleefsseerkafLqFvTgssr 273
            ++a+r+G+ +v+p+++l+ +t+e+++ll++G+ e++v++l ++t+++++  e+ +++    +wFw+++e++s++er++++ F+T+s++
   Q: 774  PLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLlqfkRWFWSIVEKMSMTERQDLVYFWTSSPS 862
           ***********************************************9999999999989999************************** PP
   S: 274  lPl..gGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           lP+  +Gf++++  +++ir   +d++lP++nTC+++L +P Yssk+ilk+kLl+Ai++ k+F++
   Q: 863  LPAseEGFQPMP--SITIRP-PDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT-KNFGF 922
           ***999******..799999.99**********************************9.99875 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

ARRERMTARE EASLRTLEGR RSNRRATLLS ARQGMMSARG DFLNYALSLM RSHNDEHSDV 60
LPVLDVCSLK HVAYVFQALI YWIKAMNQQT TLDTPQLERK RTRELLELGI DNEDSEHEND 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCGAAGAG AGAGGATGAC TGCACGAGAG GAGGCTAGTT TAAGAACGCT TGAAGGCAGA 60
CGGTATGAAA TTCTTCATGT ATGATTGTGT GTTCAGACAG AGCTCTTAAA TTCTAGGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR002004--PABP_HYD

PROSITE

PS50237--HECT
PS51309--PABC

Pfam

PF00632--HECT
PF00658--PABP

SMART

SM00119--HECTc
SM00517--PolyA

Gene Ontology

GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004577	Anolis carolinensis	94.19	0.00e+00	1516.00
IUUC-Ame-010702	Astyanax mexicanus	86.38	0.00e+00	1434.00
IUUC-Cel-018165	Caenorhabditis elegans	27.51	8.00e-83	303.00
IUUC-Cpo-022065	Cavia porcellus	94.10	0.00e+00	1006.00
IUUC-Cho-025034	Choloepus hoffmanni	86.53	0.00e+00	981.00
IUUC-Cin-025715	Ciona intestinalis	47.10	0.00e+00	724.00
IUUC-Csv-026131	Ciona savignyi	47.67	0.00e+00	687.00
IUUC-Dre-027730	Danio rerio	86.80	0.00e+00	1441.00
IUUC-Dno-029123	Dasypus novemcinctus	97.59	0.00e+00	1568.00
IUUC-Dme-032192	Drosophila melanogaster	52.31	2.00e-176	614.00
IUUC-Gmo-039589	Gadus morhua	86.78	0.00e+00	1451.00
IUUC-Gga-041195	Gallus gallus	95.94	0.00e+00	1546.00
IUUC-Gac-042538	Gasterosteus aculeatus	87.49	0.00e+00	1464.00
IUUC-Loc-052664	Lepisosteus oculatus	87.17	0.00e+00	1432.00
IUUC-Mga-059289	Meleagris gallopavo	95.94	0.00e+00	1576.00
IUUC-Ont-071951	Oreochromis niloticus	86.11	0.00e+00	1423.00
IUUC-Ola-086757	Oryzias latipes	86.18	0.00e+00	1470.00
IUUC-Pfo-096173	Poecilia formosa	87.15	0.00e+00	1430.00
IUUC-Sar-113517	Sorex araneus	97.70	0.00e+00	782.00
IUUC-Ssc-115470	Sus scrofa	97.37	0.00e+00	1560.00
IUUC-Tru-117682	Takifugu rubripes	86.93	0.00e+00	1427.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence