iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050325

Ensembl Protein ID

ENSLACP00000008432.1

UniProt Accession

H3AFL1; H3AFL1_LATCH

Genbank Protein ID

ENSLACP00000008432

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AFYH01069823

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000007465.1	ENSLACT00000008500.1	ENSLACP00000008432.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	83.75	0.00e+00	1552.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
805	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Latimeria chalumnae

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MSSPSHPDGV SSCDQSVELL KPSRVNHIPG TVDVSAARPL QVAPNTAPMD LRLDHQFSVP 60
VAESTLRDQQ LQQELLALKQ KQQVQRQLLI AEFQRQHEQL SRQHEAQLHE HIKQQQELLA 120

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Nucleotide Sequence
(Fasta)

CCTGAGCCCC AGAGATTTCA GAAGCCCCCA AACCCCTCTG ACTTGGATTA CCGTGCTTGA 60
AAGAGAGAAT GGTTCTCTGA CCTGGAGTTT CTTACAGCAG CAGTGGTGTG TGTGTCGGCC 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	83.43	0.00e+00	1592.00
IUUC-Apl-003250	Anas platyrhynchos	83.56	0.00e+00	1514.00
IUUC-Aca-004668	Anolis carolinensis	79.02	0.00e+00	1555.00
IUUC-Ang-009522	Aspergillus niger	29.44	6.00e-36	145.00
IUUC-Bta-013215	Bos taurus	83.38	0.00e+00	1571.00
IUUC-Cja-019816	Callithrix jacchus	83.69	0.00e+00	1612.00
IUUC-Cfa-020861	Canis familiaris	83.92	0.00e+00	1578.00
IUUC-Cpo-021562	Cavia porcellus	82.91	0.00e+00	1602.00
IUUC-Cre-022561	Chlamydomonas reinhardtii	50.88	6.00e-56	209.00
IUUC-Csa-023612	Chlorocebus sabaeus	83.12	0.00e+00	1580.00
IUUC-Csv-026359	Ciona savignyi	54.73	1.00e-91	328.00
IUUC-Dre-028284	Danio rerio	74.58	0.00e+00	1351.00
IUUC-Dno-029951	Dasypus novemcinctus	81.48	0.00e+00	1451.00
IUUC-Dor-030362	Dipodomys ordii	72.79	0.00e+00	1302.00
IUUC-Dme-031766	Drosophila melanogaster	59.76	2.00e-160	560.00
IUUC-Fca-036187	Felis catus	84.73	0.00e+00	1566.00
IUUC-Gmo-038473	Gadus morhua	75.00	0.00e+00	734.00
IUUC-Gga-040501	Gallus gallus	85.98	0.00e+00	1594.00
IUUC-Gac-042335	Gasterosteus aculeatus	82.59	0.00e+00	840.00
IUUC-Ggo-045380	Gorilla gorilla	83.41	0.00e+00	1580.00
IUUC-Hsa-046925	Homo sapiens	83.78	0.00e+00	1605.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	83.62	0.00e+00	1526.00
IUUC-Loc-052231	Lepisosteus oculatus	82.00	0.00e+00	1478.00
IUUC-Laf-054490	Loxodonta africana	77.45	0.00e+00	1469.00
IUUC-Mcc-055265	Macaca mulatta	82.98	0.00e+00	1589.00
IUUC-Meu-056676	Macropus eugenii	80.98	0.00e+00	706.00
IUUC-Mmr-061633	Microcebus murinus	77.02	0.00e+00	1394.00
IUUC-Mmu-063089	Mus musculus	83.46	0.00e+00	1548.00
IUUC-Mpu-065887	Mustela putorius furo	84.25	0.00e+00	1605.00
IUUC-Mlu-067470	Myotis lucifugus	84.62	0.00e+00	1579.00
IUUC-Nle-069099	Nomascus leucogenys	80.10	0.00e+00	1030.00
IUUC-Ont-071613	Oreochromis niloticus	67.46	0.00e+00	1299.00
IUUC-Oan-073275	Ornithorhynchus anatinus	84.31	0.00e+00	1559.00
IUUC-Ola-087031	Oryzias latipes	66.27	0.00e+00	1187.00
IUUC-Oga-088201	Otolemur garnettii	77.47	0.00e+00	1391.00
IUUC-Oar-089997	Ovis aries	75.98	0.00e+00	1269.00
IUUC-Ptr-091116	Pan troglodytes	83.88	0.00e+00	1620.00
IUUC-Pan-092132	Papio anubis	84.30	0.00e+00	1043.00
IUUC-Psi-093734	Pelodiscus sinensis	84.80	0.00e+00	1501.00
IUUC-Pma-094347	Petromyzon marinus	72.26	0.00e+00	718.00
IUUC-Pfo-096293	Poecilia formosa	69.47	0.00e+00	1214.00
IUUC-Pab-098491	Pongo abelii	80.80	0.00e+00	1517.00
IUUC-Pca-101004	Procavia capensis	74.58	0.00e+00	835.00
IUUC-Pva-102961	Pteropus vampyrus	63.38	0.00e+00	786.00
IUUC-Rno-105005	Rattus norvegicus	83.64	0.00e+00	1531.00
IUUC-Sha-107646	Sarcophilus harrisii	61.98	0.00e+00	904.00
IUUC-Ssc-115428	Sus scrofa	84.46	0.00e+00	1531.00
IUUC-Tgu-116776	Taeniopygia guttata	85.95	0.00e+00	1593.00
IUUC-Tru-118180	Takifugu rubripes	67.10	0.00e+00	1263.00
IUUC-Tsy-119468	Tarsius syrichta	68.29	0.00e+00	978.00
IUUC-Tni-120196	Tetraodon nigroviridis	67.83	0.00e+00	1247.00
IUUC-Ttr-128360	Tursiops truncatus	76.09	0.00e+00	897.00
IUUC-Xtr-132956	Xenopus tropicalis	78.47	0.00e+00	1418.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence