iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055427

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF146 isoform b

Genbank Nucleotide ID

JSUE03032251

Gene Name

RNF146

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000015354.3	ENSMMUT00000021523.2	ENSMMUP00000020131.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	94.17	2.00e-162	569.00	IUUC-Hsa-045790

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MMAGCGEIDH SINMLPTNRK ANESCSNTAP SLTVPECAIC LQTCVHPVSL PCKHVFCYLC 60
VKGASWLGKR CALCRQEIPE DFLDKPTLLS PEELKAASRG NGEYAWYYEG RNGWWQYDER 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTAGGCGC CCCAGGGCTT CCTCGGGATA GCAAAGCTGG ATTTTTGAGC AGCACCACCT 60
GCCGGGCCTA CACACGTTTT ACTTCCTCCA CCCCAAACCT CTCTCTGCTG GAACTGCATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome

Interpro

IPR033509--RNF146
IPR004170--WWE-dom
IPR018123--WWE-dom_subgr
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50918--WWE
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02825--WWE

SMART

SM00184--RING
SM00678--WWE

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0072572--F:poly-ADP-D-ribose binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002237	Ailuropoda melanoleuca	88.33	5.00e-155	540.00
IUUC-Apl-004143	Anas platyrhynchos	85.28	1.00e-136	478.00
IUUC-Aca-004557	Anolis carolinensis	81.44	1.00e-129	456.00
IUUC-Ame-011088	Astyanax mexicanus	61.09	1.00e-83	303.00
IUUC-Bta-012639	Bos taurus	89.72	1.00e-150	526.00
IUUC-Cel-018462	Caenorhabditis elegans	28.35	5.00e-19	87.40
IUUC-Cja-019397	Callithrix jacchus	94.44	2.00e-164	571.00
IUUC-Cfa-021140	Canis familiaris	88.33	9.00e-167	579.00
IUUC-Cpo-021387	Cavia porcellus	86.39	2.00e-167	582.00
IUUC-Csa-023503	Chlorocebus sabaeus	99.44	7.00e-160	556.00
IUUC-Cho-024895	Choloepus hoffmanni	90.49	2.00e-143	501.00
IUUC-Cin-025455	Ciona intestinalis	51.92	4.00e-43	167.00
IUUC-Dre-028824	Danio rerio	47.29	2.00e-82	299.00
IUUC-Dno-029269	Dasypus novemcinctus	91.67	6.00e-162	563.00
IUUC-Dor-030592	Dipodomys ordii	90.58	2.00e-165	574.00
IUUC-Dme-031618	Drosophila melanogaster	57.33	9.00e-56	211.00
IUUC-Ete-032478	Echinops telfairi	88.61	8.00e-163	566.00
IUUC-Eca-033389	Equus caballus	92.48	0.00e+00	625.00
IUUC-Fca-035488	Felis catus	91.92	3.00e-163	567.00
IUUC-Fal-037087	Ficedula albicollis	83.33	1.00e-155	542.00
IUUC-Gga-040401	Gallus gallus	85.00	5.00e-139	487.00
IUUC-Gac-042412	Gasterosteus aculeatus	64.53	9.00e-88	317.00
IUUC-Ggo-045417	Gorilla gorilla	94.12	1.00e-156	545.00
IUUC-Hsa-045790	Homo sapiens	94.17	9.00e-164	569.00
IUUC-Itr-048820	Ictidomys tridecemlineatus	91.09	1.00e-166	579.00
IUUC-Lch-049493	Latimeria chalumnae	68.32	1.00e-110	392.00
IUUC-Loc-052927	Lepisosteus oculatus	60.55	2.00e-102	365.00
IUUC-Laf-053904	Loxodonta africana	94.17	2.00e-160	558.00
IUUC-Mmr-060580	Microcebus murinus	92.80	3.00e-157	547.00
IUUC-Mdo-062094	Monodelphis domestica	96.97	8.00e-79	285.00
IUUC-Mmu-063363	Mus musculus	88.89	8.00e-166	576.00
IUUC-Mpu-066816	Mustela putorius furo	91.94	5.00e-158	550.00
IUUC-Mlu-067433	Myotis lucifugus	90.28	7.00e-179	619.00
IUUC-Nle-068986	Nomascus leucogenys	97.50	4.00e-176	610.00
IUUC-Ont-072670	Oreochromis niloticus	58.42	3.00e-81	295.00
IUUC-Oan-073330	Ornithorhynchus anatinus	87.06	2.00e-107	381.00
IUUC-Ocu-074161	Oryctolagus cuniculus	89.20	1.00e-163	568.00
IUUC-Ola-086902	Oryzias latipes	58.91	3.00e-84	305.00
IUUC-Oga-089159	Otolemur garnettii	93.61	0.00e+00	629.00
IUUC-Oar-089586	Ovis aries	90.83	3.00e-146	511.00
IUUC-Ptr-090987	Pan troglodytes	94.17	9.00e-164	569.00
IUUC-Pan-091867	Papio anubis	100.00	2.00e-166	578.00
IUUC-Psi-094024	Pelodiscus sinensis	84.44	3.00e-142	497.00
IUUC-Pma-094453	Petromyzon marinus	63.91	3.00e-65	241.00
IUUC-Pfo-097108	Poecilia formosa	70.73	8.00e-84	303.00
IUUC-Pab-097997	Pongo abelii	92.20	8.00e-170	589.00
IUUC-Pca-100260	Procavia capensis	91.92	4.00e-163	567.00
IUUC-Pva-103140	Pteropus vampyrus	91.14	4.00e-165	573.00
IUUC-Rno-105795	Rattus norvegicus	86.98	2.00e-164	571.00
IUUC-Sha-107033	Sarcophilus harrisii	87.50	7.00e-156	543.00
IUUC-Ssc-116395	Sus scrofa	96.67	2.00e-179	621.00
IUUC-Tgu-116685	Taeniopygia guttata	80.83	2.00e-135	474.00
IUUC-Tru-118014	Takifugu rubripes	74.88	3.00e-84	304.00
IUUC-Tsy-119326	Tarsius syrichta	89.20	2.00e-174	605.00
IUUC-Tni-120322	Tetraodon nigroviridis	69.95	3.00e-82	298.00
IUUC-Tbe-128067	Tupaia belangeri	91.14	4.00e-170	590.00
IUUC-Ttr-128530	Tursiops truncatus	93.07	4.00e-165	573.00
IUUC-Vpa-130322	Vicugna pacos	94.17	1.00e-171	595.00
IUUC-Xtr-132606	Xenopus tropicalis	65.18	3.00e-118	417.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence