iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins.

Protein Sequence
(Fasta)

MSSSPTVLEL FDVCFKQEDV DSLKKPNWFT DVSIDYVDEL IEHLWFPSYP NQANEILLLR 60
PSLVFLLAEA AISPEELKVA LPKKLMNCKY LFMPINDLDK HAAGSGGSHW SLMVASIPDG 120

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Nucleotide Sequence
(Fasta)

ATTTTAACAC TCGTGTTACT CTTCCGTTCG AGCTGTTTTG TTTGCGGACC TATTGTTTGT 60
TTAAATTCCT TTTTTTCCCC ATTTCGTACT TACTTTTAAA CAATTTTTAA ATGAGCAGTT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease

Interpro

IPR003653--Peptidase_C48_C

PROSITE

PS50600--ULP_PROTEASE

Pfam

PF02902--Peptidase_C48

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019784--F:NEDD8-specific protease activity
GO:0000338--P:protein deneddylation

KEGG

spo:SPBC17D11.01

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000648	Aegilops tauschii	28.04	3.00e-06	44.70
IUUC-Aml-001531	Ailuropoda melanoleuca	27.57	4.00e-13	65.90
IUUC-Apl-004195	Anas platyrhynchos	32.76	1.00e-16	77.40
IUUC-Aca-004786	Anolis carolinensis	28.48	3.00e-10	56.60
IUUC-Aly-005844	Arabidopsis lyrata	26.05	2.00e-09	53.50
IUUC-Ath-006941	Arabidopsis thaliana	25.36	7.00e-08	48.50
IUUC-Ame-011123	Astyanax mexicanus	29.14	3.00e-11	59.70
IUUC-Bdi-014628	Brachypodium distachyon	32.35	1.00e-05	41.60
IUUC-Bol-015265	Brassica oleracea	27.22	1.00e-12	64.70
IUUC-Bra-017473	Brassica rapa	27.81	3.00e-10	56.60
IUUC-Cel-018221	Caenorhabditis elegans	23.95	7.00e-06	42.00
IUUC-Cpo-022076	Cavia porcellus	29.19	2.00e-14	70.10
IUUC-Cre-022914	Chlamydomonas reinhardtii	32.52	3.00e-08	50.10
IUUC-Dre-027976	Danio rerio	29.65	1.00e-13	67.40
IUUC-Dme-031655	Drosophila melanogaster	29.71	4.00e-18	82.80
IUUC-Fal-037240	Ficedula albicollis	32.18	3.00e-17	79.70
IUUC-Gmo-039320	Gadus morhua	31.40	3.00e-16	76.30
IUUC-Gga-040846	Gallus gallus	29.60	8.00e-17	78.20
IUUC-Hvu-047187	Hordeum vulgare	28.85	9.00e-07	45.10
IUUC-Lpe-051072	Leersia perrieri	26.87	8.00e-03	33.10
IUUC-Loc-052263	Lepisosteus oculatus	29.07	1.00e-13	67.80
IUUC-Mtr-058308	Medicago truncatula	28.45	3.00e-11	59.70
IUUC-Mga-059787	Meleagris gallopavo	33.91	6.00e-17	78.60
IUUC-Mdo-062222	Monodelphis domestica	28.11	8.00e-15	71.60
IUUC-Mpu-065843	Mustela putorius furo	27.57	4.00e-13	66.20
IUUC-Ont-072612	Oreochromis niloticus	26.15	9.00e-08	48.10
IUUC-Oba-075541	Oryza barthii	28.68	3.00e-04	38.10
IUUC-Obr-076358	Oryza brachyantha	28.97	3.00e-03	34.70
IUUC-Ogl-077166	Oryza glaberrima	29.75	3.00e-05	40.00
IUUC-Ogu-078617	Oryza glumaepatula	25.41	8.00e-05	40.00
IUUC-Oin-080040	Oryza indica	27.55	2.00e-05	43.10
IUUC-Olo-080606	Oryza longistaminata	29.23	2.00e-06	45.10
IUUC-Ome-081960	Oryza meridionalis	22.89	2.00e-07	47.80
IUUC-Oni-082261	Oryza nivara	28.82	1.00e-07	49.70
IUUC-Oru-084632	Oryza rufipogon	28.32	4.00e-08	51.60
IUUC-Osa-085530	Oryza sativa	27.66	2.00e-05	40.40
IUUC-Ola-087005	Oryzias latipes	25.00	2.00e-03	33.50
IUUC-Oga-088415	Otolemur garnettii	28.11	2.00e-14	70.10
IUUC-Oar-089344	Ovis aries	28.49	2.00e-15	73.60
IUUC-Psi-093874	Pelodiscus sinensis	32.18	2.00e-15	73.60
IUUC-Pfo-097485	Poecilia formosa	25.15	2.00e-08	50.80
IUUC-Pop-099754	Populus trichocarpa	25.00	4.00e-09	53.10
IUUC-Ppe-101897	Prunus persica	27.09	5.00e-13	65.90
IUUC-Ptt-103823	Puccinia triticina	33.33	4.10e-02	28.90
IUUC-Rno-105791	Rattus norvegicus	29.02	4.00e-14	69.30
IUUC-Sja-107808	Schizosaccharomyces japonicus	54.55	5.00e-78	282.00
IUUC-Sit-110301	Setaria italica	29.46	9.00e-07	45.10
IUUC-Stu-112872	Solanum tuberosum	31.40	5.00e-12	62.40
IUUC-Sbi-113811	Sorghum bicolor	27.10	4.00e-05	40.40
IUUC-Sre-114940	Sporisorium reilianum	22.53	4.00e-08	49.70
IUUC-Tgu-117518	Taeniopygia guttata	32.76	4.00e-17	79.30
IUUC-Tru-118187	Takifugu rubripes	29.45	2.00e-09	53.90
IUUC-Tae-123260	Triticum aestivum	29.52	2.00e-06	44.30
IUUC-Tur-126065	Triticum urartu	25.56	4.00e-05	40.40
IUUC-Uma-129463	Ustilago maydis	26.73	1.00e-06	44.70
IUUC-Vvi-131735	Vitis vinifera	24.88	1.00e-10	57.40
IUUC-Xma-134199	Xiphophorus maculatus	25.15	2.00e-08	50.40

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence