iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046832

Ensembl Protein ID

ENSP00000265713.2

UniProt Accession

Q92794; Q76L81; KAT6A_HUMAN

Genbank Protein ID

AAC50662.1; BAD00088.1

Protein Name

Histone acetyltransferase KAT6A; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; Monocytic leukemia zinc finger protein; Runt-related transcription factor-binding protein 2; Zinc finger protein 220

Genbank Nucleotide ID

U47742; AC090571

Gene Name

KAT6A; MOZ; MYST3; RUNXBP2; ZNF220

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000083168.9	ENST00000265713.6	ENSP00000265713.2
ENSG00000083168.9	ENST00000418721.5	ENSP00000399638.1
ENSG00000083168.9	ENST00000485568.5	ENSP00000430606.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.10e-09	37.6	263	312

Active Site

Position(s)	Description	Evidence
680	Proton donor/acceptor	{ECO:0000250\|UniProtKB:Q9H7Z6}

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           k C  C+++g++ ++++ C+ C++ fH +C  ++  + +p+   wiC+ Cr 
   Q: 263  KTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPP-LTRMPKGM-WICQICRP 312
           68999******99*********************.9*****97.******85 PP

Organism

Homo sapiens

Functional Description
(View)

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.

Protein Sequence
(Fasta)

MVKLANPLYT EWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRKTVLEQ LELSVKDGTI 60
LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDNKQNVDWN KLIKRAVEGL AESGGSTLKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCACTGTCT CCAAGATGGC GGCCGTGTCA GTTTGGGGCA TCTCCGCGGT CCGGCCCGGG 60
GCCCCGGGAT CTCGGCTGTC CTTCCTCCCG GTAAGTAGCC GAGGGGCCGT TCCCGGCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0156--Chromatin regulator
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0656--Proto-oncogene
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR002717--HAT_MYST-type
IPR005818--Histone_H1/H5_H15
IPR031280--KAT6A
IPR011991--WHTH_DNA-bd_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51504--H15
PS51726--MYST_HAT
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF01853--MOZ_SAS
PF00628--PHD

SMART

SM00526--H15
SM00249--PHD

Gene Ontology

GO:0005829--C:cytosol
GO:0070776--C:MOZ/MORF histone acetyltransferase complex
GO:0016607--C:nuclear speck
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0000786--C:nucleosome
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0016407--F:acetyltransferase activity
GO:0003677--F:DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0003713--F:transcription coactivator activity
GO:0008134--F:transcription factor binding
GO:0008270--F:zinc ion binding
GO:0090398--P:cellular senescence
GO:0006323--P:DNA packaging
GO:0016573--P:histone acetylation
GO:0043966--P:histone H3 acetylation
GO:0030099--P:myeloid cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006334--P:nucleosome assembly
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006473--P:protein acetylation
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:7994

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001219	Ailuropoda melanoleuca	92.48	0.00e+00	2445.00
IUUC-Aca-004549	Anolis carolinensis	75.82	0.00e+00	1642.00
IUUC-Ame-010711	Astyanax mexicanus	67.95	0.00e+00	630.00
IUUC-Bta-013426	Bos taurus	91.18	0.00e+00	1994.00
IUUC-Cja-019124	Callithrix jacchus	97.22	0.00e+00	2150.00
IUUC-Cfa-021165	Canis familiaris	93.75	0.00e+00	2429.00
IUUC-Cpo-022332	Cavia porcellus	86.65	0.00e+00	1623.00
IUUC-Cne-026801	Cryptococcus neoformans	63.59	2.00e-73	271.00
IUUC-Dre-028624	Danio rerio	79.69	0.00e+00	677.00
IUUC-Dno-029878	Dasypus novemcinctus	87.11	0.00e+00	1934.00
IUUC-Ete-032342	Echinops telfairi	93.69	0.00e+00	1841.00
IUUC-Eca-033925	Equus caballus	92.48	0.00e+00	2384.00
IUUC-Fca-035985	Felis catus	93.75	0.00e+00	2437.00
IUUC-Gmo-039182	Gadus morhua	73.38	0.00e+00	1197.00
IUUC-Gga-041028	Gallus gallus	81.28	0.00e+00	1798.00
IUUC-Gac-042131	Gasterosteus aculeatus	73.15	0.00e+00	1185.00
IUUC-Gma-044341	Glycine max	42.37	5.00e-10	60.10
IUUC-Ggo-044664	Gorilla gorilla	99.51	0.00e+00	2166.00
IUUC-Loc-052537	Lepisosteus oculatus	76.57	0.00e+00	1245.00
IUUC-Laf-053686	Loxodonta africana	92.49	0.00e+00	2377.00
IUUC-Mcc-055429	Macaca mulatta	98.52	0.00e+00	2143.00
IUUC-Mvi-060531	Microbotryum violaceum	54.91	5.00e-72	266.00
IUUC-Mmr-061249	Microcebus murinus	90.74	0.00e+00	2868.00
IUUC-Mdo-062826	Monodelphis domestica	66.92	0.00e+00	765.00
IUUC-Mmu-063474	Mus musculus	87.51	0.00e+00	2006.00
IUUC-Mpu-066585	Mustela putorius furo	93.73	0.00e+00	2427.00
IUUC-Mlu-066965	Myotis lucifugus	91.64	0.00e+00	2325.00
IUUC-Nle-069270	Nomascus leucogenys	98.85	0.00e+00	2155.00
IUUC-Opr-070963	Ochotona princeps	78.68	0.00e+00	1656.00
IUUC-Ont-071466	Oreochromis niloticus	70.28	2.00e-180	627.00
IUUC-Oan-073367	Ornithorhynchus anatinus	86.30	0.00e+00	2236.00
IUUC-Ocu-074100	Oryctolagus cuniculus	83.33	0.00e+00	1799.00
IUUC-Ola-087293	Oryzias latipes	68.26	0.00e+00	1191.00
IUUC-Oga-089052	Otolemur garnettii	95.05	0.00e+00	844.00
IUUC-Oar-089692	Ovis aries	89.68	0.00e+00	1894.00
IUUC-Ptr-091107	Pan troglodytes	99.59	0.00e+00	2141.00
IUUC-Pan-092524	Papio anubis	98.28	0.00e+00	2139.00
IUUC-Pfo-096641	Poecilia formosa	70.24	0.00e+00	1183.00
IUUC-Pab-098311	Pongo abelii	98.69	0.00e+00	2169.00
IUUC-Pca-100810	Procavia capensis	89.63	0.00e+00	1804.00
IUUC-Pgr-103522	Puccinia graminis	50.40	1.00e-68	255.00
IUUC-Pyt-104594	Pyrenophora triticirepentis	36.67	6.00e-46	179.00
IUUC-Rno-104990	Rattus norvegicus	89.26	0.00e+00	1955.00
IUUC-Sha-106816	Sarcophilus harrisii	87.91	0.00e+00	1963.00
IUUC-Sre-115066	Sporisorium reilianum	55.56	1.00e-77	285.00
IUUC-Tgu-116639	Taeniopygia guttata	81.49	0.00e+00	1800.00
IUUC-Tru-118571	Takifugu rubripes	73.28	0.00e+00	1210.00
IUUC-Tni-119936	Tetraodon nigroviridis	75.00	0.00e+00	1229.00
IUUC-Tbe-127928	Tupaia belangeri	97.91	0.00e+00	1604.00
IUUC-Uma-129445	Ustilago maydis	56.84	2.00e-79	291.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence