iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033978

UUCD1 version

UUC-EqC-00781

Ensembl Protein ID

ENSECAP00000000730.1

UniProt Accession

F7CAI5; F7CAI5_HORSE

Protein Name

Uncharacterized protein

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000000544.1	ENSECAT00000000904.1	ENSECAP00000000730.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-121	406.5	1237	1569

Active Site

Position(s)	Description	Evidence
1537	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1237 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1322
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1323 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1405
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1406 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1492
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1493 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1569
           **************************************************************************985 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MTLQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTAGCT CAGCCCGGGA GCACCTGCTT TTTGTGCGGC GTCGAAATCC CCAGATGCGG 60
TACACACTGA GCCCAGAGAA CCTCCAGAGC CTGGCCGCCC AGAGCTCCAT GCCCGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	96.63	0.00e+00	2987.00
IUUC-Apl-003935	Anas platyrhynchos	86.13	0.00e+00	2709.00
IUUC-Aca-004558	Anolis carolinensis	83.97	0.00e+00	2647.00
IUUC-Ame-010893	Astyanax mexicanus	88.61	0.00e+00	1310.00
IUUC-Bta-013093	Bos taurus	96.47	0.00e+00	1576.00
IUUC-Cja-019651	Callithrix jacchus	95.09	0.00e+00	2834.00
IUUC-Cfa-021232	Canis familiaris	99.12	0.00e+00	1623.00
IUUC-Cpo-021770	Cavia porcellus	89.45	0.00e+00	2811.00
IUUC-Csa-023970	Chlorocebus sabaeus	96.37	0.00e+00	2931.00
IUUC-Cho-024512	Choloepus hoffmanni	87.91	0.00e+00	2633.00
IUUC-Csv-026127	Ciona savignyi	72.27	4.00e-155	540.00
IUUC-Dre-028275	Danio rerio	84.16	0.00e+00	1487.00
IUUC-Dno-029963	Dasypus novemcinctus	94.30	0.00e+00	2802.00
IUUC-Dor-030282	Dipodomys ordii	90.00	0.00e+00	2003.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	659.00
IUUC-Ete-033132	Echinops telfairi	83.31	0.00e+00	1261.00
IUUC-Eeu-035278	Erinaceus europaeus	64.65	0.00e+00	1223.00
IUUC-Fca-036157	Felis catus	96.50	0.00e+00	2949.00
IUUC-Fal-037110	Ficedula albicollis	83.12	0.00e+00	2379.00
IUUC-Gmo-039291	Gadus morhua	73.80	0.00e+00	1154.00
IUUC-Gga-040821	Gallus gallus	86.29	0.00e+00	2706.00
IUUC-Gac-042181	Gasterosteus aculeatus	84.46	0.00e+00	1425.00
IUUC-Ggo-044862	Gorilla gorilla	96.42	0.00e+00	2848.00
IUUC-Hsa-046219	Homo sapiens	96.56	0.00e+00	3005.00
IUUC-Lch-050526	Latimeria chalumnae	78.19	0.00e+00	2442.00
IUUC-Loc-052648	Lepisosteus oculatus	79.39	0.00e+00	1539.00
IUUC-Laf-054005	Loxodonta africana	95.80	0.00e+00	2982.00
IUUC-Mcc-055314	Macaca mulatta	96.44	0.00e+00	2923.00
IUUC-Meu-056356	Macropus eugenii	70.22	0.00e+00	1142.00
IUUC-Mga-060074	Meleagris gallopavo	85.82	0.00e+00	2601.00
IUUC-Mmr-061526	Microcebus murinus	96.25	0.00e+00	2912.00
IUUC-Mdo-063017	Monodelphis domestica	90.79	0.00e+00	2827.00
IUUC-Mmu-064165	Mus musculus	93.41	0.00e+00	2890.00
IUUC-Mpu-065835	Mustela putorius furo	82.88	0.00e+00	1565.00
IUUC-Mlu-067709	Myotis lucifugus	90.39	0.00e+00	2784.00
IUUC-Nle-069308	Nomascus leucogenys	96.31	0.00e+00	2968.00
IUUC-Opr-070330	Ochotona princeps	82.00	0.00e+00	2391.00
IUUC-Ont-071345	Oreochromis niloticus	78.10	0.00e+00	1454.00
IUUC-Ocu-074775	Oryctolagus cuniculus	94.66	0.00e+00	2630.00
IUUC-Ola-087225	Oryzias latipes	64.12	0.00e+00	1848.00
IUUC-Oga-088177	Otolemur garnettii	93.46	0.00e+00	2802.00
IUUC-Oar-089452	Ovis aries	97.01	0.00e+00	2978.00
IUUC-Ptr-090806	Pan troglodytes	96.50	0.00e+00	2994.00
IUUC-Pan-091838	Papio anubis	96.16	0.00e+00	2807.00
IUUC-Psi-094090	Pelodiscus sinensis	85.77	0.00e+00	2699.00
IUUC-Pfo-096520	Poecilia formosa	68.69	0.00e+00	1524.00
IUUC-Pab-098405	Pongo abelii	96.56	0.00e+00	2973.00
IUUC-Pca-100441	Procavia capensis	90.52	0.00e+00	2285.00
IUUC-Pva-102324	Pteropus vampyrus	98.74	0.00e+00	1617.00
IUUC-Rno-105943	Rattus norvegicus	93.66	0.00e+00	2976.00
IUUC-Sha-106985	Sarcophilus harrisii	88.26	0.00e+00	2355.00
IUUC-Sar-113505	Sorex araneus	95.20	0.00e+00	1531.00
IUUC-Ssc-115439	Sus scrofa	95.96	0.00e+00	1987.00
IUUC-Tgu-117078	Taeniopygia guttata	91.01	0.00e+00	1759.00
IUUC-Tru-118671	Takifugu rubripes	81.24	0.00e+00	1448.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.64	0.00e+00	1422.00
IUUC-Tbe-127975	Tupaia belangeri	93.85	0.00e+00	2454.00
IUUC-Ttr-128469	Tursiops truncatus	91.41	0.00e+00	2693.00
IUUC-Vpa-130498	Vicugna pacos	85.96	0.00e+00	2492.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence